CN102805271A - Anti-stress anti-diarrhea growth-promotion Chinese herbal medicine feed additive for weaned pig and preparation - Google Patents
Anti-stress anti-diarrhea growth-promotion Chinese herbal medicine feed additive for weaned pig and preparation Download PDFInfo
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Abstract
The invention discloses an anti-stress anti-diarrhea growth-promotion Chinese herbal medicine feed additive for a weaned pig, which is obtained by carrying out the superfine grinding and mixing on the following components at the mass ratio: 1-5 parts of Astragalus mongholicus, 1 part of Scutellaria baicalensis, 1 part of malt, 1 part of liquorice, 1-5 parts of dangshen, 1-5 parts of poria cocos and 1-5 parts of largehead atractylodes rhizome. According to the Chinese herbal medicine feed additive disclosed by the invention, the weaned pig growth performance can be improved, and the Chinese herbal medicine feed additive has the anti-diarrhea effect; the gastrointestinal tract development of the weaned pig can be promoted; the activity of the digestive enzyme of the gastrointestinal digestive tract of the wigged pig can be improved to promote the development of the pig digestive enzyme system; the micro-ecological environment of the digestive tract of the pig can be regulated and stabilized to accelerate the pig to grow; the antioxidation function of the wigged pig organism can be improved so as to improve the compensatory capability of the wigged pig organism on external irradiation; the intestinal mucosa form of the wigged pig can be improved so as to alleviate the intestinal villus withering of the wigged pig and promote the tract of the wigged pig to restore; and the immunologic function of the intestinal mucosa of the wigged pig can be regulated.
Description
Technical field
The present invention relates to the raising of weanling pig in the animal husbandry Swine Production, being specifically related to that weanling pig is anti-stress anti diar rhea growth promotion Chinese herbal feed additive.
Background technology
In animal husbandry; Early weaning piglet is the important means that improves Swine Production efficient, and this is because early weaning can improve productivity and the hurdle house utilization rate of sow, increases the annual output nest number and a year litter size of sow; Can reduce the chance of piglet pathogenic infection, improve its health degree.
Bring active influence can for the economic benefit of plant although take the early weaning measure; But because the digestive physiological characteristics of early-weaned piglets and each side that wean caused stress; Can make piglet produce malnutritive, the speed of growth slowly and ablactation stress syndromes such as diarrhea rate and death rate rising, offset the positive role that it brought to a certain extent, wherein common with diarrhoeal diseases; In the Swine Production process; The early-weaned piglets diarrhea disease percentage is up to 40%-50%, and case fatality rate reaches 30%-40%, is perplexing the development of current pig industry always.
The reason that causes diarrhea of weaned piglets is very complicated, and what the growth of digestive ferment system was unsound and feeding feed is caused stress be primary cause; The weaned piglet rear intestinal is impaired reduce with digestive enzyme activity due to egg digest and assimilate badly, corrupt at large intestine then from nutritional labelings such as matter, produce ammonia and amine substance and can increase the weight of the diarrhoea degree again; Add environmental stress and microbiological contamination is serious, factors such as abuse of antibiotics generation superinfection constitute the complicated cause of disease of early-weaned piglets diarrhoea.If diarrhoea is dealt with improperly by piglet; Add the existence of other pathogenic microorganism; Be easy to cause multisystemic wasting syndrome behind the weaned piglet; Be embodied in that premunition is poor, indigestion, fur are coarse, poor growth etc., even degradation problem under depauperation, the body weight gains also can appear in the piglet of anti-mistake.Production practices show, can 1 month the speed of growth can obviously influence the fattening later stage and obtain good production performance and carcase quality behind the weaned piglet.
Therefore, in recent years, people pay special attention to the feeding and management of weanling pig.At present; The prevention of ablactation grice diarrhoea mainly leaned in reinforcement feeding and management, the feed add enzyme, organic acid and probiotics, vaccinate waits and realizes; Then main the leaning on of treatment adopted all kinds of antibiotic formulations (as: gentamicin, Ciprofloxacin, Florfenicol, sulfanilamide (SN) etc.), and medicated feed additive such as interpolation terramycin is prevented and treated in feed.Antibiotic has the effect that promotes piglet growth and disease preventing and treating, to improving culture benefit, promotes the development of poultry industry to play bigger effect; Yet use antibiotic not only can destroy microbiota original in the animal alimentary canal for a long time; Influence the normal development of animal, also be prone to cause problems such as medicament residue, drug resistance, drug contamination, influence human beings'health through food chain; Human survival is threatened, received common people's concern.
Chinese herbal medicine is traditional rarity of China; Aboundresources not only, that the existing certain trophic function of some Chinese herbal medicine has again is antibiotic, anti-inflammatory, adjusting internal organs function, multiple function such as improve a poor appetite, have prescription flexibly, compound, the few side effects of function, source easily, advantages such as economic convenience, noresidue; As additive for farm animal feed; Not only can improve Production of Livestock and Poultry power, reduce the generation of livestock and poultry pestilence, and can not produce the medicine hazard residue.Chinese traditional compound medicine is rich in the various active composition, has medicine and nutrition double action concurrently, has to improve the piglet feed intake, promote growth, enhance immunity, reduction diarrhea rate, promote digestive organs to grow, improve enzymatic activity and improve the effect of animal product quality.
Summary of the invention
The object of the present invention is to provide additives such as a kind of alternative antibiotic, can control diarrhea of weaned piglets; Promote piglet growth, and toxic and side effect is little, noresidue, be difficult for inducing the weanling pig of drug-resistant microorganism is anti-stress anti diar rhea growth promotion Chinese herbal feed additive.
Weanling pig of the present invention is anti-stress anti diar rhea growth promotion Chinese herbal feed additive, and it is evenly to be mixed by the Radix Astragali, the root of large-flowered skullcap, Fructus Hordei Germinatus, Radix Glycyrrhizae, Radix Codonopsis, Poria cocos and the bighead atractylodes rhizome mass ratio by 1-5:1:1:1:1-5:1-5:1-5.
The mass ratio of the said Radix Astragali, the root of large-flowered skullcap, Fructus Hordei Germinatus, Radix Glycyrrhizae, Radix Codonopsis, Poria cocos and the bighead atractylodes rhizome is preferably 1-3:1:1:1:1-3:1-3:1-3, most preferably is 2:1:1:1:2:2:2.
The preparation method of Chinese herbal feed additive of the present invention, be with the Radix Astragali, the root of large-flowered skullcap, Fructus Hordei Germinatus, Radix Glycyrrhizae, Radix Codonopsis, Poria cocos and the bighead atractylodes rhizome through ultramicro grinding to micron order, mix and get final product.
Wherein, said raw material pulverizing to 10-30 micron is good.
The application of Chinese herbal feed additive according to the invention, it is that said Chinese herbal feed additive is added in the weanling pig basal diet, and the mass ratio of said Chinese herbal feed additive in the weanling pig basal diet is 0.5-2%.
This Chinese herb compound additive is on the basis of traditional treatment diarrhoea property disease, according to the new concept of diarrhea of weaned piglets, regulates the alimentary canal gastrointestinal function of diarrhoea piglet emphatically; Promote digestive organs to grow (gastrointestinal mucosa reparation), improve digestive enzyme activity, improve intestinal microecology; Reduce inflammation and ooze out, and regulate body's immunity, enhancing body resistance; Thereby shorten the grice diarrhoea course of disease, play the effect of control diarrhea of weaned piglets.
Beneficial effect of the present invention is:
1) can improve the weanling pig growth performance, and the anti diar rhea effect is arranged: the Chinese herb feed additive group is compared with control group (not adding additives such as antibiotic), and average daily gain improves, and the material anharmonic ratio reduces, and diarrhea rate, diarrhea frequency, diarrhoea index all significantly reduce;
2) can promote the intestines and stomach of weanling pig to grow: the Chinese herb feed additive group is compared with control group, and stomach weight improves, and stomach, intestines relative weight improve, and the small intestine total length improves, and the pH value of stomach, duodenum, jejunum, ileal contents all significantly reduces;
3) can improve the activity of weanling pig gastro-intestinal digestion road digestive ferment; Promote the growth of piglet digestive ferment system: the Chinese herb feed additive group is compared with control group; Pepsin, lipase enzyme are lived and are improved, and duodenum, jejunum and ileum endoproteinase, amylase and lipase enzyme are lived in all having to some extent and improved;
4) scalable and stable piglet alimentary canal micro-ecological environment; Promote piglet growth: the Chinese herb feed additive group is compared with control group; The raising of caecum lactic acid bacterium number, the minimizing of Escherichia coli quantity, lactic acid bacterium number improve with the ratio of Escherichia coli quantity; The colon lactic acid bacterium number improves, Escherichia coli quantity reduces, and lactic acid bacterium number improves with the ratio of Escherichia coli quantity;
5) can improve the anti-oxidation function of weanling pig body; Thereby improve the compensatory capacity of weanling pig body to external irritant: the Chinese herb feed additive group is compared with control group; TAC (T-AOC) improves, and the activity of glutathione peroxidase (GSH-PX) improves, and the content of MDA (MDA) and nitric oxide (NO) reduces; The activity of superoxide dismutase (SOD) improves, and the activity of catalase (CAT) improves;
6) can improve weanling pig small intestinal mucosa form; Thereby alleviate the atrophy of weanling pig intestinal villi; Promote the enteron aisle reparation: the Chinese herb feed additive group is compared with control group; The height of naps of duodenum, jejunum and ileum is significantly increased, and the crypts degree of depth all significantly reduces, and height of naps significantly improves with the ratio of the crypts degree of depth;
7) immunologic function of scalable weanling pig small intestinal mucosa: goblet cell is a kind of typical glycoprotein secretory cell, and epithelium is had protective effect, and the Chinese herb feed additive group is compared with control group, and small intestinal mucosa goblet cell quantity significantly increases; The secretory immunoglobulin A cell is the material base of alimentary canal mucosa-immune in the small intestinal mucosa layer, and the Chinese herb feed additive group is compared with control group, and small intestinal mucosa secretory immunoglobulin A (SlgA) cell quantity significantly increases; Behind the weaned piglet; Reducing nutritional labelings such as causing protein owing to enteron aisle is impaired with digestive enzyme activity digests and assimilates bad; Cause the food type irritated to weanling pig; Cause the piglet small intestine to be in the hyperimmunization state of activation, significant index is exactly that small intestinal mucosa mast cell and intraepithelial lymphocyte quantity significantly increase, and the Chinese herb feed additive group is compared with control group; Small intestinal mucosa layer intraepithelial lymphocyte quantity and mast cell quantity significantly reduce, and having slowed down the piglet height that is caused by stressor stress.
Propagation and differentiation take place in the IL-2 inducer T lymphocyte, and its content height is the reflection body's immunity directly; It is immune response that the Thl/Th2 system keeps stable; Inflammatory response is reduced to the master with Th1 rising Th2; Be the secretion that inflammatory reaction is accompanied by a large amount of pro-inflammatory cytokines, when stimulating as taking place to wait, the body inner cell factor can squint; Be the Th1/Th2 drift, TNF-α, IL-1 and the IL-6 that main performance is short inflammatory Th1 emiocytosis and IL-4, the IL-10 of anti-inflammatory Th2 type emiocytosis are unbalance.1% Chinese herb feed additive group is compared with control group, and small intestinal mucosa TNF-α concentration significantly reduces, and small intestinal mucosa IL-2, IL-4 concentration significantly increase, and shows that this Chinese herb feed additive suppresses the immune response of piglet Thl type, promotes Th2 type immune response.
The specific embodiment
Embodiment 1
Is raw material by the 2:1:1:1:2:2:2 mass ratio through ultramicro grinding to 25 a micron Chinese herb compound additive that evenly mixes with the Radix Astragali, the root of large-flowered skullcap, Fructus Hordei Germinatus, Radix Glycyrrhizae, Radix Codonopsis, Poria cocos, the bighead atractylodes rhizome; Select Du * length that 21 ages in days wean, initial weight average is 5.86kg * Dasanyuan hybridization 144 of piglets (being selected from the long wind kind of long wind animal husbandry pig farm, Anhui) for use; Be divided into control group (basal diet group), 0.5% Chinese herb feed additive group, 1% Chinese herb feed additive group and 1.5% Chinese herb feed additive group; Every group of 3 repetitions; Each repeats 12, carries out feeding experiment, is just raising 21 days phases.
1) Chinese herb feed additive is to the influence of weanling pig growth performance
1-1 can know by table, initial body weight difference not significantly (P＞0.05) between each group.The end is heavy, and the 1% Chinese herb feed additive group utmost point is significantly higher than control group (P＜0.01), and the utmost point is significantly higher than 0.5% Chinese herbal medicine interpolation group (P＜0.01), is significantly higher than 1.5% Chinese herb feed additive group (P＜0.05).
1% Chinese herb feed additive group is compared with control group, and average daily gain improves 30.32% (P＜0.01), and the material anharmonic ratio reduces by 22.13% (P＜0.01); Compare with 1.5% Chinese herb feed additive group, average daily gain improves 13.95% (P＜0.05), and the material anharmonic ratio reduces by 12.23% (P＞0.05); Compare with 0.5% Chinese herb feed additive group, average daily gain improves 21.29% (P＜0.01), and the material anharmonic ratio reduces by 17.35% (P＜0.05).1.5% Chinese herb feed additive group is compared with control group, and average daily gain improves 14.36% (P＜0.05), and the material anharmonic ratio reduces by 11.28% (P＞0.05); Compare with 0.5% Chinese herb feed additive group, average daily gain improves 6.44% (P＞0.05), and the material anharmonic ratio reduces by 5.83% (P＞0.05).0.5% Chinese herb feed additive group is compared with control group, and average daily gain improves 7.45% (P＞0.05), and the material anharmonic ratio reduces by 5.79% (P＞0.05).
Learn thus; It is best to early-weaned piglets growth performance facilitation in basal diet, to add 1% Chinese herb feed additive; The result of 3 Chinese drug-treated group is normal distribution trend; It is best promptly to add 1% Chinese herb feed additive group effect, and 1.5% Chinese herb feed additive group is taken second place, and is 0.5% Chinese herb feed additive group once more.
Table 1-1: Chinese herb feed additive is to the influence of weanling pig growth performance
Annotate: the different lowercase alphabet differentials of going together different significantly (P＜0.05); The different capitalizations of going together are represented extremely significantly (P＜0.01) (together following) of difference.
2) Chinese herb feed additive is to the influence of diarrhea of weaned piglets parameter
1-2 can know that 1% Chinese herb feed additive group is compared with control group by table, and diarrhea rate, diarrhea frequency, diarrhoea index all extremely significantly reduce; Compare with 1.5% Chinese herb feed additive group, diarrhea rate, diarrhea frequency all significantly reduce, and the diarrhoea index extremely significantly reduces; Compare with 0.5% Chinese herb feed additive group, diarrhea rate, diarrhoea index all extremely significantly reduce, and diarrhea frequency significantly reduces.1.5% Chinese herb feed additive group is compared with control group, and diarrhea rate, diarrhea frequency and diarrhoea index all extremely significantly reduce; Compare with 0.5% Chinese herb feed additive group, diarrhea rate, diarrhea frequency and diarrhoea index all decrease, but difference is not remarkable.0.5% Chinese herb feed additive group is compared with control group, and diarrhea rate reduces but difference is not remarkable, and diarrhea frequency extremely significantly reduces, and the diarrhoea index significantly reduces.Show; It is best to the effect of early-weaned piglets anti diar rhea in basal diet, to add 1% Chinese herb feed additive, and the result of 3 Chinese drug-treated group is normal distribution trend, and it is best promptly to add 1% Chinese herb feed additive group effect; 1.5% Chinese herb feed additive group is taken second place, and is 0.5% Chinese herb feed additive group once more.
Table 1-2: Chinese herb feed additive is to the influence of diarrhea of weaned piglets parameter
3) Chinese herb feed additive is to the influence of weanling pig stomach and intestine growth
1-3 can know by table, and the heavy utmost point of the stomach of 1% Chinese herb feed additive group piglet is significantly higher than control group, and the small intestine total length is significantly higher than control group.Compare with control group, 1% Chinese herb feed additive group has significantly reduced the pH value of piglet stomach, duodenum, jejunum and ileal contents, and 1.5% Chinese herb feed additive group has significantly reduced the pH value of piglet stomach, jejunum and ileal contents.
Table 1-3: the influence that Chinese herb feed additive is grown the weanling pig stomach and intestine
4) Chinese herb feed additive is to the influence of Gastrointestinal Tract of Weanling Piglets digestive enzyme activity
1-4 can know by table; 1% Chinese herb feed additive group is compared with control group; The utmost point has improved the work of piglet pepsin enzyme significantly and the gastric lipase enzyme is lived; The utmost point has significantly improved the work of piglet jejunum amylase enzyme and the lipase enzyme is lived, and has improved the amylase enzyme of duodenum and ileum significantly and has lived and the work of lipase enzyme.0.5% Chinese herb feed additive group and 1.5% Chinese herb feed additive group and control group ratio, pepsin enzyme are lived and the gastric lipase enzyme is lived, duodenum amylase enzyme is lived and the lipase enzyme is lived, jejunum amylase enzyme is lived and the lipase enzyme is lived and ileum amylase enzyme is lived and the work of lipase enzyme is improved.
Table 1-4: Chinese herb feed additive is to the influence of Gastrointestinal Tract of Weanling Piglets digestive enzyme activity
5) Chinese herb feed additive is to the influence of weanling pig caecum and colon microorganism species
1-5 can know by table; With the control group ratio; The 1% Chinese herb feed additive group utmost point has improved the content of Bacillus acidi lactici in piglet caecum and the colon significantly; Reduced colibacillary content in piglet caecum and the colon significantly, the utmost point has improved Bacillus acidi lactici and colibacillary ratio in piglet caecum and the colon significantly and significantly respectively.With the control group ratio, 1.5% Chinese herb feed additive group has improved the content of Bacillus acidi lactici in piglet caecum and the colon significantly, has improved Bacillus acidi lactici and colibacillary ratio in the piglet caecum significantly.
Table 1-5 Chinese herb feed additive is to the influence of weanling pig caecum and colon microorganism species
6) Chinese herb feed additive is to the influence of weanling pig body anti-oxidation function
1-6 can know by table, and with the control group ratio, the 1% Chinese herb feed additive group piglet serum T AOC enzyme utmost point alive significantly improves, and the work of GSH-PX enzyme significantly improves, MDA content extremely significantly descends, and the work of SOD enzyme significantly improves, and the CAT enzyme utmost point alive significantly improves.With the control group ratio, 1.5% Chinese herb feed additive group piglet serum T-AOC enzyme work significantly improves, and MDA content significantly reduces, and the work of CAT enzyme significantly improves.
Table 1-6 Chinese herb feed additive is to the influence of weanling pig serum anti oxidative function
7) Chinese herb feed additive is to the influence of weanling pig small intestinal mucosa epithelium form
1-7 can know by table; Compare with control group; 1% Chinese herb feed additive group piglet duodenum, the jejunum villi height utmost point significantly improve, the ileum height of naps significantly improves; Duodenum, the jejunum crypts degree of depth extremely significantly reduce, the ileum crypts degree of depth significantly reduces, and duodenum, jejunum villi height significantly improve with the ratio utmost point of the crypts degree of depth, the ileum height of naps significantly improves with the ratio of the crypts degree of depth.Compare with control group, 1.5% Chinese herb feed additive group piglet duodenum height of naps, height of naps significantly improve with the ratio of the crypts degree of depth, and the crypts degree of depth significantly reduces.
Table 1-7 Chinese herb feed additive is to the influence of weanling pig small intestinal mucosa form
8) Chinese herb feed additive is to the regulating action of weanling pig small intestinal mucosa immunologic function
Chinese herb feed additive is seen table 1-8 to the influence of weanling pig Intestinal Mucosal Immunity relevant cell distributed number.Compare with control group, the goblet cell numbers of poles of 1% Chinese herbal medicine interpolation group piglet duodenum mucous membrane significantly increases, and the goblet cell quantity of jejunum and ileal mucosa significantly increases; The goblet cell numbers of poles of 1.5% Chinese herbal medicine group piglet duodenum mucous membrane significantly increases.1% Chinese herbal medicine interpolation group and control group ratio, secretory immunoglobulin A (SlgA) cell quantity of piglet duodenum and jejunum mucous layer extremely significantly increases, and ileal mucosa layer secretory immunoglobulin A (SlgA) cell quantity significantly increases; Compare with control group, 1.5% Chinese herbal medicine group piglet duodenum and jejunum mucous layer secretory immunoglobulin A (SlgA) cell quantity significantly increase.Compare with control group, 1% Chinese herbal medicine interpolation group piglet duodenum, jejunum and ileal mucosa layer intraepithelial lymphocyte quantity significantly reduce, and 1.5% Chinese herbal medicine interpolation group piglet duodenum mucous layer intraepithelial lymphocyte quantity significantly reduces.Compare with control group, 1% Chinese herbal medicine interpolation group piglet duodenum, jejunum and ileal mucosa layer mast cell quantity significantly reduce.
Table 1-8 Chinese herb feed additive is to the influence of weanling pig small intestinal mucosa immunity-associated cell distributed number
Chinese herb feed additive is seen table 1-9 to the influence of weanling pig small intestinal mucosa cell factor.Compare with control group, the TNF-α concentration of 1% Chinese herbal medicine interpolation group piglet duodenum and jejunum mucous membrane extremely significantly reduces, and the TNF-α concentration of ileal mucosa significantly reduces; The TNF-α concentration of 1.5% Chinese herbal medicine interpolation group piglet jejunum mucous membrane extremely significantly reduces.1% Chinese herbal medicine interpolation group is compared with control group, and the IL-2 concentration of duodenum, jejunum mucous membrane significantly increases, and IL-4 concentration extremely significantly increases.1.5% Chinese herbal medicine interpolation group is compared with control group, and the IL-4 concentration of duodenum mucous membrane significantly increases.
Table 1-9 Chinese herb feed additive is to the influence of weanling pig small intestinal mucosa cell factor
Embodiment 2
Is raw material by the 1:1:1:1:1:1:1 mass ratio through ultramicro grinding to 25 a micron Chinese herb compound additive that evenly mixes with the Radix Astragali, the root of large-flowered skullcap, Fructus Hordei Germinatus, Radix Glycyrrhizae, Radix Codonopsis, Poria cocos, the bighead atractylodes rhizome; Select Du * length that 28 ages in days wean, initial weight average is 8.25kg * Dasanyuan hybridization 108 of piglets (being selected from Ningguo City, Anhui Province hundred Hui Muye companies) for use; Be divided into control group (basal diet group), 0.5% Chinese herb feed additive group, 1% Chinese herb feed additive group, 1.5% Chinese herb feed additive group; Every group of 3 repetitions; Each repeats 9, carries out feeding experiment, is just raising 21 days phases.
1) Chinese herb feed additive is to the influence of weanling pig growth performance and diarrhea rate
2-1 can know that 1% Chinese herb feed additive group is compared with control group by table, and the end is brought up again high by 8.67% (P＜0.05), and average daily gain improves 16.22% (P＜0.01), and the material anharmonic ratio reduces by 9.87% (P＜0.01), and diarrhea rate reduces by 37.29% (P＜0.01); Average daily ingestion amount is compared significant difference (P＜0.05) with control group.1.5% Chinese herb feed additive group is compared with control group, and the end is brought up again high by 6.22% (P＜0.05), and average daily gain improves 10.81% (P＜0.05), and the material anharmonic ratio reduces by 7.24% (P＞0.05), and diarrhea rate significantly reduces (P＜0.05); Average daily ingestion amount is compared indifference significantly (P＜0.05) with control group.Learn thus, in basal diet, add 1% and 1.5% Chinese herb feed additive and all have early-weaned piglets growth performance facilitation and anti diar rhea effect.
Table 2-1: Chinese herb feed additive is to the influence of weanling pig growth performance
Annotate: the different lowercase alphabet differentials of going together different significantly (P＜0.05); The different capitalizations of going together are represented extremely significantly (P＜0.01) (together following) of difference.
2) Chinese herb feed additive is to the influence of weanling pig stomach and intestine growth
2-2 can know that the stomach phase counterweight of 1% Chinese herb feed additive group piglet and the small intestine phase counterweight utmost point are significantly higher than control group by table.The relative representation work of the stomach of 1.5% Chinese herb feed additive group piglet is higher than control group.Compare with control group, 1% Chinese herb feed additive group has significantly reduced the pH value of piglet stomach, duodenum, jejunum and ileal contents, and 1.5% Chinese herb feed additive group has significantly reduced the pH value of piglet gastric content.
Table 2-2: the influence that Chinese herb feed additive is grown the weanling pig stomach and intestine
3) Chinese herb feed additive is to the influence of weanling pig small intestine digestive enzyme activity
2-3 can know that 1% Chinese herb feed additive group is compared with control group by table, has improved piglet duodenum protease and amylase enzyme (p＜0.05) alive, lipase enzyme (p＜0.01) alive; Work of piglet jejunum protease enzyme and lipase enzyme (p＜0.05) alive, amylase enzyme (p＜0.01) alive have been improved; Work of piglet ileum protease enzyme and amylase enzyme (p＜0.05) alive, lipase enzyme (p＜0.01) alive have been improved.1.5% Chinese herb feed additive group and control group ratio have improved piglet jejunum protease enzyme (p＜0.05) alive and ileum amylase enzyme (p＜0.05) alive.0.5% Chinese herb feed additive group and control group ratio, piglet duodenum, jejunum and ileum protease enzyme are lived, the amylase enzyme is lived and the work of lipase enzyme is improved.
Table 2-3: Chinese herb feed additive is to the influence of weanling pig small intestine digestive enzyme activity
Embodiment 3
Is raw material by the 3:1:1:1:3:3:3 mass ratio through ultramicro grinding to 25 a micron Chinese herb compound additive that evenly mixes with the Radix Astragali, the root of large-flowered skullcap, Fructus Hordei Germinatus, Radix Glycyrrhizae, Radix Codonopsis, Poria cocos, the bighead atractylodes rhizome; 21 ages in days that 96 body weight of experiment selected are close " Du * length * big " three way cross weanling pig (being selected from the long wind kind of long wind animal husbandry pig farm, Anhui); Be divided into control group (basal diet group), 0.5% Chinese herb feed additive group, 1% Chinese herb feed additive group and 1.5% Chinese herb feed additive group; Every group of 4 repetitions, each repeats 6, carries out feeding experiment; Raise 5 days phases in advance, just raising 21 days phases.
1) Chinese herb feed additive is to the influence of weanling pig growth performance
3-1 can know that 1% Chinese herb feed additive group is compared with control group by table, and average daily gain improves 25.00% (P＜0.01), and the end is brought up again high by 7.76% (P＜0.05), and the material anharmonic ratio reduces by 12.87% (P＜0.05); 1.5% Chinese herbal feed additive group is compared with control group, and average daily gain improves 14.29% (P＜0.05).Learn thus, in basal diet, add this Chinese herb feed additive and have the effect that early-weaned piglets is promoted growth.
Table 3-1: Chinese herb feed additive is to the influence of weanling pig growth performance
Annotate: the different lowercase alphabet differentials of going together different significantly (P＜0.05); The different capitalizations of going together are represented extremely significantly (P＜0.01) (together following) of difference.
2) Chinese herb feed additive is to the influence of diarrhea of weaned piglets parameter
3-2 can know that 1% Chinese herb feed additive group is compared with control group by table, and diarrhea rate, diarrhea frequency, diarrhoea index all extremely significantly reduce; Compare with 1.5% Chinese herb feed additive group, diarrhea rate significantly reduces; Compare with 0.5% Chinese herb feed additive group, diarrhea rate significantly reduces, and diarrhea frequency, diarrhoea index all significantly reduce.1.5% Chinese herb feed additive group is compared with control group, and diarrhea rate, diarrhea frequency all significantly reduce.0.5% Chinese herb feed additive group is compared diarrhea frequency with control group and is significantly reduced.Show, in daily ration, add this Chinese herb feed additive early-weaned piglets is had the anti diar rhea effect.
Table 3-2: Chinese herb feed additive is to the influence of diarrhea of weaned piglets parameter
3) Chinese herb feed additive is to the influence of weanling pig caecum and colon microorganism species
3-3 can know by table, and with the control group ratio, 1% Chinese herb feed additive group has improved the quantity of Bacillus acidi lactici in the piglet caecum significantly, and the utmost point has improved the quantity of Bacillus acidi lactici in the piglet colon significantly; The utmost point has reduced colibacillary quantity in the piglet caecum significantly, has reduced colibacillary quantity in the piglet colon significantly; The utmost point has improved Bacillus acidi lactici and colibacillary ratio in the caecum significantly, has improved Bacillus acidi lactici and colibacillary ratio in the colon significantly.With the control group ratio, 1.5% Chinese herb feed additive group has reduced colibacillary quantity in the piglet caecum significantly.
Table 3-3 Chinese herb feed additive is to the influence of weanling pig caecum and colon microorganism species
4) Chinese herb feed additive is to the influence of weanling pig small intestinal mucosa epithelium form
3-4 can know that compare with control group, 1% Chinese herb feed additive group piglet duodenum, ileum height of naps significantly improve by table, and jejunum villi extremely significantly increases; Duodenum, the jejunum crypts degree of depth extremely significantly reduce, the ileum crypts degree of depth significantly reduces; Duodenum, jejunum and ileum height of naps significantly improve with the ratio utmost point of the crypts degree of depth.Compare with control group, 1.5% Chinese herb feed additive group piglet duodenum, jejunum and ileum height of naps significantly improve, and duodenum, the ileum fine hair crypts degree of depth significantly reduce, and duodenum, jejunum and ileum height of naps significantly improve with the ratio of the crypts degree of depth.Compare with control group, 0.5% Chinese herb feed additive group piglet duodenum, jejunum and ileum height of naps all significantly increase.
Table 3-4 Chinese herb feed additive is to the influence of weanling pig small intestinal mucosa form
Embodiment 4
Is raw material by the 5:1:1:1:5:5:5 mass ratio through ultramicro grinding to 30 a micron Chinese herb compound additive that evenly mixes with the Radix Astragali, the root of large-flowered skullcap, Fructus Hordei Germinatus, Radix Glycyrrhizae, Radix Codonopsis, Poria cocos, the bighead atractylodes rhizome; Select 120 28 ages in days " Du * length * big " weanling pigs (being selected from Ningguo City, Anhui Province hundred Hui Muye companies) that body weight is close for use; Public mother half and half, the principle identical according to kind, that body weight is close, sex ratio is identical is divided into control group (basal diet group), 0.5% Chinese herb feed additive group, 1% Chinese herb feed additive group and 1.5% Chinese herb feed additive group at random with piglet; Every group of 3 repetitions; Each repeats 10, carries out feeding experiment, is just raising 28 days phases.
1) Chinese herb feed additive is to the influence of weanling pig growth performance and diarrhea rate
4-1 can know that 1% Chinese herb feed additive group is compared with control group by table, and the end is brought up again high by 12.23% (P＜0.05), and average daily gain improves 23.32% (P＜0.05), and the material anharmonic ratio reduces by 12.43% (P＜0.05), and diarrhea frequency reduces by 30.07% (P＜0.01); Average daily ingestion amount is compared significant difference (P＜0.05) with control group.1.5% Chinese herb feed additive group is compared with control group, and diarrhea rate significantly reduces (P＜0.05), and end weight, average daily gain, material anharmonic ratio and average daily ingestion amount are compared indifference significantly (P＜0.05) with control group.Learn thus, in basal diet, add 1% and 1.5% Chinese herb feed additive and all have early-weaned piglets growth performance facilitation and anti diar rhea effect.
Table 4-1: Chinese herb feed additive is to the influence of weanling pig growth performance and diarrhea frequency
Annotate: the different lowercase alphabet differentials of going together different significantly (P＜0.05); The different capitalizations of going together are represented extremely significantly (P＜0.01) (together following) of difference.
2) Chinese herb feed additive is to the influence of weanling pig body anti-oxidation function
4-2 can know by table, and with the control group ratio, 1% Chinese herb feed additive group piglet serum T-AOC enzyme utmost point alive significantly improves, and the work of GSH-PX enzyme significantly improves, MDA content extremely significantly descends, and the work of SOD enzyme significantly improves, and the work of CAT enzyme significantly improves, and serum NO levels significantly reduces.With the control group ratio, 1.5% Chinese herb feed additive group piglet serum T-AOC enzyme, SOD enzyme and the work of CAT enzyme significantly improve, and NO content significantly reduces.With the control group ratio, 0.5% each anti-oxidant index of Chinese herb feed additive group piglet serum does not all have significant difference.Show, in basal diet, add the anti-oxidation function that 1% and 1.5% Chinese herb feed additive all can significantly improve piglet.
Table 4-2 Chinese herb feed additive is to the influence of weanling pig serum anti oxidative function
Claims (6)
1. a weanling pig is anti-stress anti diar rhea growth promotion Chinese herbal feed additive, and it is evenly to be mixed by the Radix Astragali, the root of large-flowered skullcap, Fructus Hordei Germinatus, Radix Glycyrrhizae, Radix Codonopsis, Poria cocos and the bighead atractylodes rhizome mass ratio by 1-5:1:1:1:1-5:1-5:1-5.
2. Chinese herbal feed additive as claimed in claim 1 is characterized in that: the mass ratio of the said Radix Astragali, the root of large-flowered skullcap, Fructus Hordei Germinatus, Radix Glycyrrhizae, Radix Codonopsis, Poria cocos and the bighead atractylodes rhizome is 1-3:1:1:1:1-3:1-3:1-3.
3. Chinese herbal feed additive as claimed in claim 2 is characterized in that: the mass ratio of the said Radix Astragali, the root of large-flowered skullcap, Fructus Hordei Germinatus, Radix Glycyrrhizae, Radix Codonopsis, Poria cocos and the bighead atractylodes rhizome is 2:1:1:1:2:2:2.
4. the preparation method of each described Chinese herbal feed additive among the claim 1-3 is characterized in that: with the Radix Astragali, the root of large-flowered skullcap, Fructus Hordei Germinatus, Radix Glycyrrhizae, Radix Codonopsis, Poria cocos and the bighead atractylodes rhizome through ultramicro grinding to micron order, mix and get final product.
5. like the preparation method of the said Chinese herbal feed additive of claim 4, it is characterized in that: said raw material ultramicro grinding is to the 10-30 micron.
6. the application of each said Chinese herbal feed additive among the claim 1-3; It is characterized in that: said Chinese herbal feed additive is added in the weanling pig basal diet, and the mass ratio of said Chinese herbal feed additive in the weanling pig basal diet is 0.5-2%.
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