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ES2173303T3 - Composicion en emulsion oleoacuosa para gotas oftalmicas. - Google Patents

Composicion en emulsion oleoacuosa para gotas oftalmicas.

Info

Publication number
ES2173303T3
ES2173303T3 ES96925985T ES96925985T ES2173303T3 ES 2173303 T3 ES2173303 T3 ES 2173303T3 ES 96925985 T ES96925985 T ES 96925985T ES 96925985 T ES96925985 T ES 96925985T ES 2173303 T3 ES2173303 T3 ES 2173303T3
Authority
ES
Spain
Prior art keywords
composition
emulsion
water
butirate
pharmaces
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96925985T
Other languages
English (en)
Inventor
Hidekazu Suzuki
Satoshi Yamazaki
Yoshikazu Naito
Takahiro Wada
Kaei Nagoshi
Noriko Tahira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wakamoto Pharmaceutical Co Ltd
Original Assignee
Wakamoto Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wakamoto Pharmaceutical Co Ltd filed Critical Wakamoto Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2173303T3 publication Critical patent/ES2173303T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UNA COMPOSICION EN EMULSION ACEITE/AGUA PARA COLIRIOS OCULARES QUE COMPRENDE UN FARMACO SELECCIONADO DEL GRUPO QUE COMPRENDE FLUOROMETOLONA, BUTIRATO DE CLOBETASONA Y PROPIONATO DE CLOBETASOL; UN FOSFOLIPIDO; PARAFINA LIQUIDA, Y AGUA. LA COMPOSICION EN EMULSION ACEITE/AGUA ES EXCELENTE PARA LA SOLUBILIDAD DE LA FLUOROMETOLONA, EL BUTIRATO DE CLOBETASONA Y EL PROPIONATO DE CLOBETASOL EN LAS LAGRIMAS. POR LO TANTO, LA COMPOSICION MOSTRARIA UNA ACTIVIDAD ANTIINFLAMATORIA IDENTICA O SUPERIOR A LA LOGRADA CON LOS PREPARADOS FARMACEUTICOS CONVENCIONALES, POR SU ADMINISTRACION A DOSIS MAS BAJAS QUE LAS UTILIZADAS PARA ESTOS FARMACOS CONOCIDOS. LA COMPOSICION SERIA TAMBIEN OPTIMA DESDE EL PUNTO DE VISTA ECONOMICO Y PERMITE LA REDUCCION DE EFECTOS SECUNDARIOS SISTEMICOS QUE SE PRODUCEN CUANDO SE INSTILAN LOS FARMACOS CONVENCIONALES EN LOS OJOS.
ES96925985T 1995-08-04 1996-08-05 Composicion en emulsion oleoacuosa para gotas oftalmicas. Expired - Lifetime ES2173303T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21830795 1995-08-04

Publications (1)

Publication Number Publication Date
ES2173303T3 true ES2173303T3 (es) 2002-10-16

Family

ID=16717797

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96925985T Expired - Lifetime ES2173303T3 (es) 1995-08-04 1996-08-05 Composicion en emulsion oleoacuosa para gotas oftalmicas.

Country Status (12)

Country Link
US (1) US6132751A (es)
EP (1) EP0844001B1 (es)
KR (1) KR19990036175A (es)
CN (1) CN1135984C (es)
AU (1) AU697961B2 (es)
CA (1) CA2228288A1 (es)
DE (1) DE69620193T2 (es)
ES (1) ES2173303T3 (es)
HK (1) HK1017842A1 (es)
IL (1) IL123091A0 (es)
WO (1) WO1997005882A1 (es)
ZA (1) ZA966579B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020194A4 (en) * 1997-10-01 2003-05-21 Wakamoto Pharma Co Ltd OIL / WATER EMULSION COMPILATIONS
JP3450805B2 (ja) * 2000-08-08 2003-09-29 わかもと製薬株式会社 水性医薬組成物
ES2343512T3 (es) * 2001-11-01 2010-08-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Procedimiento y composicion para el tratamiento del ojo seco.
US20040115822A1 (en) * 2002-09-12 2004-06-17 Schapaugh Randal Lee Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition
BR0306662A (pt) * 2002-10-18 2005-02-22 Joel S Echols Formulação lacrimal de três camadas
FR2856301B1 (fr) * 2003-06-23 2007-08-03 Galderma Res & Dev Composition sous forme de spray comprenant un actif pharmaceutique, au moins un silicone volatile et une phase non polaire non volatile
ES2796116T3 (es) * 2006-12-21 2020-11-25 Santen Sas Procedimiento para la fabricación de emulsiones oftálmicas de tipo aceite en agua
KR20100031608A (ko) * 2007-06-26 2010-03-23 와카모토 세이야꾸 가부시끼가이샤 수성 조성물
DE102011013959A1 (de) 2011-03-14 2012-09-20 Kautex Textron Gmbh & Co. Kg Druckausgleichsventil für Kraftstoff- oder Nebenflüssigkeitsbehälter an einem KFZ
US8900626B2 (en) * 2011-06-20 2014-12-02 Senju Usa, Inc. Transdermal drug delivery system and method of using the same
US20160184431A1 (en) * 2014-03-11 2016-06-30 Promius Pharma Llc Topical compositions comprising a corticosteroid
TWI773641B (zh) 2015-05-08 2022-08-11 日商活效製藥股份有限公司 含有糖皮質類固醇（ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ）之奈米微粒子之水性懸浮液劑
US11065217B2 (en) 2017-01-27 2021-07-20 Temple University—Of the Commonwealth System of Higher Education Use of short chain fatty acids for the treatment and prevention of diseases and disorders
MY190953A (en) 2017-06-23 2022-05-24 Salvat Lab Sa An oil-in-water nanoemulsion composition of clobetasol
KR20200099547A (ko) * 2017-12-14 2020-08-24 산텐 세이야꾸 가부시키가이샤 2-아미노-3-(4-브로모벤조일)페닐아세트산 또는 그의 염을 함유하는 점안제
MX2019010618A (es) * 2019-09-06 2021-11-30 Sophia Holdings S A De C V Composicion farmacéutica oftálmica, procesos de preparación y usos de las mismas.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440371A1 (fr) * 1978-10-31 1980-05-30 Fisons Ltd Nouveaux composes azotes heterocycliques, des compositions pharmaceutiques en contenant et des procedes pour les preparer
US4670185A (en) * 1982-07-19 1987-06-02 Lion Corporation Aqueous vesicle dispersion having surface charge
IT1229075B (it) * 1985-04-05 1991-07-17 Fidia Farmaceutici Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
JPS6160620A (ja) * 1984-09-03 1986-03-28 Teijin Ltd ピログルタミン酸エステル類を含有する医薬品組成物
JPH0660101B2 (ja) * 1984-11-27 1994-08-10 参天製薬株式会社 クロベタゾン−１７−ブチレ−トの水性製剤
JPS61249918A (ja) * 1985-04-26 1986-11-07 Yutaka Mizushima 点眼剤
JPS62270521A (ja) * 1986-05-16 1987-11-24 Green Cross Corp:The フルルビプロフエン眼投与製剤
IE63392B1 (en) * 1988-02-08 1995-04-19 Insite Vision Inc Ophthalmic suspensions
AU606515B2 (en) * 1988-03-09 1991-02-07 Alcon Laboratories, Inc. Combination of tobramycin and steroids for topical ophthalmic use
JP2827295B2 (ja) * 1989-07-04 1998-11-25 大正製薬株式会社 ビタミンａ類含有点眼剤
IL98747A0 (en) * 1991-07-05 1992-07-15 Yissum Res Dev Co Ophthalmic compositions
EP0656779B1 (en) * 1992-08-28 2000-04-12 Pharmos Corporation Submicron emulsions as ocular drug delivery vehicles
EP0664699A1 (en) * 1993-08-13 1995-08-02 Vitaphore Corporation Hydrogel-based microsphere drug delivery systems
CA2153553A1 (en) * 1994-07-13 1996-01-14 Hidekazu Suzuki Stable lipid emulsion
ES2094688B1 (es) * 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
US5767153A (en) * 1995-06-07 1998-06-16 Insite Vision Incorporated Sustained release emulsions

Also Published As

Publication number Publication date
US6132751A (en) 2000-10-17
DE69620193T2 (de) 2002-10-31
AU697961B2 (en) 1998-10-22
ZA966579B (en) 1998-02-02
EP0844001A4 (en) 1998-11-18
CA2228288A1 (en) 1997-02-20
CN1135984C (zh) 2004-01-28
DE69620193D1 (de) 2002-05-02
EP0844001A1 (en) 1998-05-27
CN1196682A (zh) 1998-10-21
AU6630396A (en) 1997-03-05
HK1017842A1 (en) 1999-12-03
EP0844001B1 (en) 2002-03-27
KR19990036175A (ko) 1999-05-25
WO1997005882A1 (fr) 1997-02-20
IL123091A0 (en) 1998-09-24

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