[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

JPS557215A - Preparation of active vitamin d3 or its oh-protected derivative and/or its corresponding previtamin d3 or its oh-protected derivative - Google Patents

Preparation of active vitamin d3 or its oh-protected derivative and/or its corresponding previtamin d3 or its oh-protected derivative

Info

Publication number
JPS557215A
JPS557215A JP7862778A JP7862778A JPS557215A JP S557215 A JPS557215 A JP S557215A JP 7862778 A JP7862778 A JP 7862778A JP 7862778 A JP7862778 A JP 7862778A JP S557215 A JPS557215 A JP S557215A
Authority
JP
Japan
Prior art keywords
previtamin
active vitamin
protected derivative
precursor
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7862778A
Other languages
Japanese (ja)
Other versions
JPS6231702B2 (en
Inventor
Kenji Ishimaru
Osamu Nishikawa
Hideki Tsuruta
Yoshio Ishimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP7862778A priority Critical patent/JPS557215A/en
Publication of JPS557215A publication Critical patent/JPS557215A/en
Publication of JPS6231702B2 publication Critical patent/JPS6231702B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare an active vitamin D3 useful for the regulation of Ca-metabolism of warm-blooded animals, its derivative, or its intermediate, economically, in high yield, by irradiating a precursor of the active vitamin D3 with UV radiation under specific optimum condictions.
CONSTITUTION: 1α,3β-Dihydroxycholesta-5,7-diene derivative which is a precursor of active vitamin D3, or its OH-protected derivative is irradiated with UV-radiation to obtain a previtamin D3 or its OH-protected derivative (the 9,10 single bond of the starting material is cleaved). A specific amount of the previtamin D3 or active vitamin D3 obtained by the thermal isomerization of the previtamin D3 is accumulated in the reaction system. The title compound is separated from the system, and the unreacted precursor is recycled as the precursor to be irradiated with UV radiation. The amount of accumulation of the previtamin D3, etc. in the system is 0.03W 0.4 parts by weight per 1 part of the unreacted precursor existing in the system.
COPYRIGHT: (C)1980,JPO&Japio
JP7862778A 1978-06-30 1978-06-30 Preparation of active vitamin d3 or its oh-protected derivative and/or its corresponding previtamin d3 or its oh-protected derivative Granted JPS557215A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7862778A JPS557215A (en) 1978-06-30 1978-06-30 Preparation of active vitamin d3 or its oh-protected derivative and/or its corresponding previtamin d3 or its oh-protected derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7862778A JPS557215A (en) 1978-06-30 1978-06-30 Preparation of active vitamin d3 or its oh-protected derivative and/or its corresponding previtamin d3 or its oh-protected derivative

Publications (2)

Publication Number Publication Date
JPS557215A true JPS557215A (en) 1980-01-19
JPS6231702B2 JPS6231702B2 (en) 1987-07-09

Family

ID=13667110

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7862778A Granted JPS557215A (en) 1978-06-30 1978-06-30 Preparation of active vitamin d3 or its oh-protected derivative and/or its corresponding previtamin d3 or its oh-protected derivative

Country Status (1)

Country Link
JP (1) JPS557215A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490226A (en) * 1982-08-30 1984-12-25 The Regents Of The University Of California Efficient photochemical formation of 1-α-hydroxyprevitamin D3
JPS6399053A (en) * 1981-07-17 1988-04-30 デュファル・インテルナチオナル・レセールフ・ベー・ヴェー 1 alpha-hydroxy-previtamin d3

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4862750A (en) * 1971-12-02 1973-09-01
JPS5168556A (en) * 1974-12-09 1976-06-14 Teijin Ltd 1 arufua 244 jihidorokishikorekarushifuerooruno seizohoho
JPS51108049A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidorokishikorekarushifuerooruno seizoho
JPS51108050A (en) * 1975-02-24 1976-09-25 Hoffmann La Roche
JPS51110554A (en) * 1973-01-10 1976-09-30 Res Inst Medicine Chem
JPS52108964A (en) * 1976-03-08 1977-09-12 Eisai Co Ltd Preparation of vitamin ds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4862750A (en) * 1971-12-02 1973-09-01
JPS51110554A (en) * 1973-01-10 1976-09-30 Res Inst Medicine Chem
JPS5168556A (en) * 1974-12-09 1976-06-14 Teijin Ltd 1 arufua 244 jihidorokishikorekarushifuerooruno seizohoho
JPS51108050A (en) * 1975-02-24 1976-09-25 Hoffmann La Roche
JPS51108049A (en) * 1975-03-17 1976-09-25 Teijin Ltd 1 arufua * 24 * s * *255 torihidorokishikorekarushifuerooruno seizoho
JPS52108964A (en) * 1976-03-08 1977-09-12 Eisai Co Ltd Preparation of vitamin ds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6399053A (en) * 1981-07-17 1988-04-30 デュファル・インテルナチオナル・レセールフ・ベー・ヴェー 1 alpha-hydroxy-previtamin d3
JPH037664B2 (en) * 1981-07-17 1991-02-04 Duphar Int Res
US4490226A (en) * 1982-08-30 1984-12-25 The Regents Of The University Of California Efficient photochemical formation of 1-α-hydroxyprevitamin D3

Also Published As

Publication number Publication date
JPS6231702B2 (en) 1987-07-09

Similar Documents

Publication Publication Date Title
JPS54130544A (en) Preparation of hexamethyltetraline
JPS557215A (en) Preparation of active vitamin d3 or its oh-protected derivative and/or its corresponding previtamin d3 or its oh-protected derivative
JPS55139375A (en) Production of hydroxyflavan
JPS5695142A (en) Preparation of aliphatic aldehyde
JPS5655345A (en) Preparation of 2-pentenoate ester
JPS54106440A (en) Preparation of 2,3-dimethoxy-5-methyl-1,4-benzoquinone
JPS56120627A (en) Selective reduction of compound having acetylenic unsaturated bond
JPS5692267A (en) Preparation of active vitamin d3
JPS5334750A (en) Preparation of cyclopentadeca-4-yne-one
JPS5522656A (en) Preparation of 1alpha,24(s),25-trihydroxycholecalciferol
JPS5562050A (en) Preparation of substituted phenylacetohydroxamic acid
JPS54103855A (en) 1beta, 25-dihydroxyvitamin
JPS5626847A (en) Preparation of substituted salicylic acid derivative
JPS5692266A (en) Preparation of active vitamin d3
JPS5564551A (en) Preparation of dialkyl carbonate
JPS5522655A (en) Preparation of 1alpha,24(r),25-trihydroxycholecalciferol
JPS6438060A (en) Vitamin d3 derivative
JPS5576858A (en) 24-fluoro-25-hydroxyvitamin d3 or its oh-protected derivative, and their preparation
JPS51125252A (en) Process for preparing substituted cyclopropanecarboxylic acid esters
JPS532436A (en) Preparation of phenols
JPS5692268A (en) Preparation of active vitamin d3
JPS51125204A (en) Process for preparation of olefin derivatives containing oxygen atom
JPS5344505A (en) Isomerization of alkene-3-ol-1
JPS56147765A (en) Preparation of active vitamin d3
JPS5748934A (en) Preparation of 2-substituted cycloalkanone