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KR950007854A - 이중층 옥스카바제핀 정제 - Google Patents

이중층 옥스카바제핀 정제 Download PDF

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Publication number
KR950007854A
KR950007854A KR1019940022420A KR19940022420A KR950007854A KR 950007854 A KR950007854 A KR 950007854A KR 1019940022420 A KR1019940022420 A KR 1019940022420A KR 19940022420 A KR19940022420 A KR 19940022420A KR 950007854 A KR950007854 A KR 950007854A
Authority
KR
South Korea
Prior art keywords
azepine
dibenzo
carboxamide
dihydro
oxo
Prior art date
Application number
KR1019940022420A
Other languages
English (en)
Other versions
KR100319351B1 (ko
Inventor
부르퀸 야퀘스
Original Assignee
베르너 발데그
시바-가이기 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 베르너 발데그, 시바-가이기 에이지 filed Critical 베르너 발데그
Publication of KR950007854A publication Critical patent/KR950007854A/ko
Application granted granted Critical
Publication of KR100319351B1 publication Critical patent/KR100319351B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 백색 안료를 함유하는 친수성의 투과성 층 및 백색 안료를 철(Ⅱ)산화물 안료와의 혼합물 형태로 함유하는 친수성의 투파성 외부층이 제공된, 지료제 옥스카바제핀의 색상 안정성 정제에 관한 것이다.

Description

이중층 옥스카바제핀 정제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. a)치료학적 유효 투여량의 10, 11-디하이드로-10-옥소-5H-디벤조[b. f]아제핀-5-카복스아미드를 포함하는 정제 코어; b)백색 안료 및 추가의 임의 보조제로 이루어진 친수성의 투과성 내부 피복층; 및 c)철(Ⅱ)산화물 안료와의 혼합물 형태의 백색 안료 및 추가의 임의 보조제로 이루어진 친수성의 투과성 외부 피복층을 포함하는, 치료제 10, 11-디하이드로-10-옥소-5H-디벤조[b, f]아제핀-5-카복스아미드의 이중층 정제.
  2. 제1항에 있어서, a)치료제 10, 11-디하이드로-10-옥소-5H-디벤조[b, f]아제핀-5-카복스아미드의 투여 단위를 함유하는 정제 코어; b)이산화티탄 안료를 함유하는 폴리에틸렌 글리콜 8000 및 하이드록시프로필메틸 셀룰로즈로 이루어진 친수성의 투과성 내부층; 및 c)이산화티탄 안료를 철(Ⅱ) 산화물 안료와의 혼합물 형태로 함유하는 폴리에틸레 글리콜 8000 및 하이드록시프로필 메틸 셀루로즈로 이루어진 친수성의 투과성 외부층을 포함하는 이중층 정제.
  3. a)활성 약제인 10, 11-디하이드로-10-옥소-5H-디벤조[b, f]아제핀-5-카복스아미드를 표준 타정 방법으로 통상의 부형제와 함께 정제 코어로 압착시키고, 연속적으로 이 코어에 b)백색 안료를 함유하는 친수성의 투과성 내부 피복층 및 c)백색 안료를 철(Ⅱ) 산화물 안료와의 혼합물 형태로 함유하는 친수성의 투과성 외부피복층을 제공함을 포함하여 치료제 10, 11-디하이드로-10-옥소-5H-디벤조[b, f]아제핀-5-카복스아미드의 이중층 정제를 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940022420A 1993-09-08 1994-09-07 이중층 옥스카바제핀 정제 KR100319351B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH?02679/93-2? 1993-09-08
CH267993 1993-09-08

Publications (2)

Publication Number Publication Date
KR950007854A true KR950007854A (ko) 1995-04-15
KR100319351B1 KR100319351B1 (ko) 2002-04-06

Family

ID=4239144

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940022420A KR100319351B1 (ko) 1993-09-08 1994-09-07 이중층 옥스카바제핀 정제

Country Status (14)

Country Link
US (2) US5472714A (ko)
EP (1) EP0646374B1 (ko)
JP (1) JP3636380B2 (ko)
KR (1) KR100319351B1 (ko)
AT (1) ATE164762T1 (ko)
AU (1) AU678492B2 (ko)
CA (1) CA2131495C (ko)
DE (1) DE59405627D1 (ko)
ES (1) ES2115188T3 (ko)
IL (1) IL110863A (ko)
NZ (1) NZ264407A (ko)
PH (1) PH30478A (ko)
SG (1) SG44498A1 (ko)
ZA (1) ZA946874B (ko)

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Also Published As

Publication number Publication date
JPH07165584A (ja) 1995-06-27
ES2115188T3 (es) 1998-06-16
KR100319351B1 (ko) 2002-04-06
SG44498A1 (en) 1997-12-19
US5472714A (en) 1995-12-05
AU678492B2 (en) 1997-05-29
US5695782A (en) 1997-12-09
CA2131495C (en) 2006-01-17
JP3636380B2 (ja) 2005-04-06
ATE164762T1 (de) 1998-04-15
PH30478A (en) 1997-05-28
IL110863A0 (en) 1994-11-28
EP0646374B1 (de) 1998-04-08
AU7157194A (en) 1995-03-23
IL110863A (en) 1999-10-28
ZA946874B (en) 1995-04-24
DE59405627D1 (de) 1998-05-14
EP0646374A1 (de) 1995-04-05
NZ264407A (en) 1995-12-21
CA2131495A1 (en) 1995-03-09

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