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HK1068882A1 - Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes - Google Patents

Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Info

Publication number
HK1068882A1
HK1068882A1 HK05101300A HK05101300A HK1068882A1 HK 1068882 A1 HK1068882 A1 HK 1068882A1 HK 05101300 A HK05101300 A HK 05101300A HK 05101300 A HK05101300 A HK 05101300A HK 1068882 A1 HK1068882 A1 HK 1068882A1
Authority
HK
Hong Kong
Prior art keywords
pyrazines
diabetes
prevention
dipeptidyl peptidase
treatment
Prior art date
Application number
HK05101300A
Other languages
English (en)
Inventor
Scott D Edmondson
Michael H Fisher
Dooseop Kim
Malcolm Maccoss
Emma R Parmee
Ann E Weber
Jinyou Xu
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1068882(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HK1068882A1 publication Critical patent/HK1068882A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
HK05101300A 2001-07-06 2005-02-16 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes HK1068882A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
PCT/US2002/021349 WO2003004498A1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (1)

Publication Number Publication Date
HK1068882A1 true HK1068882A1 (en) 2005-05-06

Family

ID=23172273

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05101300A HK1068882A1 (en) 2001-07-06 2005-02-16 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Country Status (46)

Country Link
US (9) US6699871B2 (no)
EP (4) EP1625847B1 (no)
JP (1) JP3762407B2 (no)
KR (1) KR100606871B1 (no)
CN (2) CN1861077A (no)
AR (1) AR036114A1 (no)
AT (2) ATE471148T1 (no)
AU (1) AU2002320303B2 (no)
BE (1) BE2007C047I2 (no)
BG (1) BG108493A (no)
BR (1) BRPI0210866B8 (no)
CA (1) CA2450740C (no)
CR (1) CR7235A (no)
CY (3) CY2007019I2 (no)
DE (4) DE122008000046I1 (no)
DK (2) DK1625847T3 (no)
DO (1) DOP2002000438A (no)
EA (2) EA006845B1 (no)
EC (1) ECSP044935A (no)
ES (2) ES2344846T3 (no)
FR (2) FR07C0041I2 (no)
GE (2) GEP20063734B (no)
HK (1) HK1068882A1 (no)
HR (1) HRP20031098B1 (no)
HU (2) HU225695B1 (no)
IL (3) IL159109A0 (no)
IS (2) IS2218B (no)
JO (1) JO2230B1 (no)
LT (1) LTC1412357I2 (no)
LU (2) LUC91360I2 (no)
MA (1) MA27053A1 (no)
ME (1) ME00439B (no)
MX (1) MXPA04000018A (no)
MY (1) MY127961A (no)
NL (2) NL300287I2 (no)
NO (4) NO321999B1 (no)
NZ (1) NZ529833A (no)
PE (1) PE20030654A1 (no)
PL (1) PL196278B6 (no)
PT (2) PT1412357E (no)
RS (1) RS50737B (no)
SI (1) SI1412357T1 (no)
TW (1) TWI226331B (no)
UA (1) UA74912C2 (no)
WO (1) WO2003004498A1 (no)
ZA (1) ZA200309294B (no)

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