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BR0212951A - Formas de dosagens compósitas - Google Patents

Formas de dosagens compósitas

Info

Publication number
BR0212951A
BR0212951A BR0212951-5A BR0212951A BR0212951A BR 0212951 A BR0212951 A BR 0212951A BR 0212951 A BR0212951 A BR 0212951A BR 0212951 A BR0212951 A BR 0212951A
Authority
BR
Brazil
Prior art keywords
dosage forms
interface
active ingredient
composite dosage
composite
Prior art date
Application number
BR0212951-5A
Other languages
English (en)
Inventor
Frank J Bunick
Der-Yang Lee
Gerard P Mcnally
Harry S Sowden
Martin T Homas
Original Assignee
Mcneil Ppc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/966,450 external-priority patent/US6982094B2/en
Priority claimed from US09/966,497 external-priority patent/US7122143B2/en
Priority claimed from US09/966,939 external-priority patent/US6837696B2/en
Priority claimed from US09/966,509 external-priority patent/US6767200B2/en
Priority claimed from US09/967,414 external-priority patent/US6742646B2/en
Application filed by Mcneil Ppc Inc filed Critical Mcneil Ppc Inc
Publication of BR0212951A publication Critical patent/BR0212951A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/02—Apparatus specially adapted for manufacture or treatment of sweetmeats or confectionery; Accessories therefor
    • A23G3/04—Sugar-cookers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/50—Cocoa products, e.g. chocolate; Substitutes therefor characterised by shape, structure or physical form, e.g. products with an inedible support
    • A23G1/54—Composite products, e.g. layered laminated, coated, filled
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/0002—Processes of manufacture not relating to composition and compounding ingredients
    • A23G3/0004—Processes specially adapted for manufacture or treatment of sweetmeats or confectionery
    • A23G3/0019—Shaping of liquid, paste, powder; Manufacture of moulded articles, e.g. modelling, moulding, calendering
    • A23G3/0025—Processes in which the material is shaped at least partially in a mould in the hollows of a surface, a drum, an endless band, or by a drop-by-drop casting or dispensing of the material on a surface, e.g. injection moulding, transfer moulding
    • A23G3/0029—Moulding processes for hollow products, e.g. opened shell
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
    • A23G3/54—Composite products, e.g. layered, coated, filled
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
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    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
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    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
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    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
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    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
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    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/34—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses for coating articles, e.g. tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/30—Feeding material to presses
    • B30B15/302—Feeding material in particulate or plastic state to moulding presses
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T428/00—Stock material or miscellaneous articles
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Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mechanical Engineering (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Confectionery (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

"FORMAS DE DOSAGEM COMPóSITAS". Uma forma de dosagem compósita compreende no mínimo um ingrediente ativo, uma primeira porção compreendendo um primeiro material moldado, e uma segunda porção compreendendo um segundo material o qual é de composição diferente do primeiro material. As primeira e segunda porções são unidas em uma interface, e uma superfície da primeira porção na interface está presente essencialmente de modo amoldado sobre uma superfície da segunda porção da interface. Ou a primeira porção, a segunda porção, ou uma combinação das mesmas podem conter no mínimo um ingrediente ativo. A primeira porção, a segunda porção ou ambas também podem cada uma compreender uma inserção a qual pode conter no mínimo um ingrediente ativo. A forma de dosagem também pode compreender uma terceira porção a qual está localizada entre as primeira e segunda porções.
BR0212951-5A 2001-09-28 2002-09-28 Formas de dosagens compósitas BR0212951A (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US09/966,450 US6982094B2 (en) 2001-09-28 2001-09-28 Systems, methods and apparatuses for manufacturing dosage forms
US09/966,497 US7122143B2 (en) 2001-09-28 2001-09-28 Methods for manufacturing dosage forms
US09/966,939 US6837696B2 (en) 2001-09-28 2001-09-28 Apparatus for manufacturing dosage forms
US09/966,509 US6767200B2 (en) 2001-09-28 2001-09-28 Systems, methods and apparatuses for manufacturing dosage forms
US09/967,414 US6742646B2 (en) 2001-09-28 2001-09-28 Systems, methods and apparatuses for manufacturing dosage forms
PCT/US2002/031163 WO2003026627A1 (en) 2001-09-28 2002-09-28 Composite dosage forms

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BR0213593-0A BR0213593A (pt) 2001-09-28 2002-09-28 Formas de dosagens de liberação modificada
BR0212921-3A BR0212921A (pt) 2001-09-28 2002-09-28 Composição farmacêutica com base em fondant
BR0206061-2A BR0206061A (pt) 2001-09-28 2002-09-28 Formas de dosagem que apresentam um núcleo interno e um invólucro externo com diferentes formas
BR0213591-4A BR0213591A (pt) 2001-09-28 2002-09-28 Composição comestìvel e forma de dosagem compreendendo uma parte externa comestìvel
BR0212950-7A BR0212950A (pt) 2001-09-28 2002-09-28 Formas de dosagens compósitas tendo uma porção inserida
BR0213589-2A BR0213589A (pt) 2001-09-28 2002-09-28 Formas de dosagens de liberação modificada
BR0206062-0A BR0206062A (pt) 2001-09-28 2002-09-28 Formas de dosagem tendo um núcleo interno e invólucro externo
BR0206086-8A BR0206086A (pt) 2001-09-28 2002-09-28 Formas de dosagem de liberação modificada
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BR0206061-2A BR0206061A (pt) 2001-09-28 2002-09-28 Formas de dosagem que apresentam um núcleo interno e um invólucro externo com diferentes formas
BR0213591-4A BR0213591A (pt) 2001-09-28 2002-09-28 Composição comestìvel e forma de dosagem compreendendo uma parte externa comestìvel
BR0212950-7A BR0212950A (pt) 2001-09-28 2002-09-28 Formas de dosagens compósitas tendo uma porção inserida
BR0213589-2A BR0213589A (pt) 2001-09-28 2002-09-28 Formas de dosagens de liberação modificada
BR0206062-0A BR0206062A (pt) 2001-09-28 2002-09-28 Formas de dosagem tendo um núcleo interno e invólucro externo
BR0206086-8A BR0206086A (pt) 2001-09-28 2002-09-28 Formas de dosagem de liberação modificada
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CA2446759A1 (en) 2003-04-03
CA2461682A1 (en) 2003-04-03
MXPA04002992A (es) 2005-06-20
KR20040037203A (ko) 2004-05-04
PT1429738E (pt) 2007-12-14
CN1596104A (zh) 2005-03-16
MXPA04002891A (es) 2005-06-20
KR20040045031A (ko) 2004-05-31
HK1072902A1 (en) 2005-09-16
WO2003026625A1 (en) 2003-04-03
EP1429738B1 (en) 2007-10-31
NO20032362L (no) 2003-07-14
WO2003026615A3 (en) 2003-07-31
EP1432404A1 (en) 2004-06-30
CN1592613A (zh) 2005-03-09
US7635490B2 (en) 2009-12-22
JP2005509604A (ja) 2005-04-14
JP2005508328A (ja) 2005-03-31
US20040241236A1 (en) 2004-12-02
JP2005535558A (ja) 2005-11-24
MXPA04002978A (es) 2005-06-20
MXPA04002977A (es) 2005-06-20
NZ532096A (en) 2006-10-27
CO5570655A2 (es) 2005-10-31
US7968120B2 (en) 2011-06-28
US20080305150A1 (en) 2008-12-11
HUP0401686A2 (hu) 2004-11-29
CN1638740A (zh) 2005-07-13
EP1429742A2 (en) 2004-06-23
US20030235616A1 (en) 2003-12-25
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NO20032364D0 (no) 2003-05-26
US20050019407A1 (en) 2005-01-27
WO2003026628A2 (en) 2003-04-03
BR0212946A (pt) 2004-10-26
WO2003026626A2 (en) 2003-04-03
DE60228281D1 (de) 2008-09-25
KR20040045030A (ko) 2004-05-31
CA2461865A1 (en) 2003-04-03
JP2005508327A (ja) 2005-03-31
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PL369134A1 (en) 2005-04-18
US20040170750A1 (en) 2004-09-02
MXPA04002980A (es) 2005-06-20
BR0212921A (pt) 2004-10-13
US20030232083A1 (en) 2003-12-18
KR20040045032A (ko) 2004-05-31
ES2295427T3 (es) 2008-04-16
JP2005508325A (ja) 2005-03-31
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KR20040045026A (ko) 2004-05-31
ES2311073T3 (es) 2009-02-01
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BR0206086A (pt) 2003-12-23
ATE404179T1 (de) 2008-08-15
US7972624B2 (en) 2011-07-05
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US20040213849A1 (en) 2004-10-28
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JP2005509605A (ja) 2005-04-14
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US20030219484A1 (en) 2003-11-27
CN100408029C (zh) 2008-08-06
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US8545887B2 (en) 2013-10-01
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US20050266084A1 (en) 2005-12-01
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WO2003026628A3 (en) 2003-05-01
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EP1429742B1 (en) 2011-05-04
BR0213589A (pt) 2004-08-31
EP1429746B1 (en) 2008-08-13
MXPA04002975A (es) 2005-06-20
CA2461354A1 (en) 2003-04-03
US20040018327A1 (en) 2004-01-29
MXPA04002974A (es) 2005-06-20
BR0206061A (pt) 2004-01-13
CN100364515C (zh) 2008-01-30
DE60223269D1 (de) 2007-12-13
ES2444549T3 (es) 2014-02-25
MXPA04002973A (es) 2005-06-20
CA2461656A1 (en) 2003-04-03
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EP1438030A2 (en) 2004-07-21
WO2003026612A3 (en) 2003-06-26
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WO2003026616A1 (en) 2003-04-03
WO2003026629A2 (en) 2003-04-03
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US20090155372A1 (en) 2009-06-18
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CA2461659C (en) 2010-12-07
WO2003026614A9 (en) 2004-02-26
KR20040066094A (ko) 2004-07-23
WO2003026630A1 (en) 2003-04-03
WO2003026625A9 (en) 2004-05-06
BR0213588A (pt) 2004-08-31
KR20040045033A (ko) 2004-05-31
BR0206062A (pt) 2004-01-13
MXPA04002979A (es) 2005-06-20
WO2003026627A1 (en) 2003-04-03
WO2003026624A1 (en) 2003-04-03
MXPA04002981A (es) 2005-06-20
WO2003026629A3 (en) 2004-03-04
KR20040037208A (ko) 2004-05-04
NO20032362D0 (no) 2003-05-26
EP1429738A2 (en) 2004-06-23
WO2003026626A3 (en) 2003-10-16
US20040213848A1 (en) 2004-10-28
CA2446760A1 (en) 2003-04-03
BR0213593A (pt) 2004-08-31
NZ532568A (en) 2005-07-29
ATE476957T1 (de) 2010-08-15
KR20040045034A (ko) 2004-05-31
BR0212950A (pt) 2004-10-26

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