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CO5180539A1 - Derivados de resorcinol - Google Patents

Derivados de resorcinol

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Publication number
CO5180539A1
CO5180539A1 CO00020440A CO00020440A CO5180539A1 CO 5180539 A1 CO5180539 A1 CO 5180539A1 CO 00020440 A CO00020440 A CO 00020440A CO 00020440 A CO00020440 A CO 00020440A CO 5180539 A1 CO5180539 A1 CO 5180539A1
Authority
CO
Colombia
Prior art keywords
alkyl
r2on
amino
acyl
r4r5ns
Prior art date
Application number
CO00020440A
Other languages
English (en)
Inventor
Eric William Collington
Martin James Procter
Joanna Victoriagede
Andrew Fancis Browning
Original Assignee
Pfizer
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Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CO5180539A1 publication Critical patent/CO5180539A1/es

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    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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    • A61P17/00Drugs for dermatological disorders
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    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • C07C215/64Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C259/08Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
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    • C07C311/02Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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Abstract

Un compuesto de fórmula I:<EMI FILE="00020440_1" ID="1" IMF=JPEG >o una sal farmacéuticamente aceptable del mismo, en la que: R1 es un anillo de cicloalquilo (C3-C8) o anillo de cicloalquenilo (C5-C8), estando bien el anillo de cicloalquilo o bien el anillo de cicloalquenilo sustituido con uno a tres sustituyentes seleccionados independientemente del grupoque comprende ciano; halo; alquilo (C1-C6); arilo; heterocicloalquilo (C2-C9); heteroarilo (C2-C9); arilalquilo (C1-C6); =O; =CHOalquilo (C1-C6); amino; hidroxi; alcoxi (C1-C6); arilalcoxi (C1-C6)-; acilo (C1-C6); alquil (C1-C6)-amino-; arilalquil(C1-C6)-amino-; aminoalquilo (C1-C6)-; alcoxi (C1-C6)-CO-NH-; alquil (C1-C6)-amino-CO-; alquenilo (C2-C6); alquinilo (C2-C6); hidroxialquilo (C1-C6)-; alcoxi (C1-C6)-alquilo (C1-C6)-; aciloxi (C1-C6)-alquilo (C1-C6)-; nitro; cianoalquilo (C1-C6)-; haloalquilo (C1-C6)-; nitroalquilo (C1-C6)-; trifluorometilo; trifluorometilalquilo (C1-C6)-; acil (C1-C6)amino-; acil (C1-C6)-aminoalquilo (C1-C6)-; alcoxi (C1-C6)-acil (C1-C6)-amino-;aminoacilo (C1-C6) -; aminoacil (C1-C6)-alquilo (C1-C6)-;alquil (C1-C6) -aminoacilo (C1-C6)-; (alquil (C1-C6))2-amino-acilo(C1-C6)-; -CO2R2; -alquil (C1-C6) -CO2R2;-C(O)N(R2)2; -alquil (C1-C6)-C(O)N(R2)2; R2ON=; R2ON=alquilo (C1-C6)-; R2ON=CR2alquilo (C1-C6)-; -NR2(OR2);-alquil (C1-C6)-NR2(OR2); -C(O)(NR20R2); -alquil(C1-C6)-C(O)(NR2OR2); -S(O)mR2; en los que cada R2 se selecciona independientemente de hidrógeno, alquilo (C1-C6), arilo, o arilalquilo (C1-C6)-; R3C(O)O-, en el que R3 es alquilo (C1-C6), arilo, o arilalquilo (C1-C6)-; R3C(O)O-alquilo (C1-C6)-; R4R5N-C(O)-O-; R4R5NS(O)2-; R4R5NS(O)2-alquilo (C1-C6)-; R4S(O)2R5N-; R4S(O)2R5N-alquilo (C1-C6)-; siendo m 0, 1 ó 2, y R4 y R5 se seleccionan cada uno independientemente de hidrógeno o alquilo (C1-C6); -C(=NR6) (N(R4)2);o -alquilo (C1-C6)-C(=NR6)(N(R4)2) en los que R6 representa OR2 O R2, estando R2 definido se define como antes;con la condición de que el anillo de cicloalquenilo no sea aromático;con la condición de que R1 debe estar sustituido con al menos uno de R3C(O)O-, R3C(O)O-alquilo (C1-C6)-, R2ON=, R2ON=alquilo (C1-C6)-, R2ON=CR2alquilo (C1-C6)-, -NR2 (OR2),R4R5NS(O)2-, R4R5NS(O)2-alquilo (C1-C6)-, R4S(O)2R5N-, o R4S(O)2R5N-alquilo (C1-C6)-;con la condición de que cuando R1 está sustituido sólo con uno de R2ON=, entonces R2 no puede ser hidrógeno.
CO00020440A 1999-03-22 2000-03-22 Derivados de resorcinol CO5180539A1 (es)

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JP (1) JP3927772B2 (es)
KR (1) KR100488845B1 (es)
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WO2012103487A1 (en) 2011-01-27 2012-08-02 New York University Coumarin compounds as melanogenesis modifiers and uses thereof
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