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RU2012103850A - Би-арил-мета-пиримидиновые ингибиторы киназ - Google Patents

Би-арил-мета-пиримидиновые ингибиторы киназ Download PDF

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Publication number
RU2012103850A
RU2012103850A RU2012103850/04A RU2012103850A RU2012103850A RU 2012103850 A RU2012103850 A RU 2012103850A RU 2012103850/04 A RU2012103850/04 A RU 2012103850/04A RU 2012103850 A RU2012103850 A RU 2012103850A RU 2012103850 A RU2012103850 A RU 2012103850A
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RU
Russia
Prior art keywords
compound
formula
meta
aryl
kinase inhibitors
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RU2012103850/04A
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English (en)
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RU2589878C2 (ru
Inventor
Жиангуо КАО
Джон ХУД
Дэниель ЛОХС
Чи Чинг МАК
ФЕРСОН Эндрю МАК
Гленн НОРОНА
Вед ПЭТЕК
Джоэл РЕНИК
Ричард М. Солл
Бинки ЗЕНГ
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Таргеджен, Инк.
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Abstract

1. Соединение формулы 32:или его соль.2. Способ получения соединения формулы XLV:включающий взаимодействие 3-бром-N-трет-бутилбензолсульфонамида с соединением формулы 32:.3. Способ по п.2, дополнительно включающий очистку необработанного продукта, полученного на стадии взаимодействия соединения формулы 32 с 3-бром-N-трет-бутилбензолсульфонамидом.

Claims (3)

1. Соединение формулы 32:
Figure 00000001
или его соль.
2. Способ получения соединения формулы XLV:
Figure 00000002
включающий взаимодействие 3-бром-N-трет-бутилбензолсульфонамида с соединением формулы 32:
Figure 00000001
.
3. Способ по п.2, дополнительно включающий очистку необработанного продукта, полученного на стадии взаимодействия соединения формулы 32 с 3-бром-N-трет-бутилбензолсульфонамидом.
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BRPI0618179A2 (pt) 2011-08-23
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US20070191405A1 (en) 2007-08-16
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CN103626742B (zh) 2017-04-26
US8138199B2 (en) 2012-03-20
RU2589878C2 (ru) 2016-07-10
KR20130100380A (ko) 2013-09-10
JP2009513703A (ja) 2009-04-02
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RU2012103851A (ru) 2013-08-10
CY2021013I1 (el) 2021-10-15
IL191167A0 (en) 2008-12-29
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PL1951684T3 (pl) 2017-03-31
BR122021011788B1 (pt) 2022-01-25
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HK1121148A1 (zh) 2009-04-17
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CN103626742A (zh) 2014-03-12
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AU2006309013A1 (en) 2007-05-10
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FIC20210010I1 (fi) 2021-05-12
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EP1951684B1 (en) 2016-07-13
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