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CO5320600A1 - Agentes antibacterianos de 3-aminoquinazolin-2,4-dionas - Google Patents

Agentes antibacterianos de 3-aminoquinazolin-2,4-dionas

Info

Publication number
CO5320600A1
CO5320600A1 CO01004183A CO01004183A CO5320600A1 CO 5320600 A1 CO5320600 A1 CO 5320600A1 CO 01004183 A CO01004183 A CO 01004183A CO 01004183 A CO01004183 A CO 01004183A CO 5320600 A1 CO5320600 A1 CO 5320600A1
Authority
CO
Colombia
Prior art keywords
substituted
alkyl
alkynyl
alkenyl
heterocyclic
Prior art date
Application number
CO01004183A
Other languages
English (en)
Inventor
Paul Bird
Edmund Lee Ellsworth
Dai Quoc Nguyen
Joseph Peter Sanchez
Howard Daniel Hollis Showalter
Rajesshwar Singh
Michael Andrew Stier
Tuan Phong Tran
Brian Morgan Watson
Judy Yip
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CO5320600A1 publication Critical patent/CO5320600A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/95Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96Two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paper (AREA)

Abstract

Un compuespo de la fórmula I<EMI FILE="01004183_1" ID="1" IMF=JPEG >o una sal farmacéuticamente aceptable de ellos en donde:R1 y R3 independientemente son H,Alquilo y alquilo sustituido de C1-C12,AIquenilo y alquenilo sustituido de C2-C12,AlquiniIo y alquinilo sustituido de C2-C12,Cicloalquilo y cicloalquiIo sustituido de C3-C12,Arilo y arilo sustituido,Heterocíclico y heterocíclico sustituido,o heteroarilo y heteroarilo sustituido;R5, R6 y R8 independientemente son H,(O)nalquilo de C1-C12, y alquilo sustituido;(O)nalquenilo de C2-C12 y alquenilo sustituido;(O)nalquinilo de C2-C12 y alquinilo sustituido,en donde n es 0 o 1,halo,NO2,CN,NR´R´´;R´ y R´´ independientemente son H,alquilo y alquilo sustituido de C1-C12,alquenilo y alquenilo sustituido de C2-C12,alquinilo y alquinilo sustituido de C2-C12,CO-alquilo de C1-C12 y alquilo sustituido,o R´ y R´´ tomados junto con el nitrógeno al cual están unidos forman un anillo de 3 a 7 miembros que contiene de 1 a 3 heteroátomos seleccionados de N, O y S, dicho anillo es no sustituido o sustituido con hasta 4 grupos sustituyentes;R1 y R8 pueden ser tomados junto con los átomos a los cuales están unidos para formar un anillo cíclico que tiene de 1 a 3 heteroátomos seleccionados de N, O y S y optativamente sustituidos por R´ y R´´; - 2 -R7 es hidrógeno,alquilo y alquilo sustituido de C1-C12,alquenilo y alquenilo sustituido de C2-C12,alquinilo y alquinilo sustituido de C2-C12,halo,NO2,CN,NR´R´´,COOR´ ,arilo,arilo fusionado,heterocíclico,heterocíclico bicíclico, oespiro heterocíclicoen donde todos los grupos del anillo pueden ser sustituidos; yJ y K independientemente son C o N, siempre que cuando J o K es N, R6 o R8 esté ausente en esa posición.
CO01004183A 2000-01-24 2001-01-22 Agentes antibacterianos de 3-aminoquinazolin-2,4-dionas CO5320600A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17825200P 2000-01-24 2000-01-24
US24126700P 2000-10-18 2000-10-18

Publications (1)

Publication Number Publication Date
CO5320600A1 true CO5320600A1 (es) 2003-09-30

Family

ID=26874138

Family Applications (1)

Application Number Title Priority Date Filing Date
CO01004183A CO5320600A1 (es) 2000-01-24 2001-01-22 Agentes antibacterianos de 3-aminoquinazolin-2,4-dionas

Country Status (38)

Country Link
US (2) US7094780B1 (es)
EP (1) EP1255739B1 (es)
JP (1) JP4811978B2 (es)
KR (1) KR20020067701A (es)
CN (1) CN1425008A (es)
AP (1) AP2002002603A0 (es)
AR (1) AR030186A1 (es)
AT (1) ATE398110T1 (es)
AU (1) AU783078B2 (es)
BG (1) BG107023A (es)
BR (1) BR0017010A (es)
CA (1) CA2393802C (es)
CO (1) CO5320600A1 (es)
CR (1) CR6709A (es)
DE (1) DE60039194D1 (es)
EA (1) EA005585B1 (es)
EE (1) EE200200412A (es)
ES (1) ES2304992T3 (es)
GE (1) GEP20053429B (es)
HK (1) HK1054237A1 (es)
HN (1) HN2001000009A (es)
HR (1) HRP20020696A2 (es)
HU (1) HUP0204101A3 (es)
IL (1) IL150393A0 (es)
IS (1) IS6448A (es)
MA (1) MA26866A1 (es)
MX (1) MXPA02005989A (es)
NO (1) NO20023516D0 (es)
OA (1) OA12316A (es)
PA (1) PA8510101A1 (es)
PE (1) PE20011060A1 (es)
PL (1) PL356837A1 (es)
SK (1) SK10572002A3 (es)
SV (1) SV2001000288A (es)
TN (1) TNSN01011A1 (es)
UY (1) UY26551A1 (es)
WO (1) WO2001053273A1 (es)
YU (1) YU55902A (es)

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JP2007505096A (ja) * 2003-09-12 2007-03-08 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー キノロン抗菌剤
WO2005026153A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinazoline-2, 4-diones as antibacterial agents
JP2007511597A (ja) * 2003-11-18 2007-05-10 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 抗菌アミノキナゾリヂンヂオン誘導体
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WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
AR085806A1 (es) 2011-03-15 2013-10-30 Trius Therapeutics Inc Inhibidores triciclicos de girasa
RU2618673C2 (ru) * 2011-12-21 2017-05-10 Цзянсу Хэнжуй Медсин Ко., Лтд. Производные пирролопиримидина, полезные в качестве ингибиторов jak-киназы
SI3495367T1 (sl) 2012-06-13 2021-01-29 Incyte Holdings Corporation Substituirane triciklične spojine kot zaviralci FGFR
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
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MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
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US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
EA202092649A1 (ru) 2018-05-04 2021-06-21 Инсайт Корпорейшн Соли ингибитора fgfr
CN111620866A (zh) * 2019-02-27 2020-09-04 南京药石科技股份有限公司 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
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Also Published As

Publication number Publication date
EP1255739A1 (en) 2002-11-13
US20060287308A1 (en) 2006-12-21
HN2001000009A (es) 2001-06-13
HK1054237A1 (zh) 2003-11-21
CN1425008A (zh) 2003-06-18
OA12316A (en) 2006-05-15
HRP20020696A2 (en) 2003-12-31
AU2089901A (en) 2001-07-31
BR0017010A (pt) 2002-11-05
EE200200412A (et) 2003-10-15
GEP20053429B (en) 2005-01-25
NO20023516L (no) 2002-07-23
UY26551A1 (es) 2001-04-30
ATE398110T1 (de) 2008-07-15
HUP0204101A3 (en) 2004-05-28
US20060183762A1 (en) 2006-08-17
DE60039194D1 (de) 2008-07-24
MXPA02005989A (es) 2002-10-23
AR030186A1 (es) 2003-08-13
BG107023A (en) 2003-04-30
AP2002002603A0 (en) 2002-09-30
CR6709A (es) 2003-11-25
HUP0204101A2 (hu) 2003-04-28
ES2304992T3 (es) 2008-11-01
AU783078B2 (en) 2005-09-22
PA8510101A1 (es) 2003-06-30
EA005585B1 (ru) 2005-04-28
US7582627B2 (en) 2009-09-01
SV2001000288A (es) 2001-11-30
MA26866A1 (fr) 2004-12-20
JP2003520277A (ja) 2003-07-02
IS6448A (is) 2002-06-27
YU55902A (sh) 2006-01-16
EP1255739B1 (en) 2008-06-11
US7094780B1 (en) 2006-08-22
JP4811978B2 (ja) 2011-11-09
NO20023516D0 (no) 2002-07-23
CA2393802C (en) 2011-04-19
IL150393A0 (en) 2002-12-01
SK10572002A3 (sk) 2003-10-07
PE20011060A1 (es) 2001-10-12
WO2001053273A1 (en) 2001-07-26
KR20020067701A (ko) 2002-08-23
TNSN01011A1 (en) 2005-11-10
CA2393802A1 (en) 2001-07-26
PL356837A1 (en) 2004-07-12
EA200200661A1 (ru) 2003-02-27

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