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CY2016046I1 - Κιναζολινονες ως αναστολεις της ανθρωπινης 3-κινασης δελτα της φωσφατιδυλινοσιτολης - Google Patents

Κιναζολινονες ως αναστολεις της ανθρωπινης 3-κινασης δελτα της φωσφατιδυλινοσιτολης

Info

Publication number
CY2016046I1
CY2016046I1 CY2016046C CY2016046C CY2016046I1 CY 2016046 I1 CY2016046 I1 CY 2016046I1 CY 2016046 C CY2016046 C CY 2016046C CY 2016046 C CY2016046 C CY 2016046C CY 2016046 I1 CY2016046 I1 CY 2016046I1
Authority
CY
Cyprus
Prior art keywords
quinazolinones
kinase
delta
inhibitors
human phosphatidylinositol
Prior art date
Application number
CY2016046C
Other languages
English (en)
Other versions
CY2016046I2 (el
Original Assignee
Icos Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34969603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2016046(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Icos Corporation filed Critical Icos Corporation
Publication of CY2016046I2 publication Critical patent/CY2016046I2/el
Publication of CY2016046I1 publication Critical patent/CY2016046I1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/02—Ophthalmic agents
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
CY2016046C 2004-05-13 2016-11-24 Κιναζολινονες ως αναστολεις της ανθρωπινης 3-κινασης δελτα της φωσφατιδυλινοσιτολης CY2016046I1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57078404P 2004-05-13 2004-05-13
PCT/US2005/016778 WO2005113556A1 (en) 2004-05-13 2005-05-12 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta

Publications (2)

Publication Number Publication Date
CY2016046I2 CY2016046I2 (el) 2017-11-14
CY2016046I1 true CY2016046I1 (el) 2017-11-14

Family

ID=34969603

Family Applications (3)

Application Number Title Priority Date Filing Date
CY2016046C CY2016046I1 (el) 2004-05-13 2016-11-24 Κιναζολινονες ως αναστολεις της ανθρωπινης 3-κινασης δελτα της φωσφατιδυλινοσιτολης
CY20161101299T CY1118493T1 (el) 2004-05-13 2016-12-14 Κιναζολινονες ως αναστολεις της ανθρωπινης 3-κινασης δελτα της φωσφατιδυλινοσιτολης
CY20161101359T CY1118516T1 (el) 2004-05-13 2016-12-28 Κιναζολινονες ως αναστολεις της ανθρωπινης 3-κινασης δελτα της φωσφατιδυλινοσιτολης

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY20161101299T CY1118493T1 (el) 2004-05-13 2016-12-14 Κιναζολινονες ως αναστολεις της ανθρωπινης 3-κινασης δελτα της φωσφατιδυλινοσιτολης
CY20161101359T CY1118516T1 (el) 2004-05-13 2016-12-28 Κιναζολινονες ως αναστολεις της ανθρωπινης 3-κινασης δελτα της φωσφατιδυλινοσιτολης

Country Status (22)

Country Link
US (14) USRE44638E1 (el)
EP (4) EP3943494A1 (el)
JP (1) JP2007537291A (el)
CN (2) CN101031569B (el)
AU (2) AU2005245875C1 (el)
BE (1) BE2017C002I2 (el)
CA (1) CA2566609C (el)
CY (3) CY2016046I1 (el)
DK (2) DK2612862T3 (el)
ES (3) ES2605792T3 (el)
HR (2) HRP20161657T1 (el)
HU (3) HUE030950T2 (el)
IL (4) IL179176A (el)
LT (3) LT2612862T (el)
LU (1) LUC00005I2 (el)
ME (2) ME02688B (el)
NL (1) NL300867I2 (el)
PL (3) PL3153514T3 (el)
PT (3) PT2612862T (el)
RS (2) RS55551B1 (el)
SI (2) SI3153514T1 (el)
WO (2) WO2005113554A2 (el)

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US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
WO2005016348A1 (en) * 2003-08-14 2005-02-24 Icos Corporation Method of inhibiting immune responses stimulated by an endogenous factor
CA2730540A1 (en) * 2004-05-13 2005-12-01 Vanderbilt University Phosphoinositide 3-kinase delta selective inhibitors for inhibiting angiogenesis
EP3943494A1 (en) 2004-05-13 2022-01-26 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
US9512125B2 (en) * 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
US20080287469A1 (en) * 2005-02-17 2008-11-20 Diacovo Thomas G Phosphoinositide 3-Kinase Inhibitors for Inhibiting Leukocyte Accumulation
GB2431156A (en) * 2005-10-11 2007-04-18 Piramed Ltd 1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase
JP2009532507A (ja) * 2006-04-04 2009-09-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｐｉ３キナーゼアンタゴニスト
CN101605797A (zh) 2006-11-13 2009-12-16 伊莱利利公司 治疗炎症疾病和癌症的噻吩并嘧啶酮
EP1953163A1 (en) 2007-02-01 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Pteridinone derivatives as PI3-kinases inhibitors
US20110123486A1 (en) * 2007-06-25 2011-05-26 Prolexys Pharmaceuticals, Inc. Methods of treating multiple myeloma and resistant cancers
FR2918668B1 (fr) * 2007-07-09 2009-08-21 Arkema France Procede ameliore de preparation d'alcoxyamines issues de nitroxydes beta-phosphores.
GB2467670B (en) * 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
GEP20125635B (en) * 2007-11-13 2012-09-10 Icos Corp Inhibitors of human phosphatidyl-inositol 3-kinase delta
AU2014203687B2 (en) * 2008-01-04 2016-04-14 Intellikine Llc Certain chemical entities, compositions and methods
RU2537549C2 (ru) * 2008-01-04 2015-01-10 Интелликайн ЭлЭлСи Некоторые химические структуры, композиции и способы
WO2009088986A1 (en) * 2008-01-04 2009-07-16 Intellikine, Inc. Certain chemical entities, compositions and methods
US8193182B2 (en) * 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US8637542B2 (en) 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
WO2009128520A1 (ja) * 2008-04-18 2009-10-22 塩野義製薬株式会社 Ｐ１３ｋ阻害活性を有する複素環化合物
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LUC00005I1 (el) 2017-02-21
US9149477B2 (en) 2015-10-06
EP2612862B1 (en) 2016-09-14
ES2873875T3 (es) 2021-11-04
HRP20161751T1 (hr) 2017-04-07
PT2612862T (pt) 2016-12-15
WO2005113554A2 (en) 2005-12-01
HUE030950T2 (en) 2017-06-28
US8207153B2 (en) 2012-06-26
US20100256167A1 (en) 2010-10-07
PL3153514T3 (pl) 2022-01-10
US8586597B2 (en) 2013-11-19
EP1761540B1 (en) 2016-09-28
LUC00005I2 (el) 2017-05-02
US20100256168A1 (en) 2010-10-07
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US20140121223A1 (en) 2014-05-01
LT1761540T (lt) 2017-02-27
US10906907B2 (en) 2021-02-02
LTC1761540I2 (lt) 2019-04-10
US7932260B2 (en) 2011-04-26
CN102229609A (zh) 2011-11-02
PT3153514T (pt) 2021-06-25
RS55551B1 (sr) 2017-05-31
US20140121224A1 (en) 2014-05-01
US8980901B2 (en) 2015-03-17
IL179176A0 (en) 2007-03-08
USRE44638E1 (en) 2013-12-10
US20130231356A1 (en) 2013-09-05
CN101031569A (zh) 2007-09-05
ME02688B (me) 2017-10-20
EP3153514A1 (en) 2017-04-12
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US20210332047A1 (en) 2021-10-28
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SI2612862T1 (sl) 2017-04-26
US20160075705A1 (en) 2016-03-17
EP1761540A1 (en) 2007-03-14
CY1118493T1 (el) 2017-07-12
AU2005245875B2 (en) 2009-07-30
US20130116266A1 (en) 2013-05-09
US8993583B2 (en) 2015-03-31
CY1118516T1 (el) 2017-07-12
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AU2005245875C1 (en) 2017-08-31
JP2007537291A (ja) 2007-12-20
EP3153514B1 (en) 2021-04-21
RS55546B1 (sr) 2017-05-31
ES2605792T3 (es) 2017-03-16
BE2017C002I2 (el) 2024-08-08
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US20200017503A1 (en) 2020-01-16
PT1761540T (pt) 2016-12-07

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