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LU91470I2 - Beta-amino-tétrahydroimidazo (1,2-A) pyrazines et betaamino-tétrahydrotrioazolo (4,3-A) pyrazines utilisées en tant qu'inhibiteurs de la dipeptidyl peptibase dans le traitement ou la prévention du diabète - Google Patents

Beta-amino-tétrahydroimidazo (1,2-A) pyrazines et betaamino-tétrahydrotrioazolo (4,3-A) pyrazines utilisées en tant qu'inhibiteurs de la dipeptidyl peptibase dans le traitement ou la prévention du diabète

Info

Publication number
LU91470I2
LU91470I2 LU91470C LU91470C LU91470I2 LU 91470 I2 LU91470 I2 LU 91470I2 LU 91470 C LU91470 C LU 91470C LU 91470 C LU91470 C LU 91470C LU 91470 I2 LU91470 I2 LU 91470I2
Authority
LU
Luxembourg
Prior art keywords
pyrazines
diabetes
inhibitors
prevention
treatment
Prior art date
Application number
LU91470C
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU91470(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of LU91470I2 publication Critical patent/LU91470I2/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
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    • A61P5/28—Antiandrogens
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
LU91470C 2001-07-06 2008-08-18 Beta-amino-tétrahydroimidazo (1,2-A) pyrazines et betaamino-tétrahydrotrioazolo (4,3-A) pyrazines utilisées en tant qu'inhibiteurs de la dipeptidyl peptibase dans le traitement ou la prévention du diabète LU91470I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
PCT/US2002/021349 WO2003004498A1 (fr) 2001-07-06 2002-07-05 Pyrazines beta-amino tetrahydroimidazo (1, 2-a) et pyrazines tetrahydrotrioazolo (4, 3-a) utilisees en tant qu'inhibiteurs de la dipeptidyl peptidase dans le traitement ou la prevention du diabete

Publications (1)

Publication Number Publication Date
LU91470I2 true LU91470I2 (fr) 2008-10-20

Family

ID=23172273

Family Applications (2)

Application Number Title Priority Date Filing Date
LU91360C LUC91360I2 (fr) 2001-07-06 2007-09-05
LU91470C LU91470I2 (fr) 2001-07-06 2008-08-18 Beta-amino-tétrahydroimidazo (1,2-A) pyrazines et betaamino-tétrahydrotrioazolo (4,3-A) pyrazines utilisées en tant qu'inhibiteurs de la dipeptidyl peptibase dans le traitement ou la prévention du diabète

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LU91360C LUC91360I2 (fr) 2001-07-06 2007-09-05

Country Status (46)

Country Link
US (9) US7125873B2 (fr)
EP (4) EP1412357B1 (fr)
JP (1) JP3762407B2 (fr)
KR (1) KR100606871B1 (fr)
CN (2) CN1290848C (fr)
AR (1) AR036114A1 (fr)
AT (2) ATE321048T1 (fr)
AU (1) AU2002320303B2 (fr)
BE (1) BE2007C047I2 (fr)
BG (1) BG108493A (fr)
BR (1) BRPI0210866B8 (fr)
CA (1) CA2450740C (fr)
CR (1) CR7235A (fr)
CY (3) CY2007019I2 (fr)
DE (4) DE122007000056I1 (fr)
DK (2) DK1412357T3 (fr)
DO (1) DOP2002000438A (fr)
EA (2) EA006845B1 (fr)
EC (1) ECSP044935A (fr)
ES (2) ES2344846T3 (fr)
FR (2) FR07C0041I2 (fr)
GE (2) GEP20063734B (fr)
HK (1) HK1068882A1 (fr)
HR (1) HRP20031098B1 (fr)
HU (2) HU225695B1 (fr)
IL (3) IL159109A0 (fr)
IS (2) IS2218B (fr)
JO (1) JO2230B1 (fr)
LT (1) LTC1412357I2 (fr)
LU (2) LUC91360I2 (fr)
MA (1) MA27053A1 (fr)
ME (1) ME00439B (fr)
MX (1) MXPA04000018A (fr)
MY (1) MY127961A (fr)
NL (2) NL300287I2 (fr)
NO (4) NO321999B1 (fr)
NZ (1) NZ529833A (fr)
PE (1) PE20030654A1 (fr)
PL (1) PL196278B6 (fr)
PT (2) PT1412357E (fr)
RS (1) RS50737B (fr)
SI (1) SI1412357T1 (fr)
TW (1) TWI226331B (fr)
UA (1) UA74912C2 (fr)
WO (1) WO2003004498A1 (fr)
ZA (1) ZA200309294B (fr)

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JP4491346B2 (ja) * 2002-10-07 2010-06-30 メルク・シャープ・エンド・ドーム・コーポレイション 抗糖尿病ベータアミノ複素環ジペプチジルペプチダーゼ阻害剤
JP2006516573A (ja) * 2003-01-31 2006-07-06 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体

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