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Citing the Human Protein Atlas

To cite us, please use:

The Human Protein Atlas

 Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F.
Tissue-based map of the human proteome.
Science 2015 347(6220):1260419.
PubMed: 25613900 DOI: 10.1126/science.1260419

Brain

 Sjöstedt E, Zhong W, Fagerberg L, Karlsson M, Mitsios N, Adori C, Oksvold P, Edfors F, Limiszewska A, Hikmet F, Huang J, Du Y, Lin L, Dong Z, Yang L, Liu X, Jiang H, Xu X, Wang J, Yang H, Bolund L, Mardinoglu A, Zhang C, von Feilitzen K, Lindskog C, Pontén F, Luo Y, Hökfelt T, Uhlén M, Mulder J.
An atlas of the protein-coding genes in the human, pig, and mouse brain.
Science. 2020 367(6482)
PubMed: 32139519 DOI: 10.1126/science.aay5947

Single Cell Type

 Karlsson M, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzen K, Zwahlen M, Arif M, Altay O, Li X, Ozcan M, Mardinoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlén M, Lindskog C.
A single-cell type transcriptomics map of human tissues.
Sci Adv. 2021 7(31):.
PubMed: 34321199 DOI: 10.1126/sciadv.abh2169

Pathology / Cancer

 Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.
A pathology atlas of the human cancer transcriptome.
Science. 2017 357(6352)
PubMed: 28818916 DOI: 10.1126/science.aan2507

Cell line

 Jin H, Zhang C, Zwahlen M, von Feilitzen K, Karlsson M, Shi M, Yuan M, Song X, Li X, Yang H, Turkez H, Fagerberg L, Uhlén M, Mardinoglu A.
Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation.
Nat Commun. 2023 14(1):5417.
PubMed: 37669926 DOI: 10.1038/s41467-023-41132-w

Immune Cells

 Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P.
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.
Science. 2019 366(6472)
PubMed: 31857451 DOI: 10.1126/science.aax9198

Human Secretome

 Uhlén M, Karlsson MJ, Hober A, Svensson AS, Scheffel J, Kotol D, Zhong W, Tebani A, Strandberg L, Edfors F, Sjöstedt E, Mulder J, Mardinoglu A, Berling A, Ekblad S, Dannemeyer M, Kanje S, Rockberg J, Lundqvist M, Malm M, Volk AL, Nilsson P, Månberg A, Dodig-Crnkovic T, Pin E, Zwahlen M, Oksvold P, von Feilitzen K, Häussler RS, Hong MG, Lindskog C, Ponten F, Katona B, Vuu J, Lindström E, Nielsen J, Robinson J, Ayoglu B, Mahdessian D, Sullivan D, Thul P, Danielsson F, Stadler C, Lundberg E, Bergström G, Gummesson A, Voldborg BG, Tegel H, Hober S, Forsström B, Schwenk JM, Fagerberg L, Sivertsson Å.
The human secretome.
Sci Signal. 2019 12(609)
PubMed: 31772123 DOI: 10.1126/scisignal.aaz0274 Free access: Abstract, Full text, Reprint

Subcellular

 Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.
A subcellular map of the human proteome.
Science. 2017 356(6340): eaal3321
PubMed: 28495876 DOI: 10.1126/science.aal3321 Free access: Abstract, Full text, Reprint

The original Human Protein Atlas publication

 Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Pontén F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Mol Cell Proteomics. 2005 4(12):1920-32.
PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200

Publications

921 Di Nunzio G, Hellberg S, Zhang Y, Ahmed O, Wang J, Zhang X, Björck HM, Chizh V, Schipper R, Aulin H, Francis R, Fagerberg L, Gisterå A, Metso J, Manfé V, Franco-Cereceda A, Eriksson P, Jauhiainen M, Hagberg CE, Olofsson PS, Malin SG.
Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult.
Nat Cardiovasc Res. 2024 3(3):356-371.
PubMed: 39196121 DOI: 10.1038/s44161-024-00448-6
920 Snanoudj S, Derambure C, Zhang C, Hai Yen NT, Lesueur C, Coutant S, Abily-Donval L, Marret S, Yang H, Mardinoglu A, Bekri S, Tebani A.
Genome-wide expression analysis in a Fabry disease human podocyte cell line.
Heliyon. 2024 10(14):e34357.
PubMed: 39100494 DOI: 10.1016/j.heliyon.2024.e34357
919 Becirovic T, Zhang B, Lindskog C, Norberg E, Vakifahmetoglu-Norberg H, Kaminskyy VO, Kochetkova E.
Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer.
Cell Death Discov. 2024 10(1):342.
PubMed: 39075050 DOI: 10.1038/s41420-024-02111-2
918 Kaynar A, Ozcan M, Li X, Turkez H, Zhang C, Uhlén M, Shoaie S, Mardinoglu A.
Discovery of a Therapeutic Agent for Glioblastoma Using a Systems Biology-Based Drug Repositioning Approach.
Int J Mol Sci. 2024 25(14):.
PubMed: 39063109 DOI: 10.3390/ijms25147868
917 Lee S, Portlock T, Le Chatelier E, Garcia-Guevara F, Clasen F, Oñate FP, Pons N, Begum N, Harzandi A, Proffitt C, Rosario D, Vaga S, Park J, von Feilitzen K, Johansson F, Zhang C, Edwards LA, Lombard V, Gauthier F, Steves CJ, Gomez-Cabrero D, Henrissat B, Lee D, Engstrand L, Shawcross DL, Proctor G, Almeida M, Nielsen J, Mardinoglu A, Moyes DL, Ehrlich SD, Uhlen M, Shoaie S.
Global compositional and functional states of the human gut microbiome in health and disease.
Genome Res. 2024 34(6):967-978.
PubMed: 39038849 DOI: 10.1101/gr.278637.123
916 Xu S, Larsson A, Lind L, Lindskog C, Ärnlöv J, Venge P.
The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Increased Glomerular Production or Permeability in Diabetes Mellitus?
J Clin Med. 2024 13(9):.
PubMed: 38731158 DOI: 10.3390/jcm13092629
915 Xu S, Hultström M, Larsson A, Lipcsey M, Lindskog C, Bülow S, Frithiof R, Venge P.
The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Activity in COVID-19 and Diabetes Mellitus.
J Clin Med. 2024 13(9):.
PubMed: 38731071 DOI: 10.3390/jcm13092540
914 Jotanovic J, Tebani A, Hekmati N, Sivertsson Å, Lindskog C, Uhlèn M, Gudjonsson O, Tsatsaris E, Engström BE, Wikström J, Pontén F, Casar-Borota O.
Transcriptome Analysis Reveals Distinct Patterns Between the Invasive and Noninvasive Pituitary Neuroendocrine Tumors.
J Endocr Soc. 2024 8(5):bvae040.
PubMed: 38505563 DOI: 10.1210/jendso/bvae040
913 Omenn GS, Lane L, Overall CM, Lindskog C, Pineau C, Packer NH, Cristea IM, Weintraub ST, Orchard S, Roehrl MHA, Nice E, Guo T, Van Eyk JE, Liu S, Bandeira N, Aebersold R, Moritz RL, Deutsch EW.
The 2023 Report on the Proteome from the HUPO Human Proteome Project.
J Proteome Res. 2024 23(2):532-549.
PubMed: 38232391 DOI: 10.1021/acs.jproteome.3c00591
912 Fredolini C, Dodig-Crnković T, Bendes A, Dahl L, Dale M, Albrecht V, Mattsson C, Thomas CE, Torinsson Naluai Å, Gisslen M, Beck O, Roxhed N, Schwenk JM.
Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections.
Commun Med (Lond). 2024 4(1):55.
PubMed: 38565620 DOI: 10.1038/s43856-024-00480-4
911 Kotliar IB, Bendes A, Dahl L, Chen Y, Saarinen M, Ceraudo E, Dodig-Crnković T, Uhlén M, Svenningsson P, Schwenk JM, Sakmar TP.
Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins.
Sci Adv. 2024 10(31):eado9959.
PubMed: 39083597 DOI: 10.1126/sciadv.ado9959
910 Öling S, Struck E, Noreen-Thorsen M, Zwahlen M, von Feilitzen K, Odeberg J, Pontén F, Lindskog C, Uhlén M, Dusart P, Butler LM.
A human stomach cell type transcriptome atlas.
BMC Biol. 2024 22(1):36.
PubMed: 38355543 DOI: 10.1186/s12915-024-01812-5
909 Dannemeyer M, Berling A, Kanje S, Enstedt H, Xu L, Afshari D, Westin M, Hober G, Uhlén M, Hober S, Tegel H.
Fast and robust recombinant protein production utilizing episomal stable pools in WAVE bioreactors.
Protein Expr Purif. 2024 221():106505.
PubMed: 38768672 DOI: 10.1016/j.pep.2024.106505
908 Dou DR, Zhao Y, Belk JA, Zhao Y, Casey KM, Chen DC, Li R, Yu B, Srinivasan S, Abe BT, Kraft K, Hellström C, Sjöberg R, Chang S, Feng A, Goldman DW, Shah AA, Petri M, Chung LS, Fiorentino DF, Lundberg EK, Wutz A, Utz PJ, Chang HY.
Xist ribonucleoproteins promote female sex-biased autoimmunity.
Cell. 2024 187(3):733-749.e16.
PubMed: 38306984 DOI: 10.1016/j.cell.2023.12.037
907 King MR, Ruff KM, Lin AZ, Pant A, Farag M, Lalmansingh JM, Wu T, Fossat MJ, Ouyang W, Lew MD, Lundberg E, Vahey MD, Pappu RV.
Macromolecular condensation organizes nucleolar sub-phases to set up a pH gradient.
Cell. 2024 187(8):1889-1906.e24.
PubMed: 38503281 DOI: 10.1016/j.cell.2024.02.029
906 Cesnik A, Schaffer LV, Gaur I, Jain M, Ideker T, Lundberg E.
Mapping the Multiscale Proteomic Organization of Cellular and Disease Phenotypes.
Annu Rev Biomed Data Sci. 2024 7(1):369-389.
PubMed: 38748859 DOI: 10.1146/annurev-biodatasci-102423-113534
905 Mravinacová S, Alanko V, Bergström S, Bridel C, Pijnenburg Y, Hagman G, Kivipelto M, Teunissen C, Nilsson P, Matton A, Månberg A.
CSF protein ratios with enhanced potential to reflect Alzheimer's disease pathology and neurodegeneration.
Mol Neurodegener. 2024 19(1):15.
PubMed: 38350954 DOI: 10.1186/s13024-024-00705-z
904 Barde S, Aguila J, Zhong W, Solarz A, Mei I, Prud'homme J, Palkovits M, Turecki G, Mulder J, Uhlén M, Nagy C, Mechawar N, Hedlund E, Hökfelt T.
Substance P, NPY, CCK and their receptors in five brain regions in major depressive disorder with transcriptomic analysis of locus coeruleus neurons.
Eur Neuropsychopharmacol. 2024 78():54-63.
PubMed: 37931511 DOI: 10.1016/j.euroneuro.2023.09.004
903 Zheng T, Kotol D, Sjöberg R, Mitsios N, Uhlén M, Zhong W, Edfors F, Mulder J.
Characterization of reduced astrocyte creatine kinase levels in Alzheimer's disease.
Glia. 2024 72(9):1590-1603.
PubMed: 38856187 DOI: 10.1002/glia.24569
902 Liu L, Chen A, Li Y, Mulder J, Heyn H, Xu X.
Spatiotemporal omics for biology and medicine.
Cell. 2024 187(17):4488-4519.
PubMed: 39178830 DOI: 10.1016/j.cell.2024.07.040
901 Johansson C, Hunt H, Signorelli S, Edfors F, Hober A, Svensson AS, Tegel H, Forstström B, Aartsma-Rus A, Niks E, Spitali P, Uhlén M, Al-Khalili Szigyarto C
Orthogonal proteomics methods warrant the development of Duchenne muscular dystrophy biomarkers
Clinical Proteomics 2023 23
PubMed: 37308827 DOI: 10.1186/s12014-023-09412-1
900 Cederroth CR, Hong MG, Freydin MB, Edvall NK, Trpchevska N, Jarach C, Schlee W, Schwenk JM, Lopez-Escamez JA, Gallus S, Canlon B, Bulla J, Williams FMK.
Screening for Circulating Inflammatory Proteins Does Not Reveal Plasma Biomarkers of Constant Tinnitus.
J Assoc Res Otolaryngol. 2023 24(6):593-606.
PubMed: 38079022 DOI: 10.1007/s10162-023-00920-3
899 Mälarstig A, Grassmann F, Dahl L, Dimitriou M, McLeod D, Gabrielson M, Smith-Byrne K, Thomas CE, Huang TH, Forsberg SKG, Eriksson P, Ulfstedt M, Johansson M, Sokolov AV, Schiöth HB, Hall P, Schwenk JM, Czene K, Hedman ÅK.
Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation.
Nat Commun. 2023 14(1):7680.
PubMed: 37996402 DOI: 10.1038/s41467-023-43485-8
898 Quardokus EM, Saunders DC, McDonough E, Hickey JW, Werlein C, Surrette C, Rajbhandari P, Casals AM, Tian H, Lowery L, Neumann EK, Björklund F, Neelakantan TV, Croteau J, Wiblin AE, Fisher J, Livengood AJ, Dowell KG, Silverstein JC, Spraggins JM, Pryhuber GS, Deutsch G, Ginty F, Nolan GP, Melov S, Jonigk D, Caldwell MA, Vlachos IS, Muller W, Gehlenborg N, Stockwell BR, Lundberg E, Snyder MP, Germain RN, Camarillo JM, Kelleher NL, Börner K, Radtke AJ.
Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging.
Nat Methods. 2023 20(8):1174-1178.
PubMed: 37468619 DOI: 10.1038/s41592-023-01846-7
897 Ullgren A, Öijerstedt L, Olofsson J, Bergström S, Remnestål J, van Swieten JC, Jiskoot LC, Seelaar H, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Synofzik M, Galimberti D, Rowe JB, Masellis M, Tartaglia MC, Finger E, Vandenberghe R, de Mendonça A, Tirabosch P, Santana I, Ducharme S, Butler CR, Gerhard A, Otto M, Bouzigues A, Russell L, Swift IJ, Sogorb-Esteve A, Heller C, Rohrer JD, Månberg A, Nilsson P, Graff C, Genetic Frontotemporal Dementia Initiative (GENFI).
Altered plasma protein profiles in genetic FTD - a GENFI study.
Mol Neurodegener. 2023 18(1):85.
PubMed: 37968725 DOI: 10.1186/s13024-023-00677-6
896 Lindqvist I, Cunningham JL, Mulder J, Feresiadou A, Rostami E, Virhammar J, Kumlien E.
Myoclonus in patients with COVID-19: Findings of autoantibodies against brain structures in cerebrospinal fluid.
Eur J Neurol. 2023 30(10):3142-3148.
PubMed: 37392418 DOI: 10.1111/ene.15958
895 Chen A, Sun Y, Lei Y, Li C, Liao S, Meng J, Bai Y, Liu Z, Liang Z, Zhu Z, Yuan N, Yang H, Wu Z, Lin F, Wang K, Li M, Zhang S, Yang M, Fei T, Zhuang Z, Huang Y, Zhang Y, Xu Y, Cui L, Zhang R, Han L, Sun X, Chen B, Li W, Huangfu B, Ma K, Ma J, Li Z, Lin Y, Wang H, Zhong Y, Zhang H, Yu Q, Wang Y, Liu X, Peng J, Liu C, Chen W, Pan W, An Y, Xia S, Lu Y, Wang M, Song X, Liu S, Wang Z, Gong C, Huang X, Yuan Y, Zhao Y, Chai Q, Tan X, Liu J, Zheng M, Li S, Huang Y, Hong Y, Huang Z, Li M, Jin M, Li Y, Zhang H, Sun S, Gao L, Bai Y, Cheng M, Hu G, Liu S, Wang B, Xiang B, Li S, Li H, Chen M, Wang S, Li M, Liu W, Liu X, Zhao Q, Lisby M, Wang J, Fang J, Lin Y, Xie Q, Liu Z, He J, Xu H, Huang W, Mulder J, Yang H, Sun Y, Uhlen M, Poo M, Wang J, Yao J, Wei W, Li Y, Shen Z, Liu L, Liu Z, Xu X, Li C.
Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex.
Cell. 2023 186(17):3726-3743.e24.
PubMed: 37442136 DOI: 10.1016/j.cell.2023.06.009
894 Jin H, Zhang C, Zwahlen M, von Feilitzen K, Karlsson M, Shi M, Yuan M, Song X, Li X, Yang H, Turkez H, Fagerberg L, Uhlén M, Mardinoglu A.
Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation.
Nat Commun. 2023 14(1):5417.
PubMed: 37669926 DOI: 10.1038/s41467-023-41132-w
893 Hikmet F, Rassy M, Backman M, Méar L, Mattsson JSM, Djureinovic D, Botling J, Brunnström H, Micke P, Lindskog C.
Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer.
Mol Oncol. 2023 17(12):2603-2617.
PubMed: 37341056 DOI: 10.1002/1878-0261.13474
892 Dénes A, Bontell TO, Barchéus H, Vega SF, Carén H, Lindskog C, Jakola AS, Smits A.
The clinical value of proneural, classical and mesenchymal protein signatures in WHO 2021 adult-type diffuse lower-grade gliomas.
PLoS One. 2023 18(5):e0285732.
PubMed: 37192181 DOI: 10.1371/journal.pone.0285732
891 Sountoulidis A, Marco Salas S, Braun E, Avenel C, Bergenstråhle J, Theelke J, Vicari M, Czarnewski P, Liontos A, Abalo X, Andrusivová Ž, Mirzazadeh R, Asp M, Li X, Hu L, Sariyar S, Martinez Casals A, Ayoglu B, Firsova A, Michaëlsson J, Lundberg E, Wählby C, Sundström E, Linnarsson S, Lundeberg J, Nilsson M, Samakovlis C.
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung.
Nat Cell Biol. 2023 25(2):351-365.
PubMed: 36646791 DOI: 10.1038/s41556-022-01064-x
890 Rossi R, Johansson C, Heywood W, Vinette H, Jensen G, Tegel H, Jiménez-Requena A, Torelli S, Al-Khalili Szigyarto C, Ferlini A.
A Proof of Principle Proteomic Study Detects Dystrophin in Human Plasma: Implications in DMD Diagnosis and Clinical Monitoring.
Int J Mol Sci. 2023 24(6):.
PubMed: 36982290 DOI: 10.3390/ijms24065215
889 Hober A, Rekanovic M, Forsström B, Hansson S, Kotol D, Percy AJ, Uhlén M, Oscarsson J, Edfors F, Miliotis T.
Targeted proteomics using stable isotope labeled protein fragments enables precise and robust determination of total apolipoprotein(a) in human plasma.
PLoS One. 2023 18(2):e0281772.
PubMed: 36791076 DOI: 10.1371/journal.pone.0281772
888 Edfeldt G, Kaldhusdal V, Czarnewski P, Bradley F, Bergström S, Lajoie J, Xu J, Månberg A, Kimani J, Oyugi J, Nilsson P, Tjernlund A, Fowke KR, Kwon DS, Broliden K.
Distinct cervical tissue-adherent and luminal microbiome communities correlate with mucosal host gene expression and protein levels in Kenyan sex workers.
Microbiome. 2023 11(1):67.
PubMed: 37004130 DOI: 10.1186/s40168-023-01502-4
887 Geroldinger-Simić M, Bayati S, Pohjanen E, Sepp N, Nilsson P, Pin E.
Autoantibodies against PIP4K2B and AKT3 Are Associated with Skin and Lung Fibrosis in Patients with Systemic Sclerosis.
Int J Mol Sci. 2023 24(6):.
PubMed: 36982700 DOI: 10.3390/ijms24065629
886 Hauser J, Dale M, Beck O, Schwenk JM, Stemme G, Fredolini C, Roxhed N.
Microfluidic Device for Patient-Centric Multiplexed Assays with Readout in Centralized Laboratories.
Anal Chem. 2023 95(2):1350-1358.
PubMed: 36548393 DOI: 10.1021/acs.analchem.2c04318
885 Allesøe RL, Lundgaard AT, Hernández Medina R, Aguayo-Orozco A, Johansen J, Nissen JN, Brorsson C, Mazzoni G, Niu L, Biel JH, Leal Rodríguez C, Brasas V, Webel H, Benros ME, Pedersen AG, Chmura PJ, Jacobsen UP, Mari A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Hong MG, Musholt PB, De Masi F, Vogt J, Pedersen HK, Gudmundsdottir V, Jones A, Kennedy G, Bell J, Thomas EL, Frost G, Thomsen H, Hansen E, Hansen TH, Vestergaard H, Muilwijk M, Blom MT, 't Hart LM, Pattou F, Raverdy V, Brage S, Kokkola T, Heggie A, McEvoy D, Mourby M, Kaye J, Hattersley A, McDonald T, Ridderstråle M, Walker M, Forgie I, Giordano GN, Pavo I, Ruetten H, Pedersen O, Hansen T, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, McCarthy MI, Pearson E, Banasik K, Rasmussen S, Brunak S, IMI DIRECT Consortium.
Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
Nat Biotechnol. 2023 41(3):399-408.
PubMed: 36593394 DOI: 10.1038/s41587-022-01520-x
884 Ribet F, Bendes A, Fredolini C, Dobielewski M, Böttcher M, Beck O, Schwenk JM, Stemme G, Roxhed N.
Microneedle Patch for Painless Intradermal Collection of Interstitial Fluid Enabling Multianalyte Measurement of Small Molecules, SARS-CoV-2 Antibodies, and Protein Profiling.
Adv Healthc Mater. 2023 12(13):e2202564.
PubMed: 36748807 DOI: 10.1002/adhm.202202564
883 Kotliar IB, Lorenzen E, Schwenk JM, Hay DL, Sakmar TP.
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins.
Pharmacol Rev. 2023 75(1):1-34.
PubMed: 36757898 DOI: 10.1124/pharmrev.120.000180
882 Kotliar IB, Ceraudo E, Kemelmakher-Liben K, Oren DA, Lorenzen E, Dodig-Crnković T, Horioka-Duplix M, Huber T, Schwenk JM, Sakmar TP.
Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins.
J Biol Chem. 2023 299(5):104664.
PubMed: 37003505 DOI: 10.1016/j.jbc.2023.104664
881 Zenlander R, Fredolini C, Schwenk JM, Rydén I, Påhlsson P, Löwbeer C, Eggertsen G, Stål P.
A wide scan of plasma proteins demonstrates thioredoxin reductase 1 as a potential new diagnostic biomarker for hepatocellular carcinoma.
Scand J Gastroenterol. 2023 ():1-11.
PubMed: 37017178 DOI: 10.1080/00365521.2023.2194008
880 Sendic S, Mansouri L, Hong MG, Schwenk JM, Eriksson MJ, Hylander B, Lundahl J, Jacobson SH.
Soluble CD14 and osteoprotegerin associate with ankle-brachial index as a measure of arterial stiffness in patients with mild to moderate chronic kidney disease in a five-year prospective study.
Cardiorenal Med. 2023 ():1.
PubMed: 37231818 DOI: 10.1159/000530985
879 Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral-Pointner JB, Hong MG, Suchon P, Germain M, Schottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmström M, Magnusson M, Silveira A, Uhlén M, Renné T, Martinez-Perez A, Emmerich J, Deleuze JF, Antovic J, Soria Fernandez JM, Assinger A, Schwenk JM, Souto Andres JC, Morange PE, Butler LM, Trégouët DA, Odeberg J.
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
Nat Commun. 2023 14(1):3280.
PubMed: 37286573 DOI: 10.1038/s41467-023-38383-y
878 Dahl L, Kotliar IB, Bendes A, Dodig-Crnković T, Fromm S, Elofsson A, Uhlén M, Sakmar TP, Schwenk JM.
Multiplexed selectivity screening of anti-GPCR antibodies.
Sci Adv. 2023 9(18):eadf9297.
PubMed: 37134173 DOI: 10.1126/sciadv.adf9297
877 Digre A, Lindskog C.
The human protein atlas-Integrated omics for single cell mapping of the human proteome.
Protein Sci. 2023 32(2):e4562.
PubMed: 36604173 DOI: 10.1002/pro.4562
876 Battisti UM, Gao C, Nilsson O, Akladios F, Lulla A, Bogucka A, Nain-Perez A, Håversen L, Kim W, Boren J, Hyvönen M, Uhlen M, Mardinoglu A, Grøtli M.
Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase.
Chembiochem. 2023 24(1):e202200339.
PubMed: 36250581 DOI: 10.1002/cbic.202200339
875 Battisti UM, Gao C, Akladios F, Kim W, Yang H, Bayram C, Bolat I, Kiliclioglu M, Yuksel N, Tozlu OO, Zhang C, Sebhaoui J, Iqbal S, Shoaie S, Hacimuftuoglu A, Yildirim S, Turkez H, Uhlen M, Boren J, Mardinoglu A, Grøtli M.
Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase.
Nutrients. 2023 15(3):.
PubMed: 36771285 DOI: 10.3390/nu15030577
874 Turkez H, Altay O, Yildirim S, Li X, Yang H, Bayram C, Bolat I, Oner S, Tozlu OO, Arslan ME, Arif M, Yulug B, Hanoglu L, Cankaya S, Lam S, Velioglu HA, Coskun E, Idil E, Nogaylar R, Ozsimsek A, Hacimuftuoglu A, Shoaie S, Zhang C, Nielsen J, Borén J, Uhlén M, Mardinoglu A.
Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases.
Life Sci. 2023 314():121325.
PubMed: 36581096 DOI: 10.1016/j.lfs.2022.121325
873 Arslan ME, Türkez H, Sevim Y, Selvitopi H, Kadi A, Öner S, Mardinoğlu A.
Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson's Disease Model.
Cells. 2023 12(7):.
PubMed: 37048065 DOI: 10.3390/cells12070992
872 Rutten MGS, Lei Y, Hoogerland JH, Bloks VW, Yang H, Bos T, Krishnamurthy KA, Bleeker A, Koster MH, Thomas RE, Wolters JC, van den Bos H, Mithieux G, Rajas F, Mardinoglu A, Spierings DCJ, de Bruin A, van de Sluis B, Oosterveer MH.
Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia.
Cancer Metab. 2023 11(1):5.
PubMed: 37085901 DOI: 10.1186/s40170-023-00305-3
871 Battisti UM, Monjas L, Akladios F, Matic J, Andresen E, Nagel CH, Hagkvist M, Håversen L, Kim W, Uhlen M, Borén J, Mardinoğlu A, Grøtli M.
Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase.
Pharmaceuticals (Basel). 2023 16(5):.
PubMed: 37242451 DOI: 10.3390/ph16050668
870 Graves OK, Kim W, Özcan M, Ashraf S, Turkez H, Yuan M, Zhang C, Mardinoglu A, Li X.
Discovery of drug targets and therapeutic agents based on drug repositioning to treat lung adenocarcinoma.
Biomed Pharmacother. 2023 161():114486.
PubMed: 36906970 DOI: 10.1016/j.biopha.2023.114486
869 Bayraktar A, Li X, Kim W, Zhang C, Turkez H, Shoaie S, Mardinoglu A.
Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients.
J Transl Med. 2023 21(1):332.
PubMed: 37210557 DOI: 10.1186/s12967-023-04192-6
868 Yang H, Li X, Jin H, Turkez H, Ozturk G, Doganay HL, Zhang C, Nielsen J, Uhlén M, Borén J, Mardinoglu A.
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators.
Free Radic Biol Med. 2023 204():347-358.
PubMed: 37245532 DOI: 10.1016/j.freeradbiomed.2023.05.013
867 Li X, Yang H, Jin H, Turkez H, Ozturk G, Doganay HL, Zhang C, Nielsen J, Uhlén M, Borén J, Mardinoglu A.
The acute effect of different NAD precursors included in the combined metabolic activators.
Free Radic Biol Med. 2023 205():77-89.
PubMed: 37271226 DOI: 10.1016/j.freeradbiomed.2023.05.032
866 Yulug B, Altay O, Li X, Hanoglu L, Cankaya S, Lam S, Velioglu HA, Yang H, Coskun E, Idil E, Nogaylar R, Ozsimsek A, Bayram C, Bolat I, Oner S, Tozlu OO, Arslan ME, Hacimuftuoglu A, Yildirim S, Arif M, Shoaie S, Zhang C, Nielsen J, Turkez H, Borén J, Uhlén M, Mardinoglu A.
Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial.
Transl Neurodegener. 2023 12(1):4.
PubMed: 36703196 DOI: 10.1186/s40035-023-00336-2
865 Omenn GS, Lane L, Overall CM, Pineau C, Packer NH, Cristea IM, Lindskog C, Weintraub ST, Orchard S, Roehrl MHA, Nice E, Liu S, Bandeira N, Chen YJ, Guo T, Aebersold R, Moritz RL, Deutsch EW.
The 2022 Report on the Human Proteome from the HUPO Human Proteome Project.
J Proteome Res. 2023 22(4):1024-1042.
PubMed: 36318223 DOI: 10.1021/acs.jproteome.2c00498
864 Méar L, Sutantiwanichkul T, Östman J, Damdimopoulou P, Lindskog C.
Spatial Proteomics for Further Exploration of Missing Proteins: A Case Study of the Ovary.
J Proteome Res. 2023 22(4):1071-1079.
PubMed: 36108145 DOI: 10.1021/acs.jproteome.2c00392
863 Gilvesy A, Husen E, Magloczky Z, Mihaly O, Hortobágyi T, Kanatani S, Heinsen H, Renier N, Hökfelt T, Mulder J, Uhlen M, Kovacs GG, Adori C.
Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus-pericoerulear complex by three-dimensional imaging.
Acta Neuropathol. 2022 144(4):651-676.
PubMed: 36040521 DOI: 10.1007/s00401-022-02477-6
862 Kovács T, Szinyákovics J, Billes V, Murányi G, Varga VB, Bjelik A, Légrádi Á, Szabó M, Sándor S, Kubinyi E, Szekeres-Paracky C, Szocsics P, Lőke J, Mulder J, Gulyás B, Renner É, Palkovits M, Gulya K, Maglóczky Z, Vellai T.
A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging.
Sci Rep. 2022 12(1):21817.
PubMed: 36528685 DOI: 10.1038/s41598-022-24843-w
861 Arslan ME, Tatar A, Yıldırım ÖÇ, Şahin İO, Ozdemir O, Sonmez E, Hacımuftuoglu A, Acikyildiz M, Geyikoğlu F, Mardinoğlu A, Türkez H.
In Vitro Transcriptome Analysis of Cobalt Boride Nanoparticles on Human Pulmonary Alveolar Cells.
Materials (Basel). 2022 15(23):.
PubMed: 36500178 DOI: 10.3390/ma15238683
860 Türkez H, Yıldırım ÖÇ, Öner S, Kadı A, Mete A, Arslan ME, Şahin İO, Yapça ÖE, Mardinoğlu A.
Lipoic Acid Conjugated Boron Hybrids Enhance Wound Healing and Antimicrobial Processes.
Pharmaceutics. 2022 15(1):.
PubMed: 36678778 DOI: 10.3390/pharmaceutics15010149
859 Liu Z, Xu J, Que S, Geng L, Zhou L, Mardinoglu A, Zheng S.
Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation.
J Clin Transl Hepatol. 2022 10(2):363-373.
PubMed: 35528975 DOI: 10.14218/JCTH.2021.00219
858 Nain-Perez A, Foller Füchtbauer A, Håversen L, Lulla A, Gao C, Matic J, Monjas L, Rodríguez A, Brear P, Kim W, Hyvönen M, Borén J, Mardinoglu A, Uhlen M, Grøtli M.
Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.
Eur J Med Chem. 2022 234():114270.
PubMed: 35290845 DOI: 10.1016/j.ejmech.2022.114270
857 Kori M, Arga KY, Mardinoglu A, Turanli B.
Repositioning of Anti-Inflammatory Drugs for the Treatment of Cervical Cancer Sub-Types.
Front Pharmacol. 2022 13():884548.
PubMed: 35770086 DOI: 10.3389/fphar.2022.884548
856 Emanuelsson EB, Berry DB, Reitzner SM, Arif M, Mardinoglu A, Gustafsson T, Ward SR, Sundberg CJ, Chapman MA.
MRI characterization of skeletal muscle size and fatty infiltration in long-term trained and untrained individuals.
Physiol Rep. 2022 10(14):e15398.
PubMed: 35854646 DOI: 10.14814/phy2.15398
855 Yıldırım ÖÇ, Arslan ME, Öner S, Cacciatore I, Di Stefano A, Mardinoglu A, Turkez H.
Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer's Disease Treatment.
Int J Mol Sci. 2022 23(15):.
PubMed: 35897815 DOI: 10.3390/ijms23158249
854 Turkez H, Yıldırım S, Sahin E, Arslan ME, Emsen B, Tozlu OO, Alak G, Ucar A, Tatar A, Hacimuftuoglu A, Keles MS, Geyikoglu F, Atamanalp M, Saruhan F, Mardinoglu A.
Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study.
Toxics. 2022 10(8):.
PubMed: 36006107 DOI: 10.3390/toxics10080428
853 Baboota RK, Rawshani A, Bonnet L, Li X, Yang H, Mardinoglu A, Tchkonia T, Kirkland JL, Hoffmann A, Dietrich A, Boucher J, Blüher M, Smith U.
BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH.
Nat Metab. 2022 4(8):1007-1021.
PubMed: 35995996 DOI: 10.1038/s42255-022-00620-x
852 Aydin N, Turkez H, Tozlu OO, Arslan ME, Yavuz M, Sonmez E, Ozpolat OF, Cacciatore I, Di Stefano A, Mardinoglu A.
Ameliorative Effects by Hexagonal Boron Nitride Nanoparticles against Beta Amyloid Induced Neurotoxicity.
Nanomaterials (Basel). 2022 12(15):.
PubMed: 35957121 DOI: 10.3390/nano12152690
851 Tozlu ÖÖ, Türkez H, Okkay U, Ceylan O, Bayram C, Hacımüftüoğlu A, Mardinoğlu A.
Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer's disease: and studies.
Front Nutr. 2022 9():981889.
PubMed: 36159454 DOI: 10.3389/fnut.2022.981889
850 Zhang C, Shi M, Kim W, Arif M, Klevstig M, Li X, Yang H, Bayram C, Bolat I, Tozlu ÖÖ, Hacımuftuoglu A, Yıldırım S, Sebhaoui J, Iqbal S, Wei Y, Shi X, Nielsen J, Turkez H, Uhlen M, Boren J, Mardinoglu A.
Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning.
EBioMedicine. 2022 83():104214.
PubMed: 35988463 DOI: 10.1016/j.ebiom.2022.104214
849 Turkez H, Arslan ME, Barboza JN, Kahraman CY, de Sousa DP, Mardinoğlu A.
Therapeutic Potential of Ferulic Acid in Alzheimer's Disease.
Curr Drug Deliv. 2022 19(8):860-873.
PubMed: 34963433 DOI: 10.2174/1567201819666211228153801
848 Baboota RK, Spinelli R, Erlandsson MC, Brandao BB, Lino M, Yang H, Mardinoglu A, Bokarewa MI, Boucher J, Kahn CR, Smith U.
Chronic hyperinsulinemia promotes human hepatocyte senescence.
Mol Metab. 2022 64():101558.
PubMed: 35872305 DOI: 10.1016/j.molmet.2022.101558
847 Turkez H, Ozdemir Tozlu O, Tatar A, Arslan ME, Cadirci K, Marinelli L, Yapca OE, Cacciatore I, Di Stefano A, Mardinoglu A.
Toxicity of Glycyl-l-Prolyl-l-Glutamate Pseudotripeptides: Cytotoxic, Oxidative, Genotoxic, and Embryotoxic Perspectives.
J Toxicol. 2022 2022():3775194.
PubMed: 36444193 DOI: 10.1155/2022/3775194
846 Cornacchia C, Marinelli L, Di Rienzo A, Dimmito MP, Serra F, Di Biase G, De Filippis B, Turkez H, Mardinoglu A, Bellezza I, Di Stefano A, Cacciatore I.
Development of l-Dopa-containing diketopiperazines as blood-brain barrier shuttle.
Eur J Med Chem. 2022 243():114746.
PubMed: 36099749 DOI: 10.1016/j.ejmech.2022.114746
845 Smati S, Polizzi A, Fougerat A, Ellero-Simatos S, Blum Y, Lippi Y, Régnier M, Laroyenne A, Huillet M, Arif M, Zhang C, Lasserre F, Marrot A, Al Saati T, Wan J, Sommer C, Naylies C, Batut A, Lukowicz C, Fougeray T, Tramunt B, Dubot P, Smith L, Bertrand-Michel J, Hennuyer N, Pradere JP, Staels B, Burcelin R, Lenfant F, Arnal JF, Levade T, Gamet-Payrastre L, Lagarrigue S, Loiseau N, Lotersztajn S, Postic C, Wahli W, Bureau C, Guillaume M, Mardinoglu A, Montagner A, Gourdy P, Guillou H.
Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.
Gut. 2022 71(4):807-821.
PubMed: 33903148 DOI: 10.1136/gutjnl-2020-323323
844 Sparreman Mikus M, Kolmert J, Andersson LI, Östling J, Knowles RG, Gómez C, Ericsson M, Thörngren JO, Emami Khoonsari P, Dahlén B, Kupczyk M, De Meulder B, Auffray C, Bakke PS, Beghe B, Bel EH, Caruso M, Chanez P, Chawes B, Fowler SJ, Gaga M, Geiser T, Gjomarkaj M, Horváth I, Howarth PH, Johnston SL, Joos G, Krug N, Montuschi P, Musial J, Niżankowska-Mogilnicka E, Olsson HK, Papi A, Rabe KF, Sandström T, Shaw DE, Siafakas NM, Uhlén M, Riley JH, Bates S, Middelveld RJM, Wheelock CE, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Nilsson P, Dahlén SE, James A, U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group and the BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium.
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation.
Eur Respir J. 2022 59(2):.
PubMed: 34737220 DOI: 10.1183/13993003.00142-2021
843 Blixt L, Bogdanovic G, Buggert M, Gao Y, Hober S, Healy K, Johansson H, Kjellander C, Mravinacova S, Muschiol S, Nilsson P, Palma M, Pin E, Smith CIE, Stromberg O, Sällberg Chen M, Zain R, Hansson L, Österborg A.
Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients.
Leukemia. 2022 36(2):476-481.
PubMed: 34564699 DOI: 10.1038/s41375-021-01424-w
842 Havervall S, Ng H, Jernbom Falk A, Greilert-Norin N, Månberg A, Marking U, Laurén I, Gabrielsson L, Salomonsson AC, Aguilera K, Kihlgren M, Månsson M, Rosell A, Hellström C, Andersson E, Olofsson J, Skoglund L, Yousef J, Pin E, Lord M, Åberg M, Hedhammar M, Tegel H, Dönnes P, Phillipson M, Nilsson P, Klingström J, Mangsbo S, Hober S, Thålin C.
Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19.
J Intern Med. 2022 291(1):72-80.
PubMed: 34459525 DOI: 10.1111/joim.13387
841 Asplund Högelin K, Ruffin N, Pin E, Hober S, Nilsson P, Starvaggi Cucuzza C, Khademi M, Olsson T, Piehl F, Al Nimer F.
B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patients.
Eur J Neurol. 2022 29(11):3317-3328.
PubMed: 35808856 DOI: 10.1111/ene.15492
840 Moffitt JR, Lundberg E, Heyn H.
The emerging landscape of spatial profiling technologies.
Nat Rev Genet. 2022 23(12):741-759.
PubMed: 35859028 DOI: 10.1038/s41576-022-00515-3
839 Blixt L, Gao Y, Wullimann D, Murén Ingelman-Sundberg H, Muschiol S, Healy K, Bogdanovic G, Pin E, Nilsson P, Kjellander C, Grifoni A, Sette A, Sällberg Chen M, Ljunggren HG, Buggert M, Hansson L, Österborg A.
Hybrid immunity in immunocompromised patients with CLL after SARS-CoV-2 infection followed by booster mRNA vaccination.
Blood. 2022 140(22):2403-2407.
PubMed: 36150168 DOI: 10.1182/blood.2022016815
838 Yu X, Schwenk JM, Xu P, LaBaer J.
Advances in plasma proteomics: Moving from technology to precision medicine.
Proteomics Clin Appl. 2022 16(6):e2200083.
PubMed: 36377435 DOI: 10.1002/prca.202200083
837 Havervall S, Marking U, Svensson J, Greilert-Norin N, Bacchus P, Nilsson P, Hober S, Gordon M, Blom K, Klingström J, Åberg M, Smed-Sörensen A, Thålin C.
Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection.
N Engl J Med. 2022 387(14):1333-1336.
PubMed: 36103621 DOI: 10.1056/NEJMc2209651
836 Gurke R, Bendes A, Bowes J, Koehm M, Twyman RM, Barton A, Elewaut D, Goodyear C, Hahnefeld L, Hillenbrand R, Hunter E, Ibberson M, Ioannidis V, Kugler S, Lories RJ, Resch E, Rüping S, Scholich K, Schwenk JM, Waddington JC, Whitfield P, Geisslinger G, FitzGerald O, Behrens F, Pennington SR, HIPPOCRATES Consortium.
Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis.
Biomedicines. 2022 10(10):.
PubMed: 36289648 DOI: 10.3390/biomedicines10102387
835 Gyllensten U, Hedlund-Lindberg J, Svensson J, Manninen J, Öst T, Ramsell J, Åslin M, Ivansson E, Lomnytska M, Lycke M, Axelsson T, Liljedahl U, Nordlund J, Edqvist PH, Sjöblom T, Uhlén M, Stålberg K, Sundfeldt K, Åberg M, Enroth S.
Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.
Cancers (Basel). 2022 14(7):.
PubMed: 35406529 DOI: 10.3390/cancers14071757
834 Malm M, Kuo CC, Barzadd MM, Mebrahtu A, Wistbacka N, Razavi R, Volk AL, Lundqvist M, Kotol D, Tegel H, Hober S, Edfors F, Gräslund T, Chotteau V, Field R, Varley PG, Roth RG, Lewis NE, Hatton D, Rockberg J.
Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins.
Metab Eng. 2022 72():171-187.
PubMed: 35301123 DOI: 10.1016/j.ymben.2022.03.009
833 Danielsson H, Tebani A, Zhong W, Fagerberg L, Brusselaers N, Hård AL, Uhlén M, Hellström A.
Blood protein profiles related to preterm birth and retinopathy of prematurity.
Pediatr Res. 2022 91(4):937-946.
PubMed: 33895781 DOI: 10.1038/s41390-021-01528-0
832 Li X, Shong K, Kim W, Yuan M, Yang H, Sato Y, Kume H, Ogawa S, Turkez H, Shoaie S, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A.
Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach.
EBioMedicine. 2022 78():103963.
PubMed: 35339898 DOI: 10.1016/j.ebiom.2022.103963
831 Bergman-Larsson J, Gustafsson S, Méar L, Huvila J, Tolf A, Olovsson M, Pontén F, Edqvist PD.
Combined expression of HOXA11 and CD10 identifies endometriosis versus normal tissue and tumors.
Ann Diagn Pathol. 2022 56():151870.
PubMed: 34844098 DOI: 10.1016/j.anndiagpath.2021.151870
830 Karlsson M, Sjöstedt E, Oksvold P, Sivertsson Å, Huang J, Álvez MB, Arif M, Li X, Lin L, Yu J, Ma T, Xu F, Han P, Jiang H, Mardinoglu A, Zhang C, von Feilitzen K, Xu X, Wang J, Yang H, Bolund L, Zhong W, Fagerberg L, Lindskog C, Pontén F, Mulder J, Luo Y, Uhlen M.
Genome-wide annotation of protein-coding genes in pig.
BMC Biol. 2022 20(1):25.
PubMed: 35073880 DOI: 10.1186/s12915-022-01229-y
829 Birgersson M, Katona B, Lindskog C, Pontén F, Williams C.
Antibody Validation for Estrogen Receptor Beta.
Methods Mol Biol. 2022 2418():1-23.
PubMed: 35119656 DOI: 10.1007/978-1-0716-1920-9_1
828 Vessby J, Wisniewski JR, Lindskog C, Eriksson N, Gabrysch K, Zettl K, Wanders A, Carlson M, Rorsman F, Åberg M.
AGPAT1 as a Novel Colonic Biomarker for Discriminating Between Ulcerative Colitis With and Without Primary Sclerosing Cholangitis.
Clin Transl Gastroenterol. 2022 13(5):e00486.
PubMed: 35363634 DOI: 10.14309/ctg.0000000000000486
827 Abdulla M, Hollander P, Lindskog C, Sundström C, Enblad G, Saft L, Amini RM.
Outcome in PCNSL patients and its association with PD-L1+ leukocytes in the tumor microenvironment.
Acta Oncol. 2022 61(7):824-829.
PubMed: 35621149 DOI: 10.1080/0284186X.2022.2075239
826 Corell A, Gómez Vecchio T, Ferreyra Vega S, Dénes A, Neimantaite A, Hagerius A, Barchéus H, Solheim O, Lindskog C, Bontell TO, Carén H, Jakola AS, Smits A.
Stemness and clinical features in relation to the subventricular zone in diffuse lower-grade glioma: an exploratory study.
Neurooncol Adv. 2022 4(1):vdac074.
PubMed: 35795469 DOI: 10.1093/noajnl/vdac074
825 Norreen-Thorsen M, Struck EC, Öling S, Zwahlen M, Von Feilitzen K, Odeberg J, Lindskog C, Pontén F, Uhlén M, Dusart PJ, Butler LM.
A human adipose tissue cell-type transcriptome atlas.
Cell Rep. 2022 40(2):111046.
PubMed: 35830816 DOI: 10.1016/j.celrep.2022.111046
824 Lindskog C, Méar L, Virhammar J, Fällmar D, Kumlien E, Hesselager G, Casar-Borota O, Rostami E.
Protein Expression Profile of ACE2 in the Normal and COVID-19-Affected Human Brain.
J Proteome Res. 2022 21(9):2137-2145.
PubMed: 35901083 DOI: 10.1021/acs.jproteome.2c00184
823 Yuan M, Shong K, Li X, Ashraf S, Shi M, Kim W, Nielsen J, Turkez H, Shoaie S, Uhlen M, Zhang C, Mardinoglu A.
A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma.
Cancers (Basel). 2022 14(6):.
PubMed: 35326724 DOI: 10.3390/cancers14061573
822 Edfors F, Iglesias MJ, Butler LM, Odeberg J.
Proteomics in thrombosis research.
Res Pract Thromb Haemost. 2022 6(3):e12706.
PubMed: 35494505 DOI: 10.1002/rth2.12706
821 Ambikan AT, Yang H, Krishnan S, Svensson Akusjärvi S, Gupta S, Lourda M, Sperk M, Arif M, Zhang C, Nordqvist H, Ponnan SM, Sönnerborg A, Treutiger CJ, O'Mahony L, Mardinoglu A, Benfeitas R, Neogi U.
Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity.
Cell Syst. 2022 13(8):665-681.e4.
PubMed: 35933992 DOI: 10.1016/j.cels.2022.06.006
820 Hickey JW, Neumann EK, Radtke AJ, Camarillo JM, Beuschel RT, Albanese A, McDonough E, Hatler J, Wiblin AE, Fisher J, Croteau J, Small EC, Sood A, Caprioli RM, Angelo RM, Nolan GP, Chung K, Hewitt SM, Germain RN, Spraggins JM, Lundberg E, Snyder MP, Kelleher NL, Saka SK.
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging.
Nat Methods. 2022 19(3):284-295.
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819 Bagheri N, Carpenter AE, Lundberg E, Plant AL, Horwitz R.
The new era of quantitative cell imaging-challenges and opportunities.
Mol Cell. 2022 82(2):241-247.
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818 Melani RD, Gerbasi VR, Anderson LC, Sikora JW, Toby TK, Hutton JE, Butcher DS, Negrão F, Seckler HS, Srzentić K, Fornelli L, Camarillo JM, LeDuc RD, Cesnik AJ, Lundberg E, Greer JB, Fellers RT, Robey MT, DeHart CJ, Forte E, Hendrickson CL, Abbatiello SE, Thomas PM, Kokaji AI, Levitsky J, Kelleher NL.
The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells.
Science. 2022 375(6579):411-418.
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817 Kustatscher G, Collins T, Gingras AC, Guo T, Hermjakob H, Ideker T, Lilley KS, Lundberg E, Marcotte EM, Ralser M, Rappsilber J.
An open invitation to the Understudied Proteins Initiative.
Nat Biotechnol. 2022 40(6):815-817.
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816 Mund A, Coscia F, Kriston A, Hollandi R, Kovács F, Brunner AD, Migh E, Schweizer L, Santos A, Bzorek M, Naimy S, Rahbek-Gjerdrum LM, Dyring-Andersen B, Bulkescher J, Lukas C, Eckert MA, Lengyel E, Gnann C, Lundberg E, Horvath P, Mann M.
Deep Visual Proteomics defines single-cell identity and heterogeneity.
Nat Biotechnol. 2022 40(8):1231-1240.
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815 Burnum-Johnson KE, Conrads TP, Drake RR, Herr AE, Iyengar R, Kelly RT, Lundberg E, MacCoss MJ, Naba A, Nolan GP, Pevzner PA, Rodland KD, Sechi S, Slavov N, Spraggins JM, Van Eyk JE, Vidal M, Vogel C, Walt DR, Kelleher NL.
New Views of Old Proteins: Clarifying the Enigmatic Proteome.
Mol Cell Proteomics. 2022 21(7):100254.
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814 Andrews B, Chang JB, Collinson L, Li D, Lundberg E, Mahamid J, Manley S, Mhlanga M, Nakano A, Schöneberg J, Van Valen D, Wu T', Zaritsky A.
Imaging cell biology.
Nat Cell Biol. 2022 24(8):1180-1185.
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813 Le T, Winsnes CF, Axelsson U, Xu H, Mohanakrishnan Kaimal J, Mahdessian D, Dai S, Makarov IS, Ostankovich V, Xu Y, Benhamou E, Henkel C, Solovyev RA, Banić N, Bošnjak V, Bošnjak A, Miličević A, Ouyang W, Lundberg E.
Analysis of the Human Protein Atlas Weakly Supervised Single-Cell Classification competition.
Nat Methods. 2022 19(10):1221-1229.
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812 Han L, Wei X, Liu C, Volpe G, Zhuang Z, Zou X, Wang Z, Pan T, Yuan Y, Zhang X, Fan P, Guo P, Lai Y, Lei Y, Liu X, Yu F, Shangguan S, Lai G, Deng Q, Liu Y, Wu L, Shi Q, Yu H, Huang Y, Cheng M, Xu J, Liu Y, Wang M, Wang C, Zhang Y, Xie D, Yang Y, Yu Y, Zheng H, Wei Y, Huang F, Lei J, Huang W, Zhu Z, Lu H, Wang B, Wei X, Chen F, Yang T, Du W, Chen J, Xu S, An J, Ward C, Wang Z, Pei Z, Wong CW, Liu X, Zhang H, Liu M, Qin B, Schambach A, Isern J, Feng L, Liu Y, Guo X, Liu Z, Sun Q, Maxwell PH, Barker N, Muñoz-Cánoves P, Gu Y, Mulder J, Uhlen M, Tan T, Liu S, Yang H, Wang J, Hou Y, Xu X, Esteban MA, Liu L.
Cell transcriptomic atlas of the non-human primate Macaca fascicularis.
Nature. 2022 604(7907):723-731.
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811 Chen A, Liao S, Cheng M, Ma K, Wu L, Lai Y, Qiu X, Yang J, Xu J, Hao S, Wang X, Lu H, Chen X, Liu X, Huang X, Li Z, Hong Y, Jiang Y, Peng J, Liu S, Shen M, Liu C, Li Q, Yuan Y, Wei X, Zheng H, Feng W, Wang Z, Liu Y, Wang Z, Yang Y, Xiang H, Han L, Qin B, Guo P, Lai G, Muñoz-Cánoves P, Maxwell PH, Thiery JP, Wu QF, Zhao F, Chen B, Li M, Dai X, Wang S, Kuang H, Hui J, Wang L, Fei JF, Wang O, Wei X, Lu H, Wang B, Liu S, Gu Y, Ni M, Zhang W, Mu F, Yin Y, Yang H, Lisby M, Cornall RJ, Mulder J, Uhlén M, Esteban MA, Li Y, Liu L, Xu X, Wang J.
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays.
Cell. 2022 185(10):1777-1792.e21.
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810 Wang F, Ding P, Liang X, Ding X, Brandt CB, Sjöstedt E, Zhu J, Bolund S, Zhang L, de Rooij LPMH, Luo L, Wei Y, Zhao W, Lv Z, Haskó J, Li R, Qin Q, Jia Y, Wu W, Yuan Y, Pu M, Wang H, Wu A, Xie L, Liu P, Chen F, Herold J, Kalucka J, Karlsson M, Zhang X, Helmig RB, Fagerberg L, Lindskog C, Pontén F, Uhlen M, Bolund L, Jessen N, Jiang H, Xu X, Yang H, Carmeliet P, Mulder J, Chen D, Lin L, Luo Y.
Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level.
Nat Commun. 2022 13(1):3620.
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809 Zhong W, Barde S, Mitsios N, Adori C, Oksvold P, Feilitzen KV, O'Leary L, Csiba L, Hortobágyi T, Szocsics P, Mechawar N, Maglóczky Z, Renner É, Palkovits M, Uhlén M, Mulder J, Hökfelt T.
The neuropeptide landscape of human prefrontal cortex.
Proc Natl Acad Sci U S A. 2022 119(33):e2123146119.
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808 Leifsdottir K, Jost K, Siljehav V, Thelin EP, Lassarén P, Nilsson P, Haraldsson Á, Eksborg S, Herlenius E.
The cerebrospinal fluid proteome of preterm infants predicts neurodevelopmental outcome.
Front Pediatr. 2022 10():921444.
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807 Blom K, Marking U, Havervall S, Norin NG, Gordon M, García M, Tecleab T, Christ W, Forsell M, Phillipson M, Nilsson P, Mangsbo S, Hober S, Åberg M, Klingström J, Thålin C.
Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection.
Lancet Infect Dis. 2022 22(7):943-945.
PubMed: 35691303 DOI: 10.1016/S1473-3099(22)00362-0
806 Bradley F, Franzén Boger M, Kaldhusdal V, Åhlberg A, Edfeldt G, Lajoie J, Bergström S, Omollo K, Damdimopoulos A, Czarnewski P, Månberg A, Oyugi J, Kimani J, Nilsson P, Fowke K, Tjernlund A, Broliden K.
Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate.
PLoS Pathog. 2022 18(5):e1010494.
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805 Bronge M, Högelin KA, Thomas OG, Ruhrmann S, Carvalho-Queiroz C, Nilsson OB, Kaiser A, Zeitelhofer M, Holmgren E, Linnerbauer M, Adzemovic MZ, Hellström C, Jelcic I, Liu H, Nilsson P, Hillert J, Brundin L, Fink K, Kockum I, Tengvall K, Martin R, Tegel H, Gräslund T, Al Nimer F, Guerreiro-Cacais AO, Khademi M, Gafvelin G, Olsson T, Grönlund H.
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis.
Sci Adv. 2022 8(17):eabn1823.
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804 Havervall S, Marking U, Greilert-Norin N, Gordon M, Ng H, Christ W, Phillipson M, Nilsson P, Hober S, Blom K, Klingström J, Mangsbo S, Åberg M, Thålin C.
Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time.
Clin Transl Immunology. 2022 11(4):e1388.
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803 Laurén I, Havervall S, Ng H, Lord M, Pettke A, Greilert-Norin N, Gabrielsson L, Chourlia A, Amoêdo-Leite C, Josyula VS, Eltahir M, Kerzeli I, Falk AJ, Hober J, Christ W, Wiberg A, Hedhammar M, Tegel H, Burman J, Xu F, Pin E, Månberg A, Klingström J, Christoffersson G, Hober S, Nilsson P, Philipson M, Dönnes P, Lindsay R, Thålin C, Mangsbo S.
Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology.
Immun Inflamm Dis. 2022 10(4):e595.
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802 Marking U, Havervall S, Greilert-Norin N, Ng H, Blom K, Nilsson P, Phillipson M, Hober S, Nilsson C, Mangsbo S, Christ W, Klingström J, Gordon M, Åberg M, Thålin C.
Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines.
Vaccines (Basel). 2022 10(3):.
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801 Leifsdottir K, Thelin EP, Lassarén P, Siljehav V, Nilsson P, Eksborg S, Herlenius E.
Proteomic profiles in cerebrospinal fluid predicted death and disability in term infants with perinatal asphyxia: A pilot study.
Acta Paediatr. 2022 111(5):961-970.
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800 Healy K, Pin E, Chen P, Söderdahl G, Nowak P, Mielke S, Hansson L, Bergman P, Smith CIE, Ljungman P, Valentini D, Blennow O, Österborg A, Gabarrini G, Al-Manei K, Alkharaan H, Sobkowiak MJ, Yousef J, Mravinacova S, Cuapio A, Xu X, Akber M, Loré K, Hellström C, Muschiol S, Bogdanovic G, Buggert M, Ljunggren HG, Hober S, Nilsson P, Aleman S, Sällberg Chen M.
Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals.
Med (N Y). 2022 3(2):137-153.e3.
PubMed: 35075450 DOI: 10.1016/j.medj.2022.01.001
799 Juanes-Velasco P, Galicia N, Pin E, Jara-Acevedo R, Carabias-Sánchez J, García-Valiente R, Lecrevisse Q, Pedreira CE, Gongora R, Sanchez-Santos JM, Lorenzo-Gil H, Landeira-Viñuela A, Bareke H, Orfao A, Nilsson P, Fuentes M.
Deciphering Biomarkers for Leptomeningeal Metastasis in Malignant Hemopathies (Lymphoma/Leukemia) Patients by Comprehensive Multipronged Proteomics Characterization of Cerebrospinal Fluid.
Cancers (Basel). 2022 14(2):.
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798 Havervall S, Jernbom Falk A, Klingström J, Ng H, Greilert-Norin N, Gabrielsson L, Salomonsson AC, Isaksson E, Rudberg AS, Hellström C, Andersson E, Olofsson J, Skoglund L, Yousef J, Pin E, Christ W, Olausson M, Hedhammar M, Tegel H, Mangsbo S, Phillipson M, Månberg A, Hober S, Nilsson P, Thålin C.
SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection.
PLoS One. 2022 17(1):e0262169.
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797 Marabita F, James T, Karhu A, Virtanen H, Kettunen K, Stenlund H, Boulund F, Hellström C, Neiman M, Mills R, Perheentupa T, Laivuori H, Helkkula P, Byrne M, Jokinen I, Honko H, Kallonen A, Ermes M, Similä H, Lindholm M, Widén E, Ripatti S, Perälä-Heape M, Engstrand L, Nilsson P, Moritz T, Miettinen T, Sallinen R, Kallioniemi O.
Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health.
Cell Syst. 2022 13(3):241-255.e7.
PubMed: 34856119 DOI: 10.1016/j.cels.2021.11.001
796 Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Prehn C, Artati A, Hong MG, Musholt PB, Kurbasic A, De Masi F, Tsirigos K, Pedersen HK, Gudmundsdottir V, Thomas CE, Banasik K, Jennison C, Jones A, Kennedy G, Bell J, Thomas L, Frost G, Thomsen H, Allin K, Hansen TH, Vestergaard H, Hansen T, Rutters F, Elders P, t'Hart L, Bonnefond A, Canouil M, Brage S, Kokkola T, Heggie A, McEvoy D, Hattersley A, McDonald T, Teare H, Ridderstrale M, Walker M, Forgie I, Giordano GN, Froguel P, Pavo I, Ruetten H, Pedersen O, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, Pearson E, McCarthy MI, Brunak S, IMI DIRECT Consortium.
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study.
Cell Rep Med. 2022 3(1):100477.
PubMed: 35106505 DOI: 10.1016/j.xcrm.2021.100477
795 Thomas CE, Dahl L, Byström S, Chen Y, Uhlén M, Mälarstig A, Czene K, Hall P, Schwenk JM, Gabrielson M.
Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer.
Transl Oncol. 2022 17():101339.
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794 Yang Z, Macdonald-Dunlop E, Chen J, Zhai R, Li T, Richmond A, Klarić L, Pirastu N, Ning Z, Zheng C, Wang Y, Huang T, He Y, Guo H, Ying K, Gustafsson S, Prins B, Ramisch A, Dermitzakis ET, Png G, Eriksson N, Haessler J, Hu X, Zanetti D, Boutin T, Hwang SJ, Wheeler E, Pietzner M, Raffield LM, Kalnapenkis A, Peters JE, Viñuela A, Gilly A, Elmståhl S, Dedoussis G, Petrie JR, Polašek O, Folkersen L, Chen Y, Yao C, Võsa U, Pairo-Castineira E, Clohisey S, Bretherick AD, Rawlik K, GenOMICC Consortium†, IMI-DIRECT Consortium†, Esko T, Enroth S, Johansson Å, Gyllensten U, Langenberg C, Levy D, Hayward C, Assimes TL, Kooperberg C, Manichaikul AW, Siegbahn A, Wallentin L, Lind L, Zeggini E, Schwenk JM, Butterworth AS, Michaëlsson K, Pawitan Y, Joshi PK, Baillie JK, Mälarstig A, Reiner AP, Wilson JF, Shen X.
Genetic Landscape of the ACE2 Coronavirus Receptor.
Circulation. 2022 145(18):1398-1411.
PubMed: 35387486 DOI: 10.1161/CIRCULATIONAHA.121.057888
793 Katona B, Lindskog C.
The Human Protein Atlas and Antibody-Based Tissue Profiling in Clinical Proteomics.
Methods Mol Biol. 2022 2420():191-206.
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792 Rossi R, Falzarano MS, Osman H, Armaroli A, Scotton C, Mantuano P, Boccanegra B, Cappellari O, Schwartz E, Yuryev A, Mercuri E, Bertini E, D'Amico A, Mora M, Johansson C, Al-Khalili Szigyarto C, De Luca A, Ferlini A.
Circadian Genes as Exploratory Biomarkers in DMD: Results From Both the Mouse Model and Patients.
Front Physiol. 2021 12():678974.
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791 Signorelli M, Spitali P, Szigyarto CA, MARK-MD Consortium, Tsonaka R.
Penalized regression calibration: A method for the prediction of survival outcomes using complex longitudinal and high-dimensional data.
Stat Med. 2021 40(27):6178-6196.
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790 Farfaras S, Roshani L, Mulder J, Mitsios N, Hallström EK, Kartus JT.
Increased levels of inflammatory markers in the subscapularis tendon and joint capsule in patients with subacromial impingement.
Knee Surg Sports Traumatol Arthrosc. 2021 29(7):2228-2236.
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789 Suhre K, McCarthy MI, Schwenk JM.
Genetics meets proteomics: perspectives for large population-based studies.
Nat Rev Genet. 2021 22(1):19-37.
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788 Andersson L, Cinato M, Mardani I, Miljanovic A, Arif M, Koh A, Lindbom M, Laudette M, Bollano E, Omerovic E, Klevstig M, Henricsson M, Fogelstrand P, Swärd K, Ekstrand M, Levin M, Wikström J, Doran S, Hyötyläinen T, Sinisalu L, Orešič M, Tivesten Å, Adiels M, Bergo MO, Proia R, Mardinoglu A, Jeppsson A, Borén J, Levin MC.
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking.
Eur Heart J. 2021 42(43):4481-4492.
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787 Deutsch EW, Omenn GS, Sun Z, Maes M, Pernemalm M, Palaniappan KK, Letunica N, Vandenbrouck Y, Brun V, Tao SC, Yu X, Geyer PE, Ignjatovic V, Moritz RL, Schwenk JM.
Advances and Utility of the Human Plasma Proteome.
J Proteome Res. 2021 20(12):5241-5263.
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786 Papoutsoglou P, Rodrigues-Junior DM, Morén A, Bergman A, Pontén F, Coulouarn C, Caja L, Heldin CH, Moustakas A.
The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling.
Oncogene. 2021 40(21):3748-3765.
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785 Alhaidan Y, Christesen HT, Lundberg E, Balwi MAA, Brusgaard K.
CRISPR/Cas9 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion.
Front Endocrinol (Lausanne). 2021 12():657873.
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784 Bayraktar A, Lam S, Altay O, Li X, Yuan M, Zhang C, Arif M, Turkez H, Uhlén M, Shoaie S, Mardinoglu A.
Revealing the Molecular Mechanisms of Alzheimer's Disease Based on Network Analysis.
Int J Mol Sci. 2021 22(21):.
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783 Kaynar A, Altay O, Li X, Zhang C, Turkez H, Uhlén M, Shoaie S, Mardinoglu A.
Systems Biology Approaches to Decipher the Underlying Molecular Mechanisms of Glioblastoma Multiforme.
Int J Mol Sci. 2021 22(24):.
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782 Yang H, Arif M, Yuan M, Li X, Shong K, Türkez H, Nielsen J, Uhlén M, Borén J, Zhang C, Mardinoglu A.
A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease.
iScience. 2021 24(11):103222.
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781 Razzaq M, Iglesias MJ, Ibrahim-Kosta M, Goumidi L, Soukarieh O, Proust C, Roux M, Suchon P, Boland A, Daiain D, Olaso R, Havervall S, Thalin C, Butler L, Deleuze JF, Odeberg J, Morange PE, Trégouët DA.
An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism.
Sci Rep. 2021 11(1):14015.
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780 Lam S, Hartmann N, Benfeitas R, Zhang C, Arif M, Turkez H, Uhlén M, Englert C, Knight R, Mardinoglu A.
Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases.
Biomedicines. 2021 9(10):.
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779 Mailer RK, Allende M, Heestermans M, Schweizer M, Deppermann C, Frye M, Pula G, Odeberg J, Gelderblom M, Rose-John S, Sickmann A, Blankenberg S, Huber TB, Kubisch C, Maas C, Gambaryan S, Firsov D, Stavrou EX, Butler LM, Renné T.
Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate.
Blood. 2021 137(10):1392-1405.
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778 Tebani A, Jotanovic J, Hekmati N, Sivertsson Å, Gudjonsson O, Edén Engström B, Wikström J, Uhlèn M, Casar-Borota O, Pontén F.
Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis.
Acta Neuropathol Commun. 2021 9(1):181.
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777 Bergström S, Öijerstedt L, Remnestål J, Olofsson J, Ullgren A, Seelaar H, van Swieten JC, Synofzik M, Sanchez-Valle R, Moreno F, Finger E, Masellis M, Tartaglia C, Vandenberghe R, Laforce R, Galimberti D, Borroni B, Butler CR, Gerhard A, Ducharme S, Rohrer JD, Månberg A, Graff C, Nilsson P, Genetic Frontotemporal Dementia Initiative (GENFI).
A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study.
Mol Neurodegener. 2021 16(1):79.
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776 Christopher JA, Stadler C, Martin CE, Morgenstern M, Pan Y, Betsinger CN, Rattray DG, Mahdessian D, Gingras AC, Warscheid B, Lehtiö J, Cristea IM, Foster LJ, Emili A, Lilley KS.
Subcellular proteomics.
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775 Mena J, Alloza I, Tulloch Navarro R, Aldekoa A, Díez García J, Villanueva Etxebarria A, Lindskog C, Antigüedad A, Boyero S, Mendibe-Bilbao MDM, Álvarez de Arcaya A, Sánchez Menoyo JL, Midaglia L, Villarrubia N, Malhotra S, Montalban X, Villar LM, Comabella M, Vandenbroeck K.
Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the - Gene Region in Immature Dendritic Cells.
Front Immunol. 2021 12():816930.
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774 Lundberg E, Funke J, Uhlmann V, Gerlich D, Walter T, Carpenter A, Coehlo LP.
Which image-based phenotypes are most promising for using AI to understand cellular functions and why?
Cell Syst. 2021 12(5):384-387.
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773 Qin Y, Huttlin EL, Winsnes CF, Gosztyla ML, Wacheul L, Kelly MR, Blue SM, Zheng F, Chen M, Schaffer LV, Licon K, Bäckström A, Vaites LP, Lee JJ, Ouyang W, Liu SN, Zhang T, Silva E, Park J, Pitea A, Kreisberg JF, Gygi SP, Ma J, Harper JW, Yeo GW, Lafontaine DLJ, Lundberg E, Ideker T.
A multi-scale map of cell structure fusing protein images and interactions.
Nature. 2021 600(7889):536-542.
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772 Gultekin O, Gonzalez-Molina J, Hardell E, Moyano-Galceran L, Mitsios N, Mulder J, Kokaraki G, Isaksson A, Sarhan D, Lehti K, Carlson JW.
FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation.
NPJ Precis Oncol. 2021 5(1):97.
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771 Tura A, Grespan E, Göbl CS, Koivula RW, Franks PW, Pearson ER, Walker M, Forgie IM, Giordano GN, Pavo I, Ruetten H, Dermitzakis ET, McCarthy MI, Pedersen O, Schwenk JM, Adamski J, De Masi F, Tsirigos KD, Brunak S, Viñuela A, Mahajan A, McDonald TJ, Kokkola T, Vangipurapu J, Cederberg H, Laakso M, Rutters F, Elders PJM, Koopman ADM, Beulens JW, Ridderstråle M, Hansen TH, Allin KH, Hansen T, Vestergaard H, Mari A, IMI DIRECT Consortium.
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study.
Diabetes. 2021 70(9):2092-2106.
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770 Wu C, Borné Y, Gao R, López Rodriguez M, Roell WC, Wilson JM, Regmi A, Luan C, Aly DM, Peter A, Machann J, Staiger H, Fritsche A, Birkenfeld AL, Tao R, Wagner R, Canouil M, Hong MG, Schwenk JM, Ahlqvist E, Kaikkonen MU, Nilsson P, Shore AC, Khan F, Natali A, Melander O, Orho-Melander M, Nilsson J, Häring HU, Renström E, Wollheim CB, Engström G, Weng J, Pearson ER, Franks PW, White MF, Duffin KL, Vaag AA, Laakso M, Stefan N, Groop L, De Marinis Y.
Elevated circulating follistatin associates with an increased risk of type 2 diabetes.
Nat Commun. 2021 12(1):6486.
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769 Bauer W, Weber M, Diehl-Wiesenecker E, Galtung N, Prpic M, Somasundaram R, Tauber R, Schwenk JM, Micke P, Kappert K.
Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection.
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768 Kotol D, Hober A, Strandberg L, Svensson AS, Uhlén M, Edfors F.
Targeted proteomics analysis of plasma proteins using recombinant protein standards for addition only workflows.
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767 Digre A, Lindskog C.
The Human Protein Atlas-Spatial localization of the human proteome in health and disease.
Protein Sci. 2021 30(1):218-233.
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766 Jamin SP, Hikmet F, Mathieu R, Jégou B, Lindskog C, Chalmel F, Primig M.
Combined RNA/tissue profiling identifies novel Cancer/testis genes.
Mol Oncol. 2021 15(11):3003-3023.
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765 Egevad L, Delahunt B, Samaratunga H, Tsuzuki T, Olsson H, Ström P, Lindskog C, Häkkinen T, Kartasalo K, Eklund M, Ruusuvuori P.
Interobserver reproducibility of perineural invasion of prostatic adenocarcinoma in needle biopsies.
Virchows Arch. 2021 478(6):1109-1116.
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764 Abdulla M, Alexsson A, Sundström C, Ladenvall C, Mansouri L, Lindskog C, Berglund M, Cavelier L, Enblad G, Hollander P, Amini RM.
PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNS.
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763 Micke P, Strell C, Mattsson J, Martín-Bernabé A, Brunnström H, Huvila J, Sund M, Wärnberg F, Ponten F, Glimelius B, Hrynchyk I, Mauchanski S, Khelashvili S, Garcia-Vicién G, Molleví DG, Edqvist PH, O Reilly A, Corvigno S, Dahlstrand H, Botling J, Segersten U, Krzyzanowska A, Bjartell A, Elebro J, Heby M, Lundgren S, Hedner C, Borg D, Brändstedt J, Sartor H, Malmström PU, Johansson M, Nodin B, Backman M, Lindskog C, Jirström K, Mezheyeuski A.
The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types.
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762 Olpe C, Khamis D, Chukanova M, Skoufou-Papoutsaki N, Kemp R, Marks K, Tatton C, Lindskog C, Nicholson A, Brunton-Sim R, Malhotra S, Ten Hoopen R, Stanley R, Winton DJ, Morrissey E.
A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium.
Gastroenterology. 2021 161(2):548-559.e23.
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761 Backman M, La Fleur L, Kurppa P, Djureinovic D, Elfving H, Brunnström H, Mattsson JSM, Lindberg A, Pontén V, Eltahir M, Mangsbo S, Gulyas M, Isaksson J, Jirström K, Kärre K, Leandersson K, Mezheyeuski A, Pontén F, Strell C, Lindskog C, Botling J, Micke P.
Infiltration of NK and plasma cells is associated with a distinct immune subset in non-small cell lung cancer.
J Pathol. 2021 255(3):243-256.
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760 Omenn GS, Lane L, Overall CM, Paik YK, Cristea IM, Corrales FJ, Lindskog C, Weintraub S, Roehrl MHA, Liu S, Bandeira N, Srivastava S, Chen YJ, Aebersold R, Moritz RL, Deutsch EW.
Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project.
J Proteome Res. 2021 20(12):5227-5240.
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759 Pablos I, Machado Y, de Jesus HCR, Mohamud Y, Kappelhoff R, Lindskog C, Vlok M, Bell PA, Butler GS, Grin PM, Cao QT, Nguyen JP, Solis N, Abbina S, Rut W, Vederas JC, Szekely L, Szakos A, Drag M, Kizhakkedathu JN, Mossman K, Hirota JA, Jan E, Luo H, Banerjee A, Overall CM.
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL substrate degradome.
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758 Garcia-Alonso L, Handfield LF, Roberts K, Nikolakopoulou K, Fernando RC, Gardner L, Woodhams B, Arutyunyan A, Polanski K, Hoo R, Sancho-Serra C, Li T, Kwakwa K, Tuck E, Lorenzi V, Massalha H, Prete M, Kleshchevnikov V, Tarkowska A, Porter T, Mazzeo CI, van Dongen S, Dabrowska M, Vaskivskyi V, Mahbubani KT, Park JE, Jimenez-Linan M, Campos L, Kiselev VY, Lindskog C, Ayuk P, Prigmore E, Stratton MR, Saeb-Parsy K, Moffett A, Moore L, Bayraktar OA, Teichmann SA, Turco MY, Vento-Tormo R.
Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro.
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757 Ghoshal B, Hikmet F, Pineau C, Tucker A, Lindskog C.
DeepHistoClass: A Novel Strategy for Confident Classification of Immunohistochemistry Images Using Deep Learning.
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756 Iglesias MJ, Schwenk JM, Odeberg J.
Affinity Proteomics Assays for Cardiovascular and Atherosclerotic Disease Biomarkers.
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755 Bendes A, Dale M, Mattsson C, Dodig-Crnković T, Iglesias MJ, Schwenk JM, Fredolini C.
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754 Gummesson A, Björnson E, Fagerberg L, Zhong W, Tebani A, Edfors F, Schmidt C, Lundqvist A, Adiels M, Bäckhed F, Schwenk JM, Jansson PA, Uhlén M, Bergström G.
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753 Stockfelt M, Hong MG, Hesselmar B, Adlerberth I, Wold AE, Schwenk JM, Lundell AC, Rudin A.
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752 Roxhed N, Bendes A, Dale M, Mattsson C, Hanke L, Dodig-Crnković T, Christian M, Meineke B, Elsässer S, Andréll J, Havervall S, Thålin C, Eklund C, Dillner J, Beck O, Thomas CE, McInerney G, Hong MG, Murrell B, Fredolini C, Schwenk JM.
Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.
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751 Zeybel M, Altay O, Arif M, Li X, Yang H, Fredolini C, Akyildiz M, Saglam B, Gonenli MG, Ural D, Kim W, Schwenk JM, Zhang C, Shoaie S, Nielsen J, Uhlén M, Borén J, Mardinoglu A.
Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.
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750 Zhong W, Altay O, Arif M, Edfors F, Doganay L, Mardinoglu A, Uhlén M, Fagerberg L.
Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms
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749 Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM.
Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease.
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748 Mulder J, Lindqvist I, Rasmusson AJ, Husén E, Rönnelid J, Kumlien E, Rostami E, Virhammar J, Cunningham JL.
Indirect immunofluorescence for detecting anti-neuronal autoimmunity in CSF after COVID-19 - Possibilities and pitfalls.
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747 Huang J, Lin L, Dong Z, Yang L, Zheng T, Gu W, Zhang Y, Yin T, Sjöstedt E, Mulder J, Uhlén M, Kristiansen K, Bolund L, Luo Y.
A porcine brain-wide RNA editing landscape.
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746 Mulder J, Feresiadou A, Fällmar D, Frithiof R, Virhammar J, Rasmusson A, Rostami E, Kumlien E, Cunningham JL.
Autoimmune Encephalitis Presenting With Malignant Catatonia in a 40-Year-Old Male Patient With COVID-19.
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745 Adori C, Daraio T, Kuiper R, Barde S, Horvathova L, Yoshitake T, Ihnatko R, Valladolid-Acebes I, Vercruysse P, Wellendorf AM, Gramignoli R, Bozoky B, Kehr J, Theodorsson E, Cancelas JA, Mravec B, Jorns C, Ellis E, Mulder J, Uhlén M, Bark C, Hökfelt T.
Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging.
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744 Iglesias MJ, Kruse LD, Sanchez-Rivera L, Enge L, Dusart P, Hong MG, Uhlén M, Renné T, Schwenk JM, Bergstrom G, Odeberg J, Butler LM.
Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors.
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743 Gnann C, Cesnik AJ, Lundberg E.
Illuminating Non-genetic Cellular Heterogeneity with Imaging-Based Spatial Proteomics.
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742 Rozenblatt-Rosen O, Shin JW, Rood JE, Hupalowska A, Human Cell Atlas Standards and Technology Working Group, Regev A, Heyn H.
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741 Pinkard H, Stuurman N, Ivanov IE, Anthony NM, Ouyang W, Li B, Yang B, Tsuchida MA, Chhun B, Zhang G, Mei R, Anderson M, Shepherd DP, Hunt-Isaak I, Dunn RL, Jahr W, Kato S, Royer LA, Thiagarajah JR, Eliceiri KW, Lundberg E, Mehta SB, Waller L.
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740 Gómez-de-Mariscal E, García-López-de-Haro C, Ouyang W, Donati L, Lundberg E, Unser M, Muñoz-Barrutia A, Sage D.
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739 Mikus M, Zandian A, Sjöberg R, Hamsten C, Forsström B, Andersson M, Greiff L, Uhlén M, Levin M, Nilsson P, van Hage M, Ohlin M.
Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy.
J Allergy Clin Immunol. 2021 147(3):1077-1086.
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738 Hassan SS, Seigerud Å, Abdirahman R, Arroyo Mühr LS, Nordqvist Kleppe S, Pin E, Månberg A, Hober S, Nilsson P, Engstrand L, Miriam Elfström K, Blomqvist J, Conneryd Lundgren K, Dillner J.
SARS-CoV-2 infections amongst personnel providing home care services for older persons in Stockholm, Sweden.
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737 Månberg A, Skene N, Sanders F, Trusohamn M, Remnestål J, Szczepińska A, Aksoylu IS, Lönnerberg P, Ebarasi L, Wouters S, Lehmann M, Olofsson J, von Gohren Antequera I, Domaniku A, De Schaepdryver M, De Vocht J, Poesen K, Uhlén M, Anink J, Mijnsbergen C, Vergunst-Bosch H, Hübers A, Kläppe U, Rodriguez-Vieitez E, Gilthorpe JD, Hedlund E, Harris RA, Aronica E, Van Damme P, Ludolph A, Veldink J, Ingre C, Nilsson P, Lewandowski SA.
Altered perivascular fibroblast activity precedes ALS disease onset.
Nat Med. 2021 27(4):640-646.
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736 Pin E, Petricoin EF, Cortes N, Bowman TG, Andersson E, Uhlén M, Nilsson P, Caswell SV.
Immunoglobulin A Autoreactivity toward Brain Enriched and Apoptosis-Regulating Proteins in Saliva of Athletes after Acute Concussion and Subconcussive Impacts.
J Neurotrauma. 2021 38(17):2373-2383.
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735 Lourido L, Balboa-Barreiro V, Ruiz-Romero C, Rego-Pérez I, Camacho-Encina M, Paz-González R, Calamia V, Oreiro N, Nilsson P, Blanco FJ.
A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative.
Osteoarthritis Cartilage. 2021 29(8):1147-1154.
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734 Alkharaan H, Bayati S, Hellström C, Aleman S, Olsson A, Lindahl K, Bogdanovic G, Healy K, Tsilingaridis G, De Palma P, Hober S, Månberg A, Nilsson P, Pin E, Sällberg Chen M.
Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys.
J Infect Dis. 2021 224(3):407-414.
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733 Kharlamova N, Dunn N, Bedri SK, Jerling S, Almgren M, Faustini F, Gunnarsson I, Rönnelid J, Pullerits R, Gjertsson I, Lundberg K, Månberg A, Pin E, Nilsson P, Hober S, Fink K, Fogdell-Hahn A.
False Positive Results in SARS-CoV-2 Serological Tests for Samples From Patients With Chronic Inflammatory Diseases.
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732 Bergström S, Remnestål J, Yousef J, Olofsson J, Markaki I, Carvalho S, Corvol JC, Kultima K, Kilander L, Löwenmark M, Ingelsson M, Blennow K, Zetterberg H, Nellgård B, Brosseron F, Heneka MT, Bosch B, Sanchez-Valle R, Månberg A, Svenningsson P, Nilsson P.
Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.
Ann Clin Transl Neurol. 2021 8(7):1456-1470.
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731 Hober S, Hellström C, Olofsson J, Andersson E, Bergström S, Jernbom Falk A, Bayati S, Mravinacova S, Sjöberg R, Yousef J, Skoglund L, Kanje S, Berling A, Svensson AS, Jensen G, Enstedt H, Afshari D, Xu LL, Zwahlen M, von Feilitzen K, Hanke L, Murrell B, McInerney G, Karlsson Hedestam GB, Lendel C, Roth RG, Skoog I, Svenungsson E, Olsson T, Fogdell-Hahn A, Lindroth Y, Lundgren M, Maleki KT, Lagerqvist N, Klingström J, Da Silva Rodrigues R, Muschiol S, Bogdanovic G, Arroyo Mühr LS, Eklund C, Lagheden C, Dillner J, Sivertsson Å, Havervall S, Thålin C, Tegel H, Pin E, Månberg A, Hedhammar M, Nilsson P.
Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.
Clin Transl Immunology. 2021 10(7):e1312.
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730 Elfström KM, Blomqvist J, Nilsson P, Hober S, Pin E, Månberg A, Pimenoff VN, Arroyo Mühr LS, Lundgren KC, Dillner J.
Differences in risk for SARS-CoV-2 infection among healthcare workers.
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729 Asplund Högelin K, Ruffin N, Pin E, Månberg A, Hober S, Gafvelin G, Grönlund H, Nilsson P, Khademi M, Olsson T, Piehl F, Al Nimer F.
Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis.
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728 Mangsbo SM, Havervall S, Laurén I, Lindsay R, Jernbom Falk A, Marking U, Lord M, Buggert M, Dönnes P, Christoffersson G, Nilsson P, Hober S, Phillipson M, Klingström J, Thålin C.
An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses.
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727 San Segundo-Acosta P, Montero-Calle A, Jernbom-Falk A, Alonso-Navarro M, Pin E, Andersson E, Hellström C, Sánchez-Martínez M, Rábano A, Solís-Fernández G, Peláez-García A, Martínez-Useros J, Fernández-Aceñero MJ, Månberg A, Nilsson P, Barderas R.
Multiomics Profiling of Alzheimer's Disease Serum for the Identification of Autoantibody Biomarkers.
J Proteome Res. 2021 20(11):5115-5130.
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726 Just D, Rasmusson AJ, Nilsson P, Noreland M, Malmström E, Brodin P, Månberg A, Cunningham JL.
Autoantibodies against the C-terminus of Lipopolysaccharide binding protein are elevated in young adults with psychiatric disease.
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725 Dillner J, Elfström KM, Blomqvist J, Engstrand L, Uhlén M, Eklund C, Boulund F, Lagheden C, Hamsten M, Nordqvist-Kleppe S, Seifert M, Hellström C, Olofsson J, Andersson E, Falk AJ, Bergström S, Hultin E, Pin E, Pimenoff VN, Hassan S, Månberg A, Nilsson P, Hedhammar M, Hober S, Mattsson J, Arroyo Mühr LS, Lundgren KC.
High Amounts of SARS-CoV-2 Precede Sickness Among Asymptomatic Health Care Workers.
J Infect Dis. 2021 224(1):14-20.
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724 Remnestål J, Bergström S, Olofsson J, Sjöstedt E, Uhlén M, Blennow K, Zetterberg H, Zettergren A, Kern S, Skoog I, Nilsson P, Månberg A.
Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds.
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723 Paslawski W, Bergström S, Zhang X, Remnestål J, He Y, Boxer A, Månberg A, Nilsson P, Svenningsson P.
Cerebrospinal Fluid Proteins Altered in Corticobasal Degeneration.
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Antibodies to SARS-CoV-2 and risk of past or future sick leave.
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721 Lourido L, Paz-González R, Ruiz-Romero C, Nilsson P, Blanco FJ.
Serum Proteomic Profiling in Rheumatoid Arthritis by Antibody Suspension Bead Arrays.
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Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood-brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study.
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HIV-Exposed Seronegative Sex Workers Express Low T-Cell Activation and an Intact Ectocervical Tissue Microenvironment.
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718 Havervall S, Rosell A, Phillipson M, Mangsbo SM, Nilsson P, Hober S, Thålin C.
Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers.
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Autoantibody profiles associated with clinical features in psychotic disorders.
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712 Carapito R, Li R, Helms J, Carapito C, Gujja S, Rolli V, Guimaraes R, Malagon-Lopez J, Spinnhirny P, Lederle A, Mohseninia R, Hirschler A, Muller L, Bastard P, Gervais A, Zhang Q, Danion F, Ruch Y, Schenck M, Collange O, Chamaraux-Tran TN, Molitor A, Pichot A, Bernard A, Tahar O, Bibi-Triki S, Wu H, Paul N, Mayeur S, Larnicol A, Laumond G, Frappier J, Schmidt S, Hanauer A, Macquin C, Stemmelen T, Simons M, Mariette X, Hermine O, Fafi-Kremer S, Goichot B, Drenou B, Kuteifan K, Pottecher J, Mertes PM, Kailasan S, Aman MJ, Pin E, Nilsson P, Thomas A, Viari A, Sanlaville D, Schneider F, Sibilia J, Tharaux PL, Casanova JL, Hansmann Y, Lidar D, Radosavljevic M, Gulcher JR, Meziani F, Moog C, Chittenden TW, Bahram S.
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort.
Sci Transl Med. 2021 ():eabj7521.
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711 Altay O, Arif M, Li X, Yang H, Aydın M, Alkurt G, Kim W, Akyol D, Zhang C, Dinler-Doganay G, Turkez H, Shoaie S, Nielsen J, Borén J, Olmuscelik O, Doganay L, Uhlén M, Mardinoglu A.
Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19.
Adv Sci (Weinh). 2021 8(17):e2101222.
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710 Arif M, Zhang C, Li X, Güngör C, Çakmak B, Arslantürk M, Tebani A, Özcan B, Subaş O, Zhou W, Piening B, Turkez H, Fagerberg L, Price N, Hood L, Snyder M, Nielsen J, Uhlen M, Mardinoglu A.
iNetModels 2.0: an interactive visualization and database of multi-omics data.
Nucleic Acids Res. 2021 49(W1):W271-W276.
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709 Arif M, Klevstig M, Benfeitas R, Doran S, Turkez H, Uhlén M, Clausen M, Wikström J, Etal D, Zhang C, Levin M, Mardinoglu A, Boren J.
Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction.
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708 Li SL, Pereira RHM, Prete CA, Zarebski AE, Emanuel L, Alves PJH, Peixoto PS, Braga CKV, de Souza Santos AA, de Souza WM, Barbosa RJ, Buss LF, Mendrone A, de Almeida-Neto C, Ferreira SC, Salles NA, Marcilio I, Wu CH, Gouveia N, Nascimento VH, Sabino EC, Faria NR, Messina JP.
Higher risk of death from COVID-19 in low-income and non-White populations of São Paulo, Brazil.
BMJ Glob Health. 2021 6(4):.
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707 Keskinkiliç B, Shaikh I, Tekin A, Ursu P, Mardinoglu A, Mese EA.
A Resilient Health System in Response to Coronavirus Disease 2019: Experiences of Turkey.
Front Public Health. 2021 8():577021.
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706 Cinici E, Caglar O, Arslan ME, Dilekmen N, Utlu B, Mardinoglu A, Turkez H.
Targeted Gene Candidates for Treatment and Early Diagnosis of Age-Related Macular Degeneration.
Biomed Res Int. 2021 2021():6620900.
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705 Rosario D, Bidkhori G, Lee S, Bedarf J, Hildebrand F, Le Chatelier E, Uhlen M, Ehrlich SD, Proctor G, Wüllner U, Mardinoglu A, Shoaie S.
Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson's disease.
Cell Rep. 2021 34(9):108807.
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704 Li X, Kim W, Juszczak K, Arif M, Sato Y, Kume H, Ogawa S, Turkez H, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A.
Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning.
iScience. 2021 24(7):102722.
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703 Mahdessian D, Cesnik AJ, Gnann C, Danielsson F, Stenström L, Arif M, Zhang C, Le T, Johansson F, Shutten R, Bäckström A, Axelsson U, Thul P, Cho NH, Carja O, Uhlén M, Mardinoglu A, Stadler C, Lindskog C, Ayoglu B, Leonetti MD, Pontén F, Sullivan DP, Lundberg E.
Spatiotemporal dissection of the cell cycle with single-cell proteogenomics.
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702 Alkurt G, Murt A, Aydin Z, Tatli O, Agaoglu NB, Irvem A, Aydin M, Karaali R, Gunes M, Yesilyurt B, Turkez H, Mardinoglu A, Doganay M, Basinoglu F, Seyahi N, Dinler Doganay G, Doganay HL.
Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey.
PLoS One. 2021 16(3):e0247865.
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701 Türkez H, Arslan ME, Sönmez E, Tatar A, Geyikoğlu F, Açikyildiz M, Mardinoğlu A.
Safety Assessments of Nickel Boride Nanoparticles on the Human Pulmonary Alveolar Cells by Using Cell Viability and Gene Expression Analyses.
Biol Trace Elem Res. 2021 199(7):2602-2611.
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700 Turkez H, Tozlu OO, Arslan ME, Mardinoglu A.
Safety and Efficacy Assessments to Take Antioxidants in Glioblastoma Therapy: From In Vitro Experiences to Animal and Clinical Studies.
Neurochem Int. 2021 150():105168.
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699 Altay O, Zhang C, Turkez H, Nielsen J, Uhlén M, Mardinoglu A.
Revealing the Metabolic Alterations during Biofilm Development of Based on Genome-Scale Metabolic Modeling.
Metabolites. 2021 11(4):.
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698 Turkez H, Arslan ME, Tatar A, Mardinoglu A.
Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies.
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697 Yazici A, Marinelli L, Cacciatore I, Emsen B, Eusepi P, Di Biase G, Di Stefano A, Mardinoğlu A, Türkez H.
Potential Anticancer Effect of Carvacrol Codrugs on Human Glioblastoma Cells.
Curr Drug Deliv. 2021 18(3):350-356.
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696 Doran S, Arif M, Lam S, Bayraktar A, Turkez H, Uhlen M, Boren J, Mardinoglu A.
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Brief Bioinform. 2021 22(5):.
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695 van der Kolk BW, Saari S, Lovric A, Arif M, Alvarez M, Ko A, Miao Z, Sahebekhtiari N, Muniandy M, Heinonen S, Oghabian A, Jokinen R, Jukarainen S, Hakkarainen A, Lundbom J, Kuula J, Groop PH, Tukiainen T, Lundbom N, Rissanen A, Kaprio J, Williams EG, Zamboni N, Mardinoglu A, Pajukanta P, Pietiläinen KH.
Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI.
Cell Rep Med. 2021 2(4):100226.
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694 Zhao LJ, Li YY, Zhang YT, Fan QQ, Ren HM, Zhang C, Mardinoglu A, Chen WC, Pang JR, Shen DD, Wang JW, Zhao LF, Zhang JY, Wang ZY, Zheng YC, Liu HM.
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EMBO Rep. 2021 22(8):e50922.
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693 Bosley JR, Björnson E, Zhang C, Turkez H, Nielsen J, Uhlen M, Borén J, Mardinoglu A.
Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans.
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692 Arslan ME, Türkez H, Mardinoğlu A.
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Int J Neurosci. 2021 131(8):745-754.
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691 Turkez H, Cacciatore I, Marinelli L, Fornasari E, Aslan ME, Cadirci K, Kahraman CY, Caglar O, Tatar A, Di Biase G, Hacimuftuoglu A, Di Stefano A, Mardinoglu A.
Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer's Disease.
Biomolecules. 2021 11(1):.
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690 Zhang C, Wei Y, Mardinoglu A, Zhang P.
Editorial: Application of Systems Biology in Molecular Characterization and Diagnosis of Cancer.
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689 Li X, Kim W, Arif M, Gao C, Hober A, Kotol D, Strandberg L, Forsström B, Sivertsson Å, Oksvold P, Turkez H, Grøtli M, Sato Y, Kume H, Ogawa S, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A.
Discovery of Functional Alternatively Spliced Transcripts in Human Cancers.
Cancers (Basel). 2021 13(2):.
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688 Özdemir Ö, Marinelli L, Cacciatore I, Ciulla M, Emsen B, Di Stefano A, Mardinoglu A, Turkez H.
Anticancer effects of novel NSAIDs derivatives on cultured human glioblastoma cells.
Z Naturforsch C J Biosci. 2021 76(7-8):329-335.
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687 Lam S, Doran S, Yuksel HH, Altay O, Turkez H, Nielsen J, Boren J, Uhlen M, Mardinoglu A.
Addressing the heterogeneity in liver diseases using biological networks.
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686 Harzandi A, Lee S, Bidkhori G, Saha S, Hendry BM, Mardinoglu A, Shoaie S, Sharpe CC.
Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia.
iScience. 2021 24(2):102046.
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685 Karlsson M, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzen K, Zwahlen M, Arif M, Altay O, Li X, Ozcan M, Mardinoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlén M, Lindskog C.
A single-cell type transcriptomics map of human tissues.
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684 Turanli B, Altay O, Borén J, Turkez H, Nielsen J, Uhlen M, Arga KY, Mardinoglu A.
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683 Kennedy SA, Jarboui MA, Srihari S, Raso C, Bryan K, Dernayka L, Charitou T, Bernal-Llinares M, Herrera-Montavez C, Krstic A, Matallanas D, Kotlyar M, Jurisica I, Curak J, Wong V, Stagljar I, LeBihan T, Imrie L, Pillai P, Lynn MA, Fasterius E, Al-Khalili Szigyarto C, Breen J, Kiel C, Serrano L, Rauch N, Rukhlenko O, Kholodenko BN, Iglesias-Martinez LF, Ryan CJ, Pilkington R, Cammareri P, Sansom O, Shave S, Auer M, Horn N, Klose F, Ueffing M, Boldt K, Lynn DJ, Kolch W.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
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682 Previtali SC, Gidaro T, Díaz-Manera J, Zambon A, Carnesecchi S, Roux-Lombard P, Spitali P, Signorelli M, Szigyarto CA, Johansson C, Gray J, Labolle D, Porte Thomé F, Pitchforth J, Domingos J, Muntoni F.
Rimeporide as a first- in-class NHE-1 inhibitor: Results of a phase Ib trial in young patients with Duchenne Muscular Dystrophy.
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681 Kanje S, Enstedt H, Dannemeyer M, Uhlén M, Hober S, Tegel H.
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680 Tegel H, Dannemeyer M, Kanje S, Sivertsson Å, Berling A, Svensson AS, Hober A, Enstedt H, Volk AL, Lundqvist M, Moradi M, Afshari D, Ekblad S, Xu L, Westin M, Bidad F, Schiavone LH, Davies R, Mayr LM, Knight S, Göpel SO, Voldborg BG, Edfors F, Forsström B, von Feilitzen K, Zwahlen M, Rockberg J, Takanen JO, Uhlén M, Hober S.
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679 Omenn GS, Lane L, Overall CM, Cristea IM, Corrales FJ, Lindskog C, Paik YK, Van Eyk JE, Liu S, Pennington SR, Snyder MP, Baker MS, Bandeira N, Aebersold R, Moritz RL, Deutsch EW.
Research on the Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, According to the HUPO Human Proteome Project.
J Proteome Res. 2020 19(12):4735-4746.
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678 Sivertsson Å, Lindström E, Oksvold P, Katona B, Hikmet F, Vuu J, Gustavsson J, Sjöstedt E, von Feilitzen K, Kampf C, Schwenk JM, Uhlén M, Lindskog C.
Enhanced Validation of Antibodies Enables the Discovery of Missing Proteins.
J Proteome Res. 2020 19(12):4766-4781.
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677 Aasebø K, Dragomir A, Sundström M, Mezheyeuski A, Edqvist PH, Eide GE, Ponten F, Pfeiffer P, Glimelius B, Sorbye H.
CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better Mutated and a Worse Mutated Subgroup.
Front Oncol. 2020 10():8.
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676 De Piano M, Manuelli V, Zadra G, Otte J, Edqvist PD, Pontén F, Nowinski S, Niaouris A, Grigoriadis A, Loda M, Van Hemelrijck M, Wells CM.
Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases.
Oncogene. 2020 39(18):3666-3679.
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675 Ding M, Tegel H, Sivertsson Å, Hober S, Snijder A, Ormö M, Strömstedt PE, Davies R, Holmberg Schiavone L.
Secretome-Based Screening in Target Discovery.
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674 Gudmundsdottir V, Pedersen HK, Mazzoni G, Allin KH, Artati A, Beulens JW, Banasik K, Brorsson C, Cederberg H, Chabanova E, De Masi F, Elders PJ, Forgie I, Giordano GN, Grallert H, Gupta R, Haid M, Hansen T, Hansen TH, Hattersley AT, Heggie A, Hong MG, Jones AG, Koivula R, Kokkola T, Laakso M, Løngreen P, Mahajan A, Mari A, McDonald TJ, McEvoy D, Musholt PB, Pavo I, Prehn C, Ruetten H, Ridderstråle M, Rutters F, Sharma S, Slieker RC, Syed A, Tajes JF, Thomas CE, Thomsen HS, Vangipurapu J, Vestergaard H, Viñuela A, Wesolowska-Andersen A, Walker M, Adamski J, Schwenk JM, McCarthy MI, Pearson E, Dermitzakis E, Franks PW, Pedersen O, Brunak S.
Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study.
Genome Med. 2020 12(1):109.
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673 Atabaki-Pasdar N, Ohlsson M, Viñuela A, Frau F, Pomares-Millan H, Haid M, Jones AG, Thomas EL, Koivula RW, Kurbasic A, Mutie PM, Fitipaldi H, Fernandez J, Dawed AY, Giordano GN, Forgie IM, McDonald TJ, Rutters F, Cederberg H, Chabanova E, Dale M, Masi F, Thomas CE, Allin KH, Hansen TH, Heggie A, Hong MG, Elders PJM, Kennedy G, Kokkola T, Pedersen HK, Mahajan A, McEvoy D, Pattou F, Raverdy V, Häussler RS, Sharma S, Thomsen HS, Vangipurapu J, Vestergaard H, 't Hart LM, Adamski J, Musholt PB, Brage S, Brunak S, Dermitzakis E, Frost G, Hansen T, Laakso M, Pedersen O, Ridderstråle M, Ruetten H, Hattersley AT, Walker M, Beulens JWJ, Mari A, Schwenk JM, Gupta R, McCarthy MI, Pearson ER, Bell JD, Pavo I, Franks PW.
Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts.
PLoS Med. 2020 17(6):e1003149.
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672 Persson Skare T, Sjöberg E, Berglund M, Smith RO, Roche FP, Lindskog C, Sander B, Glimelius I, Gholiha AR, Enblad G, Amini RM, Claesson-Welsh L.
Marginal zone lymphoma expression of histidine-rich glycoprotein correlates with improved survival.
EJHaem. 2020 1(1):199-207.
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Publisher Correction: Analysis of the Human Protein Atlas Image Classification competition.
Nat Methods. 2020 17(2):241.
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670 Sjöstedt E, Kolnes AJ, Olarescu NC, Mitsios N, Hikmet F, Sivertsson Å, Lindskog C, Øystese KAB, Jørgensen AP, Bollerslev J, Casar-Borota O.
TGFBR3L-An Uncharacterised Pituitary Specific Membrane Protein Detected in the Gonadotroph Cells in Non-Neoplastic and Tumour Tissue.
Cancers (Basel). 2020 13(1):.
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669 Signorelli M, Ayoglu B, Johansson C, Lochmüller H, Straub V, Muntoni F, Niks E, Tsonaka R, Persson A, Aartsma-Rus A, Nilsson P, Al-Khalili Szigyarto C, Spitali P.
Longitudinal serum biomarker screening identifies malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophy.
J Cachexia Sarcopenia Muscle. 2020 11(2):505-517.
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Blood-derived biomarkers correlate with clinical progression in Duchenne muscular dystrophy.
J Neuromuscul Dis. 2020 7(3):231-246.
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667 Remnestål J, Öijerstedt L, Ullgren A, Olofsson J, Bergström S, Kultima K, Ingelsson M, Kilander L, Uhlén M, Månberg A, Graff C, Nilsson P.
Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers.
Transl Neurodegener. 2020 9(1):27.
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Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritis: A prospective study.
Semin Arthritis Rheum. 2020 50(5):1101-1108.
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SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden.
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Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson's Disease.
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Point-of-Care Approaches for Meningitis Diagnosis in a Low-Resource Setting (Southwestern Uganda): Observational Cohort Study Protocol of the "PI-POC" Trial.
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Exploring autoantibody signatures in brain tissue from patients with severe mental illness.
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The in vitro cytotoxic, genotoxic, and oxidative damage potentials of the oral artificial sweetener aspartame on cultured human blood cells
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The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.
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659 Rosario D, Boren J, Uhlen M, Proctor G, Aarsland D, Mardinoglu A, Shoaie S.
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Skeletal Muscle Transcriptomic Comparison between Long-Term Trained and Untrained Men and Women.
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657 Pagoni A, Marinelli L, Di Stefano A, Ciulla M, Turkez H, Mardinoglu A, Vassiliou S, Cacciatore I.
Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation.
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Neuroprotective effects of boron nitride nanoparticles in the experimental Parkinson's disease model against MPP+ induced apoptosis.
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650 Sinha M, Mardinoglu A, Ghose J, Singh K.
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609 Sahebekhtiari N, Saraswat M, Joenväärä S, Jokinen R, Lovric A, Kaye S, Mardinoglu A, Rissanen A, Kaprio J, Renkonen R, Pietiläinen KH.
Plasma Proteomics Analysis Reveals Dysregulation of Complement Proteins and Inflammation in Acquired Obesity-A Study on Rare BMI-Discordant Monozygotic Twin Pairs.
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591 Ouyang W, Winsnes CF, Hjelmare M, Cesnik AJ, Åkesson L, Xu H, Sullivan DP, Dai S, Lan J, Jinmo P, Galib SM, Henkel C, Hwang K, Poplavskiy D, Tunguz B, Wolfinger RD, Gu Y, Li C, Xie J, Buslov D, Fironov S, Kiselev A, Panchenko D, Cao X, Wei R, Wu Y, Zhu X, Tseng KL, Gao Z, Ju C, Yi X, Zheng H, Kappel C, Lundberg E.
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Nat Methods. 2019 16(12):1254-1261.
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590 Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P.
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.
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589 Uhlén M, Karlsson MJ, Hober A, Svensson AS, Scheffel J, Kotol D, Zhong W, Tebani A, Strandberg L, Edfors F, Sjöstedt E, Mulder J, Mardinoglu A, Berling A, Ekblad S, Dannemeyer M, Kanje S, Rockberg J, Lundqvist M, Malm M, Volk AL, Nilsson P, Månberg A, Dodig-Crnkovic T, Pin E, Zwahlen M, Oksvold P, von Feilitzen K, Häussler RS, Hong MG, Lindskog C, Ponten F, Katona B, Vuu J, Lindström E, Nielsen J, Robinson J, Ayoglu B, Mahdessian D, Sullivan D, Thul P, Danielsson F, Stadler C, Lundberg E, Bergström G, Gummesson A, Voldborg BG, Tegel H, Hober S, Forsström B, Schwenk JM, Fagerberg L, Sivertsson Å.
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588 Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, De Masi F, Groves CJ, Kokkola T, Mahajan A, Perry MH, Rauh SP, Ridderstråle M, Teare HJA, Thomas EL, Tura A, Vestergaard H, White T, Adamski J, Bell JD, Beulens JW, Brunak S, Dermitzakis ET, Froguel P, Frost G, Gupta R, Hansen T, Hattersley A, Jablonka B, Kaye J, Laakso M, McDonald TJ, Pedersen O, Schwenk JM, Pavo I, Mari A, McCarthy MI, Ruetten H, Walker M, Pearson E, Franks PW, IMI DIRECT Consortium.
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.
Diabetologia. 2019 62(9):1601-1615.
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587 Elfving H, Mattsson JSM, Lindskog C, Backman M, Menzel U, Micke P.
Programmed Cell Death Ligand 1 Immunohistochemistry: A Concordance Study Between Surgical Specimen, Biopsy, and Tissue Microarray.
Clin Lung Cancer. 2019 20(4):258-262.e1.
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586 Pineau C, Hikmet F, Zhang C, Oksvold P, Chen S, Fagerberg L, Uhlén M, Lindskog C.
Cell Type-Specific Expression of Testis Elevated Genes Based on Transcriptomics and Antibody-Based Proteomics.
J Proteome Res. 2019 18(12):4215-4230.
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585 Pin E, Sjöberg R, Andersson E, Hellström C, Olofsson J, Jernbom Falk A, Bergström S, Remnestål J, Just D, Nilsson P, Månberg A.
Array-Based Profiling of Proteins and Autoantibody Repertoires in CSF.
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584 Tengvall K, Huang J, Hellström C, Kammer P, Biström M, Ayoglu B, Lima Bomfim I, Stridh P, Butt J, Brenner N, Michel A, Lundberg K, Padyukov L, Lundberg IE, Svenungsson E, Ernberg I, Olafsson S, Dilthey AT, Hillert J, Alfredsson L, Sundström P, Nilsson P, Waterboer T, Olsson T, Kockum I.
Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk.
Proc Natl Acad Sci U S A. 2019 116(34):16955-16960.
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583 Idborg H, Zandian A, Ossipova E, Wigren E, Preger C, Mobarrez F, Checa A, Sohrabian A, Pucholt P, Sandling JK, Fernandes-Cerqueira C, Rönnelid J, Oke V, Grosso G, Kvarnström M, Larsson A, Wheelock CE, Syvänen AC, Rönnblom L, Kultima K, Persson H, Gräslund S, Gunnarsson I, Nilsson P, Svenungsson E, Jakobsson PJ.
Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.
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582 Bedri SK, Nilsson OB, Fink K, Månberg A, Hamsten C, Ayoglu B, Manouchehrinia A, Nilsson P, Olsson T, Hillert J, Grönlund H, Glaser A.
Plasma protein profiling reveals candidate biomarkers for multiple sclerosis treatment.
PLoS One. 2019 14(5):e0217208.
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581 Neiman M, Hellström C, Just D, Mattsson C, Fagerberg L, Schuppe-Koistinen I, Gummesson A, Bergström G, Kallioniemi O, Achour A, Sallinen R, Uhlén M, Nilsson P.
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580 Idborg H, Zandian A, Sandberg AS, Nilsson B, Elvin K, Truedsson L, Sohrabian A, Rönnelid J, Mo J, Grosso G, Kvarnström M, Gunnarsson I, Lehtiö J, Nilsson P, Svenungsson E, Jakobsson PJ.
Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren's syndrome differ in molecular signatures and treatment perspectives.
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579 Mikus M, Johansson C, Acevedo N, Nilsson P, Scheynius A.
The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients.
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578 Khoonsari PE, Shevchenko G, Herman S, Remnestål J, Giedraitis V, Brundin R, Degerman Gunnarsson M, Kilander L, Zetterberg H, Nilsson P, Lannfelt L, Ingelsson M, Kultima K.
Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers.
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577 Ge C, Xu B, Liang B, Lönnblom E, Lundström SL, Zubarev RA, Ayoglu B, Nilsson P, Skogh T, Kastbom A, Malmström V, Klareskog L, Toes REM, Rispens T, Dobritzsch D, Holmdahl R.
Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
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576 Steen J, Forsström B, Sahlström P, Odowd V, Israelsson L, Krishnamurthy A, Badreh S, Mathsson Alm L, Compson J, Ramsköld D, Ndlovu W, Rapecki S, Hansson M, Titcombe PJ, Bang H, Mueller DL, Catrina AI, Grönwall C, Skriner K, Nilsson P, Lightwood D, Klareskog L, Malmström V.
Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell-Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis.
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575 Månberg A, Bradley F, Qundos U, Guthrie BL, Birse K, Noël-Romas L, Lindskog C, Bosire R, Kiarie J, Farquhar C, Burgener AD, Nilsson P, Broliden K.
A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection.
Mol Cell Proteomics. 2019 18(3):461-476.
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573 Edlund K, Madjar K, Mattsson JSM, Djureinovic D, Lindskog C, Brunnström H, Koyi H, Brandén E, Jirström K, Pontén F, Rahnenführer J, Micke P, Hengstler JG.
Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC.
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572 Cadenas C, Vosbeck S, Edlund K, Grgas K, Madjar K, Hellwig B, Adawy A, Glotzbach A, Stewart JD, Lesjak MS, Franckenstein D, Claus M, Hayen H, Schriewer A, Gianmoena K, Thaler S, Schmidt M, Micke P, Pontén F, Mardinoglu A, Zhang C, Käfferlein HU, Watzl C, Frank S, Rahnenführer J, Marchan R, Hengstler JG.
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571 Wang D, Eraslan B, Wieland T, Hallström B, Hopf T, Zolg DP, Zecha J, Asplund A, Li LH, Meng C, Frejno M, Schmidt T, Schnatbaum K, Wilhelm M, Ponten F, Uhlen M, Gagneur J, Hahne H, Kuster B.
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues.
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570 Eraslan B, Wang D, Gusic M, Prokisch H, Hallström BM, Uhlén M, Asplund A, Pontén F, Wieland T, Hopf T, Hahne H, Kuster B, Gagneur J.
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569 Aasebø KØ, Dragomir A, Sundström M, Mezheyeuski A, Edqvist PH, Eide GE, Ponten F, Pfeiffer P, Glimelius B, Sorbye H.
Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients.
Cancer Med. 2019 8(7):3623-3635.
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568 Mezheyeuski A, Hrynchyk I, Herrera M, Karlberg M, Osterman E, Ragnhammar P, Edler D, Portyanko A, Ponten F, Sjöblom T, Glimelius B, Östman A.
Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer.
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567 Niinivirta M, Enblad G, Lindskog C, Pontén F, Dragomir A, Ullenhag GJ.
Tumoral Pyruvate Kinase L/R as a Predictive Marker for the Treatment of Renal Cancer Patients with Sunitinib and Sorafenib.
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566 Omenn GS, Lane L, Overall CM, Corrales FJ, Schwenk JM, Paik YK, Van Eyk JE, Liu S, Pennington S, Snyder MP, Baker MS, Deutsch EW.
Progress on Identifying and Characterizing the Human Proteome: 2019 Metrics from the HUPO Human Proteome Project.
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565 Häussler RS, Bendes A, Iglesias M, Sanchez-Rivera L, Dodig-Crnković T, Byström S, Fredolini C, Birgersson E, Dale M, Edfors F, Fagerberg L, Rockberg J, Tegel H, Uhlén M, Qundos U, Schwenk JM.
Systematic Development of Sandwich Immunoassays for the Plasma Secretome.
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564 Fredolini C, Byström S, Sanchez-Rivera L, Ioannou M, Tamburro D, Pontén F, Branca RM, Nilsson P, Lehtiö J, Schwenk JM.
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563 Edfors F, Forsström B, Vunk H, Kotol D, Fredolini C, Maddalo G, Svensson AS, Boström T, Tegel H, Nilsson P, Schwenk JM, Uhlen M.
Screening a Resource of Recombinant Protein Fragments for Targeted Proteomics.
J Proteome Res. 2019 18(7):2706-2718.
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562 Pernemalm M, Sandberg A, Zhu Y, Boekel J, Tamburro D, Schwenk JM, Björk A, Wahren-Herlenius M, Åmark H, Östenson CG, Westgren M, Lehtiö J.
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Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci.
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559 Spitali P, Hettne K, Tsonaka R, Charrout M, van den Bergen J, Koeks Z, Kan HE, Hooijmans MT, Roos A, Straub V, Muntoni F, Al-Khalili-Szigyarto C, Koel-Simmelink MJA, Teunissen CE, Lochmüller H, Niks EH, Aartsma-Rus A.
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558 Zieba A, Ponten F, Uhlén M, Landegren U.
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557 Fasterius E, Al-Khalili Szigyarto C.
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555 The M, Edfors F, Perez-Riverol Y, Payne SH, Hoopmann MR, Palmblad M, Forsström B, Käll L.
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554 Byström S, Eklund M, Hong MG, Fredolini C, Eriksson M, Czene K, Hall P, Schwenk JM, Gabrielson M.
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553 Zamani L, Lundqvist M, Zhang Y, Aberg M, Edfors F, Bidkhori G, Lindahl A, Mie A, Mardinoglu A, Field R, Turner R, Rockberg J, Chotteau V.
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552 Mardinoglu A, Gogg S, Lotta LA, Stančáková A, Nerstedt A, Boren J, Blüher M, Ferrannini E, Langenberg C, Wareham NJ, Laakso M, Smith U.
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes.
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Integrative Personal Omics Profiles during Periods of Weight Gain and Loss.
Cell Syst. 2018 6(2):157-170.e8.
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Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome.
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ESS: A Tool for Genome-Scale Quantification of Essentiality Score for Reaction/Genes in Constraint-Based Modeling.
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547 Zhang X, Mardinoglu A, Joosten LAB, Kuivenhoven JA, Li Y, Netea MG, Groen AK.
Identification of Discriminating Metabolic Pathways and Metabolites in Human PBMCs Stimulated by Various Pathogenic Agents.
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546 Turanli B, Karagoz K, Gulfidan G, Sinha R, Mardinoglu A, Arga KY.
A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine.
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544 Bidkhori G, Benfeitas R, Klevstig M, Zhang C, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes.
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543 Nicholson AM, Olpe C, Hoyle A, Thorsen AS, Rus T, Colombé M, Brunton-Sim R, Kemp R, Marks K, Quirke P, Malhotra S, Ten Hoopen R, Ibrahim A, Lindskog C, Myers MB, Parsons B, Tavaré S, Wilkinson M, Morrissey E, Winton DJ.
Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.
Cell Stem Cell. 2018 22(6):909-918.e8.
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542 Morin E, Sjöberg E, Tjomsland V, Testini C, Lindskog C, Franklin O, Sund M, Öhlund D, Kiflemariam S, Sjöblom T, Claesson-Welsh L.
VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival.
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541 Miyashita N, Horie M, Suzuki HI, Yoshihara M, Djureinovic D, Persson J, Brunnström H, Lindskog C, Elfving H, Micke P, Saito A, Nagase T.
An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1-Positive Lung Adenocarcinomas.
J Thorac Oncol. 2018 13(11):1676-1691.
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540 Strakova K, Kowalski-Jahn M, Gybel T, Valnohova J, Dhople VM, Harnos J, Bernatik O, Ganji RS, Zdrahal Z, Mulder J, Lindskog C, Bryja V, Schulte G.
Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization.
J Biol Chem. 2018 293(48):18477-18493.
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The adult human testis transcriptional cell atlas.
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538 Reuterswärd P, Bergström S, Orikiiriza J, Lindquist E, Bergström S, Andersson Svahn H, Ayoglu B, Uhlén M, Wahlgren M, Normark J, Ribacke U, Nilsson P.
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537 Quintana MDP, Ch'ng JH, Zandian A, Imam M, Hultenby K, Theisen M, Nilsson P, Qundos U, Moll K, Chan S, Wahlgren M.
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ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease.
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532 Garranzo-Asensio M, San Segundo-Acosta P, Martínez-Useros J, Montero-Calle A, Fernández-Aceñero MJ, Häggmark-Månberg A, Pelaez-Garcia A, Villalba M, Rabano A, Nilsson P, Barderas R.
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530 Weidner LD, Kannan P, Mitsios N, Kang SJ, Hall MD, Theodore WH, Innis RB, Mulder J.
The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue.
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529 Dos Remedios CG, Lal SP, Li A, McNamara J, Keogh A, Macdonald PS, Cooke R, Ehler E, Knöll R, Marston SB, Stelzer J, Granzier H, Bezzina C, van Dijk S, De Man F, Stienen GJM, Odeberg J, Pontén F, Linke WA, van der Velden J.
Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.
Biophys Rev. 2018 10(3):941.
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528 Casar-Borota O, Bollerslev J, Pontén F.
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527 Huvila J, Laajala TD, Edqvist PH, Mardinoglu A, Talve L, Pontén F, Grénman S, Carpén O, Aittokallio T, Auranen A.
Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma.
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526 Omenn GS, Lane L, Overall CM, Corrales FJ, Schwenk JM, Paik YK, Van Eyk JE, Liu S, Snyder M, Baker MS, Deutsch EW.
Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project.
J Proteome Res. 2018 17(12):4031-4041.
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525 Djureinovic D, Dodig-Crnković T, Hellström C, Holgersson G, Bergqvist M, Mattsson JSM, Pontén F, Ståhle E, Schwenk JM, Micke P.
Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer.
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524 Mönnich M, Borgeskov L, Breslin L, Jakobsen L, Rogowski M, Doganli C, Schrøder JM, Mogensen JB, Blinkenkjær L, Harder LM, Lundberg E, Geimer S, Christensen ST, Andersen JS, Larsen LA, Pedersen LB.
CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium.
Cell Rep. 2018 22(10):2584-2592.
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523 Guala D, Bernhem K, Blal HA, Jans D, Lundberg E, Brismar H, Sonnhammer ELL.
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Methods Appl Fluoresc. 2018 6(3):035007.
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522 Edfors F, Hober A, Linderbäck K, Maddalo G, Azimi A, Sivertsson Å, Tegel H, Hober S, Szigyarto CA, Fagerberg L, von Feilitzen K, Oksvold P, Lindskog C, Forsström B, Uhlen M.
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521 Lovric A, Granér M, Bjornson E, Arif M, Benfeitas R, Nyman K, Ståhlman M, Pentikäinen MO, Lundbom J, Hakkarainen A, Sirén R, Nieminen MS, Lundbom N, Lauerma K, Taskinen MR, Mardinoglu A, Boren J.
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.
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520 Sjöstedt E, Sivertsson Å, Hikmet Noraddin F, Katona B, Näsström Å, Vuu J, Kesti D, Oksvold P, Edqvist PH, Olsson I, Uhlén M, Lindskog C.
Integration of Transcriptomics and Antibody-Based Proteomics for Exploration of Proteins Expressed in Specialized Tissues.
J Proteome Res. 2018 17(12):4127-4137.
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519 Lee S, Zhang C, Arif M, Liu Z, Benfeitas R, Bidkhori G, Deshmukh S, Al Shobky M, Lovric A, Boren J, Nielsen J, Uhlen M, Mardinoglu A.
TCSBN: a database of tissue and cancer specific biological networks.
Nucleic Acids Res. 2018 46(D1):D595-D600.
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518 Mardinoglu A, Uhlen M, Borén J.
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Cell Syst. 2018 6(1):7-9.
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517 Mardinoglu A, Wu H, Bjornson E, Zhang C, Hakkarainen A, Räsänen SM, Lee S, Mancina RM, Bergentall M, Pietiläinen KH, Söderlund S, Matikainen N, Ståhlman M, Bergh PO, Adiels M, Piening BD, Granér M, Lundbom N, Williams KJ, Romeo S, Nielsen J, Snyder M, Uhlén M, Bergström G, Perkins R, Marschall HU, Bäckhed F, Taskinen MR, Borén J.
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.
Cell Metab. 2018 27(3):559-571.e5.
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516 Karnevi E, Dror LB, Mardinoglu A, Elebro J, Heby M, Olofsson SE, Nodin B, Eberhard J, Gallagher W, Uhlén M, Jirström K.
Translational study reveals a two-faced role of RBM3 in pancreatic cancer and suggests its potential value as a biomarker for improved patient stratification.
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515 Azimi A, Caramuta S, Seashore-Ludlow B, Boström J, Robinson JL, Edfors F, Tuominen R, Kemper K, Krijgsman O, Peeper DS, Nielsen J, Hansson J, Egyhazi Brage S, Altun M, Uhlen M, Maddalo G.
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.
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514 Lee CY, Wang D, Wilhelm M, Zolg DP, Schmidt T, Schnatbaum K, Reimer U, Pontén F, Uhlén M, Hahne H, Kuster B.
Mining the Human Tissue Proteome for Protein Citrullination.
Mol Cell Proteomics. 2018 17(7):1378-1391.
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513 Mardinoglu A, Boren J, Smith U, Uhlen M, Nielsen J.
Systems biology in hepatology: approaches and applications.
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512 Turanli B, Grøtli M, Boren J, Nielsen J, Uhlen M, Arga KY, Mardinoglu A.
Drug Repositioning for Effective Prostate Cancer Treatment.
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511 Zhang MD, Su J, Adori C, Cinquina V, Malenczyk K, Girach F, Peng C, Ernfors P, Löw P, Borgius L, Kiehn O, Watanabe M, Uhlén M, Mitsios N, Mulder J, Harkany T, Hökfelt T.
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J Clin Invest. 2018 128(9):3757-3768.
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510 Rosario D, Benfeitas R, Bidkhori G, Zhang C, Uhlen M, Shoaie S, Mardinoglu A.
Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling.
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509 Bidkhori G, Benfeitas R, Elmas E, Kararoudi MN, Arif M, Uhlen M, Nielsen J, Mardinoglu A.
Metabolic Network-Based Identification and Prioritization of Anticancer Targets Based on Expression Data in Hepatocellular Carcinoma.
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508 Matic LP, Jesus Iglesias M, Vesterlund M, Lengquist M, Hong MG, Saieed S, Sanchez-Rivera L, Berg M, Razuvaev A, Kronqvist M, Lund K, Caidahl K, Gillgren P, Pontén F, Uhlén M, Schwenk JM, Hansson GK, Paulsson-Berne G, Fagman E, Roy J, Hultgren R, Bergström G, Lehtiö J, Odeberg J, Hedin U.
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage.
JACC Basic Transl Sci. 2018 3(4):464-480.
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507 Dusart P, Fagerberg L, Perisic L, Civelek M, Struck E, Hedin U, Uhlén M, Trégouët DA, Renné T, Odeberg J, Butler LM.
A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein.
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506 O'Hagan S, Wright Muelas M, Day PJ, Lundberg E, Kell DB.
GeneGini: Assessment via the Gini Coefficient of Reference "Housekeeping" Genes and Diverse Human Transporter Expression Profiles.
Cell Syst. 2018 6(2):230-244.e1.
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505 Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.
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Nat Chem Biol. 2018 14(3):206-214.
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504 Sullivan DP, Winsnes CF, Åkesson L, Hjelmare M, Wiking M, Schutten R, Campbell L, Leifsson H, Rhodes S, Nordgren A, Smith K, Revaz B, Finnbogason B, Szantner A, Lundberg E.
Deep learning is combined with massive-scale citizen science to improve large-scale image classification.
Nat Biotechnol. 2018 36(9):820-828.
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503 Danielsson F, Fasterius E, Sullivan D, Hases L, Sanli K, Zhang C, Mardinoglu A, Al-Khalili C, Huss M, Uhlén M, Williams C, Lundberg E.
Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia.
Oncotarget. 2018 9(28):19730-19744.
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502 Sullivan DP, Lundberg E.
Seeing More: A Future of Augmented Microscopy.
Cell. 2018 173(3):546-548.
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501 Thul PJ, Lindskog C.
The human protein atlas: A spatial map of the human proteome.
Protein Sci. 2018 27(1):233-244.
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500 Thelin EP, Just D, Frostell A, Häggmark-Månberg A, Risling M, Svensson M, Nilsson P, Bellander BM.
Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers.
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499 Fasterius E, Raso C, Kennedy S, Rauch N, Lundin P, Kolch W, Uhlén M, Al-Khalili Szigyarto C.
A novel RNA sequencing data analysis method for cell line authentication.
PLoS One. 2017 12(2):e0171435.
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498 Carapito C, Duek P, Macron C, Seffals M, Rondel K, Delalande F, Lindskog C, Fréour T, Vandenbrouck Y, Lane L, Pineau C.
Validating Missing Proteins in Human Sperm Cells by Targeted Mass-Spectrometry- and Antibody-based Methods.
J Proteome Res. 2017 16(12):4340-4351.
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497 Sjöstedt E, Bollerslev J, Mulder J, Lindskog C, Pontén F, Casar-Borota O.
A specific antibody to detect transcription factor T-Pit: a reliable marker of corticotroph cell differentiation and a tool to improve the classification of pituitary neuroendocrine tumours.
Acta Neuropathol. 2017 134(4):675-677.
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496 Omenn GS, Lane L, Lundberg EK, Overall CM, Deutsch EW.
Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project.
J Proteome Res. 2017 16(12):4281-4287.
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495 Sastry A, Monk J, Tegel H, Uhlen M, Palsson BO, Rockberg J, Brunk E.
Machine learning in computational biology to accelerate high-throughput protein expression.
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494 Sen P, Mardinogulu A, Nielsen J.
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493 Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling C, Calvigioni D, Bains JS, Máté Z, Szabó G, Yanagawa Y, Zhang MD, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath TL, Harkany T.
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.
Nat Neurosci. 2017 20(2):176-188.
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492 Malenczyk K, Girach F, Szodorai E, Storm P, Segerstolpe Å, Tortoriello G, Schnell R, Mulder J, Romanov RA, Borók E, Piscitelli F, Di Marzo V, Szabó G, Sandberg R, Kubicek S, Lubec G, Hökfelt T, Wagner L, Groop L, Harkany T.
A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.
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491 Niinivirta M, Enblad G, Edqvist PH, Pontén F, Dragomir A, Ullenhag GJ.
Tumoral ANXA1 Is a Predictive Marker for Sunitinib Treatment of Renal Cancer Patients.
J Cancer. 2017 8(19):3975-3983.
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490 Carreras-Puigvert J, Zitnik M, Jemth AS, Carter M, Unterlass JE, Hallström B, Loseva O, Karem Z, Calderón-Montaño JM, Lindskog C, Edqvist PH, Matuszewski DJ, Ait Blal H, Berntsson RPA, Häggblad M, Martens U, Studham M, Lundgren B, Wählby C, Sonnhammer ELL, Lundberg E, Stenmark P, Zupan B, Helleday T.
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.
Nat Commun. 2017 8(1):1541.
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489 Boström J, Sramkova Z, Salašová A, Johard H, Mahdessian D, Fedr R, Marks C, Medalová J, Souček K, Lundberg E, Linnarsson S, Bryja V, Sekyrova P, Altun M, Andäng M.
Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells.
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488 Feizi A, Gatto F, Uhlen M, Nielsen J.
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J Infect Dis. 2017 215(4):590-598.
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485 Svedberg G, Jeong Y, Na H, Jang J, Nilsson P, Kwon S, Gantelius J, Svahn HA.
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484 Checa A, Idborg H, Zandian A, Sar DG, Surowiec I, Trygg J, Svenungsson E, Jakobsson PJ, Nilsson P, Gunnarsson I, Wheelock CE.
Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study.
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483 Ch'ng JH, Sirel M, Zandian A, Del Pilar Quintana M, Chun Leung Chan S, Moll K, Tellgren-Roth A, Nilsson I, Nilsson P, Qundos U, Wahlgren M.
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482 Sierra-Sánchez Á, Garrido-Martín D, Lourido L, González-González M, Díez P, Ruiz-Romero C, Sjöber R, Droste C, De Las Rivas J, Nilsson P, Blanco F, Fuentes M.
Screening and Validation of Novel Biomarkers in Osteoarticular Pathologies by Comprehensive Combination of Protein Array Technologies.
J Proteome Res. 2017 16(5):1890-1899.
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481 Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R.
Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
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Antibody Validation in Bioimaging Applications Based on Endogenous Expression of Tagged Proteins.
J Proteome Res. 2017 16(1):147-155.
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479 Alkasalias T, Alexeyenko A, Hennig K, Danielsson F, Lebbink RJ, Fielden M, Turunen SP, Lehti K, Kashuba V, Madapura HS, Bozoky B, Lundberg E, Balland M, Guvén H, Klein G, Gad AK, Pavlova T.
RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo.
Proc Natl Acad Sci U S A. 2017 114(8):E1413-E1421.
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478 Ly T, Whigham A, Clarke R, Brenes-Murillo AJ, Estes B, Madhessian D, Lundberg E, Wadsworth P, Lamond AI.
Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS.
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PD-L1 immunohistochemistry in clinical diagnostics of lung cancer: inter-pathologist variability is higher than assay variability.
Mod Pathol. 2017 30(10):1411-1421.
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476 Jedlinski A, Garvin S, Johansson AC, Edqvist PH, Ponten F, Roberg K.
Cetuximab sensitivity of head and neck squamous cell carcinoma xenografts is associated with treatment-induced reduction in EGFR, pEGFR, and pSrc.
J Oral Pathol Med. 2017 46(9):717-724.
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A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma.
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Tumoral cubilin is a predictive marker for treatment of renal cancer patients with sunitinib and sorafenib.
J Cancer Res Clin Oncol. 2017 143(6):961-970.
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473 Grinberg M, Djureinovic D, Brunnström HR, Mattsson JS, Edlund K, Hengstler JG, La Fleur L, Ekman S, Koyi H, Branden E, Ståhle E, Jirström K, Tracy DK, Pontén F, Botling J, Rahnenführer J, Micke P.
Reaching the limits of prognostication in non-small cell lung cancer: an optimized biomarker panel fails to outperform clinical parameters.
Mod Pathol. 2017 30(7):964-977.
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A nonsense mutation in CEP55 defines a new locus for a Meckel-like syndrome, an autosomal recessive lethal fetal ciliopathy.
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Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression.
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Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential.
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Serotonin, ATRX, and DAXX Expression in Pituitary Adenomas: Markers in the Differential Diagnosis of Neuroendocrine Tumors of the Sellar Region.
Am J Surg Pathol. 2017 41(9):1238-1246.
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High RBM3 expression is associated with an improved survival and oxaliplatin response in patients with metastatic colorectal cancer.
PLoS One. 2017 12(8):e0182512.
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The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.
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Breast cancer in young women and prognosis: How important are proliferation markers?
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Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development.
Cell Stem Cell. 2017 21(4):533-546.e6.
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464 Bosley J, Boren C, Lee S, Grøtli M, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
Improving the economics of NASH/NAFLD treatment through the use of systems biology.
Drug Discov Today. 2017 22(10):1532-1538.
PubMed: 28736156 DOI: 10.1016/j.drudis.2017.07.005
463 Liu Z, Que S, Mardinoglu A.
Rediscussion on linearity between fibrosis stages and mortality risk in nonalcoholic fatty liver disease patients.
Hepatology. 2017 66(4):1357-1358.
PubMed: 28727167 DOI: 10.1002/hep.29390
462 Liu Z, Que S, Zhou L, Zheng S, Romeo S, Mardinoglu A, Valenti L.
The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis.
Sci Rep. 2017 7(1):9273.
PubMed: 28839198 DOI: 10.1038/s41598-017-09548-9
461 Lee S, Zhang C, Liu Z, Klevstig M, Mukhopadhyay B, Bergentall M, Cinar R, Ståhlman M, Sikanic N, Park JK, Deshmukh S, Harzandi AM, Kuijpers T, Grøtli M, Elsässer SJ, Piening BD, Snyder M, Smith U, Nielsen J, Bäckhed F, Kunos G, Uhlen M, Boren J, Mardinoglu A.
Network analyses identify liver-specific targets for treating liver diseases.
Mol Syst Biol. 2017 13(8):938.
PubMed: 28827398
460 Mardinoglu A, Stančáková A, Lotta LA, Kuusisto J, Boren J, Blüher M, Wareham NJ, Ferrannini E, Groop PH, Laakso M, Langenberg C, Smith U.
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease.
Cell Metab. 2017 26(2):281-283.
PubMed: 28768165 DOI: 10.1016/j.cmet.2017.07.006
459 Benfeitas R, Uhlen M, Nielsen J, Mardinoglu A.
New Challenges to Study Heterogeneity in Cancer Redox Metabolism.
Front Cell Dev Biol. 2017 5():65.
PubMed: 28744456 DOI: 10.3389/fcell.2017.00065
458 Mardinoglu A, Borén J.
AUP1 (Ancient Ubiquitous Protein 1): A Molecular Link Between Hepatic Lipid Mobilization and VLDL Secretion.
Arterioscler Thromb Vasc Biol. 2017 37(4):609-610.
PubMed: 28330944 DOI: 10.1161/ATVBAHA.117.309152
457 Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J.
Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in NAFLD.
Mol Syst Biol. 2017 13(3):916.
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456 Nilsson A, Mardinoglu A, Nielsen J.
Predicting growth of the healthy infant using a genome scale metabolic model.
NPJ Syst Biol Appl. 2017 3():3.
PubMed: 28649430 DOI: 10.1038/s41540-017-0004-5
455 Schwenk JM, Omenn GS, Sun Z, Campbell DS, Baker MS, Overall CM, Aebersold R, Moritz RL, Deutsch EW.
The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays.
J Proteome Res. 2017 16(12):4299-4310.
PubMed: 28938075 DOI: 10.1021/acs.jproteome.7b00467
454 Zandian A, Wingård L, Nilsson H, Sjöstedt E, Johansson DX, Just D, Hellström C, Uhlén M, Schwenk JM, Häggmark-Månberg A, Norbeck O, Owe-Larsson B, Nilsson P, Persson MAA.
Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis.
Transl Psychiatry. 2017 7(7):e1177.
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453 Glimelius B, Melin B, Enblad G, Alafuzoff I, Beskow A, Ahlström H, Bill-Axelson A, Birgisson H, Björ O, Edqvist PH, Hansson T, Helleday T, Hellman P, Henriksson K, Hesselager G, Hultdin M, Häggman M, Höglund M, Jonsson H, Larsson C, Lindman H, Ljuslinder I, Mindus S, Nygren P, Pontén F, Riklund K, Rosenquist R, Sandin F, Schwenk JM, Stenling R, Stålberg K, Stålberg P, Sundström C, Thellenberg Karlsson C, Westermark B, Bergh A, Claesson-Welsh L, Palmqvist R, Sjöblom T.
U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
Acta Oncol. 2017 ():1-8.
PubMed: 28631533 DOI: 10.1080/0284186X.2017.1337926
452 Byström S, Fredolini C, Edqvist PH, Nyaiesh EN, Drobin K, Uhlén M, Bergqvist M, Pontén F, Schwenk JM.
Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence.
Transl Oncol. 2017 10(3):385-395.
PubMed: 28433799 DOI: 10.1016/j.tranon.2017.03.002
451 Omazic B, Ayoglu B, Löhr M, Segersvärd R, Verbeke C, Magalhaes I, Potacova Z, Mattsson J, Terman A, Ghazi S, Albiin N, Kartalis N, Nilsson P, Poiret T, Zhenjiang L, Heuchel R, Schwenk JM, Permert J, Maeurer MJ, Ringden O.
A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer.
J Immunother. 2017 40(4):132-139.
PubMed: 28338506 DOI: 10.1097/CJI.0000000000000164
450 Lourido L, Ayoglu B, Fernández-Tajes J, Oreiro N, Henjes F, Hellström C, Schwenk JM, Ruiz-Romero C, Nilsson P, Blanco FJ.
Discovery of circulating proteins associated to knee radiographic osteoarthritis.
Sci Rep. 2017 7(1):137.
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449 Zandian A, Forsström B, Häggmark-Månberg A, Schwenk JM, Uhlén M, Nilsson P, Ayoglu B.
Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy.
J Proteome Res. 2017 16(3):1300-1314.
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448 Hellström C, Dodig-Crnković T, Hong MG, Schwenk JM, Nilsson P, Sjöberg R.
High-Density Serum/Plasma Reverse Phase Protein Arrays.
Methods Mol Biol. 2017 1619():229-238.
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447 Birgersson E, Schwenk JM, Ayoglu B.
Bead-Based and Multiplexed Immunoassays for Protein Profiling via Sequential Affinity Capture.
Methods Mol Biol. 2017 1619():45-54.
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446 Häggmark-Månberg A, Nilsson P, Schwenk JM.
Neuroproteomic Profiling of Cerebrospinal Fluid (CSF) by Multiplexed Affinity Arrays.
Methods Mol Biol. 2017 1598():247-254.
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445 Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.
A pathology atlas of the human cancer transcriptome.
Science. 2017 357(6352)
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444 Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.
A subcellular map of the human proteome.
Science. 2017 356(6340): eaal3321
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443 Kannan P, Schain M, Kretzschmar WW, Weidner L, Mitsios N, Gulyás B, Blom H, Gottesman MM, Innis RB, Hall MD, Mulder J.
An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter.
J Cereb Blood Flow Metab. 2017 37(6):2062-2075.
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442 Heinonen S, Muniandy M, Buzkova J, Mardinoglu A, Rodríguez A, Frühbeck G, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Pietiläinen KH.
Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins.
Diabetologia. 2017 60(1):169-181.
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441 Delforoush M, Berglund M, Edqvist PH, Sundström C, Gullbo J, Enblad G.
Expression of possible targets for new proteasome inhibitors in diffuse large B-cell lymphoma.
Eur J Haematol. 2017 98(1):52-56.
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440 Pin E, Henjes F, Hong MG, Wiklund F, Magnusson P, Bjartell A, Uhlén M, Nilsson P, Schwenk JM.
Identification of a Novel Autoimmune Peptide Epitope of Prostein in Prostate Cancer.
J Proteome Res. 2017 16(1):204-216.
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439 Mikus M, Drobin K, Gry M, Bachmann J, Lindberg J, Yimer G, Aklillu E, Makonnen E, Aderaye G, Roach J, Fier I, Kampf C, Göpfert J, Perazzo H, Poynard T, Stephens C, Andrade RJ, Lucena MI, Arber N, Uhlén M, Watkins PB, Schwenk JM, Nilsson P, Schuppe-Koistinen I.
Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.
Liver Int. 2017 37(1):132-140.
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438 Malm M, Frejd FY, Ståhl S, Löfblom J.
Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds.
MAbs. 2016 8(7):1195-1209.
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437 Scharaw S, Iskar M, Ori A, Boncompain G, Laketa V, Poser I, Lundberg E, Perez F, Beck M, Bork P, Pepperkok R.
The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.
J Cell Biol. 2016 215(4):543-558.
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436 Sialana FJ, Gulyassy P, Májek P, Sjöstedt E, Kis V, Müller AC, Rudashevskaya EL, Mulder J, Bennett KL, Lubec G.
Mass spectrometric analysis of synaptosomal membrane preparations for the determination of brain receptors, transporters and channels.
Proteomics. 2016 16(22):2911-2920.
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435 Micke P, Mattsson JS, Djureinovic D, Nodin B, Jirström K, Tran L, Jönsson P, Planck M, Botling J, Brunnström H.
The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs.
J Thorac Oncol. 2016 11(6):862-72.
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434 Edfors F, Danielsson F, Hallström BM, Käll L, Lundberg E, Pontén F, Forsström B, Uhlén M.
Gene-specific correlation of RNA and protein levels in human cells and tissues.
Mol Syst Biol. 2016 12(10):883.
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433 van Kempen LC, Redpath M, Elchebly M, Klein KO, Papadakis AI, Wilmott JS, Scolyer RA, Edqvist PH, Pontén F, Schadendorf D, van Rijk AF, Michiels S, Dumay A, Helbling-Leclerc A, Dessen P, Wouters J, Stass M, Greenwood CM, Ghanem GE, van den Oord J, Feunteun J, Spatz A.
The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene.
Sci Transl Med. 2016 8(369):369ra177.
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432 Ten Berge JC, van Rosmalen J, Vermeer J, Hellström C, Lindskog C, Nilsson P, Qundos U, Rothova A, Schreurs MW.
Serum Autoantibody Profiling of Patients with Paraneoplastic and Non-Paraneoplastic Autoimmune Retinopathy.
PLoS One. 2016 11(12):e0167909.
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431 Mardinoglu A, Nielsen J.
Editorial: The Impact of Systems Medicine on Human Health and Disease.
Front Physiol. 2016 7():552.
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430 Casey JR, Mardinoglu A, Nielsen J, Karl DM.
Adaptive Evolution of Phosphorus Metabolism in Prochlorococcus.
mSystems. 2016 1(6):.
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429 Magnusson K, Gremel G, Rydén L, Pontén V, Uhlén M, Dimberg A, Jirström K, Pontén F.
ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer.
BMC Cancer. 2016 16(1):904.
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428 Bergman J, Botling J, Fagerberg L, Hallström BM, Djureinovic D, Uhlén M, Pontén F.
The human adrenal gland proteome defined by transcriptomics and antibody-based profiling.
Endocrinology. 2016 ():en20161758.
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427 Musunuri S, Khoonsari PE, Mikus M, Wetterhall M, Häggmark-Mänberg A, Lannfelt L, Erlandsson A, Bergquist J, Ingelsson M, Shevchenko G, Nilsson P, Kultima K.
Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain.
J Alzheimers Dis. 2016 54(4):1671-1686.
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426 Ayoglu B, Schwenk JM, Nilsson P.
Antigen arrays for profiling autoantibody repertoires.
Bioanalysis. 2016 8(10):1105-26.
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425 Schrötter A, Park YM, Marcus K, Martins-de-Souza D, Nilsson P, Magraoui FE, Meyer HE, Grinberg LT.
Key players in neurodegenerative disorders in focus-New insights into the proteomic profile of Alzheimer's disease, schizophrenia, ALS, and multiple sclerosis-24th HUPO BPP Workshop: September 29, 2015, Vancouver, Canada.
Proteomics. 2016 16(7):1047-50.
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424 Khoonsari PE, Häggmark A, Lönnberg M, Mikus M, Kilander L, Lannfelt L, Bergquist J, Ingelsson M, Nilsson P, Kultima K, Shevchenko G.
Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease.
PLoS One. 2016 11(3):e0150672.
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423 Mardinoglu A, Boren J, Smith U.
Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes.
Cell Metab. 2016 23(1):10-2.
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422 Björnson E, Borén J, Mardinoglu A.
Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools.
Front Physiol. 2016 7():2.
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421 Elsemman IE, Mardinoglu A, Shoaie S, Soliman TH, Nielsen J.
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism.
Mol Biosyst. 2016 12(5):1496-506.
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420 Lee S, Mardinoglu A, Zhang C, Lee D, Nielsen J.
Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis.
Nucleic Acids Res. 2016 44(12):5529-39.
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419 Zhang C, Lee S, Mardinoglu A, Hua Q.
Investigating the Combinatory Effects of Biological Networks on Gene Co-expression.
Front Physiol. 2016 7():160.
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418 Chaudhari A, Håversen L, Mobini R, Andersson L, Ståhlman M, Lu E, Rutberg M, Fogelstrand P, Ekroos K, Mardinoglu A, Levin M, Perkins R, Borén J.
ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism.
Biochim Biophys Acta. 2016 1861(11):1643-1651.
PubMed: 27476102 DOI: 10.1016/j.bbalip.2016.07.009
417 Larsson AH, Lehn S, Wangefjord S, Karnevi E, Kuteeva E, Sundström M, Nodin B, Uhlén M, Eberhard J, Birgisson H, Jirström K.
Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer.
J Transl Med. 2016 14(1):128.
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416 Lee S, Zhang C, Kilicarslan M, Piening BD, Bjornson E, Hallström BM, Groen AK, Ferrannini E, Laakso M, Snyder M, Blüher M, Uhlen M, Nielsen J, Smith U, Serlie MJ, Boren J, Mardinoglu A.
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance.
Cell Metab. 2016 24(1):172-84.
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415 Mardinoglu A, Uhlén M.
Liver: Phenotypic and genetic variance: a systems approach to the liver.
Nat Rev Gastroenterol Hepatol. 2016 13(8):439-40.
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414 Mattsson JS, Brunnström H, Jabs V, Edlund K, Jirström K, Mindus S, la Fleur L, Pontén F, Karlsson MG, Karlsson C, Koyi H, Brandén E, Botling J, Helenius G, Micke P, Svensson MA.
Inconsistent results in the analysis of ALK rearrangements in non-small cell lung cancer.
BMC Cancer. 2016 16():603.
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413 Boije H, Shirazi Fard S, Edqvist PH, Hallböök F.
Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease.
Front Neuroanat. 2016 10():77.
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412 Ståhl PL, Salmén F, Vickovic S, Lundmark A, Navarro JF, Magnusson J, Giacomello S, Asp M, Westholm JO, Huss M, Mollbrink A, Linnarsson S, Codeluppi S, Borg Å, Pontén F, Costea PI, Sahlén P, Mulder J, Bergmann O, Lundeberg J, Frisén J.
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.
Science. 2016 353(6294):78-82.
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411 Wallerius M, Wallmann T, Bartish M, Östling J, Mezheyeuski A, Tobin NP, Nygren E, Pangigadde P, Pellegrini P, Squadrito ML, Pontén F, Hartman J, Bergh J, De Milito A, De Palma M, Östman A, Andersson J, Rolny C.
Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages.
Cancer Res. 2016 76(11):3166-78.
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410 Mezheyeuski A, Bradic Lindh M, Guren TK, Dragomir A, Pfeiffer P, Kure EH, Ikdahl T, Skovlund E, Corvigno S, Strell C, Pietras K, Ponten F, Mulder J, Qvortrup C, Portyanko A, Tveit KM, Glimelius B, Sorbye H, Östman A.
Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer.
Oncotarget. 2016 7(27):41948-41958.
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409 Zetterling M, Roodakker KR, Berntsson SG, Edqvist PH, Latini F, Landtblom AM, Pontén F, Alafuzoff I, Larsson EM, Smits A.
Extension of diffuse low-grade gliomas beyond radiological borders as shown by the coregistration of histopathological and magnetic resonance imaging data.
J Neurosurg. 2016 ():1-12.
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408 Manojlovic-Gacic E, Skender-Gazibara M, Popovic V, Soldatovic I, Boricic N, Raicevic S, Pekic S, Doknic M, Miljic D, Alafuzoff I, Pontén F, Casar-Borota O.
Oncogene-Induced Senescence in Pituitary Adenomas--an Immunohistochemical Study.
Endocr Pathol. 2016 27(1):1-11.
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407 Landegren N, Sharon D, Freyhult E, Hallgren Å, Eriksson D, Edqvist PH, Bensing S, Wahlberg J, Nelson LM, Gustafsson J, Husebye ES, Anderson MS, Snyder M, Kämpe O.
Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1.
Sci Rep. 2016 6():20104.
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406 Hellström-Lindahl E, Danielsson A, Ponten F, Czernichow P, Korsgren O, Johansson L, Eriksson O.
GPR44 is a pancreatic protein restricted to the human beta cell.
Acta Diabetol. 2016 53(3):413-21.
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405 Lindskog C, Asplund A, Catrina A, Nielsen S, Rützler M.
A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues.
J Histochem Cytochem. 2016 64(5):287-300.
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404 Hamsten C, Häggmark A, Grundström J, Mikus M, Lindskog C, Konradsen JR, Eklund A, Pershagen G, Wickman M, Grunewald J, Melén E, Hedlin G, Nilsson P, van Hage M.
Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma.
Allergy. 2016 71(9):1357-61.
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403 Lindskog C.
The Human Protein Atlas - an important resource for basic and clinical research.
Expert Rev Proteomics. 2016 13(7):627-9.
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Looking for Missing Proteins in the Proteome of Human Spermatozoa: An Update.
J Proteome Res. 2016 15(11):3998-4019.
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401 Volk AL, Hu FJ, Berglund MM, Nordling E, Strömberg P, Uhlen M, Rockberg J.
Stratification of responders towards eculizumab using a structural epitope mapping strategy.
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400 Uhlén M, Hallström BM, Lindskog C, Mardinoglu A, Pontén F, Nielsen J.
Transcriptomics resources of human tissues and organs.
Mol Syst Biol. 2016 12(4):862.
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399 Pozniak Y, Balint-Lahat N, Rudolph JD, Lindskog C, Katzir R, Avivi C, Pontén F, Ruppin E, Barshack I, Geiger T.
System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis.
Cell Syst. 2016 2(3):172-84.
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398 Fukuhara M, Agnarsdóttir M, Edqvist PH, Coter A, Ponten F.
SATB2 is expressed in Merkel cell carcinoma.
Arch Dermatol Res. 2016 308(6):449-54.
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397 Lal S, Nguyen L, Tezone R, Ponten F, Odeberg J, Li A, Dos Remedios C.
Tissue microarray profiling in human heart failure.
Proteomics. 2016 16(17):2319-26.
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396 Fredholm H, Magnusson K, Lindström LS, Garmo H, Fält SE, Lindman H, Bergh J, Holmberg L, Pontén F, Frisell J, Fredriksson I.
Long-term outcome in young women with breast cancer: a population-based study.
Breast Cancer Res Treat. 2016 160(1):131-143.
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395 Roodakker KR, Elsir T, Edqvist PD, Hägerstrand D, Carlson J, Lysiak M, Henriksson R, Pontén F, Rosell J, Söderkvist P, Stupp R, Tchougounova E, Nistér M, Malmström A, Smits A.
PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status.
Oncotarget. 2016 7(45):72431-72442.
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394 Butler LM, Hallström BM, Fagerberg L, Pontén F, Uhlén M, Renné T, Odeberg J.
Analysis of Body-wide Unfractionated Tissue Data to Identify a Core Human Endothelial Transcriptome.
Cell Syst. 2016 3(3):287-301.e3.
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Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer.
Int J Cancer. 2010 126(10):2296-307.
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101 Holgersson G, Ekman S, Reizenstein J, Bergqvist M, Pontén F, Uhlén M, Magnusson K, Jonnalagadda P, Asplund A, Strömberg S, Linder A, Blomquist E, Liljeholm M, Lödén B, Hellström K, Bergström S.
Molecular profiling using tissue microarrays as a tool to identify predictive biomarkers in laryngeal cancer treated with radiotherapy.
Cancer Genomics Proteomics 2010 7(1):1-7.
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100 Tegel H, Tourle S, Ottosson J, Persson A.
Increased levels of recombinant human proteins with the Escherichia coli strain Rosetta(DE3).
Protein Expr Purif. 2010 69(2):159-67.
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99 Fagerberg L, Jonasson K, von Heijne G, Uhlén M, Berglund L.
Prediction of the human membrane proteome.
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98 Schwenk JM, Igel U, Kato BS, Nicholson G, Karpe F, Uhlén M, Nilsson P.
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Proteomics. 2010 10(3):532-40.
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97 Stadler C, Skogs M, Brismar H, Uhlén M, Lundberg E.
A single fixation protocol for proteome-wide immunofluorescence localization studies.
J Proteomics. 2010 73(6):1067-78.
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96 Gloriam DE, Orchard S, Bertinetti D, Björling E, Bongcam-Rudloff E, Borrebaeck CA, Bourbeillon J, Bradbury AR, de Daruvar A, Dübel S, Frank R, Gibson TJ, Gold L, Haslam N, Herberg FW, Hiltke T, Hoheisel JD, Kerrien S, Koegl M, Konthur Z, Korn B, Landegren U, Montecchi-Palazzi L, Palcy S, Rodriguez H, Schweinsberg S, Sievert V, Stoevesandt O, Taussig MJ, Ueffing M, Uhlén M, van der Maarel S, Wingren C, Woollard P, Sherman DJ, Hermjakob H.
A community standard format for the representation of protein affinity reagents.
Mol Cell Proteomics. 2010 9(1):1-10.
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95 Szigyarto CA, Sibbons P, Williams G, Uhlen M, Metcalfe SM.
The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells.
J Histochem Cytochem. 2010 58(4):301-8.
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94 Hjelm B, Fernández CD, Löfblom J, Ståhl S, Johannesson H, Rockberg J, Uhlén M.
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93 Paavilainen L, Edvinsson A, Asplund A, Hober S, Kampf C, Pontén F, Wester K.
The impact of tissue fixatives on morphology and antibody-based protein profiling in tissues and cells.
J Histochem Cytochem. 2010 58(3):237-46.
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92 Tchougounova E, Jiang Y, Bråsäter D, Lindberg N, Kastemar M, Asplund A, Westermark B, Uhrbom L.
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Oncogene. 2009 28(12):1537-48.
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91 Oberg F, Haseeb A, Ahnfelt M, Pontén F, Westermark B, El-Obeid A.
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Phytomedicine. 2009 16(5):477-84.
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90 Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, Kellner R, Kubicek M, Lottspeich F, Maser E, Mewes HW, Meyer HE, Müllner S, Mutter W, Neumaier M, Nollau P, Nothwang HG, Ponten F, Radbruch A, Reinert K, Rothe G, Stockinger H, Tárnok A, Taussig MJ, Thiel A, Thiery J, Ueffing M, Valet G, Vandekerckhove J, Wagener C, Wagner O, Schmitz G.
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89 Leja J, Essaghir A, Essand M, Wester K, Oberg K, Tötterman TH, Lloyd R, Vasmatzis G, Demoulin JB, Giandomenico V.
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88 Qu M, Aronica E, Boer K, Fällmar D, Kumlien E, Nistér M, Wester K, Pontén F, Smits A.
DLG3/SAP102 protein expression in malformations of cortical development: a study of human epileptic cortex by tissue microarray.
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87 Newberg JY, Li J, Rao A, Pontén F, Uhlén M, Lundberg E, Murphy RF.
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86 Gaber A, Johansson M, Stenman UH, Hotakainen K, Pontén F, Glimelius B, Bjartell A, Jirström K, Birgisson H.
High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer.
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85 Paulsson J, Sjöblom T, Micke P, Pontén F, Landberg G, Heldin CH, Bergh J, Brennan DJ, Jirström K, Ostman A.
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84 Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, Kellner R, Kubicek M, Lottspeich F, Maser E, Mewes HW, Meyer HE, Müllner S, Mutter W, Neumaier M, Nollau P, Nothwang HG, Ponten F, Radbruch A, Reinert K, Rothe G, Stockinger H, Tarnok A, Taussig MJ, Thiel A, Thiery J, Ueffing M, Valet G, Vandekerckhove J, Verhuven W, Wagener C, Wagner O, Schmitz G.
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81 Rimini R, Schwenk JM, Sundberg M, Sjöberg R, Klevebring D, Gry M, Uhlén M, Nilsson P.
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77 Gry M, Rimini R, Strömberg S, Asplund A, Pontén F, Uhlén M, Nilsson P.
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32 Orchard S, Heck A, Uhlen M, Ping P.
Publication Committee meeting. HUPO 5th annual World Congress. Long Beach, CA, USA 30 October 2006.
Proteomics. 2007 7(7):1009-11.
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31 Falk R, Ramström M, Ståhl S, Hober S.
Approaches for systematic proteome exploration.
Biomol Eng. 2007 24(2):155-68.
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30 Strömberg S, Björklund MG, Asplund C, Sköllermo A, Persson A, Wester K, Kampf C, Nilsson P, Andersson AC, Uhlen M, Kononen J, Ponten F, Asplund A.
A high-throughput strategy for protein profiling in cell microarrays using automated image analysis.
Proteomics. 2007 7(13):2142-50.
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29 Uhlen M.
Mapping the human proteome using antibodies
Mol Cell Proteomics 2007 6(8):1455-6.
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28 Bengtsson S, Krogh M, Szigyarto CA, Uhlen M, Schedvins K, Silfverswärd C, Linder S, Auer G, Alaiya A, James P.
Large-scale proteomics analysis of human ovarian cancer for biomarkers.
J Proteome Res. 2007 6(4):1440-50.
PubMed: 17315909 DOI: 10.1021/pr060593y
27 Lofblom J, Kronqvist N, Uhlen M, Stahl S, Wernerus H.
Optimization of electroporation-mediated transformation: Staphylococcus carnosus as model organism.
J Appl Microbiol 2007 102(3):736-47.
PubMed: 17309623 DOI: 10.1111/j.1365-2672.2006.03127.x
26 Lerner M, Corcoran M, Cepeda D, Nielsen ML, Zubarev R, Pontén F, Uhlén M, Hober S, Grandér D, Sangfelt O.
The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD.
Mol Biol Cell. 2007 18(5):1670-82.
PubMed: 17314412 DOI: 10.1091/mbc.E06-03-0248
25 Lundberg E, Sundberg M, Gräslund T, Uhlén M, Svahn HA.
A novel method for reproducible fluorescent labeling of small amounts of antibodies on solid phase.
J Immunol Methods. 2007 322(1-2):40-9.
PubMed: 17383674 DOI: 10.1016/j.jim.2007.01.023
24 Patrakka J, Xiao Z, Nukui M, Takemoto M, He L, Oddsson A, Perisic L, Kaukinen A, Szigyarto CA, Uhlén M, Jalanko H, Betsholtz C, Tryggvason K.
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik.
J Am Soc Nephrol. 2007 18(3):689-97.
PubMed: 17251388 DOI: 10.1681/ASN.2006060675
23 Taussig MJ, Stoevesandt O, Borrebaeck CA, Bradbury AR, Cahill D, Cambillau C, de Daruvar A, Dubel S, Eichler J, Frank R, Gibson TJ, Gloriam D, Gold L, Herberg FW, Hermjakob H, Hoheisel JD, Joos TO, Kallioniemi O, Koegll M, Konthur Z, Korn B, Kremmer E, Krobitsch S, Landegren U, van der Maarel S, McCafferty J, Muyldermans S, Nygren PA, Palcy S, Pluckthun A, Polic B, Przybylski M, Saviranta P, Sawyer A, Sherman DJ, Skerra A, Templin M, Ueffing M, Uhlen M.
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome.
Nature Methods 2007 4(1):13-7.
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22 Schwenk JM, Lindberg J, Sundberg M, Uhlén M, Nilsson P.
Determination of binding specificities in highly multiplexed bead-based assays for antibody proteomics.
Mol Cell Proteomics. 2007 6(1):125-32.
PubMed: 17060675 DOI: 10.1074/mcp.T600035-MCP200
21 Söderberg O, Gullberg M, Jarvius M, Ridderstråle K, Leuchowius KJ, Jarvius J, Wester K, Hydbring P, Bahram F, Larsson LG, Landegren U.
Direct observation of individual endogenous protein complexes in situ by proximity ligation.
Nat Methods. 2006 3(12):995-1000.
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20 Steen J, Uhlén M, Hober S, Ottosson J.
High-throughput protein purification using an automated set-up for high-yield affinity chromatography.
Protein Expr Purif. 2006 46(2):173-8.
PubMed: 16483795 DOI: 10.1016/j.pep.2005.12.010
19 Andrade J, Berglund L, Uhlén M, Odeberg J.
Using Grid technology for computationally intensive applied bioinformatics analyses.
In Silico Biol. 2006 6(6):495-504.
PubMed: 17518760
18 Persson A, Hober S, Uhlén M.
A human protein atlas based on antibody proteomics.
Curr Opin Mol Ther. 2006 8(3):185-90.
PubMed: 16774037
17 Ek S, Andréasson U, Hober S, Kampf C, Pontén F, Uhlén M, Merz H, Borrebaeck CA.
From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies.
Mol Cell Proteomics. 2006 5(6):1072-81.
PubMed: 16524965 DOI: 10.1074/mcp.M600077-MCP200
16 Eriksson C, Agaton C, Kånge R, Sundberg M, Nilsson P, Ek B, Uhlén M, Gustafsson M, Hober S.
Microfluidic analysis of antibody specificity in a compact disk format.
J Proteome Res. 2006 5(7):1568-74.
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15 Haab BB, Paulovich AG, Anderson NL, Clark AM, Downing GJ, Hermjakob H, Labaer J, Uhlen M.
A reagent resource to identify proteins and peptides of interest for the cancer community: a workshop report.
Mol Cell Proteomics. 2006 5(10):1996-2007.
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14 Larsson K, Wester K, Nilsson P, Uhlén M, Hober S, Wernérus H.
Multiplexed PrEST immunization for high-throughput affinity proteomics.
J Immunol Methods. 2006 315(1-2):110-20.
PubMed: 16949094 DOI: 10.1016/j.jim.2006.07.014
13 Andersson AC, Strömberg S, Bäckvall H, Kampf C, Uhlen M, Wester K, Pontén F.
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J Histochem Cytochem. 2006 54(12):1413-23.
PubMed: 16957166 DOI: 10.1369/jhc.6A7001.2006
12 Rada-Iglesias A, Wallerman O, Koch C, Ameur A, Enroth S, Clelland G, Wester K, Wilcox S, Dovey OM, Ellis PD, Wraight VL, James K, Andrews R, Langford C, Dhami P, Carter N, Vetrie D, Pontén F, Komorowski J, Dunham I, Wadelius C.
Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays.
Hum Mol Genet. 2005 14(22):3435-47.
PubMed: 16221759 DOI: 10.1093/hmg/ddi378
11 Janzi M, Odling J, Pan-Hammarström Q, Sundberg M, Lundeberg J, Uhlén M, Hammarström L, Nilsson P.
Serum microarrays for large scale screening of protein levels.
Mol Cell Proteomics. 2005 4(12):1942-7.
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10 Nilsson P, Paavilainen L, Larsson K, Odling J, Sundberg M, Andersson AC, Kampf C, Persson A, Al-Khalili Szigyarto C, Ottosson J, Björling E, Hober S, Wernérus H, Wester K, Pontén F, Uhlen M.
Towards a human proteome atlas: high-throughput generation of mono-specific antibodies for tissue profiling.
Proteomics. 2005 5(17):4327-37.
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9 Hedhammar M, Stenvall M, Lönneborg R, Nord O, Sjölin O, Brismar H, Uhlén M, Ottosson J, Hober S.
A novel flow cytometry-based method for analysis of expression levels in Escherichia coli, giving information about precipitated and soluble protein.
J Biotechnol. 2005 119(2):133-46.
PubMed: 15996784 DOI: 10.1016/j.jbiotec.2005.03.024
8 Stenvall M, Steen J, Uhlén M, Hober S, Ottosson J.
High-throughput solubility assay for purified recombinant protein immunogens.
Biochim Biophys Acta. 2005 1752(1):6-10.
PubMed: 16084133 DOI: 10.1016/j.bbapap.2005.07.002
7 Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Pontén F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Mol Cell Proteomics. 2005 4(12):1920-32.
PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200
6 Lindskog M, Rockberg J, Uhlen M, Sterky F.
Selection of protein epitopes for antibody production
Biotechniques 2005 38(5):723-7.
PubMed: 15945371
5 Uhlen M, Ponten F.
Antibody-based proteomics for human tissue profiling.
Mol Cell Proteomics. 2005 4(4):384-93.
PubMed: 15695805 DOI: 10.1074/mcp.R500009-MCP200
4 Kampf C, Andersson A-C, Wester K, Björling E, Uhlen M, Ponten F
Antibody-based tissue profiling as a tool in clinical proteomics
Clin. Proteomics 2004 1(3-4):285-300.
DOI: 10.1385/CP:1:3-4:285
3 Agaton C, Uhlén M, Hober S.
Genome-based proteomics.
Electrophoresis. 2004 25(9):1280-8.
PubMed: 15174050 DOI: 10.1002/elps.200405846
2 Agaton C, Falk R, Hoiden Guthenberg I, Gostring L, Uhlen M, Hober S.
Selective enrichment of monospecific polyclonal antibodies for antibody-based proteomics efforts.
J Chromatogr A 2004 16;1043(1):33-40.
PubMed: 15317410
1 Agaton C, Galli J, Höidén Guthenberg I, Janzon L, Hansson M, Asplund A, Brundell E, Lindberg S, Ruthberg I, Wester K, Wurtz D, Höög C, Lundeberg J, Ståhl S, Pontén F, Uhlén M.
Affinity proteomics for systematic protein profiling of chromosome 21 gene products in human tissues.
Mol Cell Proteomics. 2003 2(6):405-14.
PubMed: 12796447 DOI: 10.1074/mcp.M300022-MCP200

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