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AR004179A1 - Sales de (endo,sin)-(-)-3-(3-hidroxi-1-oxo-2-fenilpropoxi)-8-metil-8-(1- metiletil)-8-azoniabiciclo[3.2.1] octano y preparaciones medicamentosasinhalativas que las contienen. - Google Patents

Sales de (endo,sin)-(-)-3-(3-hidroxi-1-oxo-2-fenilpropoxi)-8-metil-8-(1- metiletil)-8-azoniabiciclo[3.2.1] octano y preparaciones medicamentosasinhalativas que las contienen.

Info

Publication number
AR004179A1
AR004179A1 ARP960103824A AR10382496A AR004179A1 AR 004179 A1 AR004179 A1 AR 004179A1 AR P960103824 A ARP960103824 A AR P960103824A AR 10382496 A AR10382496 A AR 10382496A AR 004179 A1 AR004179 A1 AR 004179A1
Authority
AR
Argentina
Prior art keywords
inhalative
endo
sin
oxo
salts
Prior art date
Application number
ARP960103824A
Other languages
English (en)
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of AR004179A1 publication Critical patent/AR004179A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06Oxygen atoms
    • C07D451/10Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/468-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

El invento se refiere a sales de (endo,sin)-(-)-3-(3-hidroxi-1-oxo-2-fenil propoxi)-8-metil-8-(1-metiletil)-8-azoniabiciclo[3.2.1]octano con una pureza encuanto a los enantiómeros de 90 a 100%, y a preparaciones medicamentosas inhalativasque las contienen,eventualmente junto con sustancias auxiliares y/ode soporte habituales y/u otros principios activos. Las preparaciones medicamentosas inhalativas pueden contener una dosis eficaz de un Beta2-mimético, un esteroideadministrab le por vía inhalativa o un antialérgico administrable por vía inhalativa.
ARP960103824A 1995-08-01 1996-07-31 Sales de (endo,sin)-(-)-3-(3-hidroxi-1-oxo-2-fenilpropoxi)-8-metil-8-(1- metiletil)-8-azoniabiciclo[3.2.1] octano y preparaciones medicamentosasinhalativas que las contienen. AR004179A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19528145A DE19528145A1 (de) 1995-08-01 1995-08-01 Neue Arzneimittel und ihre Verwendung

Publications (1)

Publication Number Publication Date
AR004179A1 true AR004179A1 (es) 1998-11-04

Family

ID=7768353

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103824A AR004179A1 (es) 1995-08-01 1996-07-31 Sales de (endo,sin)-(-)-3-(3-hidroxi-1-oxo-2-fenilpropoxi)-8-metil-8-(1- metiletil)-8-azoniabiciclo[3.2.1] octano y preparaciones medicamentosasinhalativas que las contienen.

Country Status (37)

Country Link
US (1) US6299861B1 (es)
EP (1) EP0843676B1 (es)
JP (1) JPH11510150A (es)
KR (1) KR100445016B1 (es)
CN (1) CN1120841C (es)
AR (1) AR004179A1 (es)
AT (1) ATE208390T1 (es)
AU (1) AU6739796A (es)
BG (1) BG63780B1 (es)
BR (1) BR9609951A (es)
CA (1) CA2226934C (es)
CO (1) CO4750836A1 (es)
CZ (1) CZ291998B6 (es)
DE (2) DE19528145A1 (es)
DK (1) DK0843676T3 (es)
EE (1) EE04614B1 (es)
ES (1) ES2167592T3 (es)
HK (2) HK1013597A1 (es)
HR (1) HRP960365B1 (es)
HU (1) HU228056B1 (es)
IL (1) IL118986A (es)
MX (1) MX9800864A (es)
MY (1) MY115201A (es)
NO (1) NO317561B1 (es)
NZ (1) NZ315645A (es)
PL (1) PL183789B1 (es)
PT (1) PT843676E (es)
RO (1) RO120260B1 (es)
RU (1) RU2171258C2 (es)
SI (1) SI0843676T1 (es)
SK (1) SK283260B6 (es)
TR (1) TR199800121T1 (es)
TW (1) TW449597B (es)
UA (1) UA55391C2 (es)
WO (1) WO1997005136A1 (es)
YU (1) YU49479B (es)
ZA (1) ZA966494B (es)

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US20100197719A1 (en) * 1999-05-12 2010-08-05 Boehringer Ingelheim Pharma Kg Medicament compositions containing anticholinergically-effective compounds and betamimetics
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
US6455028B1 (en) * 2001-04-23 2002-09-24 Pharmascience Ipratropium formulation for pulmonary inhalation
US20050070487A1 (en) * 2001-04-24 2005-03-31 Nyce Jonathan W. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
US20030140920A1 (en) * 2001-10-26 2003-07-31 Dey L.P. Albuterol inhalation soultion, system, kit and method for relieving symptoms of pediatric asthma
US6702997B2 (en) 2001-10-26 2004-03-09 Dey, L.P. Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma
JP2003221335A (ja) 2001-10-26 2003-08-05 Dey Lp 慢性閉塞性肺疾患の症状を緩和するためのアルブテロールおよびイプラトロピウム吸入溶液、システム、キットおよび方法
US20030203930A1 (en) * 2001-10-26 2003-10-30 Imtiaz Chaudry Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
US20030191151A1 (en) * 2001-10-26 2003-10-09 Imtiaz Chaudry Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US20050043343A1 (en) * 2003-07-28 2005-02-24 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a PDE IV inhibitor
US20050026948A1 (en) * 2003-07-29 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20090317476A1 (en) * 2003-07-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
PE20060826A1 (es) * 2004-12-06 2006-10-08 Smithkline Beecham Corp Derivado oleofinico de 8-azoniabiciclo[3.2.1]octano y combinacion farmaceutica que lo comprende
US20060239935A1 (en) * 2005-04-23 2006-10-26 Boehringer Ingelheim International Gmbh Compositions for inhalation
EP1879571A1 (de) * 2005-04-23 2008-01-23 Boehringer Ingelheim International GmbH Arzneimittelkombination für die inhalation enthaltend neben einem anticholinergikum ein betamimetikum und ein steroid
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
TW201311649A (zh) * 2011-09-05 2013-03-16 Everlight Chem Ind Corp 用於太陽能電池電解液之化合物及其製法、含有該化合物之電解液及太陽能電池
CN111751454B (zh) * 2019-03-29 2023-12-08 天津药业研究院股份有限公司 一种异丙托溴铵中间体i的含量和有关物质的检测方法
CN110361494B (zh) * 2019-06-26 2023-08-15 四川普锐特药业有限公司 异丙托溴铵气雾剂中杂质g的检测方法

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DE2903957A1 (de) * 1979-02-02 1980-08-07 Boehringer Sohn Ingelheim Mittel zur behandlung der nasalen hypersekretion
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Also Published As

Publication number Publication date
CA2226934C (en) 2007-05-01
NO980424L (no) 1998-01-30
SK11298A3 (en) 1998-07-08
ES2167592T3 (es) 2002-05-16
CZ225396A3 (cs) 1998-03-18
MX9800864A (es) 1998-04-30
MY115201A (en) 2003-04-30
HK1013597A1 (en) 1999-09-03
ZA966494B (en) 1997-02-03
HUP9602104A3 (en) 2000-03-28
RU2171258C2 (ru) 2001-07-27
WO1997005136A1 (de) 1997-02-13
NO317561B1 (no) 2004-11-15
NZ315645A (en) 1999-11-29
KR19990035997A (ko) 1999-05-25
CZ291998B6 (cs) 2003-07-16
TR199800121T1 (xx) 1998-04-21
HRP960365A2 (en) 1998-02-28
EE04614B1 (et) 2006-04-17
HRP960365B1 (en) 2002-04-30
CN1191535A (zh) 1998-08-26
YU49479B (sh) 2006-05-25
CN1120841C (zh) 2003-09-10
HUP9602104A2 (en) 1997-04-28
IL118986A0 (en) 1996-10-31
SI0843676T1 (en) 2002-06-30
AU6739796A (en) 1997-02-26
US6299861B1 (en) 2001-10-09
EP0843676A1 (de) 1998-05-27
PL183789B1 (pl) 2002-07-31
PL324804A1 (en) 1998-06-22
DK0843676T3 (da) 2001-12-27
HK1010879A1 (en) 1999-07-02
KR100445016B1 (ko) 2004-11-08
SK283260B6 (sk) 2003-04-01
NO980424D0 (no) 1998-01-30
BG63780B1 (bg) 2002-12-29
UA55391C2 (uk) 2003-04-15
BG102202A (en) 1998-09-30
EE9800028A (et) 1998-08-17
CA2226934A1 (en) 1997-02-13
BR9609951A (pt) 1999-02-02
DE19528145A1 (de) 1997-02-06
EP0843676B1 (de) 2001-11-07
DE59608156D1 (de) 2001-12-13
PT843676E (pt) 2002-04-29
IL118986A (en) 1998-12-06
RO120260B1 (ro) 2005-11-30
TW449597B (en) 2001-08-11
HU228056B1 (en) 2012-09-28
JPH11510150A (ja) 1999-09-07
YU44596A (sh) 1998-12-23
ATE208390T1 (de) 2001-11-15
CO4750836A1 (es) 1999-03-31
HU9602104D0 (en) 1996-09-30

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