[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

JOP20200308A1 - جزيئات إرتباط il-18 - Google Patents

جزيئات إرتباط il-18

Info

Publication number
JOP20200308A1
JOP20200308A1 JOP/2020/0308A JOP20200308A JOP20200308A1 JO P20200308 A1 JOP20200308 A1 JO P20200308A1 JO P20200308 A JOP20200308 A JO P20200308A JO P20200308 A1 JOP20200308 A1 JO P20200308A1
Authority
JO
Jordan
Prior art keywords
binding molecules
bind
bound
complex
inflammatory diseases
Prior art date
Application number
JOP/2020/0308A
Other languages
English (en)
Inventor
Carsten Silvester Kunz Christian
Diefenbach-Streiber Beate
Rene Rondeau Jean-Michel
Anselmus Van Heeke Gino
Otto Bardroff Michael
Alfred Schlaeppi Jean-Marc
Michelle Campbell Emma
Eberth Adina
Brannetti Barbara
Marshall Sylwia
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49596347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JOP20200308(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of JOP20200308A1 publication Critical patent/JOP20200308A1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

IL-18 يشارك في كلٍّ من المناعة الفطرية والمكتسبة. يتم تنظيم النشاط الحيوي لـ IL-18 سلبيا عن طريق بروتين ربط IL-18 (IL18BP)، وهو مثبط طبيعي وعالي التخصص. يشكل هذا البروتين الذائب مركّب مع IL-18 الحر يمنع تفاعله مع مستقبل IL-18، بالتالي تتمّ معادلة نشاطه البيولوجي وتثبيطه. يتضمن الإختراع الحالي جزيئات الإرتباط، وبشكل خاص الأجسام المضادة أو شظايا منها، تربط IL-18 ولا تربط IL-18 المرتبط بـ IL-18BP (معقد IL-18/IL-18BP). بعيدا عن الدور الفسيولوجي، تبيّن أنّ IL-18 يعمل كوسيطٍ في مختلف الأمراض ذاتية المناعة والإلتهابية. يمكن استخدام جزيئات الإرتباط الخاصة بالإختراع كجزيئات علاجية لمعالجة الأمراض الإلتهابية وذاتية المناعة المتعلقة بـ IL-18 أو أدوات تشخيصية لتوصيف وكشف و/أو قياس IL-18 غير المرتبط بـ IL-18BP كمكون من IL-18 الكلي.
JOP/2020/0308A 2012-09-07 2012-09-07 جزيئات إرتباط il-18 JOP20200308A1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261697981P 2012-09-07 2012-09-07

Publications (1)

Publication Number Publication Date
JOP20200308A1 true JOP20200308A1 (ar) 2017-06-16

Family

ID=49596347

Family Applications (2)

Application Number Title Priority Date Filing Date
JOP/2020/0308A JOP20200308A1 (ar) 2012-09-07 2012-09-07 جزيئات إرتباط il-18
JOP/2013/0269A JO3764B1 (ar) 2012-09-07 2013-09-05 جزيئات إرتباط il-18

Family Applications After (1)

Application Number Title Priority Date Filing Date
JOP/2013/0269A JO3764B1 (ar) 2012-09-07 2013-09-05 جزيئات إرتباط il-18

Country Status (41)

Country Link
US (4) US9376489B2 (ar)
EP (2) EP2892923B1 (ar)
JP (3) JP6404817B2 (ar)
KR (2) KR102207672B1 (ar)
CN (2) CN109517065B (ar)
AP (1) AP2015008266A0 (ar)
AR (1) AR092465A1 (ar)
AU (4) AU2013311234A1 (ar)
BR (2) BR122019028128B1 (ar)
CA (1) CA2883821C (ar)
CL (1) CL2015000532A1 (ar)
CO (1) CO7400884A2 (ar)
CR (1) CR20150121A (ar)
CU (1) CU24249B1 (ar)
CY (1) CY1123071T1 (ar)
DK (1) DK2892923T3 (ar)
EA (2) EA034610B1 (ar)
EC (1) ECSP15013209A (ar)
ES (1) ES2804704T3 (ar)
GT (1) GT201500054A (ar)
HK (1) HK1209136A1 (ar)
HR (1) HRP20200906T1 (ar)
HU (1) HUE050464T2 (ar)
IL (2) IL237161B (ar)
JO (2) JOP20200308A1 (ar)
LT (1) LT2892923T (ar)
MA (1) MA37892A1 (ar)
MX (2) MX2015002986A (ar)
MY (1) MY174691A (ar)
PE (1) PE20150649A1 (ar)
PH (1) PH12015500466B1 (ar)
PL (1) PL2892923T3 (ar)
PT (1) PT2892923T (ar)
RS (1) RS60394B1 (ar)
SG (2) SG10201706623WA (ar)
SI (1) SI2892923T1 (ar)
TN (1) TN2015000057A1 (ar)
TW (2) TWI613217B (ar)
UY (1) UY35016A (ar)
WO (1) WO2014037899A2 (ar)
ZA (1) ZA201500954B (ar)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20200308A1 (ar) * 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
ES2892923T3 (es) * 2013-09-05 2022-02-07 Ab2 Bio Sa Proteína de unión a IL-18 (IL-18BP) en enfermedades inflamatorias
WO2016020791A1 (en) 2014-08-05 2016-02-11 Novartis Ag Ckit antibody drug conjugates
KR102511343B1 (ko) 2015-03-05 2023-03-17 에이비2 바이오 에스에이 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) 및 항체
WO2017076805A1 (en) * 2015-11-02 2017-05-11 Glaxosmithkline Intellectual Property Development Limited Use of an inhibitor of il18 for treatment of acute kidney injury
UA126896C2 (uk) 2015-11-03 2023-02-22 Янссен Байотек, Інк. Антитіло, що специфічно зв’язується з pd-1, і спосіб його застосування
CN108218978B (zh) * 2016-12-13 2020-05-12 沈阳何氏眼产业集团有限公司 一种重组白细胞介素18及其制备方法与应用
WO2018162724A1 (en) 2017-03-09 2018-09-13 Mab Discovery Gmbh Antibodies specifically binding to human il-1r7
UY37758A (es) 2017-06-12 2019-01-31 Novartis Ag Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos
CN111315395A (zh) * 2017-09-06 2020-06-19 耶鲁大学 白细胞介素-18变体和使用方法
WO2019213686A1 (en) * 2018-05-10 2019-11-14 The Council Of The Queensland Institute Of Medical Research Therapeutic compositions and uses therefor
CA3117561A1 (en) * 2018-10-23 2020-04-30 Samantha NICHOLLS Rgmc-selective inhibitors and use thereof
EP3892300A4 (en) 2018-12-03 2022-12-14 Mabprotein Co.,Ltd. ANTIBODY RECOGNIZING A NEOEPITOPE OF ACTIVATED INTERLEUKIN-18 PROTEINS AND ITS USE
CN109870570A (zh) * 2018-12-29 2019-06-11 广东云天抗体生物科技有限公司 一种检测猴il-18的酶联免疫试剂盒
US12029778B2 (en) 2019-05-13 2024-07-09 Yale University Interleukin-18 mimics and methods of use
TW202233675A (zh) 2020-10-29 2022-09-01 瑞士商諾華公司 Ｉｌ－１８拮抗劑用於治療和／或預防異位性皮炎或相關病症之用途
WO2022221264A1 (en) * 2021-04-12 2022-10-20 Ethos Biosciences, Inc. Methods and compositions for analysis of acute kidney injury
IL308134A (en) 2021-06-22 2023-12-01 Novartis Ag BISPECIFIC ANTIBODIES FOR USE IN THE TREATMENT OF HIDRADENITIS SUPPURATIVA
WO2023286694A1 (ja) 2021-07-13 2023-01-19 国立大学法人東海国立大学機構 炎症性腸疾患を治療するための医薬組成物
WO2023134767A1 (zh) * 2022-01-14 2023-07-20 和径医药科技（上海）有限公司 一种靶向IL-18Rβ的抗体及其应用
WO2023178192A1 (en) 2022-03-15 2023-09-21 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
TW202400658A (zh) * 2022-04-26 2024-01-01 瑞士商諾華公司 靶向ｉｌ—１３和ｉｌ—１８的多特異性抗體
WO2024148243A1 (en) * 2023-01-06 2024-07-11 Lassen Therapeutics 1, Inc. Anti-il-18bp antibodies
WO2024148241A1 (en) * 2023-01-06 2024-07-11 Lassen Therapeutics 1, Inc. Anti-il-18bp antibodies

Family Cites Families (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
DE3572982D1 (en) 1984-03-06 1989-10-19 Takeda Chemical Industries Ltd Chemically modified lymphokine and production thereof
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4881175A (en) 1986-09-02 1989-11-14 Genex Corporation Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
ATE243754T1 (de) 1987-05-21 2003-07-15 Micromet Ag Multifunktionelle proteine mit vorbestimmter zielsetzung
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
GB8725529D0 (en) 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides
US5476996A (en) 1988-06-14 1995-12-19 Lidak Pharmaceuticals Human immune system in non-human animal
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
WO1990006952A1 (en) 1988-12-22 1990-06-28 Kirin-Amgen, Inc. Chemically modified granulocyte colony stimulating factor
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
ATE139258T1 (de) 1990-01-12 1996-06-15 Cell Genesys Inc Erzeugung xenogener antikörper
JPH03230220A (ja) 1990-02-05 1991-10-14 Seiko Epson Corp ソート処理方法
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ATE300615T1 (de) 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
DE69229477T2 (de) 1991-09-23 1999-12-09 Cambridge Antibody Technology Ltd., Melbourn Methoden zur Herstellung humanisierter Antikörper
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
DK1024191T3 (da) 1991-12-02 2008-12-08 Medical Res Council Fremstilling af autoantistoffer fremvist på fag-overflader ud fra antistofsegmentbiblioteker
JPH07503132A (ja) 1991-12-17 1995-04-06 ジェンファーム　インターナショナル，インコーポレイティド 異種抗体を産生することができるトランスジェニック非ヒト動物
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
EP0640094A1 (en) 1992-04-24 1995-03-01 The Board Of Regents, The University Of Texas System Recombinant production of immunoglobulin-like domains in prokaryotic cells
AU668423B2 (en) 1992-08-17 1996-05-02 Genentech Inc. Bispecific immunoadhesins
AU6819494A (en) 1993-04-26 1994-11-21 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ATE157100T1 (de) 1993-06-03 1997-09-15 Therapeutic Antibodies Inc Antikoerperfragmente in therapie
CA2163345A1 (en) 1993-06-16 1994-12-22 Susan Adrienne Morgan Antibodies
SE9400088D0 (sv) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
TW464656B (en) 1994-11-15 2001-11-21 Hayashibara Biochem Lab Interferon-gamma production inducing polypeptide monoclonal antibody, and agent for interferon-gamma susceptive disease
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
JP2007121310A (ja) 1996-07-31 2007-05-17 Hayashibara Biochem Lab Inc 自己免疫疾患診断剤
JP2009047705A (ja) 1996-07-31 2009-03-05 Hayashibara Biochem Lab Inc 生物学的試料の検出方法
US7141393B2 (en) 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
EP0983303B1 (en) 1997-05-21 2006-03-08 Biovation Limited Method for the production of non-immunogenic proteins
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
ATE272114T1 (de) 1998-01-23 2004-08-15 Immunex Corp Rezeptoren für il-18
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
AU3657899A (en) 1998-04-20 1999-11-08 James E. Bailey Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
CA2276216A1 (en) 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
MX353234B (es) 1999-01-15 2018-01-08 Genentech Inc Variantes de polipeptidos con función efectora alterada.
AR022952A1 (es) 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
PT1914244E (pt) 1999-04-09 2013-07-26 Kyowa Hakko Kirin Co Ltd Processo para regular a actividade de moléculas funcionais sob o ponto de vista imunológico
US6432678B1 (en) 1999-06-21 2002-08-13 Smithkline Beecham Corporation Macaca cynomolgus IL 18
DE19932688B4 (de) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen
EP1990409A3 (en) 1999-07-20 2011-05-18 MorphoSys AG Bacteriophage
WO2001014424A2 (en) 1999-08-24 2001-03-01 Medarex, Inc. Human ctla-4 antibodies and their uses
JP3230220B2 (ja) 1999-10-07 2001-11-19 独立行政法人 農業技術研究機構 ブタ由来インターロイキン−１８に対するモノクローナル抗体
EP1101772B1 (en) 1999-11-16 2009-01-21 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Antibody specific to interleukin 18 precursor
WO2001058956A2 (en) 2000-02-10 2001-08-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
UA94022C2 (ru) * 2000-02-21 2011-04-11 Апплайд Резеч Системз Арс Холдинг Н.В. Применение ингибитора il-18 для лечения и/или предупреждения алкогольного гепатита
CZ300792B6 (cs) 2000-05-05 2009-08-12 Applied Research Systems Ars Holding N. V. Farmaceutický prostredek
CA2412701A1 (en) 2000-06-28 2002-01-03 Glycofi, Inc. Methods for producing modified glycoproteins
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
WO2002032374A2 (en) 2000-10-18 2002-04-25 Immunex Corporation Methods for treating il-18 mediated disorders
ATE378403T1 (de) 2000-11-30 2007-11-15 Medarex Inc Transchromosomale transgen-nagetiere zur herstellung von humänen antikörpern
PL213568B1 (pl) 2001-01-29 2013-03-29 Serono Lab Zastosowanie inhibitora IL-18 oraz zastosowanie wektora ekspresyjnego
US20050053973A1 (en) 2001-04-26 2005-03-10 Avidia Research Institute Novel proteins with targeted binding
US20050048512A1 (en) 2001-04-26 2005-03-03 Avidia Research Institute Combinatorial libraries of monomer domains
US20040175756A1 (en) 2001-04-26 2004-09-09 Avidia Research Institute Methods for using combinatorial libraries of monomer domains
US20030157108A1 (en) 2001-10-25 2003-08-21 Genentech, Inc. Glycoprotein compositions
AU2002365269A1 (en) 2001-10-26 2003-07-24 Centocor, Inc. Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses
CN100540058C (zh) 2002-03-22 2009-09-16 应用研究系统Ars股份公司 Il-18抑制剂制备药物的用途
FR2838444B1 (fr) 2002-04-10 2016-01-01 Neovacs Nouveaux peptides et leur application en therapeutique
WO2004097019A1 (ja) 2003-04-30 2004-11-11 Japan Science And Technology Agency ヒト抗ヒトインターロイキン－１８抗体およびその断片、並びにそれらの利用方法
US20080076708A1 (en) 2003-05-13 2008-03-27 Valter Altarocca Active Variants of the Il-18 Binding Protein and Medical Uses Thereof
DE10324447A1 (de) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin
ATE414106T1 (de) 2003-06-30 2008-11-15 Domantis Ltd Pegylierte single-domain-antikörper (dab)
JP2005052021A (ja) 2003-08-07 2005-03-03 Yokohama City インターロイキン−１８変異体タンパク質
US20050075702A1 (en) 2003-10-01 2005-04-07 Medtronic, Inc. Device and method for inhibiting release of pro-inflammatory mediator
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
US20050100965A1 (en) * 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
WO2005075648A1 (en) 2004-01-28 2005-08-18 Gifu University Interleukin-18 mutant proteins
EP1744734A2 (en) 2004-02-20 2007-01-24 Novo Nordisk A/S Therapeutic combination comprising a tissue factor antagonist and anti-cancer compounds
WO2005097998A2 (en) 2004-03-31 2005-10-20 Regeneron Pharmaceuticals, Inc. Il-18 specific polypeptides and therapeutic uses thereof
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
JP4673068B2 (ja) 2005-01-19 2011-04-20 独立行政法人科学技術振興機構 Ｔｈ１型アレルギー疾患治療用組成物
EP1904846A4 (en) 2005-06-29 2009-03-18 Rules Based Medicine Inc METHOD AND KITS FOR THE DIAGNOSIS OF ACUTE CORONARY SYNDROME
US20090215992A1 (en) 2005-08-19 2009-08-27 Chengbin Wu Dual variable domain immunoglobulin and uses thereof
TWI323734B (en) 2005-08-19 2010-04-21 Abbott Lab Dual variable domain immunoglobulin and uses thereof
ES2937245T3 (es) 2005-08-23 2023-03-27 Univ Pennsylvania ARN que contiene nucleósidos modificados y métodos de uso del mismo
JP4728785B2 (ja) 2005-11-30 2011-07-20 独立行政法人科学技術振興機構 Ｉｌ−１８の生物活性を有する新規ポリペプチドの生産方法、および当該ポリペプチドの産生を阻害する物質のスクリーニング方法
NZ572565A (en) 2006-05-25 2011-04-29 Glaxo Group Ltd Modified humanised anti-interleukin-18 antibodies
EP2190861A4 (en) 2007-08-22 2011-03-30 Univ California ACTIVE BINDING POLYPEPTIDES AND METHOD FOR THEIR IDENTIFICATION AND USE
WO2009099545A1 (en) 2008-01-30 2009-08-13 Abbott Laboratories Compositions and methods for crystallizing antibody fragments
AR072000A1 (es) 2008-06-03 2010-07-28 Abbott Lab Proteinas de union multivalentes con capacidad de unir dos o mas antigenos y usos de la misma
NZ603698A (en) 2008-07-08 2014-03-28 Abbvie Inc Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
US20110150871A1 (en) 2008-08-18 2011-06-23 Glaxo Group Limited Treatment of an autoimmune disease using il-18 antagonists
WO2010040736A2 (en) 2008-10-07 2010-04-15 Ablynx Nv Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
WO2010048183A1 (en) 2008-10-20 2010-04-29 Abbott Laboratories Antibodies that bind to il-18 and methods of purifying the same
WO2010048192A2 (en) 2008-10-20 2010-04-29 Abbott Laboratories Viral inactivation during purification of antibodies
BRPI0923595A2 (pt) 2008-12-23 2016-01-26 Mtn Mobile Money Sa Pty Ltd método para processar seguramente uma transação, sistema para processar uma transação, e, dispositivo de comunicações móveis
AU2010242840B2 (en) 2009-05-01 2014-04-17 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
MX2012009167A (es) 2010-02-09 2012-08-23 Glaxo Group Ltd Tratamiento de un trastorno metabolico.
CN103339147A (zh) * 2010-12-20 2013-10-02 米迪缪尼有限公司 抗il-18抗体和其用途
JOP20200308A1 (ar) * 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
UY37758A (es) * 2017-06-12 2019-01-31 Novartis Ag Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos

Also Published As

Publication number Publication date
CY1123071T1 (el) 2021-10-29
PL2892923T3 (pl) 2020-09-07
RS60394B1 (sr) 2020-07-31
KR102207672B1 (ko) 2021-01-26
US20140112915A1 (en) 2014-04-24
AU2016201741A1 (en) 2016-04-07
AU2020201556A1 (en) 2020-03-19
TN2015000057A1 (en) 2016-06-29
EA201992614A3 (ru) 2020-05-31
DK2892923T3 (da) 2020-06-29
KR20150047138A (ko) 2015-05-04
HK1209136A1 (en) 2016-03-24
EP3725805A1 (en) 2020-10-21
AU2016201741B2 (en) 2017-09-07
EA201590523A1 (ru) 2015-06-30
BR122019028128B1 (pt) 2023-01-31
JP6404817B2 (ja) 2018-10-17
SG10201706623WA (en) 2017-09-28
JP2020072704A (ja) 2020-05-14
IL237161A0 (en) 2015-04-30
JP6944509B2 (ja) 2021-10-06
US20160376361A1 (en) 2016-12-29
CN109517065A (zh) 2019-03-26
PH12015500466A1 (en) 2015-04-20
KR20210011504A (ko) 2021-02-01
HUE050464T2 (hu) 2020-12-28
LT2892923T (lt) 2020-06-25
WO2014037899A3 (en) 2014-06-05
PT2892923T (pt) 2020-06-23
US11111293B2 (en) 2021-09-07
MY174691A (en) 2020-05-07
AU2017272201A1 (en) 2018-01-04
JP2015534546A (ja) 2015-12-03
US9376489B2 (en) 2016-06-28
AP2015008266A0 (en) 2015-02-28
ZA201500954B (en) 2018-11-28
EA201992614A2 (ru) 2020-03-31
AU2017272201B2 (en) 2020-01-02
AU2013311234A1 (en) 2015-03-05
CN104640879A (zh) 2015-05-20
BR112015004783B1 (pt) 2023-01-31
CN104640879B (zh) 2018-12-07
IL268336B (en) 2022-03-01
TWI655208B (zh) 2019-04-01
CU24249B1 (es) 2017-02-02
EP2892923A2 (en) 2015-07-15
TWI613217B (zh) 2018-02-01
MX2015002986A (es) 2015-10-08
US20190085068A1 (en) 2019-03-21
PE20150649A1 (es) 2015-05-14
MX2020007022A (es) 2020-09-07
CO7400884A2 (es) 2015-09-30
GT201500054A (es) 2015-10-15
CU20150022A7 (es) 2015-08-27
SI2892923T1 (sl) 2020-07-31
WO2014037899A2 (en) 2014-03-13
ECSP15013209A (es) 2018-09-30
TW201414747A (zh) 2014-04-16
EA034610B1 (ru) 2020-02-27
IL237161B (en) 2019-08-29
AU2020201556B2 (en) 2022-01-13
IL268336A (en) 2019-09-26
CN109517065B (zh) 2022-11-04
BR112015004783A2 (pt) 2017-11-21
JP2019037230A (ja) 2019-03-14
MA37892A1 (ar) 2016-06-30
JO3764B1 (ar) 2021-01-31
SG11201501559VA (en) 2015-03-30
EP2892923B1 (en) 2020-03-25
AR092465A1 (es) 2015-04-22
UY35016A (es) 2014-04-30
TW201827463A (zh) 2018-08-01
ES2804704T3 (es) 2021-02-09
US10081677B2 (en) 2018-09-25
PH12015500466B1 (en) 2015-04-20
CA2883821A1 (en) 2014-03-13
CR20150121A (es) 2015-05-04
US20220098296A1 (en) 2022-03-31
CL2015000532A1 (es) 2015-06-05
KR102330653B1 (ko) 2021-11-23
HRP20200906T1 (hr) 2020-09-04
CA2883821C (en) 2023-03-07

Similar Documents

Publication Publication Date Title
MX2020007022A (es) Moleculas de enlace a il-18.
CL2014003110A1 (es) Anticuerpo anti-fcrn; secuencias que lo codifican; vector; célula huésped; proceso de producción; composición farmacéutica que lo comprende; uso para el tratamiento de enfermedad autoinmune; y ensayo para probar la capacidad de un anticuerpo para bloquear la actividad de fcrn humano.
MX2010010387A (es) Anticuerpos especificos para el complejo de bcr y metodos para el uso de los mismos.
MX2010009190A (es) Anticuerpos anti-c5ar humanizados.
EA201291067A1 (ru) Гуманизированные антигенсвязывающие белки к миостатину
EA201492149A1 (ru) St2-антигенсвязывающие белки
MX356800B (es) Anticuerpo tau humanizado.
PH12016500425A1 (en) Il-18 binding protein (il-18bp) in inflammatory diseases
MX2014014218A (es) Moleculas de union il-6.
SG10201808738WA (en) Fusokines involving cytokines with strongly reduced receptor binding affinities
EP3085786A3 (en) Use of aptamers in therapy and/or diagnosis of autoimmune diseases
EA201790438A1 (ru) Антигенсвязывающие белки, которые связываются с cxcr5
UA106529C2 (uk) Гуманізоване антитіло до cxcr4 для лікування раку
PH12015500752A1 (en) Her3 antigen binding proteins binding to the beta-hairpin of her3
WO2015013508A3 (en) Methods for diagnosing and treating immune disease
UA110051C2 (uk) Антитіло, яке зв'язує tgf-альфа та епірегулін
NZ716687A (en) Il-18 binding molecules
TH167242B (th) โมเลกุลการยึดเกาะ il-18
TH167242A (th) โมเลกุลการยึดเกาะ il-18
NZ768582A (en) Antibodies and uses thereof to detect folate receptor 1