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RU2582676C3 - Некоторые химические соединения, композиции и способы - Google Patents

Некоторые химические соединения, композиции и способы

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Publication number
RU2582676C3
RU2582676C3 RU2012105071A RU2012105071A RU2582676C3 RU 2582676 C3 RU2582676 C3 RU 2582676C3 RU 2012105071 A RU2012105071 A RU 2012105071A RU 2012105071 A RU2012105071 A RU 2012105071A RU 2582676 C3 RU2582676 C3 RU 2582676C3
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RU
Russia
Prior art keywords
compositions
methods
chemical compounds
compound
kinase
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Application number
RU2012105071A
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English (en)
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RU2012105071A (ru
RU2582676C2 (ru
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Интелликайн ЭлЭлСи
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Priority to RU2012105071A priority Critical patent/RU2582676C3/ru
Publication of RU2012105071A publication Critical patent/RU2012105071A/ru
Publication of RU2582676C2 publication Critical patent/RU2582676C2/ru
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Publication of RU2582676C3 publication Critical patent/RU2582676C3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)

Claims (4)

1. Соединение
Figure 00000001
Соединение 292.
2. Фармацевтическая композиция, обладающая активностью в отношении PI3-киназы, содержащая эффективное количество соединения по п. 1 и более чем один фармацевтически приемлемый эксципиент.
RU2012105071A 2009-07-15 2010-07-15 Некоторые химические соединения, композиции и способы RU2582676C3 (ru)

Priority Applications (1)

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RU2012105071A RU2582676C3 (ru) 2009-07-15 2010-07-15 Некоторые химические соединения, композиции и способы

Applications Claiming Priority (3)

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US12/503,776 US8193182B2 (en) 2008-01-04 2009-07-15 Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US12/503,776 2009-07-15
RU2012105071A RU2582676C3 (ru) 2009-07-15 2010-07-15 Некоторые химические соединения, композиции и способы

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RU2012105071A RU2012105071A (ru) 2013-08-20
RU2582676C2 RU2582676C2 (ru) 2016-04-27
RU2582676C3 true RU2582676C3 (ru) 2022-01-17

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US (12) US8193182B2 (ru)
EP (4) EP2456444B1 (ru)
JP (2) JP5944313B2 (ru)
KR (1) KR101680406B1 (ru)
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LTPA2021526I1 (ru) 2021-12-10
ZA201200254B (en) 2013-03-27
US8785456B2 (en) 2014-07-22
MY175979A (en) 2020-07-19
CN109912599B (zh) 2021-11-02
EP3441392A1 (en) 2019-02-13
CY2021034I1 (el) 2022-03-24
MY168762A (en) 2018-12-04
US20090312319A1 (en) 2009-12-17
JP2012533541A (ja) 2012-12-27
US9206182B2 (en) 2015-12-08
EP2456444A1 (en) 2012-05-30
FIC20210039I1 (fi) 2021-11-03
EP3441392B1 (en) 2021-12-15
US20160158239A1 (en) 2016-06-09
US20190290636A1 (en) 2019-09-26
PT2456444E (pt) 2015-06-09
PH12020550450A1 (en) 2021-06-07
CA2768307A1 (en) 2011-01-20
RU2016110024A3 (ru) 2019-09-10
MX351028B (es) 2017-09-28
AU2010274075A1 (en) 2012-02-09
BR112012000968A2 (pt) 2017-12-05
IN2012DN00943A (ru) 2015-04-10
BR112012000968B8 (pt) 2021-05-25
CN102711767B (zh) 2016-08-03
RU2582676C2 (ru) 2016-04-27
KR20120097479A (ko) 2012-09-04
US9522146B2 (en) 2016-12-20
US9216982B2 (en) 2015-12-22
CY2021034I2 (el) 2022-03-24

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