JP6165380B1 - 神経回路網の再構築・賦活剤 - Google Patents
神経回路網の再構築・賦活剤 Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005510509A (ja) * | 2001-11-06 | 2005-04-21 | ザ キグリー コーポレーション | 放射線障害の予防、軽減、及び治療用の栄養性サプリメント及びその方法 |
JP2007161606A (ja) * | 2005-12-09 | 2007-06-28 | Univ Of Tokyo | 哺乳動物の海馬におけるニューロン新生を促進する組成物 |
JP2007230878A (ja) * | 2006-02-27 | 2007-09-13 | Pokka Corp | 脳機能改善剤及びそれを含有する脳機能改善組成物 |
JP2008501343A (ja) * | 2004-06-04 | 2008-01-24 | ワシントン・ユニバーシティ | 神経障害を治療するための方法および組成物 |
CN102078423A (zh) * | 2010-12-29 | 2011-06-01 | 陈永洪 | 一种治疗骨质增生的外用中草药制剂 |
WO2014112145A1 (fr) * | 2013-01-21 | 2014-07-24 | レジリオ株式会社 | Agent thérapeutique et procédé thérapeutique concernant 1,25d3-marrs pour une maladie neurologique telle que la maladie d'alzheimer |
US20150132280A1 (en) * | 2013-11-12 | 2015-05-14 | Ortho-Nutra, Llc | Theacrine-based supplement and method of use thereof |
CN104825555A (zh) * | 2015-04-23 | 2015-08-12 | 吴远华 | 一种预防帕金森病的药物、制备方法及制剂 |
JP2016027031A (ja) * | 2014-07-01 | 2016-02-18 | レジリオ株式会社 | 神経回路網の再構築・賦活用医薬または食品 |
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Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005510509A (ja) * | 2001-11-06 | 2005-04-21 | ザ キグリー コーポレーション | 放射線障害の予防、軽減、及び治療用の栄養性サプリメント及びその方法 |
JP2008501343A (ja) * | 2004-06-04 | 2008-01-24 | ワシントン・ユニバーシティ | 神経障害を治療するための方法および組成物 |
JP2007161606A (ja) * | 2005-12-09 | 2007-06-28 | Univ Of Tokyo | 哺乳動物の海馬におけるニューロン新生を促進する組成物 |
JP2007230878A (ja) * | 2006-02-27 | 2007-09-13 | Pokka Corp | 脳機能改善剤及びそれを含有する脳機能改善組成物 |
CN102078423A (zh) * | 2010-12-29 | 2011-06-01 | 陈永洪 | 一种治疗骨质增生的外用中草药制剂 |
WO2014112145A1 (fr) * | 2013-01-21 | 2014-07-24 | レジリオ株式会社 | Agent thérapeutique et procédé thérapeutique concernant 1,25d3-marrs pour une maladie neurologique telle que la maladie d'alzheimer |
US20150132280A1 (en) * | 2013-11-12 | 2015-05-14 | Ortho-Nutra, Llc | Theacrine-based supplement and method of use thereof |
JP2016027031A (ja) * | 2014-07-01 | 2016-02-18 | レジリオ株式会社 | 神経回路網の再構築・賦活用医薬または食品 |
CN104825555A (zh) * | 2015-04-23 | 2015-08-12 | 吴远华 | 一种预防帕金森病的药物、制备方法及制剂 |
Non-Patent Citations (8)
Title |
---|
BAI YANJING ET AL: "Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25", J NAT MED, vol. 65, JPN6016035533, 2011, pages 417 - 423, ISSN: 0003535195 * |
HEO JIN HO ET AL: "Effect of Antioxidant Flavanone, Naringenin, from Citrus junos on Neuroprotection", J. AGRIC. FOOD CHEM., vol. 52, JPN6016035520, 2004, pages 1520 - 1525, XP055366274, ISSN: 0003535199, DOI: 10.1021/jf035079g * |
KHAN BADRUZZAMAN M. ET AL: "Naringenin ameliorates Alzheimer's disease(AD)-type neurodegeneration with cognitive impairment(AD-T", NEUROCHEMISTRY INTERNATIONAL, vol. 61, JPN6016035517, 2012, pages 1081 - 1093, XP055366273, ISSN: 0003535198, DOI: 10.1016/j.neuint.2012.07.025 * |
WANG MEI DONG ET AL: "Naringin Enhances CaMKII Activity and Improves Long-Term Memory in a Mouse Model of Alzheimer's Dise", INT. J. MOL. SCI., vol. 14, JPN6016035522, 2013, pages 5576 - 5586, XP055366278, ISSN: 0003535200, DOI: 10.3390/ijms14035576 * |
WONG CHUN KA ET AL: "Drynaria fortunei-derived total flavonoid fraction and isolated compounds exert oestrogen-like prote", BRITISH JOURNAL OF NUTRITION, vol. 110, JPN6016035537, 2013, pages 475 - 485, XP055366287, ISSN: 0003535197, DOI: 10.1017/S0007114512005405 * |
XINLUAN WANG ET AL: "Osteogenic effects of flavonoid aglycones from an osteoprotective fraction of Drynaria fortunei-An", PHYTOMEDICINE, vol. 18, JPN6016035535, 2011, pages 868 - 872, ISSN: 0003535196 * |
ZHU HAN-YI ET AL., EFFECTS OF NARINGENIN ON LEARNING AND MEMORY DISORDER AND Β-AMYLOID PEPTIDE INDU, JPN6017012496, ISSN: 0003535201 * |
東田 千尋ら: "刺五加メタノールエキスによるシナプス再形成作用と記憶障害改善作用", 日本薬学会年会要旨集, vol. 126, JPN6016035530, 2006, pages 130, ISSN: 0003535194 * |
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