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EA199901012A1 - Фармацевтические композиции на основе тизоксанида и нитазоксанида - Google Patents

Фармацевтические композиции на основе тизоксанида и нитазоксанида

Info

Publication number
EA199901012A1
EA199901012A1 EA199901012A EA199901012A EA199901012A1 EA 199901012 A1 EA199901012 A1 EA 199901012A1 EA 199901012 A EA199901012 A EA 199901012A EA 199901012 A EA199901012 A EA 199901012A EA 199901012 A1 EA199901012 A1 EA 199901012A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
tizoxanide
nitazoxanide
compositions based
formula
Prior art date
Application number
EA199901012A
Other languages
English (en)
Other versions
EA002908B1 (ru
Inventor
Жан-Франсуа Россиньоль
Original Assignee
Ромарк Лабораториз Л.С.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27420362&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199901012(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/852,447 external-priority patent/US5968961A/en
Priority claimed from US08/887,810 external-priority patent/US5856348A/en
Priority claimed from US08/887,809 external-priority patent/US5965590A/en
Application filed by Ромарк Лабораториз Л.С. filed Critical Ромарк Лабораториз Л.С.
Publication of EA199901012A1 publication Critical patent/EA199901012A1/ru
Publication of EA002908B1 publication Critical patent/EA002908B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Фармацевтическая композиция, содержащая в качестве активного агента, по крайней мере, одно соединение, выбранное из группы, состоящей из соединений формулы (I)и формулы (II)Предпочтительней, активный агент находится в форме частиц размером менее 200 мкм, причем средний размер частиц более 10 мкм. Фармацевтические композиции стабилизированы, по крайней мере, одной фармацевтически приемлемой кислотой. Эти фармацевтические композиции особенно полезны для лечения условно-патогенных инфекций у больных с нарушенной или подавленной иммунной системой и для лечения трематодных инфекций.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199901012A 1997-05-07 1998-05-06 Фармацевтические композиции на основе тизоксанида и нитазоксанида EA002908B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/852,447 US5968961A (en) 1997-05-07 1997-05-07 Pharmaceutical compositions of tizoxanide and nitazoxanide
US08/887,810 US5856348A (en) 1994-09-08 1997-07-03 Method for treatment of trematodes with pharmaceutical compositions of tizoxanide and nitazoxanide
US08/887,809 US5965590A (en) 1994-09-08 1997-07-03 Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
PCT/US1998/009229 WO1998050035A1 (en) 1997-05-07 1998-05-06 Pharmaceutical compositions of tizoxanide and nitazoxanide

Publications (2)

Publication Number Publication Date
EA199901012A1 true EA199901012A1 (ru) 2000-08-28
EA002908B1 EA002908B1 (ru) 2002-10-31

Family

ID=27420362

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200100956A EA002920B1 (ru) 1997-05-07 1998-05-06 Фармацевтические композиции на основе тизоксанида и нитазоксанида
EA199901012A EA002908B1 (ru) 1997-05-07 1998-05-06 Фармацевтические композиции на основе тизоксанида и нитазоксанида

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200100956A EA002920B1 (ru) 1997-05-07 1998-05-06 Фармацевтические композиции на основе тизоксанида и нитазоксанида

Country Status (35)

Country Link
EP (2) EP1005342B1 (ru)
JP (1) JP3739802B2 (ru)
KR (2) KR100576646B1 (ru)
CN (2) CN100515420C (ru)
AP (1) AP1103A (ru)
AR (1) AR057242A2 (ru)
AT (2) ATE281166T1 (ru)
AU (1) AU740022B2 (ru)
BG (2) BG109365A (ru)
BR (1) BR9808722A (ru)
CA (2) CA2418634C (ru)
CZ (2) CZ298270B6 (ru)
DE (2) DE69827417T2 (ru)
DK (2) DK1222921T3 (ru)
EA (2) EA002920B1 (ru)
EE (1) EE04870B1 (ru)
ES (2) ES2232687T3 (ru)
GE (1) GEP20032970B (ru)
HK (1) HK1025907A1 (ru)
HU (1) HU229641B1 (ru)
IL (2) IL155799A (ru)
IS (1) IS2087B (ru)
LV (1) LV12492B (ru)
ME (1) ME00530B (ru)
NO (2) NO313983B1 (ru)
NZ (2) NZ513881A (ru)
OA (1) OA11169A (ru)
PL (1) PL193275B1 (ru)
PT (2) PT1005342E (ru)
RO (1) RO120605B1 (ru)
SI (1) SI20149B (ru)
SK (2) SK283946B6 (ru)
TR (1) TR199902733T2 (ru)
UA (2) UA57079C2 (ru)
WO (1) WO1998050035A1 (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2467321A1 (en) 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
EA015560B1 (ru) * 2006-01-09 2011-08-30 Ромарк Лэборетериз, Эл.Си. Способ лечения вирусного гепатита
CN107260695A (zh) * 2009-02-13 2017-10-20 罗马克实验室有限公司 硝唑尼特的控制释放药物剂型
US8846727B2 (en) 2009-05-12 2014-09-30 Romark Laboratories, L.C. Haloalkyl heteroaryl benzamide compounds
CN108042535A (zh) 2009-06-26 2018-05-18 罗马克实验室有限公司 用于治疗流感的化合物和方法
WO2013110975A1 (es) 2012-01-27 2013-08-01 Siegfried Rhein S.A. De C.V. Composición de nitazoxanida mejorada y proceso para prepararla
KR20170081228A (ko) * 2014-11-11 2017-07-11 로마크 레버러토리즈, 엘.씨. 티족사나이드, 그의 유사체 또는 염의 전구 약물을 이용한 치료 조성물 및 방법
KR20200121816A (ko) 2018-02-02 2020-10-26 리플 테라퓨틱스 코포레이션 스테로이드 이량체를 포함하는 유리 제제 및 이의 용도
WO2021220061A2 (en) 2020-05-01 2021-11-04 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders
WO2022130406A1 (en) * 2020-12-15 2022-06-23 Cipla Limited Inhalation composition of nitazoxanide or its derivatives for use in coronavirus disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1437800A (en) * 1973-08-08 1976-06-03 Phavic Sprl Derivatives of 2-benzamido-5-nitro-thiazoles
US4315018A (en) * 1978-12-07 1982-02-09 Rossignol Jean F Specific parasiticidal use of 2-benzamido-5-nitro-thiazole derivatives
US5387598A (en) * 1994-04-13 1995-02-07 Rossignol; Jean-Francois Composition and galenic formulation suitable for combatting affections of the lower abdomen
US5578621A (en) * 1994-09-08 1996-11-26 Romark Lab Lc Benzamide derivatives

Also Published As

Publication number Publication date
SI20149A (sl) 2000-08-31
ES2150404T1 (es) 2000-12-01
EA002908B1 (ru) 2002-10-31
NO20021832D0 (no) 2002-04-18
EP1005342A4 (en) 2001-02-07
CA2418634A1 (en) 1998-11-12
EE9900578A (et) 2000-08-15
AP9901675A0 (en) 1999-12-31
CA2418634C (en) 2004-10-26
DE69809928T2 (de) 2003-04-24
UA57079C2 (ru) 2003-06-16
KR100576646B1 (ko) 2006-05-08
LV12492A (en) 2000-06-20
BR9808722A (pt) 2000-07-11
BG103958A (en) 2000-07-31
HUP0003330A3 (en) 2002-10-28
IS5223A (is) 1999-10-19
CN1158074C (zh) 2004-07-21
IL132516A0 (en) 2001-03-19
HK1025907A1 (en) 2000-12-01
UA74388C2 (ru) 2005-12-15
NO995406L (no) 2000-01-04
NZ513881A (en) 2002-10-25
GEP20032970B (en) 2003-05-27
NO995406D0 (no) 1999-11-04
CZ391199A3 (cs) 2000-07-12
NO335781B1 (no) 2015-02-16
TR199902733T2 (xx) 2000-03-21
DK1005342T3 (da) 2003-03-24
ATE281166T1 (de) 2004-11-15
ME00530B (me) 2011-10-10
IL155799A (en) 2004-08-31
CA2288003A1 (en) 1998-11-12
EP1222921B1 (en) 2004-11-03
BG64973B1 (bg) 2006-11-30
SK283947B6 (sk) 2004-05-04
EP1222921A1 (en) 2002-07-17
AP1103A (en) 2002-09-04
CZ298269B6 (cs) 2007-08-08
KR20010020322A (ko) 2001-03-15
ES2150404T3 (es) 2003-07-01
EE04870B1 (et) 2007-08-15
EA002920B1 (ru) 2002-10-31
IS2087B (is) 2006-03-15
IL132516A (en) 2003-12-10
EA200100956A1 (ru) 2002-02-28
JP2001503067A (ja) 2001-03-06
PT1005342E (pt) 2003-02-28
ES2232687T3 (es) 2005-06-01
LV12492B (en) 2001-01-20
SI20149B (en) 2001-08-31
KR100426657B1 (ko) 2004-04-13
CN1255060A (zh) 2000-05-31
WO1998050035A1 (en) 1998-11-12
NO20021832L (no) 2000-01-04
CN100515420C (zh) 2009-07-22
OA11169A (en) 2003-04-25
SK283946B6 (sk) 2004-05-04
NO313983B1 (no) 2003-01-13
PT1222921E (pt) 2005-02-28
JP3739802B2 (ja) 2006-01-25
IL155799A0 (en) 2003-12-23
AU7289598A (en) 1998-11-27
ATE228839T1 (de) 2002-12-15
BG109365A (en) 2006-08-31
HUP0003330A2 (hu) 2001-05-28
CN1552322A (zh) 2004-12-08
DE69827417D1 (de) 2004-12-09
EP1005342B1 (en) 2002-12-04
PL336805A1 (en) 2000-07-17
CA2288003C (en) 2003-10-21
SK151199A3 (en) 2000-07-11
HU229641B1 (en) 2014-03-28
AR057242A2 (es) 2007-11-21
NZ500149A (en) 2001-11-30
KR20040004544A (ko) 2004-01-13
DK1222921T3 (da) 2005-03-07
EP1005342A1 (en) 2000-06-07
DE69809928D1 (de) 2003-01-16
PL193275B1 (pl) 2007-01-31
CZ298270B6 (cs) 2007-08-08
DE69827417T2 (de) 2005-10-27
RO120605B1 (ro) 2006-05-30
AU740022B2 (en) 2001-10-25

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU