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CL2020001255A1 - Terapias de combinación. - Google Patents

Terapias de combinación.

Info

Publication number
CL2020001255A1
CL2020001255A1 CL2020001255A CL2020001255A CL2020001255A1 CL 2020001255 A1 CL2020001255 A1 CL 2020001255A1 CL 2020001255 A CL2020001255 A CL 2020001255A CL 2020001255 A CL2020001255 A CL 2020001255A CL 2020001255 A1 CL2020001255 A1 CL 2020001255A1
Authority
CL
Chile
Prior art keywords
inhibitor
cancer
treatment
combination therapies
agents
Prior art date
Application number
CL2020001255A
Other languages
English (en)
Inventor
Anne Sabatos-Peyton Catherine
Marie Mataraza Jennifer
Macisaac Kenzie
KWAK Eunice
Faris Jason
Dranoff Glenn
Wiesmann Marion
Sharp Fiona
Crystal Adam
Scott Cameron John
Martin Strieter Robert
Petruzzelli Lilli
Kazani Shamsah
Andrew Sandham David
John Press Neil
Hoffmaster Keith
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2020001255A1 publication Critical patent/CL2020001255A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

TERAPIAS DE COMBINACIÓN QUE COMPRENDEN INHIBIDORES DE PD-1 Y OTROS AGENTES TERAPÉUTICOS QUE SE USAN PARA EL TRATAMIENTO O LA PREVENCIÓN DE LAS AFECCIONES Y LOS TRASTORNOS CANCEROSOS COMO SIGUEN. TERAPIAS DE COMBINACIÓN DE TRES AGENTES QUE SON UN INHIBIDOR DE PD-1, UN INHIBIDOR DE CXCR2 Y UN AGENTE DE ENLACE DE CSF-1/1R PARA EL TRATAMIENTO DE UN CÁNCER PANCREÁTICO O DE UN CÁNCER COLO RECTAL. TERAPIAS DE COMBINACIÓN DE TRES AGENTES QUE SON UN INHIBIDOR DE PD-1, UN INHIBIDOR DE CXCR2 Y UN INHIBIDOR DE CUALQUIERA DE TIM3, C-MET O A2AR, PARA EL TRATAMIENTO DE UN CÁNCER PANCREÁTICO O DE UN CÁNCER COLO RECTAL. TERAPIAS DE COMBINACIÓN DE TRES AGENTES QUE SON UN INHIBIDOR DE PD-1, UN INHIBIDOR DE LAG-3 Y (I) UN INHIBIDOR DE CUALQUIERA DE TGF-BETA, TIM-3, C-MET, IL-1B O MEK, O (II) UN AGONISTA DE GITR, O (III) UN ANTAGONISTA DE A2AR, O (IV) UN AGENTE DE ENLACE DE CSF-1/1R, PARA EL TRATAMIENTO DE UN CÁNCER DE MAMA. TERAPIAS DE COMBINACIÓN DE DOS AGENTES QUE SON UN INHIBIDOR DE PD-1 Y UN INHIBIDOR DE CXCR2 PARA EL TRATAMIENTO DE UN CÁNCER PANCREÁTICO, DE UN CÁNCER COLO RECTAL, DE UN CÁNCER DE PULMÓN, O DE UN CÁNCER DE MAMA.
CL2020001255A 2017-11-16 2020-05-12 Terapias de combinación. CL2020001255A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762587370P 2017-11-16 2017-11-16
US201862645588P 2018-03-20 2018-03-20
US201862703736P 2018-07-26 2018-07-26

Publications (1)

Publication Number Publication Date
CL2020001255A1 true CL2020001255A1 (es) 2020-09-04

Family

ID=64870550

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2020001255A CL2020001255A1 (es) 2017-11-16 2020-05-12 Terapias de combinación.
CL2020003059A CL2020003059A1 (es) 2017-11-16 2020-11-25 Terapias de combinación

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2020003059A CL2020003059A1 (es) 2017-11-16 2020-11-25 Terapias de combinación

Country Status (14)

Country Link
US (1) US20200277378A1 (es)
EP (1) EP3710053A1 (es)
JP (1) JP2021503478A (es)
KR (1) KR20200089286A (es)
CN (1) CN111655288A (es)
AU (1) AU2018368731A1 (es)
BR (1) BR112020008888A2 (es)
CA (1) CA3081602A1 (es)
CL (2) CL2020001255A1 (es)
IL (1) IL274407A (es)
MX (1) MX2020004756A (es)
RU (1) RU2020119578A (es)
TW (1) TW201922291A (es)
WO (1) WO2019099838A1 (es)

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US20200277378A1 (en) 2020-09-03
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IL274407A (en) 2020-06-30
EP3710053A1 (en) 2020-09-23
AU2018368731A1 (en) 2020-05-14
WO2019099838A1 (en) 2019-05-23
JP2021503478A (ja) 2021-02-12
CN111655288A (zh) 2020-09-11
CA3081602A1 (en) 2019-05-23
RU2020119578A (ru) 2021-12-17
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KR20200089286A (ko) 2020-07-24
BR112020008888A2 (pt) 2020-10-20

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