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ES2322323T1 - Procedimientos para producir miembros de pares de union especificos. - Google Patents

Procedimientos para producir miembros de pares de union especificos. Download PDF

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Publication number
ES2322323T1
ES2322323T1 ES09001901T ES09001901T ES2322323T1 ES 2322323 T1 ES2322323 T1 ES 2322323T1 ES 09001901 T ES09001901 T ES 09001901T ES 09001901 T ES09001901 T ES 09001901T ES 2322323 T1 ES2322323 T1 ES 2322323T1
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binding
molecule
particle
filamentous bacteriophage
filamentous
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ES2322323T3 (es
Inventor
John Mccafferty
Anthony Richard Pope
Kevin Stuart Johnson
Hendricus Renerus Jacobus Mattheus Hoogenboom
Andrew David Griffiths
Ronald Henry Jackson
Kaspar Philipp Holliger
James David Marks
Timothy Piers Clackson
David John Chiswell
Gregory Paul Winter
Timothy Peter Bonnert
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Medical Research Council
MedImmune Ltd
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Medical Research Council
MedImmune Ltd
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Priority claimed from GB909024503A external-priority patent/GB9024503D0/en
Priority claimed from GB919104744A external-priority patent/GB9104744D0/en
Priority claimed from GB919110549A external-priority patent/GB9110549D0/en
Application filed by Medical Research Council, MedImmune Ltd filed Critical Medical Research Council
Publication of ES2322323T1 publication Critical patent/ES2322323T1/es
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Publication of ES2322323T3 publication Critical patent/ES2322323T3/es
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/46—Hybrid immunoglobulins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
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    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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Abstract

Procedimiento para producir una molécula con especificidad de unión para un objetivo particular, cuyo procedimiento comprende: producir una población de partículas de bacteriófago filamentoso que presentan en su superficie una población de moléculas de unión que tienen un grupo de propiedades de unión, donde las moléculas de unión comprenden dominios de anticuerpo de unión a antígeno para miembros de pares de unión específicos complementarios, las moléculas de unión se presentan en la superficie de las partículas de bacteriófago filamentoso por fusión con una proteína de gen III de las partículas de bacteriófago filamentoso, y donde cada partícula de bacteriófago filamentoso contiene ácido nucleico que codifica la molécula de unión expresada del ácido nucleico y presentadas por la partícula en su superficie; seleccionar una partícula de bacteriófago filamentoso que presenta una molécula de unión con una propiedad de unión deseada, mediante la puesta en contacto de la población de partículas de bacteriófago filamentoso con un objetivo, a los efectos de que las moléculas de unión individuales presentadas sobre las partículas de bacteriófago filamentoso con la propiedad de unión deseada se unan a dicha diana; separar partículas de unión del bacteriófago filamentoso de la diana; recuperar partículas de bacteriófago filamentoso separadas que presentan una molécula de unión con la propiedad de unión deseada; aislar ácido nucleico que codifica la molécula de unión de partículas de bacteriófago filamentoso separadas; insertar ácido nucleico que codifica la molécula de unión, o un fragmento o derivado del mismo con especificidad de unión para la diana, en un sistema recombinante; y producir en el sistema recombinante separado de las partículas de bacteriófago filamentoso una molécula con especificidad de unión para la diana, donde la molécula es dicha molécula de unión o un fragmento o derivado del mismo con especificidad de unión para el objetivo.

Claims (5)

1. Procedimiento para producir una molécula con especificidad de unión para un objetivo particular, cuyo procedimiento comprende:
producir una población de partículas de bacteriófago filamentoso que presentan en su superficie una población de moléculas de unión que tienen un grupo de propiedades de unión, donde las moléculas de unión comprenden dominios de anticuerpo de unión a antígeno para miembros de pares de unión específicos complementarios, las moléculas de unión se presentan en la superficie de las partículas de bacteriófago filamentoso por fusión con una proteína de gen III de las partículas de bacteriófago filamentoso, y donde cada partícula de bacteriófago filamentoso contiene ácido nucleico que codifica la molécula de unión expresada del ácido nucleico y presentadas por la partícula en su superficie;
seleccionar una partícula de bacteriófago filamentoso que presenta una molécula de unión con una propiedad de unión deseada, mediante la puesta en contacto de la población de partículas de bacteriófago filamentoso con un objetivo, a los efectos de que las moléculas de unión individuales presentadas sobre las partículas de bacteriófago filamentoso con la propiedad de unión deseada se unan a dicha diana;
separar partículas de unión del bacteriófago filamentoso de la diana;
recuperar partículas de bacteriófago filamentoso separadas que presentan una molécula de unión con la propiedad de unión deseada;
aislar ácido nucleico que codifica la molécula de unión de partículas de bacteriófago filamentoso separadas;
insertar ácido nucleico que codifica la molécula de unión, o un fragmento o derivado del mismo con especificidad de unión para la diana, en un sistema recombinante; y
producir en el sistema recombinante separado de las partículas de bacteriófago filamentoso una molécula con especificidad de unión para la diana, donde la molécula es dicha molécula de unión o un fragmento o derivado del mismo con especificidad de unión para el objetivo.
2. Procedimiento según la reivindicación 1 donde el ácido nucleico que codifica las moléculas de unión en la población se obtiene mediante la combinación in vitro de segmentos V no reordenados con segmentos D y J.
3. Procedimiento según la reivindicación 2 donde el ácido nucleico que codifica las moléculas de unión en la población es derivado por medio de mutagénesis in vitro de una secuencia de codificación de anticuerpo existente.
4. Una partícula de bacteriófago filamentosa que presenta en su superficie una molécula de unión que comprende un dominio de unión capaz de unir un miembro de pares de unión, donde la molécula de unión se presenta en la superficie de la partícula de bacteriófago filamentoso mediante fusión con una proteína de gen III de la partícula de bacteriófago filamentoso, donde el dominio de unión es un dominio de anticuerpo de unión a antígeno, conteniendo la partícula ácido nucleico que codifica la molécula de unión expresada desde el ácido nucleico y presentada por la partícula en su superficie.
5. Población de partículas de bacteriófago filamentoso según la reivindicación 4 que presentan una población de dichas moléculas de unión que tiene un rango de propiedades de unión.
ES09001901T 1990-07-10 1991-07-10 Procedimientos para producir miembros de pares de union especificos. Expired - Lifetime ES2322323T3 (es)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB9015198 1990-07-10
GB909015198A GB9015198D0 (en) 1990-07-10 1990-07-10 Binding substance
GB909022845A GB9022845D0 (en) 1990-07-10 1990-10-19 Antibodies
GB9022845 1990-10-19
GB909024503A GB9024503D0 (en) 1990-11-12 1990-11-12 Binding substances
GB9024503 1990-11-12
GB919104744A GB9104744D0 (en) 1991-03-06 1991-03-06 Binding substances
GB9104744 1991-03-06
GB9110549 1991-05-15
GB919110549A GB9110549D0 (en) 1991-05-15 1991-05-15 Binding substances

Publications (2)

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ES2322323T1 true ES2322323T1 (es) 2009-06-19
ES2322323T3 ES2322323T3 (es) 2010-04-08

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Application Number Title Priority Date Filing Date
ES04005419T Expired - Lifetime ES2285292T3 (es) 1990-07-10 1991-07-10 Particulas de bacteriofagos que presenta dabs.
ES96112510T Expired - Lifetime ES2171581T3 (es) 1990-07-10 1991-07-10 Procedimiento a base de fagemidos de produccion de fragmentos de bacteriofagos filamentosos que presentan moleculas de anticuerpos y los fragmentos de bacteriofagos correspondientes.
ES97120149T Expired - Lifetime ES2275280T3 (es) 1990-07-10 1991-07-10 Procedimientos de produccion de miembros de pares de ligandos especificos.
ES09001901T Expired - Lifetime ES2322323T3 (es) 1990-07-10 1991-07-10 Procedimientos para producir miembros de pares de union especificos.
ES91913039T Expired - Lifetime ES2096655T5 (es) 1990-07-10 1991-07-10 Procedimiento para la produccion de fragmentos funcionales de anticuerpos fv de cadena simple en la superficie de particulas de bacteriofagos.

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ES04005419T Expired - Lifetime ES2285292T3 (es) 1990-07-10 1991-07-10 Particulas de bacteriofagos que presenta dabs.
ES96112510T Expired - Lifetime ES2171581T3 (es) 1990-07-10 1991-07-10 Procedimiento a base de fagemidos de produccion de fragmentos de bacteriofagos filamentosos que presentan moleculas de anticuerpos y los fragmentos de bacteriofagos correspondientes.
ES97120149T Expired - Lifetime ES2275280T3 (es) 1990-07-10 1991-07-10 Procedimientos de produccion de miembros de pares de ligandos especificos.

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ES91913039T Expired - Lifetime ES2096655T5 (es) 1990-07-10 1991-07-10 Procedimiento para la produccion de fragmentos funcionales de anticuerpos fv de cadena simple en la superficie de particulas de bacteriofagos.

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US (7) US5969108A (es)
EP (7) EP1433846B1 (es)
JP (1) JP3176917B2 (es)
KR (1) KR100222326B1 (es)
AT (6) ATE358720T1 (es)
AU (1) AU664155B2 (es)
CA (1) CA2086936C (es)
DE (7) DE09001901T1 (es)
DK (5) DK1433846T3 (es)
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GB (2) GB9015198D0 (es)
GR (1) GR3022126T3 (es)
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LU (1) LU91623I2 (es)
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