MA28562B1 - 1,3,4-oxadiazol-2-ones comme modulateurs de ppar delta et leur utilisation - Google Patents
1,3,4-oxadiazol-2-ones comme modulateurs de ppar delta et leur utilisationInfo
- Publication number
- MA28562B1 MA28562B1 MA29428A MA29428A MA28562B1 MA 28562 B1 MA28562 B1 MA 28562B1 MA 29428 A MA29428 A MA 29428A MA 29428 A MA29428 A MA 29428A MA 28562 B1 MA28562 B1 MA 28562B1
- Authority
- MA
- Morocco
- Prior art keywords
- modulators
- oxadiazol
- ones
- ppar delta
- compounds
- Prior art date
Links
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 title 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000016192 Demyelinating disease Diseases 0.000 abstract 2
- WTSXVIMLKCKWIW-UHFFFAOYSA-N 3h-1,3,4-oxadiazol-2-one Chemical class O=C1NN=CO1 WTSXVIMLKCKWIW-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 108010015181 PPAR delta Proteins 0.000 abstract 1
- 230000004129 fatty acid metabolism Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55841904P | 2004-04-01 | 2004-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA28562B1 true MA28562B1 (fr) | 2007-04-03 |
Family
ID=34972933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA29428A MA28562B1 (fr) | 2004-04-01 | 2006-10-31 | 1,3,4-oxadiazol-2-ones comme modulateurs de ppar delta et leur utilisation |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7576109B2 (fr) |
| EP (1) | EP1735303B1 (fr) |
| JP (1) | JP4813460B2 (fr) |
| KR (1) | KR20060135854A (fr) |
| CN (1) | CN100516065C (fr) |
| AT (1) | ATE507226T1 (fr) |
| AU (1) | AU2005230837A1 (fr) |
| BR (1) | BRPI0509468A (fr) |
| CA (1) | CA2561738A1 (fr) |
| DE (1) | DE602005027677D1 (fr) |
| IL (1) | IL178167A0 (fr) |
| MA (1) | MA28562B1 (fr) |
| NO (1) | NO20064982L (fr) |
| NZ (1) | NZ550857A (fr) |
| RU (1) | RU2375358C2 (fr) |
| WO (1) | WO2005097762A2 (fr) |
| ZA (1) | ZA200607851B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1956984B (zh) * | 2004-04-01 | 2010-06-09 | 安万特药物公司 | 1,3,4-二唑-2-酮作为PPAR-δ调节剂 |
| WO2005105726A1 (fr) | 2004-05-05 | 2005-11-10 | Novo Nordisk A/S | Nouveaux composes, leur preparation et leur utilisation |
| EP1745014B1 (fr) | 2004-05-05 | 2011-07-06 | High Point Pharmaceuticals, LLC | Nouveaux composes, leur preparation et leur utilisation |
| RU2412935C2 (ru) | 2005-06-30 | 2011-02-27 | Хай Пойнт Фармасьютикалс, ЛЛС | Феноксиуксусные кислоты в качестве активаторов дельта рецепторов ppar |
| RU2008112198A (ru) | 2005-09-29 | 2009-10-10 | Санофи-Авентис (Fr) | Производные фенил-1,2,4-оксадиазолона, способы их получения и их применение в качестве фармацевтических средств |
| SI1931660T1 (sl) | 2005-09-29 | 2012-12-31 | Sanofi | Derivati fenil-(1,2,4)-oksadiazol-5-ona s fenilno skupino, postopki za njihovo pripravo in njihova uporaba kot zdravila |
| WO2007071766A2 (fr) | 2005-12-22 | 2007-06-28 | Transtech Pharma | Nouveaux composes, leur preparation et leur utilisation |
| WO2007101864A2 (fr) | 2006-03-09 | 2007-09-13 | High Point Pharmaceuticals, Llc | Nouveaux composés, leur préparation et utilisation |
| US20080004281A1 (en) * | 2006-06-28 | 2008-01-03 | Kalypsys, Inc. | Methods for the modulation of crp by the selective modulation of ppar delta |
| US20120020931A1 (en) * | 2010-06-02 | 2012-01-26 | Rutgers, The State University Of New Jersey | Therapeutic encapsulated embryonic stem cells and mesenchymal stromal cells |
| EP3043789B1 (fr) | 2013-09-09 | 2020-07-08 | vTv Therapeutics LLC | Utilisation des agonistes de ppar-delta pour le traitement de l'atrophie musculaire |
| WO2023147309A1 (fr) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Utilisation d'agonistes ppar-delta dans le traitement d'une maladie |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4895953A (en) * | 1987-09-30 | 1990-01-23 | American Home Products Corporation | 2-Aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
| US5103014A (en) * | 1987-09-30 | 1992-04-07 | American Home Products Corporation | Certain 3,3'-[[[(2-phenyl-4-thiazolyl)methoxy]phenyl]methylene]dithiobis-propanoic acid derivatives |
| US4826990A (en) * | 1987-09-30 | 1989-05-02 | American Home Products Corporation | 2-aryl substituted heterocyclic compounds as antiallergic and antiinflammatory agents |
| US5641796A (en) * | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
| JP2003502370A (ja) * | 1999-06-18 | 2003-01-21 | メルク エンド カムパニー インコーポレーテッド | アリールチアゾリジンジオン誘導体およびアリールオキサゾリジンジオン誘導体 |
| GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| EP1210345B1 (fr) * | 1999-09-08 | 2004-03-03 | Glaxo Group Limited | Antagonistes ppar oxazole |
| JP4145230B2 (ja) * | 2002-11-01 | 2008-09-03 | 武田薬品工業株式会社 | 神経障害の予防・治療剤 |
| TW200505441A (en) * | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
| CN1956984B (zh) * | 2004-04-01 | 2010-06-09 | 安万特药物公司 | 1,3,4-二唑-2-酮作为PPAR-δ调节剂 |
-
2005
- 2005-03-30 EP EP05766888A patent/EP1735303B1/fr not_active Expired - Lifetime
- 2005-03-30 AU AU2005230837A patent/AU2005230837A1/en not_active Abandoned
- 2005-03-30 CA CA002561738A patent/CA2561738A1/fr not_active Abandoned
- 2005-03-30 RU RU2006138485/04A patent/RU2375358C2/ru not_active IP Right Cessation
- 2005-03-30 JP JP2007506540A patent/JP4813460B2/ja not_active Expired - Fee Related
- 2005-03-30 AT AT05766888T patent/ATE507226T1/de not_active IP Right Cessation
- 2005-03-30 CN CN200580010054.5A patent/CN100516065C/zh not_active Expired - Fee Related
- 2005-03-30 DE DE602005027677T patent/DE602005027677D1/de not_active Expired - Lifetime
- 2005-03-30 KR KR1020067020431A patent/KR20060135854A/ko not_active Ceased
- 2005-03-30 NZ NZ550857A patent/NZ550857A/en unknown
- 2005-03-30 BR BRPI0509468-2A patent/BRPI0509468A/pt not_active IP Right Cessation
- 2005-03-30 WO PCT/US2005/010854 patent/WO2005097762A2/fr active Application Filing
-
2006
- 2006-09-18 IL IL178167A patent/IL178167A0/en unknown
- 2006-09-19 ZA ZA200607851A patent/ZA200607851B/en unknown
- 2006-09-26 US US11/535,227 patent/US7576109B2/en not_active Expired - Fee Related
- 2006-10-31 NO NO20064982A patent/NO20064982L/no not_active Application Discontinuation
- 2006-10-31 MA MA29428A patent/MA28562B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005097762A2 (fr) | 2005-10-20 |
| JP4813460B2 (ja) | 2011-11-09 |
| ATE507226T1 (de) | 2011-05-15 |
| AU2005230837A1 (en) | 2005-10-20 |
| CN1938305A (zh) | 2007-03-28 |
| EP1735303A2 (fr) | 2006-12-27 |
| IL178167A0 (en) | 2006-12-31 |
| DE602005027677D1 (de) | 2011-06-09 |
| EP1735303B1 (fr) | 2011-04-27 |
| NO20064982L (no) | 2006-10-31 |
| CN100516065C (zh) | 2009-07-22 |
| NZ550857A (en) | 2009-12-24 |
| BRPI0509468A (pt) | 2007-09-11 |
| CA2561738A1 (fr) | 2005-10-20 |
| ZA200607851B (en) | 2008-06-25 |
| RU2375358C2 (ru) | 2009-12-10 |
| US20070060626A1 (en) | 2007-03-15 |
| US7576109B2 (en) | 2009-08-18 |
| KR20060135854A (ko) | 2006-12-29 |
| JP2007531763A (ja) | 2007-11-08 |
| WO2005097762A3 (fr) | 2005-12-15 |
| RU2006138485A (ru) | 2008-05-10 |
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