KEGG T01001: 1132

Homo sapiens (human): 1132

Entry

1132              CDS       T01001

Symbol

CHRM4, HM4, M4R

Name

(RefSeq) cholinergic receptor muscarinic 4

K04132

muscarinic acetylcholine receptor M4

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04725

Cholinergic synapse

hsa04810

Regulation of actin cytoskeleton

Drug target

Acetylcholine (DG01133):

D00999<JP/US>

Aclatonium (DG01291):

D01955

Aclidinium bromide:

D08837<JP/US>

Anisotropine methylbromide:

D00232

Atropine (DG00052):

D00113<US> D02069<JP/US>

Atropine oxide (DG01243):

D03011 D07477

Batefenterol (DG01627):

D10545 D10546

Benapryzine hydrochloride:

D03076

Benzatropine (DG00859):

D00778<US> D07511

Benzetimide (DG01301):

D03087 D07513

Benzilone:

D03088

Bethanechol (DG00991):

D01000<JP/US>

Bevonium:

D01532

Biperiden (DG00852):

D00779 D02246<JP> D02247<JP>

Blarcamesine (DG03048):

D11383 D11549

Bornaprine:

D07302

Butropium bromide:

D01491

Butylscopolamine:

D01451<JP>

Carbachol:

D00524<US>

Carpronium (DG01289):

D01175<JP> D09752<JP>

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Choline alfoscerate:

D07349

Cimetropium bromide:

D07099

Clidinium bromide:

D00716

Cyclopentolate (DG01141):

D01002<JP/US> D07759

Darotropium bromide:

D09402

Dexetimide (DG00856):

D03711 D07804

Diethazine (DG01921):

D02603 D07823

Difemerine:

D07079

Dihexyverine (DG00033):

D03824 D07821

Diphenidol (DG02880):

D01318<JP> D03858 D03859

Diphenylpiperidinomethyldioxolan iodide:

Diponium bromide:

Elantrine:

Elucaine:

Emraclidine:

Etomidoline:

Etybenzatropine:

Eucatropine hydrochloride:

Fenpiverinium:

Fentonium:

Flutropium bromide:

Glycopyrronium (DG02467):

D10939<JP/US>

Heteronium bromide:

D04434

Homatropine (DG01142):

D01004

Homatropine methylbromide:

D02070

Hyoscyamine (DG00053):

D00147 D00719 D01648 D04479

Ipratropium bromide:

D02212<JP/US>

Mazaticol (DG00857):

D03264 D08157

Mebeverine (DG00030):

D04868 D08160

Mepenzolate (DG00040):

D00720<JP>

Methacholine:

D04970<JP/US>

Methantheline (DG00036):

D00721

Methscopolamine bromide:

D00715<US>

Methylatropine (DG01242):

D01077 D03814

Methylbenactyzium bromide:

D01315

Methylscopolamine:

D01976<JP>

Metixene (DG00853):

D01871 D08209

Metoquizine:

D05012

Milameline hydrochloride:

Otilonium bromide:

Oxapium iodide:

Oxitropium bromide:

Oxybutynin (DG00478):

D00465<US> D00722<JP/US>

Parapenzolate bromide:

D05360

Pentapiperium methylsulfate:

Penthienate:

Phencarbamide:

Phenglutarimide:

Pipenzolate:

Piperidolate (DG00034):

D01165<JP> D08382

Pipethanate (DG01255):

D01521 D08384

Pipethanate ethobromide:

D01987

Pirenzepine (DG00026):

D01297 D05276<JP> D08389

Piroheptine (DG01272):

D01231<JP> D08395

Poldine:

D05535

Pridinol (DG00774):

D02064<JP> D08418 D08419

Prifinium bromide:

D01377

Procyclidine (DG00854):

D00782 D08425

Profenamine (DG00855):

D01118 D03276 D08426

Propantheline (DG00035):

D00481<JP>

Propenzolate hydrochloride:

D05628

Propiverine (DG00479):

D01007<JP> D08441

Rapacuronium bromide:

D05703

Rocuronium bromide:

D00765<JP/US>

Scopolamine (DG00065):

D00138<US> D02071

Tazomeline citrate:

D06015

Tematropium methylsulfate:

D06061

Tiemonium (DG01254):

D08595

Tiemonium iodide:

D01201

Timepidium bromide (DG00041):

D02535<JP>

Tofenacin hydrochloride:

D06175

Toquizine:

D06192

Triampyzine sulfate:

D06217

Trihexyphenidyl (DG00851):

D00787<JP/US> D08638

Tropatepine (DG00858):

D07303 D08653

Tropicamide:

D00397<JP/US>

Umeclidinium (DG01253):

D10180

Umeclidinium bromide:

D10181<JP/US>

Valethamate:

D01538

Xanomeline (DG01300):

D06330 D06331

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1132 (CHRM4)
09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    1132 (CHRM4)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1132 (CHRM4)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    1132 (CHRM4)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7tm_4

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

11:complement(46383789..46391776)

AA seq 479 aa
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR

NT seq 1440 nt +upstreamnt +downstreamnt
atggccaacttcacacctgtcaatggcagctcgggcaatcagtccgtgcgcctggtcacg
tcatcatcccacaatcgctatgagacggtggaaatggtcttcattgccacagtgacaggc
tccctgagcctggtgactgtcgtgggcaacatcctggtgatgctgtccatcaaggtcaac
aggcagctgcagacagtcaacaactacttcctcttcagcctggcgtgtgctgatctcatc
ataggcgccttctccatgaacctctacaccgtgtacatcatcaagggctactggcccctg
ggcgccgtggtctgcgacctgtggctggccctggactacgtggtgagcaacgcctccgtc
atgaaccttctcatcatcagctttgaccgctacttctgcgtcaccaagcctctcacctac
cctgcccggcgcaccaccaagatggcaggcctcatgattgctgctgcctgggtactgtcc
ttcgtgctctgggcgcctgccatcttgttctggcagtttgtggtgggtaagcggacggtg
cccgacaaccagtgcttcatccagttcctgtccaacccagcagtgacctttggcacagcc
attgctgccttctacctgcctgtggtcatcatgacggtgctgtacatccacatctccctg
gccagtcgcagccgagtccacaagcaccggcccgagggcccgaaggagaagaaagccaag
acgctggccttcctcaagagcccactaatgaagcagagcgtcaagaagcccccgcccggg
gaggccgcccgggaggagctgcgcaatggcaagctggaggaggcccccccgccagcgctg
ccaccgccaccgcgccccgtggctgataaggacacttccaatgagtccagctcaggcagt
gccacccagaacaccaaggaacgcccagccacagagctgtccaccacagaggccaccacg
cccgccatgcccgcccctcccctgcagccgcgggccctcaacccagcctccagatggtcc
aagatccagattgtgacgaagcagacaggcaatgagtgtgtgacagccattgagattgtg
cctgccacgccggctggcatgcgccctgcggccaacgtggcccgcaagttcgccagcatc
gctcgcaaccaggtgcgcaagaagcggcagatggcggcccgggagcgcaaagtgacacga
acgatctttgccattctgctagccttcatcctcacctggacgccctacaacgtcatggtc
ctggtgaacaccttctgccagagctgcatccctgacacggtgtggtccattggctactgg
ctctgctacgtcaacagcaccatcaaccctgcctgctatgctctgtgcaacgccaccttt
aaaaagaccttccggcacctgctgctgtgccagtatcggaacatcggcactgccaggtag

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