MX2023006961A - Metodos para modular selectivamente la actividad de distintos subtipos de celulas. - Google Patents
Metodos para modular selectivamente la actividad de distintos subtipos de celulas.Info
- Publication number
- MX2023006961A MX2023006961A MX2023006961A MX2023006961A MX2023006961A MX 2023006961 A MX2023006961 A MX 2023006961A MX 2023006961 A MX2023006961 A MX 2023006961A MX 2023006961 A MX2023006961 A MX 2023006961A MX 2023006961 A MX2023006961 A MX 2023006961A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- activity
- particles
- selectively modulate
- methods
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 2
- 239000002245 particle Substances 0.000 abstract 3
- 230000001177 retroviral effect Effects 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 101710121417 Envelope glycoprotein Proteins 0.000 abstract 1
- 241000711504 Paramyxoviridae Species 0.000 abstract 1
- 102100021696 Syncytin-1 Human genes 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
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Abstract
La presente invención está relacionada con partículas tipo retrovirus o vectores retrovirales pseudotipados que comprenden tanto glicoproteínas de envoltura diseñadas derivadas de un virus de la familia Paramyxoviridae fusionadas a un dominio de direccionamiento celular y fusionadas a un dominio funcional; la presente invención también está relacionada con el uso de dichas partículas tipo retrovirus o vectores retrovirales pseudotipados para modular selectivamente la actividad de subgrupos específicos de células, en particular de células inmunes específicas; estas partículas tipo retrovirus o vectores retrovirales pseudotipados son particularmente útiles para la terapia genética, terapia inmune y/o vacunación.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16305468.7A EP3235908A1 (en) | 2016-04-21 | 2016-04-21 | Methods for selectively modulating the activity of distinct subtypes of cells |
Publications (1)
Publication Number | Publication Date |
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MX2023006961A true MX2023006961A (es) | 2023-06-23 |
Family
ID=56008561
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018012814A MX2018012814A (es) | 2016-04-21 | 2017-04-20 | Métodos para modular selectivamente la actividad de distintos sub-tipos de células. |
MX2023006961A MX2023006961A (es) | 2016-04-21 | 2018-10-19 | Metodos para modular selectivamente la actividad de distintos subtipos de celulas. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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MX2018012814A MX2018012814A (es) | 2016-04-21 | 2017-04-20 | Métodos para modular selectivamente la actividad de distintos sub-tipos de células. |
Country Status (15)
Country | Link |
---|---|
US (2) | US11608509B2 (es) |
EP (3) | EP3235908A1 (es) |
JP (4) | JP7412885B2 (es) |
KR (1) | KR20190046713A (es) |
CN (2) | CN109642243A (es) |
AU (3) | AU2017253364B2 (es) |
BR (1) | BR112018071584A2 (es) |
CA (1) | CA3021549A1 (es) |
EA (1) | EA201892369A1 (es) |
ES (1) | ES2961976T3 (es) |
IL (1) | IL262458A (es) |
MX (2) | MX2018012814A (es) |
SG (1) | SG11201809164TA (es) |
WO (1) | WO2017182585A1 (es) |
ZA (1) | ZA201807161B (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
CN110869507A (zh) | 2017-05-08 | 2020-03-06 | 旗舰先锋创新V股份有限公司 | 促进膜融合的组合物和其用途 |
WO2019222403A2 (en) * | 2018-05-15 | 2019-11-21 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
MX2021000308A (es) * | 2018-07-09 | 2021-06-08 | Flagship Pioneering Innovations V Inc | Composiciones de fusosoma y usos de estas. |
EP3880180A2 (en) * | 2018-11-14 | 2021-09-22 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for t cell delivery |
CN110004181B (zh) * | 2019-03-20 | 2022-10-11 | 东北农业大学 | 一种附加型CRISPR/Cas9表达载体及其构建方法与应用 |
AU2020278470A1 (en) | 2019-05-23 | 2021-12-02 | Massachusetts Institute Of Technology | Ligand discovery and gene delivery via retroviral surface display |
WO2021046143A1 (en) | 2019-09-03 | 2021-03-11 | Sana Biotechnology, Inc. | Cd24-associated particles and related methods and uses thereof |
CN110904116B (zh) * | 2019-10-24 | 2022-12-09 | 中国科学院遗传与发育生物学研究所 | 植物phl3基因在调控植物种子大小、干重和脂肪酸积累中的应用 |
CA3171066A1 (en) | 2020-03-11 | 2021-09-16 | Saar GILL | Methods and composition for gene delivery using an engineered viral particle |
CN116096866A (zh) * | 2020-03-31 | 2023-05-09 | 萨那生物科技公司 | 靶向脂质颗粒及其组合物和用途 |
EP4182447A4 (en) * | 2020-07-14 | 2024-10-23 | Ichilov Tech Ltd. | PSEUDOTYPED VIRUSES WITH CONFIGURATION FOR EXPRESSION OF CAR IN T CELLS |
EP3964585A1 (en) * | 2020-09-03 | 2022-03-09 | Miltenyi Biotec B.V. & Co. KG | Cd62l specific lentiviral vector particle for targeted transduction of t cell subsets |
JP2024503027A (ja) * | 2021-01-11 | 2024-01-24 | サナ バイオテクノロジー,インコーポレイテッド | Cd8標的ウイルスベクターの使用方法 |
WO2022187289A1 (en) | 2021-03-01 | 2022-09-09 | Exuma Biotech Corp. | Methods and compositions for the delivery of retroviral particles |
AU2022253020A1 (en) * | 2021-04-08 | 2023-10-26 | Sana Biotechnology, Inc. | Cd8-specific antibody constructs and compositions thereof |
US20240254168A1 (en) | 2021-05-28 | 2024-08-01 | Sana Biotechnology, Inc. | LIPID PARTICLES CONTAINING A TRUNCATED BABOON ENDOGENOUS RETROVIRUS (BaEV) ENVELOPE GLYCOPROTEIN AND RELATED METHODS AND USES |
JP2024528981A (ja) | 2021-08-04 | 2024-08-01 | サナ バイオテクノロジー,インコーポレイテッド | Cd4標的化ウイルスベクターの使用 |
WO2023114698A2 (en) * | 2021-12-13 | 2023-06-22 | Interius Biotherapeutics, Inc. | Engineered viral particles and uses of the same |
WO2023114949A1 (en) | 2021-12-16 | 2023-06-22 | Sana Biotechnology, Inc. | Methods and systems of particle production |
EP4448549A2 (en) | 2021-12-17 | 2024-10-23 | Sana Biotechnology, Inc. | Modified paramyxoviridae fusion glycoproteins |
EP4448775A1 (en) | 2021-12-17 | 2024-10-23 | Sana Biotechnology, Inc. | Modified paramyxoviridae attachment glycoproteins |
EP4463135A2 (en) | 2022-01-10 | 2024-11-20 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
EP4473097A1 (en) | 2022-02-02 | 2024-12-11 | Sana Biotechnology, Inc. | Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses |
EP4469586A1 (en) | 2022-03-01 | 2024-12-04 | Exuma Biotech Corp. | Viral particles with membrane-bound hyaluronidase |
WO2023173140A2 (en) * | 2022-03-11 | 2023-09-14 | President And Fellows Of Harvard College | Targeted delivery of armms |
WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
TW202400663A (zh) * | 2022-04-25 | 2024-01-01 | 日商常磐生化股份有限公司 | 源自rna病毒之嵌合包膜蛋白及具有該蛋白之rna病毒載體 |
WO2024026377A1 (en) | 2022-07-27 | 2024-02-01 | Sana Biotechnology, Inc. | Methods of transduction using a viral vector and inhibitors of antiviral restriction factors |
WO2024044655A1 (en) | 2022-08-24 | 2024-02-29 | Sana Biotechnology, Inc. | Delivery of heterologous proteins |
WO2024064838A1 (en) | 2022-09-21 | 2024-03-28 | Sana Biotechnology, Inc. | Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof |
WO2024081820A1 (en) | 2022-10-13 | 2024-04-18 | Sana Biotechnology, Inc. | Viral particles targeting hematopoietic stem cells |
WO2024119157A1 (en) | 2022-12-02 | 2024-06-06 | Sana Biotechnology, Inc. | Lipid particles with cofusogens and methods of producing and using the same |
WO2024220560A1 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Engineered protein g fusogens and related lipid particles and methods thereof |
WO2024220597A2 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Digital droplet based assay for detecting replication competent lentiviral vector |
WO2024220598A2 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Lentiviral vectors with two or more genomes |
WO2024220574A1 (en) | 2023-04-18 | 2024-10-24 | Sana Biotechnology, Inc. | Universal protein g fusogens and adapter systems thereof and related lipid particles and uses |
WO2024243340A1 (en) | 2023-05-23 | 2024-11-28 | Sana Biotechnology, Inc. | Tandem fusogens and related lipid particles |
WO2024254346A1 (en) * | 2023-06-07 | 2024-12-12 | The Broad Institute, Inc. | Engineered viral like particles (evlps) for the selective transduction of target cells |
CN117659133B (zh) * | 2023-12-06 | 2024-09-20 | 南京鼓楼医院 | 间皮素靶向结合蛋白、其编码核酸以及用途 |
CN118108809A (zh) * | 2024-03-15 | 2024-05-31 | 西湖实验室(生命科学和生物医学浙江省实验室) | 一种跨膜荧光蛋白、水溶荧光蛋白及其用途 |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002526085A (ja) | 1998-09-23 | 2002-08-20 | オーストリアン・ノルディック・バイオセラピューティクス・アーゲー | 補体を介した破壊から保護されたレトロウイルス粒子 |
US6896881B1 (en) * | 1999-09-24 | 2005-05-24 | Mayo Foundation For Medical Education And Research | Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family |
AU2001251138A1 (en) | 2000-03-31 | 2001-10-15 | Mayo Foundation For Medical Education And Research | Compositions and methods for tissue specific gene regulation therapy |
CA2464887A1 (en) | 2001-10-30 | 2003-05-08 | Biogen, Inc. | Methods and compositions for treating parkinson's disease |
EP2339010B1 (en) | 2002-05-01 | 2017-04-12 | Miltenyi Biotec Technology, Inc. | Lentiviral vector particles resistant to complement inactivation |
US20060045910A1 (en) | 2004-09-02 | 2006-03-02 | Ehringer William D | Preserved fusogenic vesicles |
GB0426641D0 (en) | 2004-12-03 | 2005-01-05 | Bioactive Protein Delivery The | Protein delivery system |
EP1838856A4 (en) | 2005-01-20 | 2010-07-14 | Agency Science Tech & Res | PROCESS FOR DELIVERING NUCLEIC ACIDS TO PERIPHERAL NEURONS |
CN101208104B (zh) | 2005-04-25 | 2012-10-31 | 梅瑞尔有限公司 | Nipah病毒疫苗 |
WO2007005244A1 (en) | 2005-07-05 | 2007-01-11 | The Regents Of The University Of California | Henipavirus receptor and uses thereof |
US20120121650A1 (en) | 2006-08-18 | 2012-05-17 | Johnston Robert E | Chimeric Virus Vaccines |
EP1975239A1 (en) * | 2006-09-27 | 2008-10-01 | Bundesrepublik Deutschland, letztvertreten durch den Präsidenten des Paul-Ehrlich-Instituts Prof. Dr. Johannes Löwer | Pseudotyping of retroviral vectors, methods for production and use thereof for targeted gene transfer and high-throughput screening |
WO2008071959A1 (en) | 2006-12-12 | 2008-06-19 | Oxford Biomedica (Uk) Limited | Lentiviral vectors comprising micrornas |
CA2722238C (en) | 2008-04-22 | 2017-11-28 | Life Sciences Research Partners Vzw | Liver-specific nucleic acid regulatory elements and methods and use thereof |
BRPI0823234A2 (pt) | 2008-11-07 | 2019-09-24 | Childrens Hospital Med Ct | nanovesícula para liberação de um agente para uma membrana biológica e processo para direcionar um agente para uma membrana de uma célula ou um tecido. |
DK2770061T3 (en) | 2009-07-24 | 2019-01-07 | Immune Design Corp | NON-INTEGRATING LENTIVIRUS VECTORS |
WO2011058052A1 (en) | 2009-11-13 | 2011-05-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Direct protein delivery with engineered microvesicles |
EP2476754A1 (en) | 2011-01-14 | 2012-07-18 | Bundesrepublik Deutschland, Letztvertreten Durch Den Präsidenten Des Paul-Ehrlich-Instituts | Methods for the identification and repair of amino acid residues destabilizing single-chain variable fragments (scFv) |
AU2012249474A1 (en) | 2011-04-28 | 2013-11-07 | Stc.Unm | Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same |
BR112014008932A2 (pt) * | 2011-10-14 | 2019-09-24 | Sandia Corp | bicamadas lipídicas suportadas em nanopartículas porosas (protocélulas) para administração direcionada, incluindo a administração transdérmica de uma carga e métodos associados |
GB201121070D0 (en) | 2011-12-07 | 2012-01-18 | Isis Innovation | composition for delivery of biotherapeutics |
EP2615176A1 (en) * | 2012-01-11 | 2013-07-17 | Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe | Novel pseudotyped lentiviral particles and their use in the in vitro targeted transduction of undifferentiated pluripotent human embryonic stem cells and induced pluripotent stem cells |
EP2844746A4 (en) | 2012-03-26 | 2016-07-20 | Univ California | PSEUDOTYPIZED LENTIVIRES WITH NIPAH VIRUS COVERS AND METHOD OF USE THEREOF |
JP6391582B2 (ja) | 2012-11-13 | 2018-09-19 | コディアック バイオサイエンシズ インコーポレイテッド | 治療剤の送達方法 |
US10414820B2 (en) | 2013-03-13 | 2019-09-17 | Imaginab, Inc. | Antigen binding constructs to CD8 |
GB201313249D0 (en) | 2013-07-25 | 2013-09-11 | Isis Innovation | Method |
EP3791863A1 (en) | 2014-01-21 | 2021-03-17 | Anjarium Biosciences AG | Process for the production of hybridosomes |
GB201412494D0 (en) | 2014-07-14 | 2014-08-27 | Ospedale San Raffaele And Fond Telethon | Vector production |
US10421979B2 (en) * | 2015-02-11 | 2019-09-24 | Alma Mater Studiorum Universita' Di Bologna | Retargeted herpesvirus with a glycoprotein H fusion |
US10501733B2 (en) | 2015-02-27 | 2019-12-10 | University Of Washington | Polypeptide assemblies and methods for the production thereof |
US20180135012A1 (en) | 2015-05-13 | 2018-05-17 | Rubius Therapeutics, Inc. | Membrane-receiver complex therapeutics |
US10729789B2 (en) | 2016-03-01 | 2020-08-04 | University Of Virginia Patent Foundation | Compositions and methods for adeno-associated virus mediated gene expression in myofibroblast-like cells |
EP3430136A2 (en) * | 2016-03-19 | 2019-01-23 | F1 Oncology, Inc. | Methods and compositions for transducing lymphocytes and regulated expansion thereof |
US11458097B2 (en) | 2016-03-30 | 2022-10-04 | The University Of North Carolina At Chapel Hill | Biological agent-exosome compositions and uses thereof |
EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
US20190300862A1 (en) | 2016-06-09 | 2019-10-03 | Alma Mater Studiorum Universita Di Bologna | Herpesvirus with Modified Glycoprotein H for Propagation in a Cell |
CA3030003A1 (en) | 2016-07-08 | 2018-01-11 | F1 Oncology, Inc. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
KR20190053180A (ko) | 2016-07-26 | 2019-05-17 | 센티 바이오사이언시스, 인코포레이티드 | 시공간적 조절자들 |
EP3565607A4 (en) | 2017-01-09 | 2020-11-18 | Oisin Biotechnologies | FUSOGENOUS LIPID NANOPARTICLES AND METHODS OF MANUFACTURE AND USE FOR THE PRODUCTION OF THERAPEUTIC PROTEIN AND FOR TREATMENT PURPOSES |
CN110869507A (zh) | 2017-05-08 | 2020-03-06 | 旗舰先锋创新V股份有限公司 | 促进膜融合的组合物和其用途 |
WO2019113512A1 (en) | 2017-12-07 | 2019-06-13 | Flagship Pioneering Innovations V, Inc. | Cytobiologics and therapeutic uses thereof |
MX2020008152A (es) | 2018-02-01 | 2020-11-24 | Bioverativ Therapeutics Inc | Uso de vectores lentivirales que expresan el factor viii. |
EP3752623A1 (en) | 2018-02-17 | 2020-12-23 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for membrane protein delivery |
WO2019222403A2 (en) | 2018-05-15 | 2019-11-21 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
US20210198698A1 (en) | 2018-07-09 | 2021-07-01 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions and uses thereof |
MX2021000308A (es) | 2018-07-09 | 2021-06-08 | Flagship Pioneering Innovations V Inc | Composiciones de fusosoma y usos de estas. |
SG11202105079QA (en) | 2018-11-14 | 2021-06-29 | Flagship Pioneering Innovations V Inc | Fusosome compositions for cns delivery |
EP3880180A2 (en) | 2018-11-14 | 2021-09-22 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for t cell delivery |
EP3880831A1 (en) | 2018-11-14 | 2021-09-22 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for compartment-specific cargo delivery |
US20230048166A1 (en) | 2018-11-14 | 2023-02-16 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for hematopoietic stem cell delivery |
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