ES548459A0 - Procedimiento para preparar (4,5,6r,8r)-9-oxo-11,15 dihidro-xi-16-fenoxi-17,18,19,20-tetranorprosta-4,5,13 (e) trienoatometilico cristalino - Google Patents

Procedimiento para preparar (4,5,6r,8r)-9-oxo-11,15 dihidro-xi-16-fenoxi-17,18,19,20-tetranorprosta-4,5,13 (e) trienoatometilico cristalino

Info

Publication number: ES548459A0
Authority: ES; Spain
Prior art keywords: trienoatometilico; cristalino; tetranorprosta; fenoxi; dihidro
Prior art date: 1983-12-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES548459A

Other languages

English (en)

Other versions

ES8609234A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Syntex USA LLC

Original Assignee

Syntex USA LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-12-22

Filing date

1985-10-31

Publication date

1986-08-01

1985-10-31 Application filed by Syntex USA LLC filed Critical Syntex USA LLC

1986-08-01 Publication of ES548459A0 publication Critical patent/ES548459A0/es

1986-08-01 Publication of ES8609234A1 publication Critical patent/ES8609234A1/es

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES548459A 1983-12-22 1985-10-31 Procedimiento para preparar (4,5,6r,8r)-9-oxo-11,15 dihidro-xi-16-fenoxi-17,18,19,20-tetranorprosta-4,5,13 (e) trienoatometilico cristalino Expired ES8609234A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/564,386 US4600785A (en)	1983-12-22	1983-12-22	Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives

Publications (2)

Publication Number	Publication Date
ES548459A0 true ES548459A0 (es)	1986-08-01
ES8609234A1 ES8609234A1 (es)	1986-08-01

Family

ID=24254259

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
ES538899A Expired ES8604389A1 (es)	1983-12-22	1984-12-20	Procedimientos y compuestos intermedios para preparar derivados de acidos 16-(fenoxi substituido)-prostatrinoicos y sus sales esteroisomeros
ES548459A Expired ES8609234A1 (es)	1983-12-22	1985-10-31	Procedimiento para preparar (4,5,6r,8r)-9-oxo-11,15 dihidro-xi-16-fenoxi-17,18,19,20-tetranorprosta-4,5,13 (e) trienoatometilico cristalino
ES548453A Expired ES8607228A1 (es)	1983-12-22	1985-10-31	Procedimiento para preparar derivados de acidos 16-fenoxi y 16(fenoxi sustituido)-prostatrienoicos y sus estereoisomeros
ES548460A Expired ES8607229A1 (es)	1983-12-22	1985-10-31	Procedimiento para preparar derivados de acidos 16-fenoxi y 16-(fenoxi sustituido)-prostatrienoicos y sus estereoisome- ros

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES538899A Expired ES8604389A1 (es)	1983-12-22	1984-12-20	Procedimientos y compuestos intermedios para preparar derivados de acidos 16-(fenoxi substituido)-prostatrinoicos y sus sales esteroisomeros

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
ES548453A Expired ES8607228A1 (es)	1983-12-22	1985-10-31	Procedimiento para preparar derivados de acidos 16-fenoxi y 16(fenoxi sustituido)-prostatrienoicos y sus estereoisomeros
ES548460A Expired ES8607229A1 (es)	1983-12-22	1985-10-31	Procedimiento para preparar derivados de acidos 16-fenoxi y 16-(fenoxi sustituido)-prostatrienoicos y sus estereoisome- ros

Country Status (28)

Country	Link
US (1)	US4600785A (es)
EP (1)	EP0146935B1 (es)
JP (3)	JPH0635431B2 (es)
KR (1)	KR900000684B1 (es)
CN (1)	CN85101840A (es)
AR (1)	AR241015A1 (es)
AT (1)	ATE50986T1 (es)
AU (1)	AU585844B2 (es)
CA (4)	CA1267892A (es)
CS (5)	CS600784A2 (es)
DD (2)	DD249700A5 (es)
DE (1)	DE3481610D1 (es)
DK (1)	DK617084A (es)
ES (4)	ES8604389A1 (es)
FI (1)	FI845069L (es)
GR (1)	GR82514B (es)
HU (2)	HU196732B (es)
IL (1)	IL73881A (es)
IN (1)	IN160437B (es)
MX (2)	MX158754A (es)
NO (1)	NO845148L (es)
NZ (1)	NZ210667A (es)
PH (2)	PH22893A (es)
PL (2)	PL154330B1 (es)
PT (1)	PT79720A (es)
RO (2)	RO94561A7 (es)
SU (3)	SU1473709A3 (es)
ZA (1)	ZA849967B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ213749A (en) *	1984-10-09	1989-01-06	Syntex Inc	Ethers for use as intermediates in the preparation of 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
US4929740A (en) *	1984-10-09	1990-05-29	Syntex (U.S.A.) Inc.	Process for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
US4778904A (en) *	1985-09-13	1988-10-18	Syntex (U.S.A.) Inc.	Intermediates for making 16-phenoxy- and 16-(substituted phenoxy)-prostatrienoic acid derivatives
US4755531A (en) *	1986-08-11	1988-07-05	Syntex (U.S.A.) Inc.	Thiol esters of 4,5-allenyl prostaglandins and use thereof as antigastric secretion agents
US4689419A (en) *	1986-11-14	1987-08-25	G. D. Searle & Co.	Novel intermediate compounds in a process for producing 16-phenoxy- and 16-substituted phenoxy-9-keto-prostatrienoic acid derivatives
US5248788A (en) *	1988-12-13	1993-09-28	Syntex (U.S.A.) Inc.	Process for preparing allenic prostanoic acid derivatives
US4916238A (en) *	1988-12-13	1990-04-10	Syntex (U.S.A.) Inc.	Process for preparing allenic prostanoic acid derivatives
US5571936A (en) *	1994-09-30	1996-11-05	Korea Institute Of Science And Technology	Intermediates for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4304907A (en) *	1972-05-10	1981-12-08	The Upjohn Company	Bicyclo lactone intermediates for prostaglandin analogs
JPS5434724B2 (es) *	1974-09-19	1979-10-29
GB1590022A (en) *	1976-08-23	1981-05-28	Ono Pharmaceutical Co	Prostaglandin analogues
US4178457A (en) *	1978-07-10	1979-12-11	Syntex (U.S.A.) Inc.	(dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acid derivatives and processes for the production thereof
DE3030477C2 (de) *	1980-08-12	1986-10-16	Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe	Iridoid-Derivate, Verfahren zu ihrer Herstellung und deren Verwendung
US4389414A (en) *	1981-05-11	1983-06-21	Syntex (U.S.A.) Inc.	Prostaglandin compositions
CA1216793A (en) *	1982-07-19	1987-01-20	Cheng-Der Yu	Pge-type compositions encapsulated by acid isolated gelatin
ES8607921A1 (es) *	1984-07-31	1986-06-16	Syntex Inc	Procedimiento para preparar derivados de acidos 11-sustitui-dos-16-fenoxi y 16-fenoxi sustituido-prostatrienoicos
US4618696A (en) *	1984-07-31	1986-10-21	Syntex (U.S.A.) Inc.	9-oxo-15α-hydroxy-16-phenoxy and 16-substituted phenoxy 17,18,19,20-tetranorprosta-4,5,13,(E)-trienoates
NZ213749A (en) *	1984-10-09	1989-01-06	Syntex Inc	Ethers for use as intermediates in the preparation of 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives

1983
- 1983-12-22 US US06/564,386 patent/US4600785A/en not_active Expired - Fee Related
1984
- 1984-12-19 GR GR82514A patent/GR82514B/el unknown
- 1984-12-20 DD DD84294680A patent/DD249700A5/de unknown
- 1984-12-20 PL PL1984251088A patent/PL154330B1/pl unknown
- 1984-12-20 ES ES538899A patent/ES8604389A1/es not_active Expired
- 1984-12-20 FI FI845069A patent/FI845069L/fi not_active Application Discontinuation
- 1984-12-20 AT AT84115950T patent/ATE50986T1/de not_active IP Right Cessation
- 1984-12-20 HU HU863355A patent/HU196732B/hu not_active IP Right Cessation
- 1984-12-20 NZ NZ210667A patent/NZ210667A/xx unknown
- 1984-12-20 DK DK617084A patent/DK617084A/da not_active Application Discontinuation
- 1984-12-20 PL PL25572384A patent/PL255723A1/xx unknown
- 1984-12-20 CS CS866007A patent/CS600784A2/cs unknown
- 1984-12-20 PH PH31623A patent/PH22893A/en unknown
- 1984-12-20 IL IL73881A patent/IL73881A/xx unknown
- 1984-12-20 EP EP84115950A patent/EP0146935B1/en not_active Expired - Lifetime
- 1984-12-20 NO NO845148A patent/NO845148L/no unknown
- 1984-12-20 SU SU843828202A patent/SU1473709A3/ru active
- 1984-12-20 AR AR299047A patent/AR241015A1/es active
- 1984-12-20 JP JP59270571A patent/JPH0635431B2/ja not_active Expired - Lifetime
- 1984-12-20 RO RO84124019A patent/RO94561A7/ro unknown
- 1984-12-20 PT PT79720A patent/PT79720A/pt unknown
- 1984-12-20 AU AU37120/84A patent/AU585844B2/en not_active Ceased
- 1984-12-20 MX MX203853A patent/MX158754A/es unknown
- 1984-12-20 DD DD84271309A patent/DD241254A5/de not_active IP Right Cessation
- 1984-12-20 CA CA000470699A patent/CA1267892A/en not_active Expired - Fee Related
- 1984-12-20 ZA ZA849967A patent/ZA849967B/xx unknown
- 1984-12-20 HU HU844754A patent/HU197302B/hu not_active IP Right Cessation
- 1984-12-20 IN IN1020/MAS/84A patent/IN160437B/en unknown
- 1984-12-20 CS CS8410132A patent/CS257784B2/cs unknown
- 1984-12-20 CS CS866008A patent/CS600884A2/cs unknown
- 1984-12-20 RO RO116780A patent/RO91666B/ro unknown
- 1984-12-20 KR KR1019840008147A patent/KR900000684B1/ko not_active IP Right Cessation
- 1984-12-20 DE DE8484115950T patent/DE3481610D1/de not_active Expired - Fee Related
1985
- 1985-04-01 CN CN198585101840A patent/CN85101840A/zh active Pending
- 1985-09-24 SU SU853955489A patent/SU1342411A3/ru active
- 1985-09-24 SU SU853955491A patent/SU1356959A3/ru active
- 1985-10-31 ES ES548459A patent/ES8609234A1/es not_active Expired
- 1985-10-31 ES ES548453A patent/ES8607228A1/es not_active Expired
- 1985-10-31 ES ES548460A patent/ES8607229A1/es not_active Expired
1986
- 1986-05-09 PH PH33751A patent/PH23728A/en unknown
- 1986-08-14 CS CS866007A patent/CS257796B2/cs unknown
- 1986-08-14 CS CS866008A patent/CS257797B2/cs unknown
1988
- 1988-08-09 MX MX1259988A patent/MX12599A/es unknown
- 1988-08-11 CA CA000574537A patent/CA1276931C/en not_active Expired - Fee Related
- 1988-08-11 CA CA000574538A patent/CA1283408C/en not_active Expired - Fee Related
- 1988-08-12 CA CA000574703A patent/CA1283409C/en not_active Expired - Fee Related
1991
- 1991-12-19 JP JP3336857A patent/JPH0772170B2/ja not_active Expired - Lifetime
- 1991-12-19 JP JP3336862A patent/JPH0717597B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PL255723A1 (en)	1986-07-29
CS257796B2 (en)	1988-06-15
DE3481610D1 (de)	1990-04-19
HU196732B (en)	1989-01-30
CN85101840A (zh)	1987-01-17
IL73881A0 (en)	1985-03-31
ES538899A0 (es)	1986-02-01
ES8607228A1 (es)	1986-06-01
PL251088A1 (en)	1985-12-17
CS1013284A2 (en)	1987-09-17
ES8607229A1 (es)	1986-06-01
FI845069A0 (fi)	1984-12-20
RO91666A (ro)	1987-07-30
PT79720A (en)	1985-01-01
AR241015A1 (es)	1991-04-30
JPH0772170B2 (ja)	1995-08-02
SU1342411A3 (ru)	1987-09-30
CS600784A2 (en)	1987-09-17
JPH0717597B2 (ja)	1995-03-01
PH23728A (en)	1989-11-03
IL73881A (en)	1990-01-18
JPH0635431B2 (ja)	1994-05-11
DK617084D0 (da)	1984-12-20
JPS60169459A (ja)	1985-09-02
SU1356959A3 (ru)	1987-11-30
IN160437B (es)	1987-07-11
JPH0539262A (ja)	1993-02-19
CA1267892A (en)	1990-04-17
DD249700A5 (de)	1987-09-16
NZ210667A (en)	1988-08-30
MX158754A (es)	1989-03-10
AR241015A2 (es)	1991-04-30
RO94561A7 (ro)	1988-06-30
NO845148L (no)	1985-06-24
JPH0539263A (ja)	1993-02-19
ATE50986T1 (de)	1990-03-15
ES8609234A1 (es)	1986-08-01
FI845069L (fi)	1985-06-23
CS600884A2 (en)	1987-09-17
ES548453A0 (es)	1986-06-01
CA1283409C (en)	1991-04-23
ES8604389A1 (es)	1986-02-01
ZA849967B (en)	1986-08-27
EP0146935A3 (en)	1987-05-06
ES548460A0 (es)	1986-06-01
KR900000684B1 (ko)	1990-02-03
CA1283408C (en)	1991-04-23
DK617084A (da)	1985-06-23
SU1473709A3 (ru)	1989-04-15
HUT36090A (en)	1985-08-28
HU197302B (en)	1989-03-28
CS257784B2 (en)	1988-06-15
PH22893A (en)	1989-01-19
CS257797B2 (en)	1988-06-15
EP0146935B1 (en)	1990-03-14
DD241254A5 (de)	1986-12-03
MX12599A (es)	1993-05-01
AU3712084A (en)	1985-07-04
AU585844B2 (en)	1989-06-29
US4600785A (en)	1986-07-15
RO91666B (ro)	1987-07-31
GR82514B (en)	1985-04-11
EP0146935A2 (en)	1985-07-03
PL154330B1 (en)	1991-08-30
CA1276931C (en)	1990-11-27
KR850004589A (ko)	1985-07-25

Publication	Publication Date	Title
ES534787A0 (es)	1985-10-01	Procedimiento para preparar etinglicoles
IT1178429B (it)	1987-09-09	Procedimento per produrre 5-idrossi-metilfurfurale
MX156956A (es)	1988-10-17	Procedimiento para preparar-2-(benzoilo-2-substituidas-1,3-ciclohexanodionas
ES529728A0 (es)	1984-11-01	Procedimiento para preparar amino-2-fenil-5-benzodiazepinas-1, 3
ES536138A0 (es)	1985-11-01	Procedimiento para preparar derivados azolicos
ES537992A0 (es)	1985-11-01	Procedimiento para preparar 2-fenil-imidazoles
ES533995A0 (es)	1985-06-16	Procedimiento para preparar imidasoles
ES535534A0 (es)	1987-07-01	Procedimiento para la obtencion de -aril-1h-azol-1-etanoles
ES534227A0 (es)	1986-06-01	Procedimiento para preparar piridinas
IT8423765A0 (it)	1984-11-28	Procedimento per produrre 4-alcossianiline.
AR240313A1 (es)	1990-03-30	Procedimiento para preparar nuevas 1, 2-dihidro-5-acil-2-piridinonas
ES548459A0 (es)	1986-08-01	Procedimiento para preparar (4,5,6r,8r)-9-oxo-11,15 dihidro-xi-16-fenoxi-17,18,19,20-tetranorprosta-4,5,13 (e) trienoatometilico cristalino
IT1179247B (it)	1987-09-16	Procedimento per produrre interferone
ES544773A0 (es)	1986-11-16	Procedimiento para preparar derivados de pirazol-(1,5a)piri-dina
ES538616A0 (es)	1985-11-01	Procedimiento para preparar nuevas 4-fenil-tetrahidrofurano-(2,3-c)priridinas
ES530037A0 (es)	1985-05-01	Procedimiento para preparar imidazolamidas
ES533024A0 (es)	1985-07-16	Procedimiento para preparar meta-o para-isopropenil-alfa-alfa-dimetilbencilamina
MX157611A (es)	1988-12-05	Procedimiento para preparar derivados de-3-azabiciclo(3.3.1)nonano
ES532142A0 (es)	1985-06-01	Procedimiento para preparar derivados acilaminofenolicos
ES533691A0 (es)	1985-07-01	Procedimiento de preparar 2,9-dihidrofuranos
ES529734A0 (es)	1985-09-01	Procedimiento para preparar 3-acil-2-nitrometilentetrahidro-2h-1, 3-tiazinas
ES537991A0 (es)	1985-11-01	Procedimiento para preparar imidazo (4,5-c) piridin-onas
IT8419470A0 (it)	1984-02-07	Procedimento di preparazione per eteri ossimici basici.
IT1175932B (it)	1987-08-12	Procedimento per produrre s-adenosil-l-omocisteina
ES530204A0 (es)	1985-11-01	Procedimiento para preparar cianoesteroides