EA201892369A1 - Способы селективной модуляции активности отдельных подтипов клеток - Google Patents
Способы селективной модуляции активности отдельных подтипов клетокInfo
- Publication number
- EA201892369A1 EA201892369A1 EA201892369A EA201892369A EA201892369A1 EA 201892369 A1 EA201892369 A1 EA 201892369A1 EA 201892369 A EA201892369 A EA 201892369A EA 201892369 A EA201892369 A EA 201892369A EA 201892369 A1 EA201892369 A1 EA 201892369A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- activity
- particles
- subtips
- methods
- retroviral vectors
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 2
- 239000002245 particle Substances 0.000 abstract 3
- 230000001177 retroviral effect Effects 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 241000711504 Paramyxoviridae Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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Abstract
Настоящее изобретение относится к псевдотипированным ретровирусоподобным частицам или ретровирусным векторам, содержащим и сконструированные гликопротеины оболочки, происходящие из вируса семейства Paramyxoviridae, слитые с доменом, нацеливающим на клетку, и слитые с функциональным доменом. Настоящее изобретение также относится к применению указанных псевдотипированных ретровирусоподобных частиц или ретровирусных векторов для селективной модуляции активности специфических поднаборов клеток, в частности специфических иммунных клеток. Данные псевдотипированные ретровирусоподобные частицы или ретровирусные векторы являются особенно полезными для генотерапии, иммунотерапии и/или вакцинации.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16305468.7A EP3235908A1 (en) | 2016-04-21 | 2016-04-21 | Methods for selectively modulating the activity of distinct subtypes of cells |
PCT/EP2017/059435 WO2017182585A1 (en) | 2016-04-21 | 2017-04-20 | Methods for selectively modulating the activity of distinct subtypes of cells |
Publications (1)
Publication Number | Publication Date |
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EA201892369A1 true EA201892369A1 (ru) | 2019-05-31 |
Family
ID=56008561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201892369A EA201892369A1 (ru) | 2016-04-21 | 2017-04-20 | Способы селективной модуляции активности отдельных подтипов клеток |
Country Status (15)
Country | Link |
---|---|
US (2) | US11608509B2 (ru) |
EP (3) | EP3235908A1 (ru) |
JP (4) | JP7412885B2 (ru) |
KR (1) | KR20190046713A (ru) |
CN (2) | CN117126817A (ru) |
AU (3) | AU2017253364B2 (ru) |
BR (1) | BR112018071584A2 (ru) |
CA (1) | CA3021549A1 (ru) |
EA (1) | EA201892369A1 (ru) |
ES (1) | ES2961976T3 (ru) |
IL (1) | IL262458A (ru) |
MX (2) | MX2018012814A (ru) |
SG (1) | SG11201809164TA (ru) |
WO (1) | WO2017182585A1 (ru) |
ZA (1) | ZA201807161B (ru) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
US11576872B2 (en) | 2017-05-08 | 2023-02-14 | Flagship Pioneering Innovations V, Inc. | Compositions for facilitating membrane fusion and uses thereof |
IL278665B2 (en) * | 2018-05-15 | 2024-10-01 | Flagship Pioneering Innovations V Inc | Fusosome compositions and uses thereof |
AU2019301053A1 (en) * | 2018-07-09 | 2021-01-28 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
US20230043255A1 (en) * | 2018-11-14 | 2023-02-09 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for t cell delivery |
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