RU2021123470A - Композиции и способы борьбы с насекомыми-вредителями - Google Patents
Композиции и способы борьбы с насекомыми-вредителями Download PDFInfo
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- RU2021123470A RU2021123470A RU2021123470A RU2021123470A RU2021123470A RU 2021123470 A RU2021123470 A RU 2021123470A RU 2021123470 A RU2021123470 A RU 2021123470A RU 2021123470 A RU2021123470 A RU 2021123470A RU 2021123470 A RU2021123470 A RU 2021123470A
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- phyllotreta spp
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- 238000000034 method Methods 0.000 title claims 23
- 239000000203 mixture Substances 0.000 title claims 15
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 52
- 241000196324 Embryophyta Species 0.000 claims 40
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 38
- 241000275067 Phyllotreta Species 0.000 claims 38
- 230000000749 insecticidal effect Effects 0.000 claims 32
- 108090000623 proteins and genes Proteins 0.000 claims 27
- 102000004169 proteins and genes Human genes 0.000 claims 24
- 230000000295 complement effect Effects 0.000 claims 17
- 239000002773 nucleotide Substances 0.000 claims 13
- 125000003729 nucleotide group Chemical group 0.000 claims 13
- 108020004511 Recombinant DNA Proteins 0.000 claims 11
- 241000238631 Hexapoda Species 0.000 claims 10
- 241000193386 Lysinibacillus sphaericus Species 0.000 claims 10
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 9
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- 241001301148 Brassica rapa subsp. oleifera Species 0.000 claims 8
- 241000193417 Brevibacillus laterosporus Species 0.000 claims 8
- 230000001580 bacterial effect Effects 0.000 claims 8
- 241000894007 species Species 0.000 claims 8
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 claims 7
- 240000002791 Brassica napus Species 0.000 claims 7
- 235000006008 Brassica napus var napus Nutrition 0.000 claims 7
- 235000006618 Brassica rapa subsp oleifera Nutrition 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 230000002363 herbicidal effect Effects 0.000 claims 7
- 239000004009 herbicide Substances 0.000 claims 7
- -1 matrices Substances 0.000 claims 7
- 241000219198 Brassica Species 0.000 claims 6
- 241000193830 Bacillus <bacterium> Species 0.000 claims 5
- 241000275069 Phyllotreta cruciferae Species 0.000 claims 5
- 230000000813 microbial effect Effects 0.000 claims 5
- 241000193388 Bacillus thuringiensis Species 0.000 claims 4
- 241000588881 Chromobacterium Species 0.000 claims 4
- 108020004414 DNA Proteins 0.000 claims 4
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- 241001148062 Photorhabdus Species 0.000 claims 4
- 108010089814 Plant Lectins Proteins 0.000 claims 4
- 241000607757 Xenorhabdus Species 0.000 claims 4
- 229940097012 bacillus thuringiensis Drugs 0.000 claims 4
- 230000000361 pesticidal effect Effects 0.000 claims 4
- 239000003726 plant lectin Substances 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 235000011293 Brassica napus Nutrition 0.000 claims 3
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 claims 3
- 235000005911 diet Nutrition 0.000 claims 3
- 230000037213 diet Effects 0.000 claims 3
- 238000000855 fermentation Methods 0.000 claims 3
- 230000004151 fermentation Effects 0.000 claims 3
- 239000003337 fertilizer Substances 0.000 claims 3
- 230000000855 fungicidal effect Effects 0.000 claims 3
- 239000000417 fungicide Substances 0.000 claims 3
- 239000002418 insect attractant Substances 0.000 claims 3
- 239000000575 pesticide Substances 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- 241000219195 Arabidopsis thaliana Species 0.000 claims 2
- 244000257790 Brassica carinata Species 0.000 claims 2
- 235000003351 Brassica cretica Nutrition 0.000 claims 2
- 244000178993 Brassica juncea Species 0.000 claims 2
- 244000012866 Brassica narinosa Species 0.000 claims 2
- 244000180419 Brassica nigra Species 0.000 claims 2
- 240000007124 Brassica oleracea Species 0.000 claims 2
- 240000008100 Brassica rapa Species 0.000 claims 2
- 241000499439 Brassica rapa subsp. rapa Species 0.000 claims 2
- 241000982104 Brassica rupestris Species 0.000 claims 2
- 235000003343 Brassica rupestris Nutrition 0.000 claims 2
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- 235000002725 Olea europaea Nutrition 0.000 claims 2
- 240000007594 Oryza sativa Species 0.000 claims 2
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- 241000179039 Paenibacillus Species 0.000 claims 2
- 235000004443 Ricinus communis Nutrition 0.000 claims 2
- 240000000528 Ricinus communis Species 0.000 claims 2
- 244000061456 Solanum tuberosum Species 0.000 claims 2
- 235000002595 Solanum tuberosum Nutrition 0.000 claims 2
- 244000098338 Triticum aestivum Species 0.000 claims 2
- 240000008042 Zea mays Species 0.000 claims 2
- 235000007244 Zea mays Nutrition 0.000 claims 2
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims 2
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- 239000011573 trace mineral Substances 0.000 claims 2
- 235000013619 trace mineral Nutrition 0.000 claims 2
- 230000009261 transgenic effect Effects 0.000 claims 2
- 241000902876 Alticini Species 0.000 claims 1
- 241000208306 Apium Species 0.000 claims 1
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- 241000159431 Gossia Species 0.000 claims 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
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Claims (67)
1. Способ умерщвления насекомого Phyllotreta spp., включающий предоставление в рацион насекомого Phyllotreta spp. по меньшей мере одной рекомбинантной двухцепочечной РНК (дцРНК), содержащей по меньшей мере один подавляющий экспрессию элемент, содержащий цепь РНК, идентичную или комплементарную 21 или более смежным нуклеотидам в SEQ ID NO: 335 и ее комплемент, и, где поглощение указанной рекомбинантной дцРНК указанным насекомым Phyllotreta spp. приводит к гибели указанного насекомого Phyllotreta spp..
2. Способ задержки развития насекомого Phyllotreta spp., включающий предоставление в рацион насекомого Phyllotreta spp. по меньшей мере одной рекомбинантной дцРНК, содержащей по меньшей мере один подавляющий экспрессию элемент, содержащий цепь РНК, идентичную или комплементарную 21 или более смежным нуклеотидам в SEQ ID NO: 335 и ее комплемент, и, где поглощение указанной рекомбинантной дцРНК указанным насекомым Phyllotreta spp. приводит к задержке развития указанного насекомого Phyllotreta spp..
3. Способ по п. 1 или 2, отличающийся тем, что указанный по меньшей мере один подавляющий экспрессию элемент содержит цепь РНК, имеющую последовательность, идентичную или комплементарную 21 или более смежным нуклеотидам в SEQ ID NO: 1193.
4. Способ по п. 1 или 2, отличающийся тем, что указанное насекомое Phyllotreta spp. представляет собой Phyllotreta cruciferae (блошки канолы).
5. Способ по п. 1 или 2, отличающийся тем, что указанный подавляющий экспрессию элемент содержит цепь РНК, обладающую последовательностью SEQ ID NO: 1193.
6. Способ по п. 1 или 2, отличающийся тем, что указанное насекомое Phyllotreta spp. представляет собой Phyllotreta cruciferae (блошку канолы), и указанный подавляющий экспрессию элемент содержит цепь РНК, имеющую последовательность SEQ ID NO: 1193.
7. Способ по п. 1 или 2, отличающийся тем, что указанная рекомбинантная дцРНК представлена в микробной или растительной клетке, которая экспрессирует указанную рекомбинантную РНК, или в микробном продукте ферментации, или является химически синтезированной.
8. Способ по п. 1 или 2, отличающийся тем, что:
(a) указанная дцРНК является тупоконечной или имеет "липкие" концы по меньшей мере на одном конце, или содержит по меньшей мере один стебель-петлю;
(b) указанная дцРНК является химически синтезированной, полученной путем экспрессии в микроорганизме, полученной путем экспрессии в растительной клетке, или полученной путем микробной ферментации; или
(c) указанная дцРНК является химически синтезированной.
9. Способ по п. 1 или 2, отличающийся тем, что указанная по меньшей мере одна рекомбинантная дцРНК представлена в композиции, содержащей указанную по меньшей мере одну рекомбинантную дцРНК, причем указанную композицию наносят на поверхность указанного насекомого Phyllotreta spp. или на поверхность семян или растений, нуждающихся в защите от заражения указанным насекомым Phyllotreta spp..
10. Способ по п. 9, отличающийся тем, что указанная композиция:
(a) содержит твердое вещество, жидкость, порошок, суспензию, эмульсию, спрей, инкапсуляцию, микрогранулы, частицы носителей, пленки, матрицы, пропитку почвы или обработку семян;
(b) дополнительно содержит один или более компонентов, выбранных из группы, состоящей из агента-переносчика, поверхностно-активного вещества, кремнийорганики, полинуклеотидной гербицидной молекулы, неполинуклеотидной гербицидной молекулы, неполинуклеотидного пестицида, фунгицида, антидота, удобрения, микроэлемента, аттрактанта насекомых и регулятора роста насекомых;
(c) дополнительно содержит по меньшей мере один пестицидный агент, выбранный из группы, состоящей из пататина, растительного лектина, фитоэкдистероида, инсектицидного белка Bacillus thuringiensis, инсектицидного белка Xenorhabdus, инсектицидного белка Photorhabdus, инсектицидного белка Bacillus laterosporous, инсектицидного белка Bacillus sphaericus, бактерии, которая производит инсектицидный белок, энтомицидных видов бактерий, Lysinibacillus sphaericus (Bacillus sphaericus), Brevibacillus laterosporus (Bacillus laterosporus), видов Chromobacterium, Chromobacterium subtsugae, видов Paenibacillus, Paenibacillus lentimorbus и Paenibacillus popilliae; или
(d) поглощается указанным насекомым Phyllotreta spp..
11. Способ борьбы с насекомым Phyllotreta spp., заражающим растение, включающий контакт дцРНК с насекомым Phyllotreta spp., которое заражает растение, причем указанная дцРНК содержит цепь РНК, идентичную или комплементарную 21 или более смежным нуклеотидам последовательности гена-мишени, которая имеет SEQ ID NO: 335 и ее комплемент.
12. Способ по п. 11, отличающийся тем, что указанная дцРНК содержит:
(a) последовательность SEQ ID NO: 1193, или ее комплемент; или
(b) цепь РНК, идентичную или комплементарную 21 или более смежным нуклеотидам в SEQ ID NO:1193.
13. Способ по п. 11, отличающийся тем, что указанное насекомое Phyllotreta spp. представляет собой Phyllotreta cruciferae (блошку канолы.
14. Способ по п. 11, отличающийся тем, что указанное растение представляет собой:
(a) выбранное из декоративного растения или сельскохозяйственного растения;
(b) растение из семейства Brassicaceae;
(c) вид рода Brassica, выбранный из группы, состоящей из B. napus, B. juncea, B. carinata, B. rapa, B. oleracea, B. rupestris, B. septiceps, B. nigra, B. narinosa, B. perviridus, B. tournefortii и B. fructiculosa;
(d) растение Brassica, выбранное из группы, включающей канолу, рапс, репы и горчицу полевую или репу масличную; или
(e) выбранное из группы, состоящей из Glycine max, Linum usitatissimum, Zea mays, Carthamus tinctorius, Helianthus annuus, Nicotiana tabacum, Arabidopsis thaliana, Betholettia excelsa, Ricinus communis, Cocos nucifera, Coriandrum sativum, Gossypium spp., Arachis hypogaea, Simmondsia chinensis, Solanum tuberosum, Elaeis guineensis, Olea europaea, Oryza sativa, Cucurbita maxima, Hordeum vulgare и Triticum aestivum.
15. Способ по п. 11, отличающийся тем, что стадия, в которой осуществляют контакт, включает:
(a) пероральное введение указанному насекомому Phyllotreta spp., непероральное введение указанному насекомому Phyllotreta spp., или комбинацию перорального и неперорального введения указанному насекомому Phyllotreta spp.;
(b) нанесение композиции, содержащей указанную дцРНК, на поверхность указанного насекомого Phyllotreta spp. или на поверхность указанного растения, заражаемого указанным насекомым Phyllotreta spp.;
(c) предоставление указанной дцРНК в композиции, которая дополнительно содержит один или более компонентов, выбранных из группы, состоящей из агента-переносчика, поверхностно-активного вещества, кремнийорганики, полинуклеотидной гербицидной молекулы, неполинуклеотидной гербицидной молекулы, неполинуклеотидного пестицида, фунгицида, антидота, удобрения, микроэлемента, аттрактанта насекомых и регулятора роста насекомых;
(d) предоставление указанной дцРНК в композиции, которая дополнительно содержит по меньшей мере один пестицидный агент, выбранный из группы, состоящей из пататина, растительного лектина, фитоэкдистероида, инсектицидного белка Bacillus thuringiensis, инсектицидного белка Xenorhabdus, инсектицидного белка Photorhabdus, инсектицидного белка Bacillus laterosporous, инсектицидного белка Bacillus sphaericus, бактерии, которая производит инсектицидный белок, энтомицидных видов бактерий, Lysinibacillus sphaericus (Bacillus sphaericus), Brevibacillus laterosporus (Bacillus laterosporus), видов Chromobacterium, Chromobacterium subtsugae, видов Paenibacillus, Paenibacillus lentimorbus и Paenibacillus popilliae; или
(e) предоставление указанной дцРНК в композиции, которая поглощается указанным насекомым Phyllotreta spp..
16. Инсектицидная композиция, обладающая инсектицидной активностью против Phyllotreta spp., содержащая инсектицидно-эффективное количество молекулы рекомбинантной дцРНК, причем указанная молекула рекомбинантной дцРНК содержит цепь РНК, идентичную или комплементарную 21 или более смежным нуклеотидам гена-мишени насекомого Phyllotreta spp., которое заражает растение, причем указанный ген-мишень имеет последовательность ДНК SEQ ID NO: 335.
17. Инсектицидная композиция по п. 16, отличающаяся тем, что указанная молекула рекомбинантной дцРНК:
(a) содержит по меньшей мере одну цепь РНК, идентичную или комплементарную 21 или более смежным нуклеотидам в SEQ ID NO: 1193;
(b) содержит дцРНК из по меньшей мере 50 пар оснований в длину;
(c) содержит тупоконечную дцРНК;
(d) содержит дцРНК с "липким" концом на по меньшей мере одном конце;
(e) содержит дцРНК, содержащую по меньшей мере один стебель-петлю;
(f) содержит дцРНК, которая является химически синтезированной;
(g) представляет собой дцРНК, содержащую цепь РНК, идентичную или комплементарную 21 или более смежным нуклеотидам в SEQ ID NO: 1193;
(h) представляет собой дцРНК, содержащую цепь РНК, имеющую последовательность SEQ ID NO: 1193; или
(i) представлена в микробной или растительной клетке, которая экспрессирует указанную рекомбинантную дцРНК, или в микробном продукте ферментации, или является химически синтезированной.
18. Инсектицидная композиция по п. 16, отличающаяся тем, что указанное насекомое Phyllotreta spp. представляет собой Phyllotreta cruciferae (блошку канолы).
19. Инсектицидная композиция по п. 16, отличающаяся тем, что указанная инсектицидная композиция:
(a) дополнительно содержит один или более компонентов, выбранных из группы, состоящей из агента-переносчика, поверхностно-активного вещества, кремнийорганики, полинуклеотидной гербицидной молекулы, неполинуклеотидной гербицидной молекулы, неполинуклеотидного пестицида, фунгицида, антидота, удобрения, микроэлемента, аттрактанта насекомых и регулятора роста насекомых;
(b) дополнительно содержит по меньшей мере один пестицидный агент, выбранный из группы, состоящей из пататина, растительного лектина, фитоэкдистероида, инсектицидного белка Bacillus thuringiensis, инсектицидного белка Xenorhabdus, инсектицидного белка Photorhabdus, инсектицидного белка Bacillus laterosporous, инсектицидного белка Bacillus sphaericus, бактерии, которая производит инсектицидный белок, энтомицидных видов бактерий, Lysinibacillus sphaericus (Bacillus sphaericus), Brevibacillus laterosporus (Bacillus laterosporus), видов Chromobacterium, Chromobacterium subtsugae, видов Paenibacillus, Paenibacillus lentimorbus и Paenibacillus popilliae; или
(c) находится в форме, выбранной из группы, состоящей из твердого вещества, жидкости, порошка, суспензии, эмульсии, спрея, инкапсуляции, микрогранул, частиц носителей, пленки, матрицы, пропитку почвы, рациона насекомых или приманки насекомых и обработки семян.
20. Растение, обработанное инсектицидной композицией по п. 16, где указанная молекула рекомбинантной дцРНК проникает в клетки указанного растения, и, где указанное растение проявляет повышенную устойчивость к указанному насекомому Phyllotreta spp. по сравнению с растением, не обработанным инсектицидной композицией по п. 16.
21. Способ, обеспечивающий растение, имеющее повышенную стойкость к насекомому Phyllotreta spp., включающий (a) подготовку рекомбинантного ДНК конструкта, содержащего ДНК, кодирующую дцРНК, имеющую последовательность, идентичную или комплементарную 21 или более смежным нуклеотидам SEQ ID NO: 335, и (b) экспрессию указанного рекомбинантного ДНК конструкта в указанном растении для продуцирования указанной дцРНК, где поглощение указанной дцРНК указанным насекомым Phyllotreta spp. приводит к гибели указанного насекомого Phyllotreta spp., таким образом, обеспечивая указанное растение повышенной стойкостью к указанному насекомому Phyllotreta spp. по сравнению с растением, не экспрессирующим указанный рекомбинантный ДНК конструкт.
22. Способ, обеспечивающий растение, имеющее повышенную стойкость к насекомому Phyllotreta spp., включающий (a) подготовку рекомбинантного ДНК конструкта, содержащего ДНК, кодирующую дцРНК, имеющую последовательность идентичную или комплементарную 21 или более смежным нуклеотидам SEQ ID NO: 335, и (b) экспрессию указанного рекомбинантного ДНК конструкта в указанном растении для продуцирования указанной дцРНК, где поглощение указанной дцРНК указанным насекомым Phyllotreta spp. приводит к задержке развития указанного насекомого Phyllotreta spp., таким образом, обеспечивая указанное растение повышенной стойкостью к указанному насекомому Phyllotreta spp. по сравнению с растением, не экспрессирующим указанный рекомбинантный ДНК конструкт.
23. Способ по п. 21 или 22, отличающийся тем, что указанная дцРНК содержит цепь, имеющую последовательность идентичную или комплементарную 21 или более смежным нуклеотидам в SEQ ID NO: 1193.
24. Способ по п. 21 или 22, отличающийся тем, что:
(a) указанное насекомое Phyllotreta spp. представляет собой Phyllotreta cruciferae (блошку канолы)
(b) указанное растение является выбранным из декоративного растения или сельскохозяйственного растения;
(c) указанное растение представляет собой растение из семейства Brassicaceae;
(d) указанное растение представляет собой вид Brassica, выбранный из группы, состоящей из B. napus, B. juncea, B. carinata, B. rapa, B. oleracea, B. rupestris, B. septiceps, B. nigra, B. narinosa, B. perviridus, B. tournefortii, и B. fructiculosa;
(e) указанное растение представляет собой растение Brassica, выбранное из группы, содержащей канолу, рапс, репу и горчицу полевую или репу масличную;
(f) указанное растение является выбранным из группы, состоящей из Glycine max, Linum usitatissimum, Zea mays, Carthamus tinctorius, Helianthus annuus, Nicotiana tabacum, Arabidopsis thaliana, Betholettia excelsa, Ricinus communis, Cocos nucifera, Coriandrum sativum, Gossypium spp., Arachis hypogaea, Simmondsia chinensis, Solanum tuberosum, Elaeis guineensis, Olea europaea, Oryza sativa, Cucurbita maxima, Hordeum vulgare и Triticum aestivum;
(g) указанный способ дополнительно включает экспрессию в указанном растении по меньшей мере одного пестицидного агента, выбранного из группы, состоящей из пататина, растительного лектина, фитоэкдистероида, инсектицидного белка Bacillus thuringiensis , инсектицидного белка Xenorhabdus, инсектицидного белка Photorhabdus, инсектицидного белка Bacillus laterosporous, инсектицидного белка Bacillus sphaericus, бактерии, которая производит инсектицидный белок, энтомицидных видов бактерий, Lysinibacillus sphaericus (Bacillus sphaericus), Brevibacillus laterosporus (Bacillus laterosporus), видов Chromobacterium, Chromobacterium subtsugae, видов Paenibacillus, Paenibacillus lentimorbus и Paenibacillus popilliae; или
(h) указанный способ дополнительно включает экспрессию в указанном растении по меньшей мере одного белка, придающего устойчивость к гербициду.
25. Растение, имеющее повышенную устойчивость к насекомому Phyllotreta spp., обеспеченное способом по п. 21 или 22, где указанное растение экспрессирует рекомбинантный ДНК конструкт, содержащий ДНК, кодирующую дцРНК, имеющую последовательность, идентичную или комплементарную 21 или более смежным нуклеотидам SEQ ID NO: 335, и, где указанное растение обладает повышенной устойчивостью к указанному насекомому Phyllotreta spp. по сравнению с растением, не экспрессирующим указанный рекомбинантный ДНК конструкт.
26. Рекомбинантный ДНК конструкт для борьбы с насекомым Phyllotreta spp., заражающим растение, содержащий гетерологичный промотор функционально связанный с ДНК, кодирующей РНК транскрипт, содержащий последовательность, идентичную или комплементарную 21 смежным нуклеотидам в SEQ ID NO: 1193.
27. Рекомбинантный ДНК конструкт по п. 26, отличающийся тем, что указанный гетерологичный промотор является функционирующим для экспрессирования указанного РНК транскрипта в бактерии или в растительной клетке.
28. Трансгенная растительная клетка для обеспечения повышенной устойчивости к насекомому Phyllotreta spp., где указанная трансгенная клетка содержит рекомбинантный ДНК конструкт по п. 26.
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- 2015-07-28 AR ARP150102403A patent/AR101348A1/es not_active Application Discontinuation
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| AR101348A1 (es) | 2016-12-14 |
| UY36243A (es) | 2016-02-29 |
| UA125244C2 (uk) | 2022-02-09 |
| US20190316130A1 (en) | 2019-10-17 |
| CN106604993A (zh) | 2017-04-26 |
| AU2015296700B2 (en) | 2021-10-21 |
| EP3174982A1 (en) | 2017-06-07 |
| RU2017106181A (ru) | 2018-08-30 |
| US20170260522A1 (en) | 2017-09-14 |
| RU2754955C2 (ru) | 2021-09-08 |
| WO2016018887A1 (en) | 2016-02-04 |
| CN114009454A (zh) | 2022-02-08 |
| EP3174982A4 (en) | 2018-06-20 |
| US11124792B2 (en) | 2021-09-21 |
| US20210403912A1 (en) | 2021-12-30 |
| RU2017106181A3 (ru) | 2019-02-19 |
| CA2955842A1 (en) | 2016-02-04 |
| US10378012B2 (en) | 2019-08-13 |
| AU2015296700A1 (en) | 2017-02-02 |
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