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JO3215B1 - حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy - Google Patents

حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy

Info

Publication number
JO3215B1
JO3215B1 JOP/2013/0163A JOP20130163A JO3215B1 JO 3215 B1 JO3215 B1 JO 3215B1 JO P20130163 A JOP20130163 A JO P20130163A JO 3215 B1 JO3215 B1 JO 3215B1
Authority
JO
Jordan
Prior art keywords
modulators
nuclear receptor
carboxamide
orphan nuclear
substituted nitrogen
Prior art date
Application number
JOP/2013/0163A
Other languages
English (en)
Inventor
Kinzel Olaf
Hoffmann Thomas
Kleymann Gerald
Steeneck Christoph
Gege Christian
Original Assignee
Phenex Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46754230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3215(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Phenex Pharmaceuticals Ag filed Critical Phenex Pharmaceuticals Ag
Application granted granted Critical
Publication of JO3215B1 publication Critical patent/JO3215B1/ar

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract

يتعلق الاختراع الحالي بمُعدلات للمستقبل النووي الغير محمي (اليتيم) ROR? وطرق لعلاج أمراض يساهم في حدوثها ROR? بواسطة إعطاء مُعدلات ROR? إلى إنسان أو كائن ثديي بحاجة إلى العلاج. بشكل خاص، يوفر الاختراع الحالي مركبات حلقية تحتوي على كربوكساميد لها الصيغة (1) إلى الصيغة (5) ومتشاكلات، ومزدوجات تجاسم، ومركبات صنوية، وأكاسيد N، وذوابات وأملاح مقبولة صيدلانياً منها.
JOP/2013/0163A 2012-08-09 2013-05-28 حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy JO3215B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12005789 2012-08-09

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JO3215B1 true JO3215B1 (ar) 2018-03-08

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JOP/2013/0163A JO3215B1 (ar) 2012-08-09 2013-05-28 حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy

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TWI659019B (zh) * 2014-02-28 2019-05-11 日商帝人製藥股份有限公司 吡唑醯胺衍生物
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