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EA201992558A1 - Варианты белка bmp7 человека - Google Patents

Варианты белка bmp7 человека

Info

Publication number
EA201992558A1
EA201992558A1 EA201992558A EA201992558A EA201992558A1 EA 201992558 A1 EA201992558 A1 EA 201992558A1 EA 201992558 A EA201992558 A EA 201992558A EA 201992558 A EA201992558 A EA 201992558A EA 201992558 A1 EA201992558 A1 EA 201992558A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bmp7
relates
present
human protein
options
Prior art date
Application number
EA201992558A
Other languages
English (en)
Inventor
Джеймс Дэвид Пэнкук
Скотт Уильям Роулинсон
Луи Франк Станкато
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201992558A1 publication Critical patent/EA201992558A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2857—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, orphan receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Настоящее изобретение относится к новым вариантам белка BMP7 человека. Настоящее изобретение относится к векторам и клеткам-хозяевам для воспроизводства последовательностей нуклеиновой кислоты, кодирующих указанные белки, и их получения. Настоящее изобретение также относится к способам лечения злокачественного новообразования, повреждения и дегенерации хрящевой ткани, боли, ассоциированной с остеоартритом, или сращения кости.
EA201992558A 2017-04-27 2018-04-20 Варианты белка bmp7 человека EA201992558A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762490910P 2017-04-27 2017-04-27
PCT/US2018/028496 WO2018200322A1 (en) 2017-04-27 2018-04-20 Variants of human bmp7 protein

Publications (1)

Publication Number Publication Date
EA201992558A1 true EA201992558A1 (ru) 2020-03-04

Family

ID=62196685

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992558A EA201992558A1 (ru) 2017-04-27 2018-04-20 Варианты белка bmp7 человека

Country Status (17)

Country Link
US (1) US11466066B2 (ru)
EP (1) EP3615561B1 (ru)
JP (1) JP7308151B2 (ru)
KR (1) KR20200012870A (ru)
CN (1) CN110997708A (ru)
AU (1) AU2018258100B2 (ru)
BR (1) BR112019022566A2 (ru)
CA (1) CA3061606A1 (ru)
CL (1) CL2019003074A1 (ru)
CO (1) CO2019013150A2 (ru)
CR (1) CR20190539A (ru)
EA (1) EA201992558A1 (ru)
MX (1) MX2019012871A (ru)
PE (1) PE20200385A1 (ru)
PH (1) PH12019502442A1 (ru)
SG (1) SG11201910009UA (ru)
WO (1) WO2018200322A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101885737B1 (ko) 2018-04-30 2018-08-06 주식회사 이지요구르트 요구르트발효기 및 요구르트발효기의 자동 온도제어 방법
KR20230003879A (ko) 2021-06-30 2023-01-06 현대자동차주식회사 하이브리드 차량의 림프홈 후진 주행 제어 시스템 및 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2561809A1 (en) 2004-03-31 2005-10-20 Xencor, Inc. Bmp-7 variants with improved properties
WO2008082563A2 (en) * 2006-12-21 2008-07-10 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
WO2008151258A2 (en) * 2007-06-04 2008-12-11 Neose Technologies, Inc. O-linked glycosylation using n-acetylglucosaminyl transferases
US7846428B2 (en) 2007-10-05 2010-12-07 Merial Limited Articular cartilage gene therapy with recombinant vector encoding BMP-7
EP2222696A1 (en) 2007-12-21 2010-09-01 Stryker Corporation Bmp mutants with decreased susceptibility to noggin

Also Published As

Publication number Publication date
CL2019003074A1 (es) 2020-05-08
JP7308151B2 (ja) 2023-07-13
WO2018200322A1 (en) 2018-11-01
PH12019502442A1 (en) 2020-10-05
MX2019012871A (es) 2021-01-08
SG11201910009UA (en) 2019-11-28
KR20200012870A (ko) 2020-02-05
CO2019013150A2 (es) 2020-02-28
US20210115100A1 (en) 2021-04-22
CA3061606A1 (en) 2018-11-01
US11466066B2 (en) 2022-10-11
PE20200385A1 (es) 2020-02-24
CN110997708A (zh) 2020-04-10
EP3615561C0 (en) 2024-01-10
CR20190539A (es) 2020-03-26
EP3615561A1 (en) 2020-03-04
EP3615561B1 (en) 2024-01-10
AU2018258100A1 (en) 2019-11-14
BR112019022566A2 (pt) 2020-05-19
AU2018258100B2 (en) 2022-04-14
JP2020517706A (ja) 2020-06-18

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