MX2018006979A - Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos. - Google Patents
Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos.Info
- Publication number
- MX2018006979A MX2018006979A MX2018006979A MX2018006979A MX2018006979A MX 2018006979 A MX2018006979 A MX 2018006979A MX 2018006979 A MX2018006979 A MX 2018006979A MX 2018006979 A MX2018006979 A MX 2018006979A MX 2018006979 A MX2018006979 A MX 2018006979A
- Authority
- MX
- Mexico
- Prior art keywords
- agonists
- apj
- apelin receptor
- improved
- improved apelin
- Prior art date
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/415—1,2-Diazoles
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Abstract
Esta divulgación se refiere a agonistas del receptor de la apelina (APJ) y a usos de dichos agonistas.
Applications Claiming Priority (3)
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US201562265177P | 2015-12-09 | 2015-12-09 | |
US201562265168P | 2015-12-09 | 2015-12-09 | |
PCT/US2016/065808 WO2017100558A1 (en) | 2015-12-09 | 2016-12-09 | Improved apelin receptor (apj) agonists and uses thereof |
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MX2018006979A true MX2018006979A (es) | 2019-05-16 |
Family
ID=57796972
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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MX2018006979A MX2018006979A (es) | 2015-12-09 | 2016-12-09 | Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos. |
MX2022002026A MX2022002026A (es) | 2015-12-09 | 2018-06-07 | Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos. |
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MX2022002026A MX2022002026A (es) | 2015-12-09 | 2018-06-07 | Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos. |
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US (4) | US10100059B2 (es) |
EP (1) | EP3386976A1 (es) |
JP (2) | JP2019501899A (es) |
KR (1) | KR20180090852A (es) |
CN (1) | CN108602806B (es) |
AU (1) | AU2016366310C1 (es) |
BR (1) | BR112018011784A2 (es) |
CA (1) | CA3006205A1 (es) |
CO (1) | CO2018005871A2 (es) |
HK (1) | HK1255452A1 (es) |
IL (1) | IL259634A (es) |
MA (1) | MA43417A (es) |
MX (2) | MX2018006979A (es) |
PE (1) | PE20190258A1 (es) |
RU (2) | RU2766148C1 (es) |
WO (1) | WO2017100558A1 (es) |
ZA (1) | ZA201803301B (es) |
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BR112016028119A2 (pt) | 2014-06-06 | 2017-08-22 | Res Triangle Inst | Agonistas receptores de apelina (apj) e usos dos mesmos |
MX2017014818A (es) | 2015-05-20 | 2018-02-09 | Amgen Inc | Agonistas de triazol del receptor apj. |
UY36705A (es) | 2015-06-03 | 2016-11-30 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Compuestos de 4-hidroxi-3-(heteroaril)piridin-2-ona como agonistas de apj |
CN108602806B (zh) | 2015-12-09 | 2022-07-12 | 研究三角协会 | 改进的爱帕琳肽受体(apj)激动剂及其用途 |
EP3452466B1 (en) | 2016-05-03 | 2020-08-12 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the apj receptor |
CA3033913A1 (en) | 2016-10-12 | 2018-04-19 | Research Triangle Institute | Heterocyclic apelin receptor (apj) agonists and uses thereof |
MA46824A (fr) | 2016-11-16 | 2019-09-25 | Amgen Inc | Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj |
US10736883B2 (en) | 2016-11-16 | 2020-08-11 | Amgen Inc. | Triazole furan compounds as agonists of the APJ receptor |
US10906890B2 (en) | 2016-11-16 | 2021-02-02 | Amgen Inc. | Triazole phenyl compounds as agonists of the APJ receptor |
EP3541803B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
US11020395B2 (en) | 2016-11-16 | 2021-06-01 | Amgen Inc. | Cycloalkyl substituted triazole compounds as agonists of the APJ receptor |
EP3541805B1 (en) | 2016-11-16 | 2020-10-14 | Amgen Inc. | Heteroaryl-substituted triazoles as apj receptor agonists |
SG11202001684PA (en) | 2017-10-06 | 2020-03-30 | Forma Therapeutics Inc | Inhibiting ubiquitin specific peptidase 30 |
MA50509A (fr) | 2017-11-03 | 2021-06-02 | Amgen Inc | Agonistes de triazole fusionnés du récepteur apj |
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PE20190258A1 (es) | 2019-02-25 |
CO2018005871A2 (es) | 2018-07-10 |
CN108602806A (zh) | 2018-09-28 |
USRE49594E1 (en) | 2023-08-01 |
WO2017100558A1 (en) | 2017-06-15 |
MX2022002026A (es) | 2022-03-11 |
MA43417A (fr) | 2018-10-17 |
CA3006205A1 (en) | 2017-06-15 |
HK1255452A1 (zh) | 2019-08-16 |
US20210070767A1 (en) | 2021-03-11 |
AU2016366310C1 (en) | 2021-09-09 |
KR20180090852A (ko) | 2018-08-13 |
AU2016366310B2 (en) | 2021-05-20 |
US10954247B2 (en) | 2021-03-23 |
US10100059B2 (en) | 2018-10-16 |
CN108602806B (zh) | 2022-07-12 |
RU2766148C1 (ru) | 2022-02-08 |
US11535630B2 (en) | 2022-12-27 |
ZA201803301B (en) | 2019-07-31 |
JP7195356B2 (ja) | 2022-12-23 |
EP3386976A1 (en) | 2018-10-17 |
IL259634A (en) | 2018-07-31 |
US20180265518A1 (en) | 2018-09-20 |
BR112018011784A2 (pt) | 2018-12-04 |
AU2016366310B8 (en) | 2021-06-03 |
JP2021100934A (ja) | 2021-07-08 |
US20170166577A1 (en) | 2017-06-15 |
RU2021133849A (ru) | 2022-03-21 |
AU2016366310A1 (en) | 2018-06-07 |
AU2016366310A8 (en) | 2021-06-03 |
JP2019501899A (ja) | 2019-01-24 |
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