CN105746898A - Chinese herbal medicine feed additive with Folium Callicarpae Nudiflorae and preparation method and application thereof - Google Patents
Chinese herbal medicine feed additive with Folium Callicarpae Nudiflorae and preparation method and application thereof Download PDFInfo
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- CN105746898A CN105746898A CN201610133748.8A CN201610133748A CN105746898A CN 105746898 A CN105746898 A CN 105746898A CN 201610133748 A CN201610133748 A CN 201610133748A CN 105746898 A CN105746898 A CN 105746898A
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- feed additive
- callicarpa nudiflora
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- 239000011781 sodium selenite Substances 0.000 description 1
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- 239000005720 sucrose Substances 0.000 description 1
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- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
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Classifications
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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Abstract
The invention provides a Chinese herbal medicine feed additive with Folium Callicarpae Nudiflorae and a preparation method and application thereof.The feed additive is made from the following materials according to parts by weight: 60-100 parts of Folium Callicarpae Nudiflorae, 30-60 parts of Radix Astragali, 15-45 parts of Radix Codonopsitis Pilosulae, 30-60 parts of Poria, 15-45 parts of Rhizoma Atractylodis Macrocephalae, 6-20 parts of Radix Glycyrrhizae, 15-40 parts of Fructus Crataegi, 10-30 parts of Fructus Forsythiae, 10-30 parts of Radix Scutellariae, 30-90 parts of Radix Puerariae, 10-45 parts of Radix Isatidis, 20-45 parts of bone fat, 15-30 parts of Semen Myristicae, 10-15 parts of Fructus Schisandrae, 15-30 parts of Fructus Evodiae, and 30-60 parts of Ramulus Taxilli.The feed additive is safe and free of toxic and side effect, is safe and reliable owing to the absence of medicine residue, can improve immunity of piglets, has the effects such as antibiosis and anti-inflammation, hemostasis by astringing, helping digest and harmonizing stomach, clearing heat and stopping diarrhea, tonifying qi and strengthening spleen and promoting healthy growth of animals, and is effective in controlling diarrhea in piglets.
Description
Technical field
The present invention relates to superfine powder Chinese herbal feed additive of a kind of improved pigling immunity containing Callicarpa nudiflora and preventing and treating piglet diarrhea and its preparation method and application, belong to feed additive field.
Background technology
Callicarpa nudiflora is the dry aerial parts of Verenaceae Callicarpa plant Callicarpa nudiflora.Main product, in China Hainan, Guangdong, Guangxi, Jiangxi and other places, is Hainan large property authentic medicinal herbs, belongs to the medical material that Nationality in Hainan Province is conventional.Callicarpa nudiflora, bitter in the mouth, micro-pungent, flat；Return spleen, stomach, Liver Channel；There is eliminating inflammation and expelling toxin, anastaltic effect, be mainly used in suppurative inflammation, acute infectious hepatitis, burn or scald, the treatment of traumatic hemorrhage.Hainan black powder " in " Hainan black powder " refer to is exactly Callicarpa nudiflora.Current Callicarpa nudiflora is widely used in people's prescription face, but yet there are no the report using it for additive for feed for piglets.Callicarpa nudiflora has high using and is worth, and has the advantages such as nonhazardous, noresidue, safe ready, diverse biological activities as feed additive, can promote animal growth to some extent, and disease preventing and treating has broad based growth prospect.
Piglet diarrhea is a kind of typical multi-factor disease.Its cause of disease is of a great variety, and speed of mutation is fast, causes that the M & M of piglet diarrhoea in recent years remains high, causes huge economic loss to aquaculture.Piglet diarrhea is divided into the piglet red dysentery etc. that yellow and white dysentery of piglet that bacterial diarrhea such as escherichia coli etc. cause, clostridieum welchii cause；Viral diarrhea is transmissible gastroenteritis, epidemic diarrhea, rotavirus illness etc. such as；Parasitic diarrhea such as coccidiosis, ascariasis and avirulence diarrhoea as stress, temperature, nutritional imbalance etc..Piglet diarrhea can cause piglet constitution to die down, poor growth, piglet survival ratio decline, efficiency of feed utilization reduces, and serious meeting causes the mortality of piglet, therefore, how to prevent and treat piglet diarrhea and is still the focus that cultivation industry is paid close attention to now.
The general therapeutic cure of piglet diarrhea is to use antibiotic therapy, but is as antibiotic and applies on a large scale in breeding production, and drug residue and Resistant strain also occur therewith, and human health causes very big harm.At present, the attention of the livestock worker that antibiotic abuse problem has caused, general office of the Ministry of Agriculture is about the letter consulted on about forbidding using the announcement of the bulletin of the various salt of 4 kinds of crude drug, fat and the various preparations thereof such as lomefloxacin, pefloxacin, ofloxacin, norfloxacin in food animal, and antibiotic use will progressively be restricted.Chinese herbal medicine is the product of the distinctive Chinese medical theory of China and practice, China's Chinese herbal medicine resource enriches, wide variety, with a long history, Chinese herbal medicine has the dual function of nutrition and medicine concurrently, have natural, have no side effect, remain without chemicals, be not likely to produce the feature such as drug resistance, complete function, be used for preventing and treating piglet diarrhea, cause the very big concern of livestock worker.Therefore, the development of Chinese herbal feed additive, for development unpolluted animal husbandry, ensure that the health of the mankind has important effect.Chinese herbal feed additive refers to theoretical (the healthy energy internal memory of Chinese veterinarian that application China is traditional, heresy can not be done) and the physical property (yin, yang, cold, cool, warm, hot) of Chinese herbal medicine, thing taste (sour, peppery, bitter, sweet, salty) and thing between relation, feedstuff adds some there is the strengthening vital QI to eliminate pathogenic factors such as replenishing QI to invigorate the spleen, digesting and appetizing, benefiting qi and nourishing blood, Yin-nourishing and body fluid promoting, tranquillizing and allaying excitement and regulate the Chinese herbal medicine of equilibrium between yin and yang, be aided with and raise and the subjects theory technology such as feed industry and the pure natural fodder additive made.Its most prominent advantage is to improve animal productiong and efficiency of feed utilization for target, and to guarantee the pure natural fodder additive with Chinese characteristics that health is final purpose.
Callicarpa nudiflora, antiinflammatory, removing toxic substances, convergence, hemostasis.The inflammation caused, acute infectious hepatitis, respiratory tract and digestive tract hemorrhage is infected for antibacterial.Pharmacologically there is bacteriostasis widely, as to staphylococcus aureus, Staphylococcus albus extreme sensitivity, to pseudomonas aeruginosa, Bacillus typhi, meningococcus, dysentery bacterium, addicted to oxygen bacterium, escherichia coli medium sensitivity, to streptococcus, Bacillus proteus slight sensitive；The fungistatic effect of staphylococcus aureus is similar to streptomycin, gentamycin and tetracycline, but not as good as erythromycin；The fungistatic effect of chlorine pus bacillus is similar to neomycin, but not as good as gentamycin；Colibacillary fungistatic effect is similar to penicillin, oxytetracycline, polymyxin.Gastral anastalsis is caused mechanical pressure and vasoconstriction to work mainly by the contraction affecting smooth muscle by it.
The Radix Astragali, sweet in flavor and warm in property, return lung, spleen channel, there is the effects such as invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation, inducing diuresis to remove edema.The Radix Astragali containing various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper, have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and wide antibacterial action.Radix Codonopsis, property is flat, sweet in the mouth, enters spleen, lung meridian, and energy invigorating the spleen and replenishing QI, stomach function regulating nourish blood.There is enhancing immunologic function, resisting pathogenic microbes effect, improve organism adaptation, Gastrointestinal motility adjustment, antiulcer, antibacterial, anticancer, antiinflammatory, antioxidation, defying age, analgesia and stress ability, improve blood function etc..The Rhizoma Atractylodis Macrocephalae, warm in nature, bitter in the mouth, sweet, enter spleen, stomach warp.Air making-up and spleen enlivening, dampness diuretic, strengthening superficial resistance to stop perspiration.Cure mainly the cards such as the unable anorexia and loose stool of deficiency of spleen-QI and stomach-QI, transporting, distension and fullness in the abdomen, the soft Mental fatigue of limb.Pharmacologically have strong, Gastrointestinal motility adjustment, diuresis, blood sugar lowering, protect the liver, anticoagulant, the effect such as suppression antibacterial and fungus, Rhizoma Atractylodis polysaccharide can strengthen immunologic function.Radix Glycyrrhizae, invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency is detoxified, and is in harmonious proportion hundred medicines.The Radix Astragali and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae are share and can strengthen strengthening QI of middle-JIAO, improve the effect of immunity of organisms.
Radix Scutellariae, all has inhibitory action to multiple malignant bacterias such as dysentery bacterium, Bacillus typhi, tubercule bacillus, staphylococcus aureus, Hemolytic streptococcuss, it is possible to heat clearing away, dampness, pathogenic fire purging, removing toxic substances.Radix Puerariae, sweet in the mouth, pungent, property is put down, and returns spleen, stomach, lung, bladder warp.Expelling pathogenic factors from muscles for reducing heat, delivers and examines, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.Can induce sweat and bring down a fever, the gas and antidiarrheal of sending out taste sun clearly can be risen again.Radix Puerariae and Radix Scutellariae share, and play in outer dredging clear, the effect for the treatment of both the exterior and interior at the same time.
In Callicarpa nudiflora, flavones ingredient has antiinflammatory, anastalsis, it can substantially shorten clotting time of mice and docking bleeding time, and there is certain anti-inflammation activity, and flavone compound such as luteolin has the effects such as antioxidation, antitumor, antiinflammatory, immunomodulating.The multiple pharmacological effect such as Radix Astragali flavone constituents has adjustment immunity, resists myocardial ischemia, protects the liver, antiinflammatory, mutation, scavenging free radicals.And flavones ingredient is the basis that Radix Scutellariae plays pharmacologically active in Radix Scutellariae; in Radix Scutellariae extract, flavones ingredient has stronger anti-inflammatory activity; flavone compound has strong antioxidant activity, has the liver protecting and the effect such as cardiovascular, defying age and antiinflammatory and resistance state.Meanwhile, also having certain antibacterial activity, external all have inhibitory action in various degree to staphylococcus aureus, Hemolytic streptococcus, meningococcus, escherichia coli, bacillus pyocyaneus, diphtheria corynebacterium etc..
Poria, sweet in the mouth, light, property is put down, GUIXIN, lung, spleen, kidney channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Pharmacologically there are calmness, antiulcer, prevent hepatic necrosis, protect the liver, increase cardiac muscular tissue K+Content, antineoplastic action.Fructus Crataegi, has promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, taenifugal effect.Poria, the Rhizoma Atractylodis Macrocephalae share the merit strengthening invigorating the spleen to clear away damp pathogen, help the effect strengthening digesting and appetizing with Fructus Crataegi.
Fructus Forsythiae, the Chinese medicine of heat-clearing and toxic substances removing, cure mainly calentura from the beginning of, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, acute nephritis etc..
Radix Isatidis, it is cold in nature, and taste is first micro-sweet rear pained, has effect of heat-clearing and toxic substances removing, preventing cold, sore-throat relieving.Fructus Forsythiae, Radix Isatidis, Radix Scutellariae three medicine share enhancing heat-clearing and toxic substances removing, the effect of anti-inflammation.
Fructus Psoraleae, warm in nature, acrid in the mouth is bitter, returns kidney, spleen channel, has reinforcing the kidney and supporting YANG, the merit of warm spleen antidiarrheal, attacks and arrogates to oneself supplementing the fire of vital gate to invigo rate YANG, have the property of astringent therapy concurrently, for controlling the key medicine of deficiency of spleen-YANG and kidneyYANG, instability of kidney-QI.Pharmacologically there is enhancing immunity, promote the effects such as bone marrow hematogenesis, leukocyte increasing, defying age, antitumor, antibacterial, promotion growth.
Herba Taxilli, property is put down, and bitter in the mouth is done, and returns liver, kidney channel, have nourish blood, liver and kidney tonifying, bone and muscle strengthening effect, pharmacologically can calm diuresis, enterovirus is had obvious inhibitory action, it is also possible to improve microcirculation, strengthens immunologic function, promote growth etc..Join Fructus Psoraleae and have the effect of obvious the kidney invigorating, bone and muscle strengthening.
Semen Myristicae, acrid in the mouth, warm in nature, its gas is fragrant, for the key medicine that appetizing of being amusing, the dyspepsia that disappears, stopping leak rush down.Pharmacologically can dispelling-wind invigorating stomach, increase gastric secretion, stimulating gastrointestinal wriggle, facilitating digestion.
Fructus Schisandrae Chinensis, the five tastes are had, sweet based on acid, though warm in nature, but temperature and not dry, GUIXIN, kidney, lung meridian, have and restrain astringent or styptic treatment for spontaneous sweating effect widely, on can restrain lung qi and cough-relieving, lower nourishing kidney-yin and arresting seminal emission, external enwergy convergence hidroschesis, interior can relieving diarrhea with astringents, QI invigorating and promote the production of body fluid.And can the benefit motive, the moon that nourishes heart, tranquilizing mind.Pharmacologically there is calmness, the effect of antiviral.
Fructus Evodiae, energy dispersing cold for relieving pain, supporing yang antidiarrheal, compatibility Fructus Psoraleae, Semen Myristicae, Fructus Schisandrae Chinensis can strengthen the effect of warming and recuperating the spleen and kidney, relieving diarrhea with astringents.
The application for a patent for invention of application number 201410257975.2 discloses a kind of bird feed containing Callicarpa nudiflora and preparation method thereof, and the described bird feed containing Callicarpa nudiflora is prepared by the component of following weight portion: fish flour 40-60 part, bone meal 10-30 part, sodium chloride 1-5 part, Gypsum Fibrosum 5-10 part, sodium glutamate 1-2 part, Callicarpa nudiflora 10-30 part.The application for a patent for invention of application number 201510163950.0 discloses a kind of containing cassava grain stillage powder beef cattle forage, is made up of the raw material of following weight portion: Testa Tritici 80-90, Semen Maydis 30-40, Rhizoma Dioscoreae 10-13, Oryza sativa L. 4-5, peel of Semen Viciae fabae 14-18, Semen Glycines Germinatus 20-25, sweet soybean paste 5-9, butter 4-6, Nori 8-10, spirulina 7-10, Fructus Crataegi 20-25, dried Fructus Vitis viniferae 5-10, Fructus actinidiae chinensis 15-20, Herba Portulacae 20-25, Flos Hibisci 1-2, Callicarpa nudiflora 2-3, Ailanthus altissima flower 2-3, manioc vinasse slag 20-30, Os Caprae seu Ovis soup 30-40, yeast 2-3, phagostimulant 3-4, water are appropriate.The application for a patent for invention of application number 201410788756.7 discloses a kind of feedstuff alleviating beef cattle heat stress, and it is made up of the raw material of following percentage by weight: Semen Maydis 30～40%；Testa Tritici 30～40%；Bean cake 16%；Callicarpa nudiflora 5%；Semen phaseoli radiati 2～5%；Herba mesonae chinensis 2～4%；Potassium chloride 0.5%；Sal 0.5%；Sodium bicarbonate 1%；Magnesium oxide 0.5%；Sodium ascorbate 1.5%.Prior art not yet has the Chinese herbal feed additive of Callicarpa nudiflora and the improved pigling immunity of multiple Chinese herbal medicine compatibility, preventing and treating piglet diarrhea.
Summary of the invention
It is an object of the present invention to provide the superfine powder Chinese herbal feed additive of a kind of improved pigling immunity containing Callicarpa nudiflora, preventing and treating piglet diarrhea.Described feed additive safe without toxic side effect, drug residue free, safe and reliable, pigling immunity can be improved, also there is anti-inflammation, astringing to arrest bleeding, help digestion stomach function regulating, clearing away heat to stop diarrhea, air making-up and spleen enlivening simultaneously, promote the effects such as animal health growth, can effectively prevent and treat the generation of piglet diarrhea.In the present invention, the major function of Callicarpa nudiflora is eliminating inflammation and expelling toxin, astringing to arrest bleeding, can be used for antibacterial and infects the inflammation caused, and respiratory tract and digestive tract hemorrhage etc., as Chinese herbal feed additive, for being applied in livestock first, its effect is notable.
It is an object of the invention to be achieved through the following technical solutions:
The present invention provides a kind of Chinese herbal feed additive for preventing and treating piglet diarrhea and raising pigling immunity containing Callicarpa nudiflora, the component being prepared by parts by weight prepares: Callicarpa nudiflora 60～100 parts, the Radix Astragali 30～60 parts, Radix Codonopsis 15～45 parts, 30～60 parts of Poria, the Rhizoma Atractylodis Macrocephalae 15～45 parts, 6～20 parts of Radix Glycyrrhizae, Fructus Crataegi 15～40 parts, Fructus Forsythiae 10～30 parts, Radix Scutellariae 10～30 parts, Radix Puerariae 30～90 parts, Radix Isatidis 10～45 parts, bone fat 20～45 parts, Semen Myristicae 15～30 parts, Fructus Schisandrae Chinensis 10～15 parts, Fructus Evodiae 15～30 parts, Herba Taxilli 30～60 parts.
Preferably, described Chinese herbal feed additive is prepared by the component of following parts by weight: Callicarpa nudiflora 60～90 parts, the Radix Astragali 30～45 parts, Radix Codonopsis 15～30 parts, 30～45 parts of Poria, the Rhizoma Atractylodis Macrocephalae 20～30 parts, 10～15 parts of Radix Glycyrrhizae, Fructus Crataegi 20～30 parts, Fructus Forsythiae 10～20 parts, Radix Scutellariae 10～20 parts, Radix Puerariae 40～60 parts, Radix Isatidis 15～30 parts, bone fat 20～35 parts, Semen Myristicae 15～25 parts, Fructus Schisandrae Chinensis 10～15 parts, Fructus Evodiae 15～25 parts, Herba Taxilli 30～45 parts.
The preparation method that the present invention also provides for a kind of said herbal medicine feed additive, it is characterised in that comprise the steps:
(1) by Callicarpa nudiflora remove impurity, chopping, standby；
(2) by the Radix Astragali, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Fructus Crataegi, Fructus Forsythiae, Radix Scutellariae, Radix Puerariae, Radix Isatidis, bone fat, Semen Myristicae, Fructus Schisandrae Chinensis, Fructus Evodiae, Herba Taxilli Chinese crude drug, dry 2h for 80 DEG C, pulverize after mixing, cross 50 mesh sieves and obtain A powder；
(3) take A powder, pulverize after mixing with Callicarpa nudiflora, cross 80 mesh sieves and obtain B powder；
(4) take B powder, micronizing, the material after pulverizing is crossed 200-400 eye mesh screen and obtains C powder；
(5) take C powder, mix 30min and get final product.
The present invention also provides for the application of the above-mentioned feed additive containing Callicarpa nudiflora.The product of the present invention is added in piglet basal diet with the ratio of 5-10kg/ ton, after stirring, gets final product Direct-fed.Feedstuff additive product of the present invention is applied in pig starter feed can improve pigling immunity and preventing and treating piglet diarrhea.
Beneficial effect:
The feed additive of the present invention physiological characteristics according to kind of piglet, rationally selecting Chinese traditional herbs genuine medicinal materials, this prescription has anti-inflammation, astringing to arrest bleeding, help digestion stomach function regulating, clearing away heat to stop diarrhea, air making-up and spleen enlivening, promote the effects such as animal health growth, can effectively prevent and treat the generation of piglet diarrhea.This prescription medical material has wide material sources, diverse in function, noresidue simultaneously, the feature such as have no side effect, the present invention is a kind of raising pigling immunity containing Callicarpa nudiflora, the superfine powder Chinese herbal feed additive of preventing and treating piglet diarrhea, piglet resistance can be improved, anti-inflammation, astringing to arrest bleeding, help digestion stomach function regulating, clearing away heat to stop diarrhea, air making-up and spleen enlivening, promote animal health growth.Wherein Callicarpa nudiflora has eliminating inflammation and expelling toxin, astringing to arrest bleeding effect, for principal agent；Radix Isatidis, Fructus Forsythiae, Radix Scutellariae have effect of heat-clearing and toxic substances removing, anti-inflammation hemostasis, for principal agent；Poria spleen invigorating, dampness, hawthorn digesting stomach function regulating；The Radix Astragali, Radix Puerariae QI invigorating righting, yang invigorating antidiarrheal, for accessory drugs.Thus Chinese herbal feed additive of the present invention, there is anti-inflammation, astringing to arrest bleeding, enhancing immunity, help digestion stomach function regulating, clearing away heat to stop diarrhea, air making-up and spleen enlivening, it is possible to effectively prevent and treat the generation of piglet diarrhea, improve pigling immunity, promote piglet growth.And, feed additive of the present invention adopts ultrastructurepower technology technique to prepare, this superfine communication technique can make medical material granularity reach cell breakage level, makes between drug cell and in cell, effective ingredient directly discharges, significantly improve dissolution rate and the dissolution rate of effective ingredient in medicine.Compared with conventional powder, the effective ingredient that Chinese herbal medicine ultra-fine powder feed additive discharges in animal gastrointestinal tract dramatically increases, and can greatly reduce medicine addition, reduces cost.
Detailed description of the invention
Below in conjunction with specific embodiment further describe the present invention, advantages of the present invention and feature will be with describe and apparent.But these examples are only exemplary, the scope of the present invention is not constituted any restriction.It will be understood by those skilled in the art that and the details of technical solution of the present invention and form can be modified or replace lower without departing from the spirit and scope of the present invention, but these amendments and replacement each fall within protection scope of the present invention.Method, composition and the consumption related in following embodiment, if no special instructions, conventional method all known to those skilled in the art.
Embodiment 1
A kind of Chinese herbal feed additive containing Callicarpa nudiflora, is prepared by the component of following parts by weight: Callicarpa nudiflora 60 parts, the Radix Astragali 30 parts, Radix Codonopsis 15 parts, 30 parts of Poria, the Rhizoma Atractylodis Macrocephalae 20 parts, 15 parts of Radix Glycyrrhizae, Fructus Crataegi 20 parts, Fructus Forsythiae 15 parts, Radix Scutellariae 15 parts, Radix Puerariae 45 parts, Radix Isatidis 15 parts, bone fat 30 parts, Semen Myristicae 15 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Evodiae 15 parts, Herba Taxilli 30 parts.
The preparation method of above-mentioned feed additive comprises the steps:
(1) by Callicarpa nudiflora remove impurity, chopping, standby；
(2) by the Radix Astragali, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Fructus Crataegi, Fructus Forsythiae, Radix Scutellariae, Radix Puerariae, Radix Isatidis, bone fat, Semen Myristicae, Fructus Schisandrae Chinensis, Fructus Evodiae, Herba Taxilli Chinese crude drug, dry 2h for 80 DEG C, pulverize after mixing, cross 50 mesh sieves and obtain A powder；
(3) take A powder, pulverize after mixing with Callicarpa nudiflora, cross 80 mesh sieves and obtain B powder；
(4) take B powder, micronizing, the material after pulverizing is crossed 200-400 eye mesh screen and obtains C powder；
(5) take C powder, mix 30min and get final product.
Embodiment 2
A kind of Chinese herbal feed additive containing Callicarpa nudiflora, is prepared by the component of following parts by weight: Callicarpa nudiflora 100 parts, the Radix Astragali 60 parts, Radix Codonopsis 30 parts, 60 parts of Poria, the Rhizoma Atractylodis Macrocephalae 15 parts, 6 parts of Radix Glycyrrhizae, Fructus Crataegi 40 parts, Fructus Forsythiae 10 parts, Radix Scutellariae 10 parts, Radix Puerariae 30 parts, Radix Isatidis 10 parts, bone fat 20 parts, Semen Myristicae 20 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Evodiae 20 parts, Herba Taxilli 45 parts.
The preparation method of above-mentioned feed additive comprises the steps:
(1) by Callicarpa nudiflora remove impurity, chopping, standby；
(2) by the Radix Astragali, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Fructus Crataegi, Fructus Forsythiae, Radix Scutellariae, Radix Puerariae, Radix Isatidis, bone fat, Semen Myristicae, Fructus Schisandrae Chinensis, Fructus Evodiae, Herba Taxilli Chinese crude drug, dry 2h for 80 DEG C, pulverize after mixing, cross 50 mesh sieves and obtain A powder；
(3) take A powder, pulverize after mixing with Callicarpa nudiflora, cross 80 mesh sieves and obtain B powder；
(4) take B powder, micronizing, the material after pulverizing is crossed 200-400 eye mesh screen and obtains C powder；
(5) take C powder, mix 30min and get final product.
Embodiment 3
A kind of Chinese herbal feed additive containing Callicarpa nudiflora, is prepared by the component of following parts by weight: Callicarpa nudiflora 90 parts, the Radix Astragali 45 parts, Radix Codonopsis 45 parts, 45 parts of Poria, the Rhizoma Atractylodis Macrocephalae 45 parts, 20 parts of Radix Glycyrrhizae, Fructus Crataegi 25 parts, Fructus Forsythiae 30 parts, Radix Scutellariae 30 parts, Radix Puerariae 90 parts, Radix Isatidis 45 parts, bone fat 45 parts, Semen Myristicae 30 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Evodiae 30 parts, Herba Taxilli 60 parts.
The preparation method of above-mentioned feed additive comprises the steps:
(1) by Callicarpa nudiflora remove impurity, chopping, standby；
(2) by the Radix Astragali, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Fructus Crataegi, Fructus Forsythiae, Radix Scutellariae, Radix Puerariae, Radix Isatidis, bone fat, Semen Myristicae, Fructus Schisandrae Chinensis, Fructus Evodiae, Herba Taxilli Chinese crude drug, dry 2h for 80 DEG C, pulverize after mixing, cross 50 mesh sieves and obtain A powder；
(3) take A powder, pulverize after mixing with Callicarpa nudiflora, cross 80 mesh sieves and obtain B powder；
(4) take B powder, micronizing, the material after pulverizing is crossed 200-400 eye mesh screen and obtains C powder；
(5) take C powder, mix 30min and get final product.
Embodiment 4
A kind of Chinese herbal feed additive containing Callicarpa nudiflora, is prepared by the component of following parts by weight: Callicarpa nudiflora 90 parts, Radix Codonopsis 45 parts, 45 parts of Poria, the Rhizoma Atractylodis Macrocephalae 45 parts, 20 parts of Radix Glycyrrhizae, Fructus Crataegi 25 parts, Fructus Forsythiae 30 parts, Radix Puerariae 90 parts, Radix Isatidis 45 parts, bone fat 45 parts, Semen Myristicae 30 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Evodiae 30 parts, Herba Taxilli 60 parts (without the Radix Astragali and Radix Scutellariae).
The preparation method of above-mentioned feed additive comprises the steps:
(1) by Callicarpa nudiflora remove impurity, chopping, standby；
(2) by Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Fructus Crataegi, Fructus Forsythiae, Radix Puerariae, Radix Isatidis, bone fat, Semen Myristicae, Fructus Schisandrae Chinensis, Fructus Evodiae, Herba Taxilli Chinese crude drug, dry 2h for 80 DEG C, pulverize after mixing, cross 50 mesh sieves and obtain A powder；
(3) take A powder, pulverize after mixing with Callicarpa nudiflora, cross 80 mesh sieves and obtain B powder；
(4) take B powder, micronizing, the material after pulverizing is crossed 200-400 eye mesh screen and obtains C powder；
(5) take C powder, mix 30min and get final product.
Embodiment 5
A kind of Chinese herbal feed additive containing Callicarpa nudiflora, is prepared by the component of following parts by weight: Radix Codonopsis 45 parts, 45 parts of Poria, the Rhizoma Atractylodis Macrocephalae 45 parts, 20 parts of Radix Glycyrrhizae, Fructus Crataegi 25 parts, Fructus Forsythiae 30 parts, Radix Puerariae 90 parts, Radix Isatidis 45 parts, bone fat 45 parts, Semen Myristicae 30 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Evodiae 30 parts, Herba Taxilli 60 parts (without Callicarpa nudiflora).
The preparation method of above-mentioned feed additive comprises the steps:
(1) by Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Fructus Crataegi, Fructus Forsythiae, Radix Puerariae, Radix Isatidis, bone fat, Semen Myristicae, Fructus Schisandrae Chinensis, Fructus Evodiae, Herba Taxilli Chinese crude drug, dry 2h for 80 DEG C, pulverize after mixing, cross 50 mesh sieves and obtain A powder；
(2) take A powder, pulverize, cross 80 mesh sieves and obtain B powder；
(4) take B powder, micronizing, the material after pulverizing is crossed 200-400 eye mesh screen and obtains C powder；
(5) take C powder, mix 30min and get final product.
Embodiment 6
The sodium selenite 300 of average weight (8.5 ± 0.5) kg of test and Selection Guangdong plant, statistical analysis weight differences is not notable, is randomly divided into 6 groups (5 test group and 1 matched group), often group 50, male and female half and half.Without Chinese herbal feed additive of the present invention in matched group daily ration, test group daily ration adds Chinese herbal feed additive 6kg/ ton that embodiment 1～5 prepares respectively, piglet free choice feeding and drinking-water, carry out immunity and anthelmintic routinely, observe and record the diarrhoea situation of piglet in experimental period every day, totally 30 days experimental period.
Experimental result is following table such as:
Conclusion (of pressure testing): by above result of the test it can be seen that the feed additive of the present invention is improving the daily ingestion amount of piglet and daily gain, and the aspect such as diarrhea rate reducing piglet all obtains good effect.The embodiment of the present invention 4 is without the Radix Astragali and Radix Scutellariae, and embodiment 5 is without the feed additive of Callicarpa nudiflora, in average daily gain, feed intake and feed-weight ratio, and effect all formula not as embodiment of the present invention 1-3.Illustrate that the Callicarpa nudiflora added in the present invention and the Radix Astragali, Radix Scutellariae share, the mutual reinforcement between mutual-assistance, it is added and plays a synergism, effect of medicine can be effectively increased.Feed additive of the present invention can effectively facilitate piglet healthy growth, reduces feedstuff-meat ratio, can effectively save feeding cost, has good marketing prospect.
Embodiment 7
Selecting diarrhoea piglet 120, stochastic averagina is divided into 4 groups (3 test group and 1 matched group), 30/group, and wherein test group feeds the feedstuff of the additive 6kg/ ton containing embodiment 1～3 preparation respectively, and matched group adopts conventional western medicine treatment；Test pig free choice feeding and drinking-water, observe and record rehabilitation situation and the mental status of pig every day in experimental period, totally 30 days experimental period.Weigh during off-test, and ramming material；Observe each process group diarrhoea situation, and calculate daily gain, feedstuff-meat ratio (feed intake/weightening finish) and rehabilitation rate.
Experimental result is following table such as:
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Matched group |
| Original body mass (kg) | 14.8 | 15.4 | 15.3 | 15.5 |
| Daily gain (kg) | 352 | 331 | 342 | 320 |
| Feed-weight ratio | 1.69 | 1.71 | 1.78 | 1.89 |
| Rehabilitation rate (%) | 94 | 90 | 88 | 96 |
Result of the test shows that product of the present invention treatment piglet diarrhea effect is suitable with Western medicine, but daily gain is apparently higher than matched group, and feedstuff-meat ratio significantly reduces, and advantageously reduces feeding cost, increases culture benefit.Simultaneously product of the present invention belongs to green product, is absent from residual and causes drug resistance equivalent risk, this be Western medicine the advantage that do not possess completely.
Above-mentioned result of the test shows, the present invention has the effect strengthening pigling immunity and preventing and treating piglet diarrhea preferably.
Claims (8)
1. the Chinese herbal feed additive containing Callicarpa nudiflora, it is characterized in that, described feed additive is prepared by the component of following parts by weight: Callicarpa nudiflora 60～100 parts, the Radix Astragali 30～60 parts, Radix Codonopsis 15～45 parts, 30～60 parts of Poria, the Rhizoma Atractylodis Macrocephalae 15～45 parts, 6～20 parts of Radix Glycyrrhizae, Fructus Crataegi 15～40 parts, Fructus Forsythiae 10～30 parts, Radix Scutellariae 10～30 parts, Radix Puerariae 30～90 parts, Radix Isatidis 10～45 parts, bone fat 20～45 parts, Semen Myristicae 15～30 parts, Fructus Schisandrae Chinensis 10～15 parts, Fructus Evodiae 15～30 parts, Herba Taxilli 30～60 parts.
2. a kind of Chinese herbal feed additive containing Callicarpa nudiflora as claimed in claim 1, it is characterized in that, described feed additive is prepared by the component of following parts by weight: Callicarpa nudiflora 60～90 parts, the Radix Astragali 30～45 parts, Radix Codonopsis 15～30 parts, 30～45 parts of Poria, the Rhizoma Atractylodis Macrocephalae 20～30 parts, 10～15 parts of Radix Glycyrrhizae, Fructus Crataegi 20～30 parts, Fructus Forsythiae 10～20 parts, Radix Scutellariae 10～20 parts, Radix Puerariae 40～60 parts, Radix Isatidis 15～30 parts, bone fat 20～35 parts, Semen Myristicae 15～25 parts, Fructus Schisandrae Chinensis 10～15 parts, Fructus Evodiae 15～25 parts, Herba Taxilli 30～45 parts.
3. a kind of Chinese herbal feed additive containing Callicarpa nudiflora as claimed in claim 1, it is characterized in that, described feed additive is prepared by the component of following parts by weight: Callicarpa nudiflora 60 parts, the Radix Astragali 30 parts, Radix Codonopsis 15 parts, 30 parts of Poria, the Rhizoma Atractylodis Macrocephalae 20 parts, 15 parts of Radix Glycyrrhizae, Fructus Crataegi 20 parts, Fructus Forsythiae 15 parts, Radix Scutellariae 15 parts, Radix Puerariae 45 parts, Radix Isatidis 15 parts, bone fat 30 parts, Semen Myristicae 15 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Evodiae 15 parts, Herba Taxilli 30 parts.
4. a kind of Chinese herbal feed additive containing Callicarpa nudiflora as claimed in claim 1, it is characterized in that, described feed additive is prepared by the component of following parts by weight: Callicarpa nudiflora 100 parts, the Radix Astragali 60 parts, Radix Codonopsis 30 parts, 60 parts of Poria, the Rhizoma Atractylodis Macrocephalae 15 parts, 6 parts of Radix Glycyrrhizae, Fructus Crataegi 40 parts, Fructus Forsythiae 10 parts, Radix Scutellariae 10 parts, Radix Puerariae 30 parts, Radix Isatidis 10 parts, bone fat 20 parts, Semen Myristicae 20 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Evodiae 20 parts, Herba Taxilli 45 parts.
5. a kind of Chinese herbal feed additive containing Callicarpa nudiflora as claimed in claim 1, it is characterized in that, described feed additive is prepared by the component of following parts by weight: Callicarpa nudiflora 90 parts, the Radix Astragali 45 parts, Radix Codonopsis 45 parts, 45 parts of Poria, the Rhizoma Atractylodis Macrocephalae 45 parts, 20 parts of Radix Glycyrrhizae, Fructus Crataegi 25 parts, Fructus Forsythiae 30 parts, Radix Scutellariae 30 parts, Radix Puerariae 90 parts, Radix Isatidis 45 parts, bone fat 45 parts, Semen Myristicae 30 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Evodiae 30 parts, Herba Taxilli 60 parts.
6. the preparation method of the arbitrary described Chinese herbal feed additive containing Callicarpa nudiflora of claim 1-5, comprises the steps:
(1) by Callicarpa nudiflora remove impurity, chopping, standby；
(2) by the Radix Astragali, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Fructus Crataegi, Fructus Forsythiae, Radix Scutellariae, Radix Puerariae, Radix Isatidis, bone fat, Semen Myristicae, Fructus Schisandrae Chinensis, Fructus Evodiae, Herba Taxilli Chinese crude drug, dry 2h for 80 DEG C, pulverize after mixing, cross 50 mesh sieves and obtain A powder；
(3) take A powder, pulverize after mixing with Callicarpa nudiflora, cross 80 mesh sieves and obtain B powder；
(4) take B powder, micronizing, the material after pulverizing is crossed 200-400 eye mesh screen and obtains C powder；
(5) take C powder, mix 30min and get final product.
7. the purposes of the arbitrary described Chinese herbal feed additive containing Callicarpa nudiflora of claim 1-5, it is characterised in that described feed additive adds in piglet diet for improving pigling immunity and preventing and treating piglet diarrhea.
8. the purposes of the Chinese herbal feed additive containing Callicarpa nudiflora as claimed in claim 7, it is characterised in that described feed additive adds in piglet diet with the ratio of 5-10kg/ ton.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0416892B1 (en) * | 1989-09-05 | 1994-11-09 | Ajinomoto Co., Inc. | Agents for the prevention and treatment of diarrhoea |
| CN102805271A (en) * | 2012-08-28 | 2012-12-05 | 安徽农业大学 | Anti-stress anti-diarrhea growth-promotion Chinese herbal medicine feed additive for weaned pig and preparation |
| CN104012801A (en) * | 2014-06-11 | 2014-09-03 | 湖南中医药大学 | Poultry feed containing callicarpa nudiflora and preparing method of poultry feed |
-
2016
- 2016-03-09 CN CN201610133748.8A patent/CN105746898A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0416892B1 (en) * | 1989-09-05 | 1994-11-09 | Ajinomoto Co., Inc. | Agents for the prevention and treatment of diarrhoea |
| CN102805271A (en) * | 2012-08-28 | 2012-12-05 | 安徽农业大学 | Anti-stress anti-diarrhea growth-promotion Chinese herbal medicine feed additive for weaned pig and preparation |
| CN104012801A (en) * | 2014-06-11 | 2014-09-03 | 湖南中医药大学 | Poultry feed containing callicarpa nudiflora and preparing method of poultry feed |
Non-Patent Citations (2)
| Title |
|---|
| 吴树兰等: "《养猪用药指南》", 30 April 2002, 中国农业出版社 * |
| 张泉鑫等: "《猪病》", 30 June 2007, 中国农业出版社 * |
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