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MX2023004923A - Compuestos heterociclicos como inmunomoduladores. - Google Patents

Compuestos heterociclicos como inmunomoduladores.

Info

Publication number
MX2023004923A
MX2023004923A MX2023004923A MX2023004923A MX2023004923A MX 2023004923 A MX2023004923 A MX 2023004923A MX 2023004923 A MX2023004923 A MX 2023004923A MX 2023004923 A MX2023004923 A MX 2023004923A MX 2023004923 A MX2023004923 A MX 2023004923A
Authority
MX
Mexico
Prior art keywords
immunomodulators
compounds
heterocyclic compounds
infections
disorders
Prior art date
Application number
MX2023004923A
Other languages
English (en)
Inventor
Liangxing Wu
Jingwei Li
Wenqing Yao
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2023004923A publication Critical patent/MX2023004923A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

En la presente se describen compuestos de Fórmula (I'), métodos para usar los compuestos como inmunomoduladores y composiciones farmacéuticas que comprenden los compuestos. Los compuestos son útiles para tratar, prevenir o mejorar enfermedades o trastornos tales como el cáncer o infecciones. (ver Fórmula).
MX2023004923A 2018-03-30 2020-09-30 Compuestos heterociclicos como inmunomoduladores. MX2023004923A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862650821P 2018-03-30 2018-03-30
US201862687964P 2018-06-21 2018-06-21

Publications (1)

Publication Number Publication Date
MX2023004923A true MX2023004923A (es) 2023-05-17

Family

ID=66429535

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020010321A MX2020010321A (es) 2018-03-30 2019-03-29 Compuestos heterociclicos como inmunomoduladores.
MX2023004923A MX2023004923A (es) 2018-03-30 2020-09-30 Compuestos heterociclicos como inmunomoduladores.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020010321A MX2020010321A (es) 2018-03-30 2019-03-29 Compuestos heterociclicos como inmunomoduladores.

Country Status (31)

Country Link
US (3) US10669271B2 (es)
EP (2) EP3774791B1 (es)
JP (2) JP7372255B2 (es)
KR (1) KR20210018204A (es)
CN (1) CN112135824B (es)
AU (2) AU2019245288C1 (es)
BR (1) BR112020019700A2 (es)
CA (1) CA3095758A1 (es)
CL (1) CL2020002511A1 (es)
CO (1) CO2020013601A2 (es)
CR (1) CR20200520A (es)
DK (1) DK3774791T3 (es)
EC (1) ECSP20069418A (es)
ES (1) ES2940750T3 (es)
FI (1) FI3774791T3 (es)
HR (1) HRP20230090T1 (es)
HU (1) HUE061258T2 (es)
IL (2) IL313101A (es)
LT (1) LT3774791T (es)
MD (1) MD3774791T2 (es)
MX (2) MX2020010321A (es)
PE (1) PE20211911A1 (es)
PH (1) PH12020551572A1 (es)
PL (1) PL3774791T3 (es)
PT (1) PT3774791T (es)
RS (1) RS64055B1 (es)
SG (1) SG11202009440WA (es)
SI (1) SI3774791T1 (es)
TW (1) TWI851563B (es)
UA (1) UA128453C2 (es)
WO (1) WO2019191707A1 (es)

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