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ES8607229A1 - Procedimiento para preparar derivados de acidos 16-fenoxi y 16-(fenoxi sustituido)-prostatrienoicos y sus estereoisome- ros - Google Patents

Procedimiento para preparar derivados de acidos 16-fenoxi y 16-(fenoxi sustituido)-prostatrienoicos y sus estereoisome- ros

Info

Publication number
ES8607229A1
ES8607229A1 ES548460A ES548460A ES8607229A1 ES 8607229 A1 ES8607229 A1 ES 8607229A1 ES 548460 A ES548460 A ES 548460A ES 548460 A ES548460 A ES 548460A ES 8607229 A1 ES8607229 A1 ES 8607229A1
Authority
ES
Spain
Prior art keywords
phenoxy
making
intermediates
processes
stereoisomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548460A
Other languages
English (en)
Other versions
ES548460A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES8607229A1 publication Critical patent/ES8607229A1/es
Publication of ES548460A0 publication Critical patent/ES548460A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE ACIDOS 16-FENOXI Y 16-(FENOXI SUSTITUIDO)-PROSTATRIENOICOS Y SUS ESTEREOISOMEROS DE FORMULA (I) EN DONDE R ES HIDROGENO O ALQUILO INFERIOR (METILO); X ESHIDROGENO, HALO, TRIFLUOROMETILO, ALQUILO INFERIOR O ALCOXI Y LAS LINEAS ONDULADAS REPRESENTAN LA CONFIGURACION A O B. CONSISTENTE EN HACER REACCIONAR UN ALCOHOL PROPARGILICO CON UN ORTOACETATO TRIALQUILICO INFERIOR, OBTENIENDOSE UN ESTER QUE POR HOMOLOGACION Y POSTERIOR HIDROLISIS SE TRANSFORMA EN UNA SAL. ESTE COMPUESTO ES ACIDIFICADO PARA DEJAR LA BASE LIBRE Y ESTERIFICAR EL ACIDO, U OPCIONALMENTE OXIDAR DICHO ACIDO. EL PRODUCTO OBTENIDO SE SOMETE A HIDROLISIS, DANDO LUGAR AL COMPUESTO (I).
ES548460A 1983-12-22 1985-10-31 Procedimiento para preparar derivados de acidos 16-fenoxi y 16-(fenoxi sustituido)-prostatrienoicos y sus estereoisome- ros Expired ES8607229A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/564,386 US4600785A (en) 1983-12-22 1983-12-22 Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives

Publications (2)

Publication Number Publication Date
ES8607229A1 true ES8607229A1 (es) 1986-06-01
ES548460A0 ES548460A0 (es) 1986-06-01

Family

ID=24254259

Family Applications (4)

Application Number Title Priority Date Filing Date
ES538899A Expired ES8604389A1 (es) 1983-12-22 1984-12-20 Procedimientos y compuestos intermedios para preparar derivados de acidos 16-(fenoxi substituido)-prostatrinoicos y sus sales esteroisomeros
ES548459A Expired ES8609234A1 (es) 1983-12-22 1985-10-31 Procedimiento para preparar (4,5,6r,8r)-9-oxo-11,15 dihidro-xi-16-fenoxi-17,18,19,20-tetranorprosta-4,5,13 (e) trienoatometilico cristalino
ES548453A Expired ES8607228A1 (es) 1983-12-22 1985-10-31 Procedimiento para preparar derivados de acidos 16-fenoxi y 16(fenoxi sustituido)-prostatrienoicos y sus estereoisomeros
ES548460A Expired ES8607229A1 (es) 1983-12-22 1985-10-31 Procedimiento para preparar derivados de acidos 16-fenoxi y 16-(fenoxi sustituido)-prostatrienoicos y sus estereoisome- ros

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES538899A Expired ES8604389A1 (es) 1983-12-22 1984-12-20 Procedimientos y compuestos intermedios para preparar derivados de acidos 16-(fenoxi substituido)-prostatrinoicos y sus sales esteroisomeros
ES548459A Expired ES8609234A1 (es) 1983-12-22 1985-10-31 Procedimiento para preparar (4,5,6r,8r)-9-oxo-11,15 dihidro-xi-16-fenoxi-17,18,19,20-tetranorprosta-4,5,13 (e) trienoatometilico cristalino
ES548453A Expired ES8607228A1 (es) 1983-12-22 1985-10-31 Procedimiento para preparar derivados de acidos 16-fenoxi y 16(fenoxi sustituido)-prostatrienoicos y sus estereoisomeros

Country Status (28)

Country Link
US (1) US4600785A (es)
EP (1) EP0146935B1 (es)
JP (3) JPH0635431B2 (es)
KR (1) KR900000684B1 (es)
CN (1) CN85101840A (es)
AR (1) AR241015A1 (es)
AT (1) ATE50986T1 (es)
AU (1) AU585844B2 (es)
CA (4) CA1267892A (es)
CS (5) CS600784A2 (es)
DD (2) DD249700A5 (es)
DE (1) DE3481610D1 (es)
DK (1) DK617084A (es)
ES (4) ES8604389A1 (es)
FI (1) FI845069L (es)
GR (1) GR82514B (es)
HU (2) HU196732B (es)
IL (1) IL73881A (es)
IN (1) IN160437B (es)
MX (2) MX158754A (es)
NO (1) NO845148L (es)
NZ (1) NZ210667A (es)
PH (2) PH22893A (es)
PL (2) PL154330B1 (es)
PT (1) PT79720A (es)
RO (2) RO94561A7 (es)
SU (3) SU1473709A3 (es)
ZA (1) ZA849967B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ213749A (en) * 1984-10-09 1989-01-06 Syntex Inc Ethers for use as intermediates in the preparation of 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
US4929740A (en) * 1984-10-09 1990-05-29 Syntex (U.S.A.) Inc. Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
US4778904A (en) * 1985-09-13 1988-10-18 Syntex (U.S.A.) Inc. Intermediates for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
US4755531A (en) * 1986-08-11 1988-07-05 Syntex (U.S.A.) Inc. Thiol esters of 4,5-allenyl prostaglandins and use thereof as antigastric secretion agents
US4689419A (en) * 1986-11-14 1987-08-25 G. D. Searle & Co. Novel intermediate compounds in a process for producing 16-phenoxy- and 16-substituted phenoxy-9-keto-prostatrienoic acid derivatives
US5248788A (en) * 1988-12-13 1993-09-28 Syntex (U.S.A.) Inc. Process for preparing allenic prostanoic acid derivatives
US4916238A (en) * 1988-12-13 1990-04-10 Syntex (U.S.A.) Inc. Process for preparing allenic prostanoic acid derivatives
US5571936A (en) * 1994-09-30 1996-11-05 Korea Institute Of Science And Technology Intermediates for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304907A (en) * 1972-05-10 1981-12-08 The Upjohn Company Bicyclo lactone intermediates for prostaglandin analogs
JPS5434724B2 (es) * 1974-09-19 1979-10-29
GB1590022A (en) * 1976-08-23 1981-05-28 Ono Pharmaceutical Co Prostaglandin analogues
US4178457A (en) * 1978-07-10 1979-12-11 Syntex (U.S.A.) Inc. (dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof
DE3030477C2 (de) * 1980-08-12 1986-10-16 Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe Iridoid-Derivate, Verfahren zu ihrer Herstellung und deren Verwendung
US4389414A (en) * 1981-05-11 1983-06-21 Syntex (U.S.A.) Inc. Prostaglandin compositions
CA1216793A (en) * 1982-07-19 1987-01-20 Cheng-Der Yu Pge-type compositions encapsulated by acid isolated gelatin
ES8607921A1 (es) * 1984-07-31 1986-06-16 Syntex Inc Procedimiento para preparar derivados de acidos 11-sustitui-dos-16-fenoxi y 16-fenoxi sustituido-prostatrienoicos
US4618696A (en) * 1984-07-31 1986-10-21 Syntex (U.S.A.) Inc. 9-oxo-15α-hydroxy-16-phenoxy and 16-substituted phenoxy 17,18,19,20-tetranorprosta-4,5,13,(E)-trienoates
NZ213749A (en) * 1984-10-09 1989-01-06 Syntex Inc Ethers for use as intermediates in the preparation of 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives

Also Published As

Publication number Publication date
PL255723A1 (en) 1986-07-29
CS257796B2 (en) 1988-06-15
DE3481610D1 (de) 1990-04-19
HU196732B (en) 1989-01-30
CN85101840A (zh) 1987-01-17
IL73881A0 (en) 1985-03-31
ES538899A0 (es) 1986-02-01
ES8607228A1 (es) 1986-06-01
ES548459A0 (es) 1986-08-01
PL251088A1 (en) 1985-12-17
CS1013284A2 (en) 1987-09-17
FI845069A0 (fi) 1984-12-20
RO91666A (ro) 1987-07-30
PT79720A (en) 1985-01-01
AR241015A1 (es) 1991-04-30
JPH0772170B2 (ja) 1995-08-02
SU1342411A3 (ru) 1987-09-30
CS600784A2 (en) 1987-09-17
JPH0717597B2 (ja) 1995-03-01
PH23728A (en) 1989-11-03
IL73881A (en) 1990-01-18
JPH0635431B2 (ja) 1994-05-11
DK617084D0 (da) 1984-12-20
JPS60169459A (ja) 1985-09-02
SU1356959A3 (ru) 1987-11-30
IN160437B (es) 1987-07-11
JPH0539262A (ja) 1993-02-19
CA1267892A (en) 1990-04-17
DD249700A5 (de) 1987-09-16
NZ210667A (en) 1988-08-30
MX158754A (es) 1989-03-10
AR241015A2 (es) 1991-04-30
RO94561A7 (ro) 1988-06-30
NO845148L (no) 1985-06-24
JPH0539263A (ja) 1993-02-19
ATE50986T1 (de) 1990-03-15
ES8609234A1 (es) 1986-08-01
FI845069L (fi) 1985-06-23
CS600884A2 (en) 1987-09-17
ES548453A0 (es) 1986-06-01
CA1283409C (en) 1991-04-23
ES8604389A1 (es) 1986-02-01
ZA849967B (en) 1986-08-27
EP0146935A3 (en) 1987-05-06
ES548460A0 (es) 1986-06-01
KR900000684B1 (ko) 1990-02-03
CA1283408C (en) 1991-04-23
DK617084A (da) 1985-06-23
SU1473709A3 (ru) 1989-04-15
HUT36090A (en) 1985-08-28
HU197302B (en) 1989-03-28
CS257784B2 (en) 1988-06-15
PH22893A (en) 1989-01-19
CS257797B2 (en) 1988-06-15
EP0146935B1 (en) 1990-03-14
DD241254A5 (de) 1986-12-03
MX12599A (es) 1993-05-01
AU3712084A (en) 1985-07-04
AU585844B2 (en) 1989-06-29
US4600785A (en) 1986-07-15
RO91666B (ro) 1987-07-31
GR82514B (en) 1985-04-11
EP0146935A2 (en) 1985-07-03
PL154330B1 (en) 1991-08-30
CA1276931C (en) 1990-11-27
KR850004589A (ko) 1985-07-25

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