MA27316A1 - Derives d'indoline-phenylsulfonamide - Google Patents
Derives d'indoline-phenylsulfonamideInfo
- Publication number
- MA27316A1 MA27316A1 MA28032A MA28032A MA27316A1 MA 27316 A1 MA27316 A1 MA 27316A1 MA 28032 A MA28032 A MA 28032A MA 28032 A MA28032 A MA 28032A MA 27316 A1 MA27316 A1 MA 27316A1
- Authority
- MA
- Morocco
- Prior art keywords
- derivatives
- indoline
- indolinephenylsulfonamide
- phenylsulfonamide derivatives
- phenylsulfonamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
DERIVES D'INDOLINEPHENYLSULFONAMIDE La présente demande concerne de nouveaux dérivés d'indolinephénylsulfonamide substitués, des procédés pour leur préparation, et leur utilisation dans des médicaments, en particulier en tant que composés puissants d'activation de PPAR-delta pour la prophylaxie et/ou le traitement de troubles cardiovasculaires, en particulier de dyslipidémies et de maladies coronariennes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10229777A DE10229777A1 (de) | 2002-07-03 | 2002-07-03 | Indolin-Phenylsulfonamid-Derivate |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27316A1 true MA27316A1 (fr) | 2005-05-02 |
Family
ID=29796112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28032A MA27316A1 (fr) | 2002-07-03 | 2005-01-03 | Derives d'indoline-phenylsulfonamide |
Country Status (26)
Country | Link |
---|---|
US (1) | US20060100230A1 (fr) |
EP (1) | EP1519919A1 (fr) |
JP (1) | JP2005535649A (fr) |
CN (1) | CN1678581A (fr) |
AR (1) | AR040352A1 (fr) |
AU (1) | AU2003246638A1 (fr) |
BR (1) | BR0312549A (fr) |
CA (1) | CA2491477A1 (fr) |
DE (1) | DE10229777A1 (fr) |
EC (1) | ECSP055524A (fr) |
GT (1) | GT200300135A (fr) |
HN (1) | HN2003000196A (fr) |
HR (1) | HRP20050108A2 (fr) |
IL (1) | IL165924A0 (fr) |
MA (1) | MA27316A1 (fr) |
MX (1) | MXPA05000133A (fr) |
MY (1) | MY134641A (fr) |
NO (1) | NO20050579L (fr) |
NZ (1) | NZ537486A (fr) |
PE (1) | PE20040645A1 (fr) |
RU (1) | RU2328485C2 (fr) |
TW (1) | TW200418794A (fr) |
UA (1) | UA79003C2 (fr) |
UY (1) | UY27878A1 (fr) |
WO (1) | WO2004005253A1 (fr) |
ZA (1) | ZA200500013B (fr) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10335450A1 (de) * | 2003-08-02 | 2005-02-17 | Bayer Ag | Indolin-Sulfanilsäureamide |
DE10337839A1 (de) * | 2003-08-18 | 2005-03-17 | Bayer Healthcare Ag | Indolin-Derivate |
AR045582A1 (es) * | 2003-09-05 | 2005-11-02 | Neurogen Corp | Piridinas pirazinas y pirimidinas heteroarilo fusionadas como ligandos receptores de crf1 |
AR048523A1 (es) * | 2004-04-07 | 2006-05-03 | Kalypsys Inc | Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos |
ES2352085T3 (es) | 2004-05-05 | 2011-02-15 | High Point Pharmaceuticals, Llc | Nuevos compuestos, su preparación y uso. |
JP4981662B2 (ja) | 2004-05-05 | 2012-07-25 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 新規の化合物、その製法と使用 |
FR2869904B1 (fr) | 2004-05-07 | 2006-07-28 | Fournier S A Sa Lab | Modulateurs des recepteurs lxr |
FR2873694B1 (fr) * | 2004-07-27 | 2006-12-08 | Merck Sante Soc Par Actions Si | Nouveaux aza-indoles inhibiteurs de la mtp et apob |
CN101421258B (zh) * | 2004-10-29 | 2013-08-21 | 凯利普西斯公司 | 作为ppar调节剂的磺酰基取代的双环化合物 |
HUE039584T2 (hu) | 2004-10-29 | 2019-01-28 | Kalypsys Inc | PPAR-modulátor szulfonil-szubsztituált biciklusos vegyületek |
CA2593483A1 (fr) * | 2005-01-18 | 2006-07-27 | Novartis Ag | Procedes d'utilisation de composes agonistes doubles vis-a-vis des recepteurs ppar, et dispositifs de delivrance de medicaments contenant ces composes |
DE102005020230A1 (de) * | 2005-04-30 | 2006-11-09 | Bayer Healthcare Ag | Verwendung von Indolin-Phenylsulfonamid-Derivaten |
DE102005020229A1 (de) * | 2005-04-30 | 2006-11-09 | Bayer Healthcare Ag | Verwendung von Indolin-Phenylsulfonamid-Derivaten |
FR2886293B1 (fr) * | 2005-05-30 | 2007-08-24 | Fournier S A Sa Lab | Nouveaux composes de l'indoline |
US7943669B2 (en) | 2005-06-30 | 2011-05-17 | High Point Pharmaceuticals, Llc | Phenoxy acetic acids as PPAR delta activators |
FR2890072A1 (fr) * | 2005-09-01 | 2007-03-02 | Fournier S A Sa Lab | Nouveaux composesde pyrrolopyridine |
CN103224477A (zh) | 2005-12-22 | 2013-07-31 | 高点制药有限责任公司 | 作为PPAR-δ活化剂的苯氧基乙酸 |
CA2645719A1 (fr) | 2006-03-09 | 2007-09-13 | High Point Pharmaceuticals, Llc | Nouveaux composes, leur preparation et utilisation |
TWI315304B (en) | 2006-08-31 | 2009-10-01 | Univ Taipei Medical | Indoline-sulfonamides compounds |
EP1932843A1 (fr) | 2006-12-14 | 2008-06-18 | sanofi-aventis | Dérivés de sulfonyl-phenyl-2H(1,2,4) oxadiazole-5-one, procédés de préparation de ceux-ci et leur usage sous forme de médicaments |
WO2008091863A1 (fr) | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Composés bicycliques substitués par sulfonyle utilisés comme modulateurs de ppar dans le traitement de la stéatohépatite non alcoolique |
TW200848021A (en) | 2007-03-06 | 2008-12-16 | Wyeth Corp | Sulfonylated heterocycles useful for modulation of the progesterone receptor |
PE20090159A1 (es) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
WO2010000353A1 (fr) * | 2008-06-09 | 2010-01-07 | Sanofi-Aventis | Sulfonamides comprenant un hétérocycle et un groupe de tête oxadiazolone, procédés pour les préparer et leur utilisation comme produits pharmaceutiques |
BRPI0914978A2 (pt) * | 2008-06-09 | 2015-10-27 | Sanofi Aventis | sulfonamidas n-heterocíclicas reforçadas com grupo principal de oxadiazolona, processos para sua preparação e seu uso como farmacêuticos |
US8410284B2 (en) | 2008-10-22 | 2013-04-02 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
CN102271509A (zh) | 2008-10-31 | 2011-12-07 | 默沙东公司 | 用于抗糖尿病药的新型环苯并咪唑衍生物 |
CA2786314A1 (fr) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Nouveaux derives benzimidazole cycliques utiles comme agents antidiabetiques |
PE20140192A1 (es) | 2010-10-06 | 2014-02-24 | Glaxosmithkline Llc | Derivados de bencimidazol como inhibidores de cinasa pi3 |
WO2012064744A2 (fr) | 2010-11-08 | 2012-05-18 | Lycera Corporation | Tétrahydroquinoline et composés bicycliques associés pour l'inhibition de l'activité rorγ et le traitement de maladies |
CN103476258B (zh) | 2011-02-25 | 2017-04-26 | 默沙东公司 | 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物 |
MX367341B (es) * | 2012-05-08 | 2019-08-14 | Merck Sharp & Dohme | Tetrahidronaftiridina y compuestos biciclicos relacionados para la inhibicion de la actividad de rorgamma y el tratamiento de enfermedades. |
US9394315B2 (en) | 2012-05-08 | 2016-07-19 | Lycera Corporation | Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
CA2880901A1 (fr) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Composes tricycliques antidiabetiques |
RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
EP2970119B1 (fr) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Nouveaux dérivés d'indole utiles en tant qu'agents antidiabétiques |
US9745297B2 (en) * | 2013-07-30 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Compounds as modulators of RORC |
US9487493B2 (en) | 2013-09-09 | 2016-11-08 | Vtv Therapeutics Llc | Use of a PPAR-delta agonist for treating muscle atrophy |
WO2015051496A1 (fr) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Composés tricycliques antidiabétiques |
CN103626767A (zh) * | 2013-12-04 | 2014-03-12 | 上海药明康德新药开发有限公司 | 区域选择性的氮杂吲哚及其合成方法 |
WO2015095795A1 (fr) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Tétrahydronaphtyridine, benzoxazine, aza-benzoxazine et composés bicycliques apparentés pour l'inhibition de l'activité de rorgamma et le traitement de maladie |
WO2015095792A1 (fr) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Acides propioniques de carbamate benzoxazine et dérivés acides pour la modulation de l'activité de rorgamma et le traitement de maladie |
WO2015095788A1 (fr) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Benzoxazine carbamates de 2-acylamidométhyle et de sulfonylamidométhyle pour l'inhibition de l'activité du rorgamma et le traitement d'une maladie |
US10532088B2 (en) | 2014-02-27 | 2020-01-14 | Lycera Corporation | Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods |
WO2015171558A2 (fr) | 2014-05-05 | 2015-11-12 | Lycera Corporation | Benzènesulfonamido et composés apparentés utilisés en tant qu'agonistes de rorγ et pour le traitement de maladie |
JP6728061B2 (ja) | 2014-05-05 | 2020-07-22 | リセラ・コーポレイションLycera Corporation | RORγアゴニストとして用いるテトラヒドロキノリンスルホンアミド及び関連化合物ならびに疾患の治療 |
WO2016130818A1 (fr) | 2015-02-11 | 2016-08-18 | Merck Sharp & Dohme Corp. | Composés pyrazole substitués utilisés en tant qu'inhibiteurs de rorgammat et utilisations desdits composés |
US10421751B2 (en) | 2015-05-05 | 2019-09-24 | Lycera Corporation | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
JP6838004B2 (ja) | 2015-06-11 | 2021-03-03 | リセラ・コーポレイションLycera Corporation | RORγのアゴニストとしての使用及び疾患の治療のためのアリールジヒドロ−2H−ベンゾ[b][1,4]オキサジンスルホンアミド及び関連化合物 |
JP2018531957A (ja) | 2015-10-27 | 2018-11-01 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | RORγT阻害薬としての置換二環式ピラゾール化合物及びその使用 |
EP3368535B1 (fr) | 2015-10-27 | 2020-12-02 | Merck Sharp & Dohme Corp. | Acides benzoïques à substitution hétéroaryle en tant qu'inhibiteurs de rorgammat et leurs utilisations |
MX2018005004A (es) | 2015-10-27 | 2018-09-12 | Merck Sharp & Dohme | Compuestos de indazol substituidos como inhibidores de rorgammat y sus usos. |
US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
US10968232B2 (en) | 2016-12-20 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
CN110483509B (zh) * | 2019-09-04 | 2020-08-25 | 温州大学 | 一种合成含氮杂环衍生物的方法 |
CN110627785B (zh) * | 2019-09-19 | 2021-06-25 | 温州大学 | 一种1,5-四氢萘啶衍生物的制备方法 |
JP2023506951A (ja) * | 2019-12-18 | 2023-02-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Lin28の阻害剤及びその使用方法 |
TW202220958A (zh) * | 2020-08-07 | 2022-06-01 | 美商卡司馬療法公司 | Trpml調節劑 |
WO2023147309A1 (fr) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Utilisation d'agonistes ppar-delta dans le traitement d'une maladie |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
US5795890A (en) * | 1995-09-27 | 1998-08-18 | Ono Pharmaceutical Co., Ltd. | Sulfonamide derivatives |
FR2757157B1 (fr) * | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
WO2002014291A1 (fr) * | 2000-08-11 | 2002-02-21 | Nippon Chemiphar Co.,Ltd. | ACTIVATEURS DE PPAR$G(d) |
-
2002
- 2002-07-03 DE DE10229777A patent/DE10229777A1/de not_active Withdrawn
-
2003
- 2003-06-30 RU RU2005102592/04A patent/RU2328485C2/ru not_active IP Right Cessation
- 2003-06-30 EP EP03762547A patent/EP1519919A1/fr not_active Withdrawn
- 2003-06-30 BR BR0312549-1A patent/BR0312549A/pt not_active IP Right Cessation
- 2003-06-30 CA CA002491477A patent/CA2491477A1/fr not_active Abandoned
- 2003-06-30 MX MXPA05000133A patent/MXPA05000133A/es unknown
- 2003-06-30 US US10/519,125 patent/US20060100230A1/en not_active Abandoned
- 2003-06-30 CN CNA038209446A patent/CN1678581A/zh active Pending
- 2003-06-30 UA UAA200500952A patent/UA79003C2/uk unknown
- 2003-06-30 WO PCT/EP2003/006896 patent/WO2004005253A1/fr not_active Application Discontinuation
- 2003-06-30 JP JP2004518622A patent/JP2005535649A/ja not_active Withdrawn
- 2003-06-30 NZ NZ537486A patent/NZ537486A/en unknown
- 2003-06-30 AR ARP030102373A patent/AR040352A1/es not_active Application Discontinuation
- 2003-06-30 AU AU2003246638A patent/AU2003246638A1/en not_active Abandoned
- 2003-07-01 MY MYPI20032474A patent/MY134641A/en unknown
- 2003-07-02 GT GT200300135A patent/GT200300135A/es unknown
- 2003-07-02 UY UY27878A patent/UY27878A1/es not_active Application Discontinuation
- 2003-07-02 TW TW092118027A patent/TW200418794A/zh unknown
- 2003-07-02 PE PE2003000668A patent/PE20040645A1/es not_active Application Discontinuation
- 2003-07-02 HN HN2003000196A patent/HN2003000196A/es unknown
-
2004
- 2004-12-22 IL IL16592404A patent/IL165924A0/xx unknown
-
2005
- 2005-01-03 EC EC2005005524A patent/ECSP055524A/es unknown
- 2005-01-03 ZA ZA200500013A patent/ZA200500013B/en unknown
- 2005-01-03 MA MA28032A patent/MA27316A1/fr unknown
- 2005-02-02 NO NO20050579A patent/NO20050579L/no not_active Application Discontinuation
- 2005-02-02 HR HR20050108A patent/HRP20050108A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
RU2328485C2 (ru) | 2008-07-10 |
TW200418794A (en) | 2004-10-01 |
US20060100230A1 (en) | 2006-05-11 |
CA2491477A1 (fr) | 2004-01-15 |
MXPA05000133A (es) | 2005-04-11 |
WO2004005253A1 (fr) | 2004-01-15 |
AU2003246638A1 (en) | 2004-01-23 |
AR040352A1 (es) | 2005-03-30 |
PE20040645A1 (es) | 2004-10-29 |
ECSP055524A (es) | 2005-03-10 |
UA79003C2 (en) | 2007-05-10 |
UY27878A1 (es) | 2004-02-27 |
CN1678581A (zh) | 2005-10-05 |
ZA200500013B (en) | 2006-03-29 |
DE10229777A1 (de) | 2004-01-29 |
HRP20050108A2 (hr) | 2006-04-30 |
JP2005535649A (ja) | 2005-11-24 |
MY134641A (en) | 2007-12-31 |
NO20050579L (no) | 2005-02-02 |
BR0312549A (pt) | 2005-04-26 |
EP1519919A1 (fr) | 2005-04-06 |
NZ537486A (en) | 2006-07-28 |
RU2005102592A (ru) | 2005-07-10 |
HN2003000196A (es) | 2004-11-22 |
IL165924A0 (en) | 2006-01-15 |
GT200300135A (es) | 2004-03-17 |
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