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BR112012008858A2 - métodos para preparar éster do ácido aril-2-tetrazolil-etil carbânico, e um composto de álcool. - Google Patents

métodos para preparar éster do ácido aril-2-tetrazolil-etil carbânico, e um composto de álcool.

Info

Publication number
BR112012008858A2
BR112012008858A2 BR112012008858A BR112012008858A BR112012008858A2 BR 112012008858 A2 BR112012008858 A2 BR 112012008858A2 BR 112012008858 A BR112012008858 A BR 112012008858A BR 112012008858 A BR112012008858 A BR 112012008858A BR 112012008858 A2 BR112012008858 A2 BR 112012008858A2
Authority
BR
Brazil
Prior art keywords
acid ester
methods
alcohol compound
tetrazolyl
preparing aryl
Prior art date
Application number
BR112012008858A
Other languages
English (en)
Other versions
BR112012008858B1 (pt
Inventor
Dae Won Lee
Dong Ho Lee
Hui Ho Kim
Hyun Seok Lee
Moo Yong Uhm
Sang Chul Lim
Original Assignee
Sk Biopharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sk Biopharmaceuticals Co Ltd filed Critical Sk Biopharmaceuticals Co Ltd
Publication of BR112012008858A2 publication Critical patent/BR112012008858A2/pt
Publication of BR112012008858B1 publication Critical patent/BR112012008858B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C07D257/06—Five-membered rings with nitrogen atoms directly attached to the ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

métodos para preparar éster do ácido aril-2-tetrazolil-etil carbânico, e um composto de álcool - é descrito um método para a preparação de éster do ácido (r)-1-aril-2-tetrazolil-etil carbâmico, que compreende a redução da enzima enantiosseletiva da arilcetona correspondente e a carbamação do álcool resultante.
BR112012008858-0A 2009-10-15 2010-10-15 Métodos para preparar um éster do ácido aril-2-tetrazolil-etil carbâmico e um composto de álcool BR112012008858B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25186709P 2009-10-15 2009-10-15
US61/251,867 2009-10-15
PCT/KR2010/007069 WO2011046380A2 (en) 2009-10-15 2010-10-15 Method for preparation of carbamic acid (r)-1-aryl-2-tetrazolyl-ethyl ester

Publications (2)

Publication Number Publication Date
BR112012008858A2 true BR112012008858A2 (pt) 2015-09-22
BR112012008858B1 BR112012008858B1 (pt) 2021-07-20

Family

ID=43876717

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012008858-0A BR112012008858B1 (pt) 2009-10-15 2010-10-15 Métodos para preparar um éster do ácido aril-2-tetrazolil-etil carbâmico e um composto de álcool

Country Status (19)

Country Link
US (3) US8404461B2 (pt)
EP (1) EP2488505B1 (pt)
JP (1) JP5797656B2 (pt)
KR (1) KR101708437B1 (pt)
CN (1) CN102574821B (pt)
AU (1) AU2010307466B2 (pt)
BR (1) BR112012008858B1 (pt)
CA (1) CA2776743C (pt)
CL (1) CL2012000959A1 (pt)
ES (1) ES2536488T3 (pt)
HK (1) HK1172625A1 (pt)
HU (1) HUE025816T2 (pt)
IL (1) IL218787A0 (pt)
MX (1) MX2012004055A (pt)
MY (1) MY162997A (pt)
PL (1) PL2488505T3 (pt)
RU (1) RU2539983C2 (pt)
WO (1) WO2011046380A2 (pt)
ZA (1) ZA201202629B (pt)

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US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
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KR102421006B1 (ko) * 2016-05-19 2022-07-14 에스케이바이오팜 주식회사 두통의 예방학적 치료를 위한 카바메이트 화합물의 용도
KR102421013B1 (ko) * 2016-05-19 2022-07-14 에스케이바이오팜 주식회사 삼차신경통을 예방 또는 치료하기 위한 카바메이트 화합물의 용도
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US10905675B2 (en) 2016-12-14 2021-02-02 Sk Biopharmaceuticals Co., Ltd. Use of carbamate compound for prevention, alleviation or treatment of pruritus
WO2018111006A1 (ko) 2016-12-14 2018-06-21 에스케이바이오팜 주식회사 탈수초성 질환의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도
MX2019006940A (es) 2016-12-14 2019-09-06 Sk Biopharmaceuticals Co Ltd Uso de compuestos de carbamato para prevencion, alivio o tratamiento del trastorno bipolar.
KR20200074157A (ko) 2017-11-14 2020-06-24 에스케이바이오팜 주식회사 카바메이트 화합물을 포함하는 조현병의 예방, 경감 또는 치료용 배합물
CN111432812A (zh) 2017-11-14 2020-07-17 爱思开生物制药株式会社 用于预防、减轻或治疗失神发作或显示失神发作的癫痫的氨基甲酸酯化合物的用途
WO2019098632A1 (ko) 2017-11-14 2019-05-23 에스케이바이오팜 주식회사 근긴장증의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도
EP3711757A4 (en) 2017-11-14 2021-11-24 SK Biopharmaceuticals Co., Ltd. USE OF A CARBAMATE COMPOUND TO PREVENT, RELIEVE OR TREAT VISCERALGIA OR PAIN CAUSED BY VISCERAL DISEASE
JP7258902B2 (ja) 2017-11-14 2023-04-17 エスケー バイオファーマスティカルズ カンパニー リミテッド 脆弱ｘ症候群、アンジェルマン症候群又はレット症候群を含む発達障害の軽減又は治療のためのカルバメート化合物の使用
KR20200074152A (ko) 2017-11-14 2020-06-24 에스케이바이오팜 주식회사 후기 나트륨 전류의 증가와 관련된 질환을 예방 또는 치료하기 위한 카바메이트 화합물의 용도
JP7417595B2 (ja) 2018-09-21 2024-01-18 エスケー バイオファーマスティカルズ カンパニー リミテッド てんかん重積状態の予防、軽減又は治療のためのカルバメート化合物の使用
BR112021005193A2 (pt) 2018-09-21 2021-06-08 Sk Biopharmaceuticals Co., Ltd. medicamento e combinação para a prevenção, alívio ou tratamento de transtorno de estresse agudo ou transtorno de estresse pós-traumático, e, medicamento para a prevenção, alívio ou tratamento de sintoma de transtorno de estresse pós-traumático
EP3868375A4 (en) 2018-10-19 2022-06-29 SK Biopharmaceuticals Co., Ltd. Use of carbamate compound for preventing, alleviating or treating diabetic peripheral neuropathy or chemotherapy-induced peripheral neuropathy
US10611737B1 (en) 2019-10-24 2020-04-07 Sk Biopharmaceuticals Co., Ltd. Method for preparing aryl 2-tetrazol-2-yl ketone with improved selectivity
CN118221604A (zh) * 2019-10-24 2024-06-21 爱思开生物制药株式会社 具有改进的选择性的制备芳基2-四唑-2-基酮的方法
EP4062906A4 (en) 2019-11-22 2024-01-03 SK Biopharmaceuticals Co., Ltd. ORAL PHARMACEUTICAL COMPOSITION COMPRISING A CARBAMATE COMPOUND AND METHOD FOR PREPARING THIS COMPOSITION
CN111705096A (zh) * 2020-06-29 2020-09-25 上海舒泽生物科技研究所 一种酶转化法生产β-烟酰胺单核苷酸的方法
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ES2931000B2 (es) * 2022-07-14 2023-07-07 Univ Madrid Complutense Proceso para la preparación de cenobamato

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US20150252398A1 (en) 2015-09-10
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