DE60332483D1 - Methoden zur verhinderung und behandlung von krebs-metastasierung und mit krebs-metastasierung einhergehendem knochenverlust - Google Patents
Methoden zur verhinderung und behandlung von krebs-metastasierung und mit krebs-metastasierung einhergehendem knochenverlustInfo
- Publication number
- DE60332483D1 DE60332483D1 DE60332483T DE60332483T DE60332483D1 DE 60332483 D1 DE60332483 D1 DE 60332483D1 DE 60332483 T DE60332483 T DE 60332483T DE 60332483 T DE60332483 T DE 60332483T DE 60332483 D1 DE60332483 D1 DE 60332483D1
- Authority
- DE
- Germany
- Prior art keywords
- cancer
- methods
- cancer metastasis
- prevention
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title 3
- 201000011510 cancer Diseases 0.000 title 3
- 206010027476 Metastases Diseases 0.000 title 2
- 230000009401 metastasis Effects 0.000 title 2
- 230000002265 prevention Effects 0.000 title 1
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 abstract 4
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 abstract 4
- 239000005557 antagonist Substances 0.000 abstract 3
- 206010027452 Metastases to bone Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000037819 metastatic cancer Diseases 0.000 abstract 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42678102P | 2002-11-15 | 2002-11-15 | |
PCT/US2003/036679 WO2004045532A2 (en) | 2002-11-15 | 2003-11-17 | Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60332483D1 true DE60332483D1 (de) | 2010-06-17 |
Family
ID=32326424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60332483T Expired - Lifetime DE60332483D1 (de) | 2002-11-15 | 2003-11-17 | Methoden zur verhinderung und behandlung von krebs-metastasierung und mit krebs-metastasierung einhergehendem knochenverlust |
Country Status (14)
Country | Link |
---|---|
EP (3) | EP1572106B1 (de) |
JP (2) | JP4727992B2 (de) |
CN (1) | CN1787837A (de) |
AT (1) | ATE466885T1 (de) |
AU (1) | AU2003291002A1 (de) |
CA (1) | CA2505994A1 (de) |
CY (1) | CY1110305T1 (de) |
DE (1) | DE60332483D1 (de) |
DK (1) | DK1572106T3 (de) |
ES (1) | ES2345885T3 (de) |
IL (3) | IL168531A (de) |
PT (1) | PT1572106E (de) |
SI (1) | SI1572106T1 (de) |
WO (1) | WO2004045532A2 (de) |
Families Citing this family (74)
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US7108852B2 (en) | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
DE60332483D1 (de) | 2002-11-15 | 2010-06-17 | Novartis Vaccines & Diagnostic | Methoden zur verhinderung und behandlung von krebs-metastasierung und mit krebs-metastasierung einhergehendem knochenverlust |
AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
US20090324604A1 (en) * | 2004-01-07 | 2009-12-31 | Chiron Corporation | M-csf specific monoclonal antibody and uses thereof |
JP2007524671A (ja) * | 2004-01-21 | 2007-08-30 | カイロン コーポレイション | M−csfムテインおよびその使用 |
US20060024677A1 (en) * | 2004-07-20 | 2006-02-02 | Morris David W | Novel therapeutic targets in cancer |
CA2600836A1 (en) * | 2005-03-08 | 2006-09-14 | Pharmacia & Upjohn Company Llc | Composition comprising an antibody against macrophage colony-stimulating factor (m-csf) and a chelating agent |
EP1858928A2 (de) * | 2005-03-08 | 2007-11-28 | Pharmacia & Upjohn Company LLC | Anti-m-csf-antikörperzusammensetzungen mit verringerten endotoxinniveaus |
ES2538036T3 (es) * | 2005-07-28 | 2015-06-16 | Novartis Ag | Uso de anticuerpo a M-CSF |
JP5457671B2 (ja) * | 2005-07-28 | 2014-04-02 | ノバルティス アーゲー | M−csf特異的モノクローナル抗体およびその使用 |
EP1977238B1 (de) * | 2005-12-22 | 2016-09-28 | Novartis AG | Löslicher menschlicher m-csf-rezeptor und verwendungen davon |
EP1984024A2 (de) * | 2006-01-05 | 2008-10-29 | Novartis AG | Methoden zur verhinderung und behandlung von krebs-metastasierung und mit krebs-metastasierung einhergehendem knochenverlust |
ES2650224T3 (es) | 2007-08-21 | 2018-01-17 | Amgen, Inc. | Proteínas de unión al antígeno C-FMS humano |
WO2010062401A2 (en) | 2008-11-26 | 2010-06-03 | Five Prime Therapeutics, Inc. | Treatment of osteolytic disorders and cancer using csf1r extracellular domain fusion molecules |
WO2010062399A2 (en) | 2008-11-26 | 2010-06-03 | Five Prime Therapeutics, Inc. | Csf1r extracellular domain fusion molecules and treatments using same |
LT2949670T (lt) | 2009-12-10 | 2019-05-27 | F. Hoffmann-La Roche Ag | Antikūnai, prisijungiantys pirmiausiai prie žmogaus csf-1 ekstraląstelinio domeno 4, ir jų naudojimo būdai |
BR112012020372A8 (pt) | 2010-03-05 | 2018-01-02 | Hoffmann La Roche | anticorpo que se liga ao csf-1r humano, composição farmacêutica, ácido nucleico, vetores de expressão, célula hospedeira e método para a produção de um anticorpo recombinante |
RU2617966C2 (ru) | 2010-03-05 | 2017-04-28 | Ф.Хоффманн-Ля Рош Аг | Антитела против csf-1r человека и их применение |
AR080698A1 (es) * | 2010-04-01 | 2012-05-02 | Imclone Llc | Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e |
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WO2013057290A1 (en) | 2011-10-21 | 2013-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A m-dc8+ monocyte depleting agent for the prevention or the treatment of a condition associated with a chronic hyperactivation of the immune system |
KR20140113683A (ko) | 2011-12-15 | 2014-09-24 | 에프. 호프만-라 로슈 아게 | 인간 csf-1r에 대한 항체 및 이의 용도 |
US9452215B2 (en) | 2012-02-22 | 2016-09-27 | The Regents Of The University Of Colorado | Bourvadin derivatives and therapeutic uses thereof |
EP3345624A1 (de) * | 2012-02-22 | 2018-07-11 | The Regents Of The University Of Colorado | Bouvardin-derivate und therapeutische verwendungen davon |
AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
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AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
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- 2003-11-17 WO PCT/US2003/036679 patent/WO2004045532A2/en active Application Filing
- 2003-11-17 SI SI200331835T patent/SI1572106T1/sl unknown
- 2003-11-17 JP JP2004553807A patent/JP4727992B2/ja not_active Expired - Lifetime
- 2003-11-17 DK DK03783587.3T patent/DK1572106T3/da active
- 2003-11-17 PT PT03783587T patent/PT1572106E/pt unknown
- 2003-11-17 ES ES03783587T patent/ES2345885T3/es not_active Expired - Lifetime
- 2003-11-17 CA CA002505994A patent/CA2505994A1/en not_active Abandoned
- 2003-11-17 EP EP03783587A patent/EP1572106B1/de not_active Expired - Lifetime
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- 2003-11-17 CN CNA2003801088289A patent/CN1787837A/zh active Pending
- 2003-11-17 EP EP10004581A patent/EP2246363A1/de not_active Withdrawn
- 2003-11-17 EP EP10178225.8A patent/EP2287192B1/de not_active Revoked
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Also Published As
Publication number | Publication date |
---|---|
JP4727992B2 (ja) | 2011-07-20 |
DK1572106T3 (da) | 2010-08-23 |
IL204987A0 (en) | 2011-08-01 |
IL168531A (en) | 2012-08-30 |
IL198884A0 (en) | 2011-08-01 |
CN1787837A (zh) | 2006-06-14 |
AU2003291002A8 (en) | 2004-06-15 |
PT1572106E (pt) | 2010-06-17 |
EP1572106B1 (de) | 2010-05-05 |
ATE466885T1 (de) | 2010-05-15 |
ES2345885T3 (es) | 2010-10-05 |
EP1572106A2 (de) | 2005-09-14 |
CY1110305T1 (el) | 2015-01-14 |
IL204987A (en) | 2015-02-26 |
JP2006519163A (ja) | 2006-08-24 |
WO2004045532A2 (en) | 2004-06-03 |
WO2004045532A3 (en) | 2006-01-26 |
CA2505994A1 (en) | 2004-06-03 |
AU2003291002A1 (en) | 2004-06-15 |
EP2287192B1 (de) | 2015-08-26 |
JP2011006488A (ja) | 2011-01-13 |
EP1572106A4 (de) | 2007-06-13 |
EP2246363A1 (de) | 2010-11-03 |
EP2287192A1 (de) | 2011-02-23 |
IL198884A (en) | 2013-10-31 |
SI1572106T1 (sl) | 2010-08-31 |
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