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MX2023006961A - Metodos para modular selectivamente la actividad de distintos subtipos de celulas. - Google Patents

Metodos para modular selectivamente la actividad de distintos subtipos de celulas.

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Publication number
MX2023006961A
MX2023006961A MX2023006961A MX2023006961A MX2023006961A MX 2023006961 A MX2023006961 A MX 2023006961A MX 2023006961 A MX2023006961 A MX 2023006961A MX 2023006961 A MX2023006961 A MX 2023006961A MX 2023006961 A MX2023006961 A MX 2023006961A
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Mexico
Prior art keywords
cells
activity
particles
selectively modulate
methods
Prior art date
Application number
MX2023006961A
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English (en)
Inventor
Fejoz Caroline Costa
Els Verhoeyen
François Loïc Cosset
Ruben Bender
Christian Buchholz
Qi Zhou
Original Assignee
Ecole Normale Superieure Lyon
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Filing date
Publication date
Application filed by Ecole Normale Superieure Lyon filed Critical Ecole Normale Superieure Lyon
Publication of MX2023006961A publication Critical patent/MX2023006961A/es

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Abstract

La presente invención está relacionada con partículas tipo retrovirus o vectores retrovirales pseudotipados que comprenden tanto glicoproteínas de envoltura diseñadas derivadas de un virus de la familia Paramyxoviridae fusionadas a un dominio de direccionamiento celular y fusionadas a un dominio funcional; la presente invención también está relacionada con el uso de dichas partículas tipo retrovirus o vectores retrovirales pseudotipados para modular selectivamente la actividad de subgrupos específicos de células, en particular de células inmunes específicas; estas partículas tipo retrovirus o vectores retrovirales pseudotipados son particularmente útiles para la terapia genética, terapia inmune y/o vacunación.
MX2023006961A 2016-04-21 2018-10-19 Metodos para modular selectivamente la actividad de distintos subtipos de celulas. MX2023006961A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16305468.7A EP3235908A1 (en) 2016-04-21 2016-04-21 Methods for selectively modulating the activity of distinct subtypes of cells

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MX2023006961A true MX2023006961A (es) 2023-06-23

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MX2018012814A MX2018012814A (es) 2016-04-21 2017-04-20 Métodos para modular selectivamente la actividad de distintos sub-tipos de células.
MX2023006961A MX2023006961A (es) 2016-04-21 2018-10-19 Metodos para modular selectivamente la actividad de distintos subtipos de celulas.

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US (2) US11608509B2 (es)
EP (3) EP3235908A1 (es)
JP (4) JP7412885B2 (es)
KR (1) KR20190046713A (es)
CN (2) CN109642243A (es)
AU (3) AU2017253364B2 (es)
BR (1) BR112018071584A2 (es)
CA (1) CA3021549A1 (es)
EA (1) EA201892369A1 (es)
ES (1) ES2961976T3 (es)
IL (1) IL262458A (es)
MX (2) MX2018012814A (es)
SG (1) SG11201809164TA (es)
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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3235908A1 (en) 2016-04-21 2017-10-25 Ecole Normale Superieure De Lyon Methods for selectively modulating the activity of distinct subtypes of cells
CN110869507A (zh) 2017-05-08 2020-03-06 旗舰先锋创新V股份有限公司 促进膜融合的组合物和其用途
WO2019222403A2 (en) * 2018-05-15 2019-11-21 Flagship Pioneering Innovations V, Inc. Fusosome compositions and uses thereof
MX2021000308A (es) * 2018-07-09 2021-06-08 Flagship Pioneering Innovations V Inc Composiciones de fusosoma y usos de estas.
EP3880180A2 (en) * 2018-11-14 2021-09-22 Flagship Pioneering Innovations V, Inc. Fusosome compositions for t cell delivery
CN110004181B (zh) * 2019-03-20 2022-10-11 东北农业大学 一种附加型CRISPR/Cas9表达载体及其构建方法与应用
AU2020278470A1 (en) 2019-05-23 2021-12-02 Massachusetts Institute Of Technology Ligand discovery and gene delivery via retroviral surface display
WO2021046143A1 (en) 2019-09-03 2021-03-11 Sana Biotechnology, Inc. Cd24-associated particles and related methods and uses thereof
CN110904116B (zh) * 2019-10-24 2022-12-09 中国科学院遗传与发育生物学研究所 植物phl3基因在调控植物种子大小、干重和脂肪酸积累中的应用
CA3171066A1 (en) 2020-03-11 2021-09-16 Saar GILL Methods and composition for gene delivery using an engineered viral particle
CN116096866A (zh) * 2020-03-31 2023-05-09 萨那生物科技公司 靶向脂质颗粒及其组合物和用途
EP4182447A4 (en) * 2020-07-14 2024-10-23 Ichilov Tech Ltd. PSEUDOTYPED VIRUSES WITH CONFIGURATION FOR EXPRESSION OF CAR IN T CELLS
EP3964585A1 (en) * 2020-09-03 2022-03-09 Miltenyi Biotec B.V. & Co. KG Cd62l specific lentiviral vector particle for targeted transduction of t cell subsets
JP2024503027A (ja) * 2021-01-11 2024-01-24 サナ バイオテクノロジー,インコーポレイテッド Cd8標的ウイルスベクターの使用方法
WO2022187289A1 (en) 2021-03-01 2022-09-09 Exuma Biotech Corp. Methods and compositions for the delivery of retroviral particles
AU2022253020A1 (en) * 2021-04-08 2023-10-26 Sana Biotechnology, Inc. Cd8-specific antibody constructs and compositions thereof
US20240254168A1 (en) 2021-05-28 2024-08-01 Sana Biotechnology, Inc. LIPID PARTICLES CONTAINING A TRUNCATED BABOON ENDOGENOUS RETROVIRUS (BaEV) ENVELOPE GLYCOPROTEIN AND RELATED METHODS AND USES
JP2024528981A (ja) 2021-08-04 2024-08-01 サナ バイオテクノロジー,インコーポレイテッド Cd4標的化ウイルスベクターの使用
WO2023114698A2 (en) * 2021-12-13 2023-06-22 Interius Biotherapeutics, Inc. Engineered viral particles and uses of the same
WO2023114949A1 (en) 2021-12-16 2023-06-22 Sana Biotechnology, Inc. Methods and systems of particle production
EP4448549A2 (en) 2021-12-17 2024-10-23 Sana Biotechnology, Inc. Modified paramyxoviridae fusion glycoproteins
EP4448775A1 (en) 2021-12-17 2024-10-23 Sana Biotechnology, Inc. Modified paramyxoviridae attachment glycoproteins
EP4463135A2 (en) 2022-01-10 2024-11-20 Sana Biotechnology, Inc. Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
EP4473097A1 (en) 2022-02-02 2024-12-11 Sana Biotechnology, Inc. Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
EP4469586A1 (en) 2022-03-01 2024-12-04 Exuma Biotech Corp. Viral particles with membrane-bound hyaluronidase
WO2023173140A2 (en) * 2022-03-11 2023-09-14 President And Fellows Of Harvard College Targeted delivery of armms
WO2023193015A1 (en) 2022-04-01 2023-10-05 Sana Biotechnology, Inc. Cytokine receptor agonist and viral vector combination therapies
TW202400663A (zh) * 2022-04-25 2024-01-01 日商常磐生化股份有限公司 源自rna病毒之嵌合包膜蛋白及具有該蛋白之rna病毒載體
WO2024026377A1 (en) 2022-07-27 2024-02-01 Sana Biotechnology, Inc. Methods of transduction using a viral vector and inhibitors of antiviral restriction factors
WO2024044655A1 (en) 2022-08-24 2024-02-29 Sana Biotechnology, Inc. Delivery of heterologous proteins
WO2024064838A1 (en) 2022-09-21 2024-03-28 Sana Biotechnology, Inc. Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
WO2024081820A1 (en) 2022-10-13 2024-04-18 Sana Biotechnology, Inc. Viral particles targeting hematopoietic stem cells
WO2024119157A1 (en) 2022-12-02 2024-06-06 Sana Biotechnology, Inc. Lipid particles with cofusogens and methods of producing and using the same
WO2024220560A1 (en) 2023-04-18 2024-10-24 Sana Biotechnology, Inc. Engineered protein g fusogens and related lipid particles and methods thereof
WO2024220597A2 (en) 2023-04-18 2024-10-24 Sana Biotechnology, Inc. Digital droplet based assay for detecting replication competent lentiviral vector
WO2024220598A2 (en) 2023-04-18 2024-10-24 Sana Biotechnology, Inc. Lentiviral vectors with two or more genomes
WO2024220574A1 (en) 2023-04-18 2024-10-24 Sana Biotechnology, Inc. Universal protein g fusogens and adapter systems thereof and related lipid particles and uses
WO2024243340A1 (en) 2023-05-23 2024-11-28 Sana Biotechnology, Inc. Tandem fusogens and related lipid particles
WO2024254346A1 (en) * 2023-06-07 2024-12-12 The Broad Institute, Inc. Engineered viral like particles (evlps) for the selective transduction of target cells
CN117659133B (zh) * 2023-12-06 2024-09-20 南京鼓楼医院 间皮素靶向结合蛋白、其编码核酸以及用途
CN118108809A (zh) * 2024-03-15 2024-05-31 西湖实验室(生命科学和生物医学浙江省实验室) 一种跨膜荧光蛋白、水溶荧光蛋白及其用途

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002526085A (ja) 1998-09-23 2002-08-20 オーストリアン・ノルディック・バイオセラピューティクス・アーゲー 補体を介した破壊から保護されたレトロウイルス粒子
US6896881B1 (en) * 1999-09-24 2005-05-24 Mayo Foundation For Medical Education And Research Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family
AU2001251138A1 (en) 2000-03-31 2001-10-15 Mayo Foundation For Medical Education And Research Compositions and methods for tissue specific gene regulation therapy
CA2464887A1 (en) 2001-10-30 2003-05-08 Biogen, Inc. Methods and compositions for treating parkinson's disease
EP2339010B1 (en) 2002-05-01 2017-04-12 Miltenyi Biotec Technology, Inc. Lentiviral vector particles resistant to complement inactivation
US20060045910A1 (en) 2004-09-02 2006-03-02 Ehringer William D Preserved fusogenic vesicles
GB0426641D0 (en) 2004-12-03 2005-01-05 Bioactive Protein Delivery The Protein delivery system
EP1838856A4 (en) 2005-01-20 2010-07-14 Agency Science Tech & Res PROCESS FOR DELIVERING NUCLEIC ACIDS TO PERIPHERAL NEURONS
CN101208104B (zh) 2005-04-25 2012-10-31 梅瑞尔有限公司 Nipah病毒疫苗
WO2007005244A1 (en) 2005-07-05 2007-01-11 The Regents Of The University Of California Henipavirus receptor and uses thereof
US20120121650A1 (en) 2006-08-18 2012-05-17 Johnston Robert E Chimeric Virus Vaccines
EP1975239A1 (en) * 2006-09-27 2008-10-01 Bundesrepublik Deutschland, letztvertreten durch den Präsidenten des Paul-Ehrlich-Instituts Prof. Dr. Johannes Löwer Pseudotyping of retroviral vectors, methods for production and use thereof for targeted gene transfer and high-throughput screening
WO2008071959A1 (en) 2006-12-12 2008-06-19 Oxford Biomedica (Uk) Limited Lentiviral vectors comprising micrornas
CA2722238C (en) 2008-04-22 2017-11-28 Life Sciences Research Partners Vzw Liver-specific nucleic acid regulatory elements and methods and use thereof
BRPI0823234A2 (pt) 2008-11-07 2019-09-24 Childrens Hospital Med Ct nanovesícula para liberação de um agente para uma membrana biológica e processo para direcionar um agente para uma membrana de uma célula ou um tecido.
DK2770061T3 (en) 2009-07-24 2019-01-07 Immune Design Corp NON-INTEGRATING LENTIVIRUS VECTORS
WO2011058052A1 (en) 2009-11-13 2011-05-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Direct protein delivery with engineered microvesicles
EP2476754A1 (en) 2011-01-14 2012-07-18 Bundesrepublik Deutschland, Letztvertreten Durch Den Präsidenten Des Paul-Ehrlich-Instituts Methods for the identification and repair of amino acid residues destabilizing single-chain variable fragments (scFv)
AU2012249474A1 (en) 2011-04-28 2013-11-07 Stc.Unm Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same
BR112014008932A2 (pt) * 2011-10-14 2019-09-24 Sandia Corp bicamadas lipídicas suportadas em nanopartículas porosas (protocélulas) para administração direcionada, incluindo a administração transdérmica de uma carga e métodos associados
GB201121070D0 (en) 2011-12-07 2012-01-18 Isis Innovation composition for delivery of biotherapeutics
EP2615176A1 (en) * 2012-01-11 2013-07-17 Paul-Ehrlich-Institut Bundesamt für Sera und Impfstoffe Novel pseudotyped lentiviral particles and their use in the in vitro targeted transduction of undifferentiated pluripotent human embryonic stem cells and induced pluripotent stem cells
EP2844746A4 (en) 2012-03-26 2016-07-20 Univ California PSEUDOTYPIZED LENTIVIRES WITH NIPAH VIRUS COVERS AND METHOD OF USE THEREOF
JP6391582B2 (ja) 2012-11-13 2018-09-19 コディアック バイオサイエンシズ インコーポレイテッド 治療剤の送達方法
US10414820B2 (en) 2013-03-13 2019-09-17 Imaginab, Inc. Antigen binding constructs to CD8
GB201313249D0 (en) 2013-07-25 2013-09-11 Isis Innovation Method
EP3791863A1 (en) 2014-01-21 2021-03-17 Anjarium Biosciences AG Process for the production of hybridosomes
GB201412494D0 (en) 2014-07-14 2014-08-27 Ospedale San Raffaele And Fond Telethon Vector production
US10421979B2 (en) * 2015-02-11 2019-09-24 Alma Mater Studiorum Universita' Di Bologna Retargeted herpesvirus with a glycoprotein H fusion
US10501733B2 (en) 2015-02-27 2019-12-10 University Of Washington Polypeptide assemblies and methods for the production thereof
US20180135012A1 (en) 2015-05-13 2018-05-17 Rubius Therapeutics, Inc. Membrane-receiver complex therapeutics
US10729789B2 (en) 2016-03-01 2020-08-04 University Of Virginia Patent Foundation Compositions and methods for adeno-associated virus mediated gene expression in myofibroblast-like cells
EP3430136A2 (en) * 2016-03-19 2019-01-23 F1 Oncology, Inc. Methods and compositions for transducing lymphocytes and regulated expansion thereof
US11458097B2 (en) 2016-03-30 2022-10-04 The University Of North Carolina At Chapel Hill Biological agent-exosome compositions and uses thereof
EP3235908A1 (en) 2016-04-21 2017-10-25 Ecole Normale Superieure De Lyon Methods for selectively modulating the activity of distinct subtypes of cells
US20190300862A1 (en) 2016-06-09 2019-10-03 Alma Mater Studiorum Universita Di Bologna Herpesvirus with Modified Glycoprotein H for Propagation in a Cell
CA3030003A1 (en) 2016-07-08 2018-01-11 F1 Oncology, Inc. Methods and compositions for transducing lymphocytes and regulating the activity thereof
KR20190053180A (ko) 2016-07-26 2019-05-17 센티 바이오사이언시스, 인코포레이티드 시공간적 조절자들
EP3565607A4 (en) 2017-01-09 2020-11-18 Oisin Biotechnologies FUSOGENOUS LIPID NANOPARTICLES AND METHODS OF MANUFACTURE AND USE FOR THE PRODUCTION OF THERAPEUTIC PROTEIN AND FOR TREATMENT PURPOSES
CN110869507A (zh) 2017-05-08 2020-03-06 旗舰先锋创新V股份有限公司 促进膜融合的组合物和其用途
WO2019113512A1 (en) 2017-12-07 2019-06-13 Flagship Pioneering Innovations V, Inc. Cytobiologics and therapeutic uses thereof
MX2020008152A (es) 2018-02-01 2020-11-24 Bioverativ Therapeutics Inc Uso de vectores lentivirales que expresan el factor viii.
EP3752623A1 (en) 2018-02-17 2020-12-23 Flagship Pioneering Innovations V, Inc. Compositions and methods for membrane protein delivery
WO2019222403A2 (en) 2018-05-15 2019-11-21 Flagship Pioneering Innovations V, Inc. Fusosome compositions and uses thereof
US20210198698A1 (en) 2018-07-09 2021-07-01 Flagship Pioneering Innovations V, Inc. Fusosome compositions and uses thereof
MX2021000308A (es) 2018-07-09 2021-06-08 Flagship Pioneering Innovations V Inc Composiciones de fusosoma y usos de estas.
SG11202105079QA (en) 2018-11-14 2021-06-29 Flagship Pioneering Innovations V Inc Fusosome compositions for cns delivery
EP3880180A2 (en) 2018-11-14 2021-09-22 Flagship Pioneering Innovations V, Inc. Fusosome compositions for t cell delivery
EP3880831A1 (en) 2018-11-14 2021-09-22 Flagship Pioneering Innovations V, Inc. Compositions and methods for compartment-specific cargo delivery
US20230048166A1 (en) 2018-11-14 2023-02-16 Flagship Pioneering Innovations V, Inc. Fusosome compositions for hematopoietic stem cell delivery

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