IL101960A - 3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them - Google Patents

3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them

Info

Publication number: IL101960A
Authority: IL; Israel
Prior art keywords: disorders; compound according; optionally substituted; substituted; alkyl
Prior art date: 1991-05-22

Application number

IL10196092A

Other languages

English (en)

Hebrew (he)

Other versions

IL101960A0 (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-22

Filing date

1992-05-21

Publication date

1999-03-12

1992-05-21 Application filed by Pfizer filed Critical Pfizer

1994-04-12 Publication of IL101960A0 publication Critical patent/IL101960A0/xx

1999-03-12 Publication of IL101960A publication Critical patent/IL101960A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Saccharide Compounds (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Medicinal Preparation (AREA)

IL10196092A 1991-05-22 1992-05-21 3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them IL101960A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP14682691		1991-05-22

Publications (2)

Publication Number	Publication Date
IL101960A0 IL101960A0 (en)	1994-04-12
IL101960A true IL101960A (en)	1999-03-12

Family

ID=15416402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10196092A IL101960A (en)	1991-05-22	1992-05-21	3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them

Country Status (25)

Country	Link
EP (1)	EP0585328B1 (da)
KR (1)	KR100246065B1 (da)
CN (1)	CN1041827C (da)
AT (1)	ATE211743T1 (da)
AU (1)	AU658898B2 (da)
BR (1)	BR9206044A (da)
CA (1)	CA2109415C (da)
CZ (1)	CZ247993A3 (da)
DE (2)	DE9290057U1 (da)
DK (1)	DK0585328T3 (da)
EG (1)	EG20218A (da)
ES (1)	ES2168260T3 (da)
FI (1)	FI935134A0 (da)
HU (1)	HUT65771A (da)
IE (1)	IE921662A1 (da)
IL (1)	IL101960A (da)
MX (1)	MX9202449A (da)
NO (1)	NO305173B1 (da)
NZ (2)	NZ272941A (da)
PL (4)	PL170525B1 (da)
PT (1)	PT100514B (da)
RU (1)	RU2092486C1 (da)
UA (1)	UA26401C2 (da)
WO (1)	WO1992020676A1 (da)
ZA (1)	ZA923773B (da)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5138060A (en) *	1991-01-03	1992-08-11	Pfizer Inc.	Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
CA2109613C (en) *	1991-06-20	1996-11-19	John Adams Lowe Iii	Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
JP2656702B2 (ja) *	1992-03-23	1997-09-24	ファイザー製薬株式会社	ペプチド性キヌクリジン
ATE208376T1 (de) *	1992-08-19	2001-11-15	Pfizer	Substituierte benzylamin-stickstoff enthaltende nichtaromatische heterocyclen
JP2656699B2 (ja) *	1992-10-21	1997-09-24	ファイザー製薬株式会社	置換ベンジルアミノキヌクリジン
US5837711A (en) *	1992-10-28	1998-11-17	Pfizer Inc.	Substituted quinuclidines as substance P antagonists
JP2656700B2 (ja) *	1992-10-28	1997-09-24	ファイザー製薬株式会社	置換キヌクリジン誘導体
EP0675886B1 (en) *	1992-12-10	2000-07-05	Pfizer Inc.	Aminomethylene substituted non-aromatic heterocycles and use as substance p antagonists
IL109646A0 (en) *	1993-05-19	1994-08-26	Pfizer	Heteroatom substituted alkyl benzylamino-quinuclidines
JP2822274B2 (ja) *	1993-05-19	1998-11-11	ファイザー製薬株式会社	Ｐ物質拮抗剤としてのヘテロ原子置換アルキルベンジルアミノキヌクリジン類
US5393762A (en) *	1993-06-04	1995-02-28	Pfizer Inc.	Pharmaceutical agents for treatment of emesis
JP2843921B2 (ja) *	1993-07-15	1999-01-06	ファイザー製薬株式会社	Ｐ物質拮抗剤としてのベンジルオキシキヌクリジン
US6083943A (en) *	1993-09-17	2000-07-04	Pfizer Inc	Substituted azaheterocyclecarboxylic acid
ES2217269T3 (es) *	1993-09-17	2004-11-01	Pfizer Inc.	Piperidinas 3-amino-5-carboxi sustituidas y pirrolidinas 3-amino-4-carboxi sustituidas como antagonistas de taquininas.
EP0653208A3 (en) *	1993-11-17	1995-10-11	Pfizer	Substance P antagonists for the treatment or prevention of sunburn.
EP0659409A3 (en) *	1993-11-23	1995-08-09	Pfizer	Substance P antagonists for the inhibition of angiogenesis.
EP0655246A1 (en) *	1993-11-30	1995-05-31	Pfizer Inc.	Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria
FR2728169A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728165A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
PE8798A1 (es) *	1995-07-17	1998-03-02	Pfizer	Procedimiento de separacion de los enantiomeros del 1-azabiciclo[2.2.2] octan-3-amina, 2-(difenilmetil) -n- [[2-metoxi-5-(1-metiletil) fenil] metil]
TW458774B (en)	1995-10-20	2001-10-11	Pfizer	Antiemetic pharmaceutical compositions
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
MX9706944A (es) *	1996-09-12	1998-08-30	Pfizer	Quinuclidinas sustituidas con tetrazolilo como antagonistas de la sustancia p.
NZ329807A (en) *	1997-04-23	2000-07-28	Pfizer	NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome
BR0015320A (pt)	1999-11-03	2002-07-09	Albany Molecular Res Inc	Composto, composição, métodos de tratamento de um distúrbio que e criado pela, ou é dependente da, disponibilidade diminuìda de serotonina, norepinefrina ou dopamina, para inibir a captação da serotonina, da dopamina e de norepinefrina sinápticas em um paciente em necessidade destes, e, kit
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
KR100821410B1 (ko)	2000-07-11	2008-04-10	에이엠알 테크놀로지, 인크.	4-페닐 치환된 테트라하이드로이소퀴놀린 및 이의치료학적 용도
DOP2002000332A (es) *	2001-02-14	2002-08-30	Warner Lambert Co	Inhibidores de piridina de metaloproteinasas de la matriz
US6861526B2 (en) *	2002-10-16	2005-03-01	Pfizer Inc.	Process for the preparation of (S,S)-cis-2-benzhydryl-3-benzylaminoquinuclidine
WO2006020049A2 (en)	2004-07-15	2006-02-23	Amr Technology, Inc.	Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US8362075B2 (en)	2005-05-17	2013-01-29	Merck Sharp & Dohme Corp.	Cyclohexyl sulphones for treatment of cancer
KR20080044840A (ko)	2005-07-15	2008-05-21	에이엠알 테크놀로지, 인크.	아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기위한 용도
CN101277960A (zh)	2005-09-29	2008-10-01	默克公司	作为黑皮质素-4受体调节剂的酰化螺哌啶衍生物
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US8173629B2 (en)	2006-09-22	2012-05-08	Merck Sharp & Dohme Corp.	Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
PL2109608T3 (pl)	2007-01-10	2011-08-31	Msd Italia Srl	Indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy)-(PARP)
EP2117538A1 (en)	2007-01-24	2009-11-18	Glaxo Group Limited	Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)
JP5319518B2 (ja)	2007-04-02	2013-10-16	Ｍｓｄ株式会社	インドールジオン誘導体
CA2690191C (en)	2007-06-27	2015-07-28	Merck Sharp & Dohme Corp.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
CA2717509A1 (en)	2008-03-03	2009-09-11	Tiger Pharmatech	Tyrosine kinase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
SG175420A1 (en)	2009-05-12	2011-12-29	Albany Molecular Res Inc	7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
MX2011011901A (es)	2009-05-12	2012-01-20	Albany Molecular Res Inc	Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
US8815894B2 (en)	2009-05-12	2014-08-26	Bristol-Myers Squibb Company	Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
MY174452A (en)	2009-10-14	2020-04-19	Schering Corp	Substituted piperidines that increase p53 activity and the uses thereof
WO2011163330A1 (en)	2010-06-24	2011-12-29	Merck Sharp & Dohme Corp.	Novel heterocyclic compounds as erk inhibitors
CN107090456B (zh)	2010-08-02	2022-01-18	瑟纳治疗公司	使用短干扰核酸的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1基因表达的抑制
RU2624045C2 (ru)	2010-08-17	2017-06-30	Сирна Терапьютикс,Инк	ОПОСРЕДУЕМОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНОВ ВИРУСА ГЕПАТИТА B (HBV) С ПРИМЕНЕНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
EP2608669B1 (en)	2010-08-23	2016-06-22	Merck Sharp & Dohme Corp.	NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
US8946216B2 (en)	2010-09-01	2015-02-03	Merck Sharp & Dohme Corp.	Indazole derivatives useful as ERK inhibitors
EP2615916B1 (en)	2010-09-16	2017-01-04	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel erk inhibitors
EP3766975A1 (en)	2010-10-29	2021-01-20	Sirna Therapeutics, Inc.	Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
WO2012087772A1 (en)	2010-12-21	2012-06-28	Schering Corporation	Indazole derivatives useful as erk inhibitors
IN2013MN02170A (da)	2011-04-21	2015-06-12	Piramal Entpr Ltd
EP2770987B1 (en)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
WO2013165816A2 (en)	2012-05-02	2013-11-07	Merck Sharp & Dohme Corp.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
AU2013323508B2 (en)	2012-09-28	2017-11-02	Merck Sharp & Dohme Corp.	Novel compounds that are ERK inhibitors
PT2925888T (pt)	2012-11-28	2017-12-13	Merck Sharp & Dohme	Composições e métodos para tratamento do cancro
CA2895504A1 (en)	2012-12-20	2014-06-26	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as hdm2 inhibitors
WO2014120748A1 (en)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
EP3041938A1 (en)	2013-09-03	2016-07-13	Moderna Therapeutics, Inc.	Circular polynucleotides
EP3525785A4 (en)	2016-10-12	2020-03-25	Merck Sharp & Dohme Corp.	KDM5 INHIBITORS
US10947234B2 (en)	2017-11-08	2021-03-16	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
EP3706747A4 (en)	2017-11-08	2021-08-04	Merck Sharp & Dohme Corp.	PRMT5 INHIBITORS
EP3833668A4 (en)	2018-08-07	2022-05-11	Merck Sharp & Dohme Corp.	PRMT5 INHIBITORS
US11981701B2 (en)	2018-08-07	2024-05-14	Merck Sharp & Dohme Llc	PRMT5 inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990005525A1 (en) *	1988-11-23	1990-05-31	Pfizer Inc.	Quinuclidine derivatives as substance p antagonists

1992
- 1992-05-19 DK DK92911350T patent/DK0585328T3/da active
- 1992-05-19 AT AT92911350T patent/ATE211743T1/de not_active IP Right Cessation
- 1992-05-19 PL PL92311527A patent/PL170525B1/pl unknown
- 1992-05-19 PL PL92311526A patent/PL171921B1/pl unknown
- 1992-05-19 UA UA93003970A patent/UA26401C2/uk unknown
- 1992-05-19 WO PCT/US1992/004002 patent/WO1992020676A1/en active IP Right Grant
- 1992-05-19 PL PL92301418A patent/PL170513B1/pl unknown
- 1992-05-19 CZ CS932479A patent/CZ247993A3/cs unknown
- 1992-05-19 ES ES92911350T patent/ES2168260T3/es not_active Expired - Lifetime
- 1992-05-19 AU AU19275/92A patent/AU658898B2/en not_active Ceased
- 1992-05-19 DE DE9290057U patent/DE9290057U1/de not_active Expired - Lifetime
- 1992-05-19 PL PL92311525A patent/PL172069B1/pl unknown
- 1992-05-19 BR BR9206044A patent/BR9206044A/pt not_active Application Discontinuation
- 1992-05-19 HU HU9303307A patent/HUT65771A/hu unknown
- 1992-05-19 EP EP92911350A patent/EP0585328B1/en not_active Expired - Lifetime
- 1992-05-19 DE DE69232334T patent/DE69232334T2/de not_active Expired - Fee Related
- 1992-05-19 CA CA002109415A patent/CA2109415C/en not_active Expired - Fee Related
- 1992-05-19 RU RU9293058351A patent/RU2092486C1/ru active
- 1992-05-21 IL IL10196092A patent/IL101960A/en not_active IP Right Cessation
- 1992-05-21 EG EG27092A patent/EG20218A/xx active
- 1992-05-22 CN CN92104860A patent/CN1041827C/zh not_active Expired - Fee Related
- 1992-05-22 MX MX9202449A patent/MX9202449A/es not_active IP Right Cessation
- 1992-05-22 ZA ZA923773A patent/ZA923773B/xx unknown
- 1992-05-22 NZ NZ272941A patent/NZ272941A/en unknown
- 1992-05-22 NZ NZ242880A patent/NZ242880A/en unknown
- 1992-05-22 PT PT100514A patent/PT100514B/pt active IP Right Grant
- 1992-07-01 IE IE166292A patent/IE921662A1/en not_active IP Right Cessation
1993
- 1993-11-19 NO NO934195A patent/NO305173B1/no not_active IP Right Cessation
- 1993-11-19 FI FI935134A patent/FI935134A0/fi unknown
- 1993-11-20 KR KR1019930703532A patent/KR100246065B1/ko not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU658898B2 (en)	1995-05-04
FI935134A (fi)	1993-11-19
DE69232334D1 (de)	2002-02-14
PT100514A (pt)	1993-09-30
PL170513B1 (en)	1996-12-31
BR9206044A (pt)	1995-03-01
HUT65771A (en)	1994-07-28
DK0585328T3 (da)	2002-02-11
PL171921B1 (pl)	1997-06-30
RU2092486C1 (ru)	1997-10-10
NZ272941A (en)	1997-05-26
NZ242880A (en)	1995-10-26
EP0585328A1 (en)	1994-03-09
WO1992020676A1 (en)	1992-11-26
ES2168260T3 (es)	2002-06-16
NO934195D0 (no)	1993-11-19
ZA923773B (en)	1993-11-22
CA2109415A1 (en)	1992-11-23
IL101960A0 (en)	1994-04-12
KR100246065B1 (en)	2000-04-01
IE921662A1 (en)	1992-12-02
DE9290057U1 (de)	1994-01-05
ATE211743T1 (de)	2002-01-15
PL172069B1 (pl)	1997-07-31
AU1927592A (en)	1992-12-30
CN1068571A (zh)	1993-02-03
EG20218A (en)	1997-11-30
PT100514B (pt)	1999-06-30
FI935134A0 (fi)	1993-11-19
NO934195L (no)	1993-11-19
CA2109415C (en)	1998-12-29
EP0585328B1 (en)	2002-01-09
CZ247993A3 (en)	1994-07-13
DE69232334T2 (de)	2002-11-14
PL170525B1 (en)	1996-12-31
UA26401C2 (uk)	1999-08-30
NO305173B1 (no)	1999-04-12
MX9202449A (es)	1993-03-01
CN1041827C (zh)	1999-01-27
HU9303307D0 (en)	1994-03-28

Publication	Publication Date	Title
IL101960A (en)	1999-03-12	3 -]) hetero (arylmethylamino [- 2 -) di) hetero (arylmethyl (converted quinuclidines and pharmaceutical preparations containing them
IE83327B1 (en)		Substituted 3-aminoquinuclidines
CA2123403C (en)	2002-02-05	Acyclic ethylenediamine derivatives as substance p receptor antagonists
EP0699199B1 (en)	2002-11-20	Heteroatom substituted alkyl benzylaminoquinuclidines as substance p antagonists
EP0632809B1 (en)	2001-09-05	Quinuclidine derivatives as substance p antagonists
EP0665844B1 (en)	2000-09-06	Substituted benzylaminoquinuclidines as substance p antagonists
US20100267766A1 (en)	2010-10-21	Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof
US5852038A (en)	1998-12-22	Substituted 3-aminoquinuclidines
RU2090565C1 (ru)	1997-09-20	Рацемические или оптически активные пергидро-1h-пиридо(1,2-а) пиразины или их фармацевтически приемлемые соли и способ их получения
US5569662A (en)	1996-10-29	Quinuclidine derivatives as substance P antagonists
US5604241A (en)	1997-02-18	Substituted benzylaminoquinuclidines as substance P antagonists
JP2719063B2 (ja)	1998-02-25	置換３−アミノキヌクリジンｐ物質拮抗剤
JP3172461B2 (ja)	2001-06-04	サブスタンスｐアンタゴニストとしての３−［（５−置換ベンジル）アミノ］−２−フェニルピペリジン

Legal Events

Date	Code	Title
1999-09-22	FF	Patent granted
2000-02-29	KB	Patent renewed
2003-02-12	MM9K	Patent not in force due to non-payment of renewal fees