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KR940011443A - 비타민 d_3-동족체 - Google Patents

비타민 d_3-동족체 Download PDF

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Publication number
KR940011443A
KR940011443A KR1019930024594A KR930024594A KR940011443A KR 940011443 A KR940011443 A KR 940011443A KR 1019930024594 A KR1019930024594 A KR 1019930024594A KR 930024594 A KR930024594 A KR 930024594A KR 940011443 A KR940011443 A KR 940011443A
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KR
South Korea
Prior art keywords
phenyl
independently
alkyl
hydrogen
general formula
Prior art date
Application number
KR1019930024594A
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English (en)
Inventor
아이. 도란 토마스
아서 맥클레인 죤
마사미 오카베
스칼로네 미켈란젤로
라도제 우스코코비크 밀란
Original Assignee
프리돌린 클라우스너 · 롤란트 보러
에프. 호프만-라 롯슈 에이지
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 프리돌린 클라우스너 · 롤란트 보러, 에프. 호프만-라 롯슈 에이지 filed Critical 프리돌린 클라우스너 · 롤란트 보러
Publication of KR940011443A publication Critical patent/KR940011443A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 과대중식성 피부질환 및 피지선 질환치료에 유용한 일반식(Ι)의 화합물에 관한 것이다.
상기식에서, R1및 R2는 수소 또는 아실이다(단,R1및 R2중 하나만이 수소이다).

Description

비타민 D3-동족체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 일반식(Ι)의 화합물
    상기식에서, R1및 R2는 수소 또는 아실이며 단,R1또는 R2중 하나만이 수소이다.
  2. 일반식(Ⅳ),(Ⅶ),(Ⅷ),(XIII),또는 (Ⅵ)의 화합물.
    일반식(Ⅳ)에서 R4,R5및 R6는 독립적으로 C1-C6알킬 또는 페닐이고, 특히, R4,및R5는 메틸이고 R6는 텍실이며;R일반식(Ⅶ)에서, R4내지 R9는 독립적으로 C1-C6알킬 또는 페닐이고,특히, R4,R5, R7및 R8은 텍실이며 R9는 3급부틸이고;일반식(Ⅷ)에서, R4내지R5는 독립적으로 알킬 또는 페닐이고, X는 -C(S)R10이며, 여기에서 R10은 이미다졸-1-일, -NHPh, -OPh, -N(CH3)2,또는 -SCH3이며, 특히 R4,R5,R7및 R8은 메틸이고 R6는 텍실이며, R9는 3급 부틸이고, R10은 -NHPh이며 Ph는 페닐이고:일반식(XⅢ)에서, R11및 R12는 독립적으로 -Si(R4,R5,R6),수소, 또는 아실이며, R4,R5및 R6는 독립적으로 C1-C6알킬 또는 페닐이며, 특히 R11은 디메틸 텍실실릴이고 R12는 -3급 부틸디메실릴이거나 R11및 R12는 수소이거나 R11및 R12는 아세틸이고;일반식 (Ⅵ)에서 R7, R8및 R9는 독립적으로 C1-C6알킬 또는 페닐을 나타낸다.
  3. 건선과 같은 과대증식성 피부질환 치료 및 여드름 및 지루성 피부염과 같은 피지선 질환 치료를 위한, 제1항에 따른 유효량의 일반식(Ι)의 화합물 및 약제학적으로 허용되는 담체를 포함하는 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930024594A 1992-11-20 1993-11-18 비타민 d_3-동족체 KR940011443A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97913392A 1992-11-20 1992-11-20
US07/979,133 1992-11-20

Publications (1)

Publication Number Publication Date
KR940011443A true KR940011443A (ko) 1994-06-21

Family

ID=25526724

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930024594A KR940011443A (ko) 1992-11-20 1993-11-18 비타민 d_3-동족체

Country Status (25)

Country Link
US (3) US5342833A (ko)
EP (1) EP0599114B1 (ko)
JP (2) JP2502931B2 (ko)
KR (1) KR940011443A (ko)
CN (1) CN1051762C (ko)
AT (1) ATE147728T1 (ko)
AU (1) AU669222B2 (ko)
BR (1) BR9304780A (ko)
CA (1) CA2108848A1 (ko)
CZ (1) CZ284415B6 (ko)
DE (1) DE69307478T2 (ko)
DK (1) DK0599114T3 (ko)
ES (1) ES2097423T3 (ko)
FI (1) FI935092A (ko)
GR (1) GR3022691T3 (ko)
HU (1) HU213609B (ko)
IL (1) IL107614A (ko)
NO (1) NO304022B1 (ko)
NZ (1) NZ250194A (ko)
PH (1) PH30991A (ko)
PL (1) PL176017B1 (ko)
RU (1) RU2126385C1 (ko)
TW (1) TW267161B (ko)
UY (1) UY23678A1 (ko)
ZA (1) ZA938478B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA95906B (en) * 1994-02-07 1996-08-06 Res Developments Foundation Non-viral vector
WO1997013518A1 (en) * 1995-10-10 1997-04-17 Marilyn Strube Treatment of pruritus with vitamin d and analogs thereof
TW403735B (en) * 1995-11-22 2000-09-01 Hoffmann La Roche 25-hydroxy-16-ene-26, 27-bishomo-cholecalciferol
US5691328A (en) * 1996-02-02 1997-11-25 Clarion Pharmaceuticals Inc. Phosphoethanolamine conjugates of vitamin D compounds
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
NO971934L (no) * 1996-05-23 1997-11-24 Hoffmann La Roche Flourinerte vitamin D3 -analoger
EP0884308B1 (en) * 1997-05-02 2003-04-16 Duphar International Research B.V A method of preparing 16-dehydro vitamin D compounds
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
EP1812011A1 (en) 2004-11-12 2007-08-01 Bioxell S.p.a. Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
KR101701382B1 (ko) 2014-01-29 2017-02-01 주식회사 휴메딕스 페길레이션된 7-디하이드로콜레스테롤 유도체
KR101702076B1 (ko) 2015-02-25 2017-02-02 주식회사 휴메딕스 지방산 컨쥬게이션된 7-데하이드로콜레스테롤 유도체

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3970676A (en) * 1974-10-29 1976-07-20 The Upjohn Company Novel process and intermediate compounds used is preparation of -Δ5,7- steroid dienes
US4116985A (en) * 1976-07-26 1978-09-26 The Upjohn Company Novel method for preparing cholesta-5,7-diene 3β,25-diol and derivatives thereof
US4360471A (en) * 1981-12-11 1982-11-23 Wisconsin Alumni Research Foundation 23-Dehydro-25-hydroxyvitamin D3
US4456553A (en) * 1982-05-07 1984-06-26 Teijin Limited Vitamin D3 derivatives, process for preparation thereof, and antigens comprising said derivatives to be used for preparation of antibodies for immunochemical assay and antibodies prepared therefrom
US4448721A (en) * 1982-09-20 1984-05-15 Wisconsin Alumni Research Foundation Hydroxyvitamin D2 compounds and process for preparing same
JPS63264452A (ja) * 1986-10-20 1988-11-01 Sumitomo Pharmaceut Co Ltd フッ素化ビタミンｄ↓３誘導体
EP0321572B1 (en) * 1987-03-30 1993-06-09 Kuraray Co., Ltd. Pregnane derivatives and process for their preparation
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5218109A (en) * 1988-07-05 1993-06-08 Kuraray Co., Ltd. Steroid compounds
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
DE69005897D1 (de) * 1989-05-18 1994-02-24 Hoffmann La Roche Dehydrocholecalciferolderivate.
WO1991003246A1 (en) * 1989-09-11 1991-03-21 Wisconsin Alumni Research Foundation Novel use of vitamin d compounds to inhibit replication of the aids virus
IL97158A (en) * 1990-02-06 1994-12-29 Schering Ag Homologous histories of vitamin D in the side chain, processes for their preparation and pharmaceutical preparations containing them
DE4101953A1 (de) * 1991-01-19 1992-07-23 Schering Ag 23-oxa-derivate in der vitamin-d-reihe, verfahren zu ihrer herstellung diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel
DE4105503A1 (de) * 1991-02-19 1992-08-20 Jenapharm Gmbh Ausgangsverbindungen zur herstellung von calcitriol sowie dessen abkoemmlingen, verfahren zur herstellung dieser ausgangsverbindungen sowie zwischenprodukte fuer dieses verfahren
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
DK0521550T3 (da) * 1991-07-05 1996-11-04 Duphar Int Res Vitamin D forbindelse, fremgangsmåde til fremstilling af denne forbindelse og mellemprodukt derfor

Also Published As

Publication number Publication date
HU9303227D0 (en) 1994-03-28
PH30991A (en) 1997-12-23
NO934197D0 (no) 1993-11-19
JP2502931B2 (ja) 1996-05-29
DK0599114T3 (da) 1997-04-14
US5342833A (en) 1994-08-30
CZ284415B6 (cs) 1998-11-11
TW267161B (ko) 1996-01-01
JPH08109191A (ja) 1996-04-30
CZ248993A3 (en) 1994-06-15
CA2108848A1 (en) 1994-05-21
JPH06199777A (ja) 1994-07-19
NO304022B1 (no) 1998-10-12
HUT66022A (en) 1994-08-29
DE69307478D1 (de) 1997-02-27
UY23678A1 (es) 1994-05-20
ZA938478B (en) 1994-05-20
IL107614A (en) 1999-09-22
FI935092A (fi) 1994-05-21
EP0599114B1 (en) 1997-01-15
RU2126385C1 (ru) 1999-02-20
FI935092A0 (fi) 1993-11-17
CN1090573A (zh) 1994-08-10
ATE147728T1 (de) 1997-02-15
NO934197L (no) 1994-05-24
BR9304780A (pt) 1994-07-05
PL176017B1 (pl) 1999-03-31
US5747478A (en) 1998-05-05
EP0599114A1 (en) 1994-06-01
HU213609B (en) 1997-08-28
NZ250194A (en) 1996-01-26
GR3022691T3 (en) 1997-05-31
US5393900A (en) 1995-02-28
ES2097423T3 (es) 1997-04-01
DE69307478T2 (de) 1997-05-28
IL107614A0 (en) 1994-02-27
AU669222B2 (en) 1996-05-30
AU5069793A (en) 1994-06-02
PL301103A1 (en) 1994-05-30
CN1051762C (zh) 2000-04-26

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