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JPS5692267A - Preparation of active vitamin d3 - Google Patents

Preparation of active vitamin d3

Info

Publication number
JPS5692267A
JPS5692267A JP16946479A JP16946479A JPS5692267A JP S5692267 A JPS5692267 A JP S5692267A JP 16946479 A JP16946479 A JP 16946479A JP 16946479 A JP16946479 A JP 16946479A JP S5692267 A JPS5692267 A JP S5692267A
Authority
JP
Japan
Prior art keywords
previtamin
diene
unreacted substance
formula
hydroxycholesta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16946479A
Other languages
Japanese (ja)
Other versions
JPS6034948B2 (en
Inventor
Osamu Nishikawa
Kenji Ishimaru
Toru Takeshita
Hideki Tsuruta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP54169464A priority Critical patent/JPS6034948B2/en
Priority to CA000362937A priority patent/CA1160217A/en
Priority to DE8080303732T priority patent/DE3070985D1/en
Priority to EP80303732A priority patent/EP0028484B1/en
Priority to DK447380A priority patent/DK160817C/en
Publication of JPS5692267A publication Critical patent/JPS5692267A/en
Priority to US06/371,870 priority patent/US4388243A/en
Publication of JPS6034948B2 publication Critical patent/JPS6034948B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To obtain the titled compound useful as a Ca metabolic regulating agent for warm-blooded animals in high yield industrially and advantageously, by irradiating a specific hydroxycholesta-5,7-diene with ultraviolet light, circulating and reusing the unreacted substance, and isomerizing the previtamin D3 under heating.
CONSTITUTION: A hydroxycholesta-5,7-diene of formula I (R1 and R2 are lower alkoxycarbonyl; R3 and R4 are H or lower alkoxycarbonyloxy), e.g. 1α,3β-diethoxycarbonyloxycholesta-5,7-diene, having hydroxyl groups protected by lower alkoxycarbonyloxy groups is irradiated with ultraviolet light up to a conversion of 10W40% to give a previtamin D3 of formula II. The unreacted substance present as a mixture is separated by using the solubility difference with an organic solvent, and circulated for reuse. The resultant previtamin D3 is isomerized by heat, and the protecting groups are removed to afford the aimed compound of formula III, e.g. 1α-hydroxycholecalciferol.
EFFECT: The unreacted substance can be readily separated.
COPYRIGHT: (C)1981,JPO&Japio
JP54169464A 1979-10-23 1979-12-27 Production method of active vitamin D↓3 types Expired JPS6034948B2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP54169464A JPS6034948B2 (en) 1979-12-27 1979-12-27 Production method of active vitamin D↓3 types
CA000362937A CA1160217A (en) 1979-10-23 1980-10-22 Process for the preparation of active-type vitamin d.sub.3 compounds
DE8080303732T DE3070985D1 (en) 1979-10-23 1980-10-22 Process for the preparation of active-type vitamin d3 compounds and of the cholesta-5,7-diene precursors, and products so obtained
EP80303732A EP0028484B1 (en) 1979-10-23 1980-10-22 Process for the preparation of active-type vitamin d3 compounds and of the cholesta-5,7-diene precursors, and products so obtained
DK447380A DK160817C (en) 1979-10-23 1980-10-22 PROCEDURE FOR THE PREPARATION OF VITAMIN D3 COMPOUNDS
US06/371,870 US4388243A (en) 1979-10-23 1982-04-26 Process for the preparation of active-type vitamin D3 compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54169464A JPS6034948B2 (en) 1979-12-27 1979-12-27 Production method of active vitamin D↓3 types

Publications (2)

Publication Number Publication Date
JPS5692267A true JPS5692267A (en) 1981-07-25
JPS6034948B2 JPS6034948B2 (en) 1985-08-12

Family

ID=15887047

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54169464A Expired JPS6034948B2 (en) 1979-10-23 1979-12-27 Production method of active vitamin D↓3 types

Country Status (1)

Country Link
JP (1) JPS6034948B2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH042106Y2 (en) * 1984-11-08 1992-01-24

Also Published As

Publication number Publication date
JPS6034948B2 (en) 1985-08-12

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