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MX2018006979A - Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos. - Google Patents

Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos.

Info

Publication number
MX2018006979A
MX2018006979A MX2018006979A MX2018006979A MX2018006979A MX 2018006979 A MX2018006979 A MX 2018006979A MX 2018006979 A MX2018006979 A MX 2018006979A MX 2018006979 A MX2018006979 A MX 2018006979A MX 2018006979 A MX2018006979 A MX 2018006979A
Authority
MX
Mexico
Prior art keywords
agonists
apj
apelin receptor
improved
improved apelin
Prior art date
Application number
MX2018006979A
Other languages
English (en)
Inventor
P Runyon Scott
Maitra Rangan
Narayanan Sanju
Barnwell Thomas James
S Rehder Kenneth
Olepu Srinivas
Original Assignee
Res Triangle Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Triangle Inst filed Critical Res Triangle Inst
Publication of MX2018006979A publication Critical patent/MX2018006979A/es

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    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Esta divulgación se refiere a agonistas del receptor de la apelina (APJ) y a usos de dichos agonistas.
MX2018006979A 2015-12-09 2016-12-09 Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos. MX2018006979A (es)

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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016028119A2 (pt) 2014-06-06 2017-08-22 Res Triangle Inst Agonistas receptores de apelina (apj) e usos dos mesmos
MX2017014818A (es) 2015-05-20 2018-02-09 Amgen Inc Agonistas de triazol del receptor apj.
UY36705A (es) 2015-06-03 2016-11-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Compuestos de 4-hidroxi-3-(heteroaril)piridin-2-ona como agonistas de apj
CN108602806B (zh) 2015-12-09 2022-07-12 研究三角协会 改进的爱帕琳肽受体(apj)激动剂及其用途
EP3452466B1 (en) 2016-05-03 2020-08-12 Amgen Inc. Heterocyclic triazole compounds as agonists of the apj receptor
CA3033913A1 (en) 2016-10-12 2018-04-19 Research Triangle Institute Heterocyclic apelin receptor (apj) agonists and uses thereof
MA46824A (fr) 2016-11-16 2019-09-25 Amgen Inc Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj
US10736883B2 (en) 2016-11-16 2020-08-11 Amgen Inc. Triazole furan compounds as agonists of the APJ receptor
US10906890B2 (en) 2016-11-16 2021-02-02 Amgen Inc. Triazole phenyl compounds as agonists of the APJ receptor
EP3541803B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole pyridyl compounds as agonists of the apj receptor
US11020395B2 (en) 2016-11-16 2021-06-01 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the APJ receptor
EP3541805B1 (en) 2016-11-16 2020-10-14 Amgen Inc. Heteroaryl-substituted triazoles as apj receptor agonists
SG11202001684PA (en) 2017-10-06 2020-03-30 Forma Therapeutics Inc Inhibiting ubiquitin specific peptidase 30
MA50509A (fr) 2017-11-03 2021-06-02 Amgen Inc Agonistes de triazole fusionnés du récepteur apj
WO2019213006A1 (en) 2018-05-01 2019-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the apj receptor
CN112513036B (zh) 2018-05-17 2024-05-24 福马治疗有限公司 用作泛素特异性肽酶30抑制剂的稠合双环化合物
US11535618B2 (en) 2018-10-05 2022-12-27 Forma Therapeutics, Inc. Fused pyrrolines which act as ubiquitin-specific protease 30 (USP30) inhibitors
CA3145074A1 (en) 2019-08-29 2021-03-04 Research Triangle Institute Methods and uses for apelin receptor agonists
WO2022182547A1 (en) * 2021-02-25 2022-09-01 Research Triangle Institute Heteroaryl derivatives as apelin receptor agonists
WO2024148104A1 (en) * 2023-01-03 2024-07-11 BioAge Labs, Inc. Combination therapy of apelin receptor agonist and glp-1 receptor agonist for treating a disease or condition associated with weight gain

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5998004A (ja) 1982-11-25 1984-06-06 Kureha Chem Ind Co Ltd 1,2,4―トリアゾール誘導体及び除草剤
DE3316300A1 (de) 1982-05-07 1983-11-24 Kureha Kagaku Kogyo K.K., Tokyo Heribizide zusammensetzung mit einem gehalt an einem derivat des 1,2,4-triazols als wirkstoff
JPS58194866A (ja) 1982-05-07 1983-11-12 Kureha Chem Ind Co Ltd トリアゾ−ル誘導体及び該誘導体を含有する除草剤
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5811387A (en) 1990-05-15 1998-09-22 Chiron Corporation Peptoid mixtures
FR2665898B1 (fr) 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2713225B1 (fr) 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
FR2711140B1 (fr) 1993-10-12 1996-01-05 Sanofi Sa 1-Naphtylpyrazole-3-carboxamides substitués actifs sur la neurotensine, leur préparation, les compositions pharmaceutiques en contenant.
FR2732967B1 (fr) 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
FR2741621B1 (fr) 1995-11-23 1998-02-13 Sanofi Sa Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2757869B1 (fr) 1996-12-31 1999-05-21 Rhodia Chimie Sa Utilisation de melanges a base de pt et de composes de metaux de transition autres que le pt pour ameliorer les proprietes de resistance a l'arc des elastomeres silicones
US7045532B2 (en) 1999-04-30 2006-05-16 Millennium Pharmaceuticals, Inc. ACE-2 modulating compounds and methods of use thereof
GB9925962D0 (en) 1999-11-02 1999-12-29 Novartis Ag Organic compounds
GEP20053466B (en) 2001-05-03 2005-02-25 Hoffmann La Roche Pharmaceutical Dosage Form of Amorphous Nelfinavir Mesylate, Method for its Production and Use
EP1392262A1 (en) 2001-05-24 2004-03-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
TWI231757B (en) 2001-09-21 2005-05-01 Solvay Pharm Bv 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
US7109216B2 (en) 2001-09-21 2006-09-19 Solvay Pharmaceuticals B.V. 1H-imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
GT200200188A (es) 2001-09-24 2003-06-25 Preparacion y uso de derivados de imidazol para el tratamiento de la obesidad
AR038967A1 (es) 2002-03-18 2005-02-02 Solvay Pharm Bv Derivados de 2,3 - diaril - pirazolidinas como inhibidores de enzimas que degradan la neurotensina
US7319110B2 (en) 2002-09-19 2008-01-15 Solvay Pharmaceuticals B.V. 1H-1,2,4-triazole-3-carboxamide derivatives having cannabinoid-CB1 receptor agonistic, partial agonistic, inverse agonistic or antagonistic activity
US20060014813A1 (en) 2003-11-26 2006-01-19 Patrick Connelly Pharmaceutical compounds that regenerate in vivo
TW200526641A (en) * 2003-12-26 2005-08-16 Daiichi Seiyaku Co Amidopyrazole derivatives
WO2005099705A2 (en) 2004-03-24 2005-10-27 Bayer Pharmaceuticals Corporation Preparation of imidazole derivatives and methods of use
CN101076319A (zh) 2004-09-29 2007-11-21 科迪斯公司 稳定的非晶形雷帕霉素样化合物的药物剂型
MX2007004643A (es) 2004-10-19 2007-06-08 Daiichi Seiyaku Co Derivado de 1,5-diheterociclo-1h-triazol.
WO2006133926A1 (en) 2005-06-17 2006-12-21 Carex Sa Pyrazole derivates as cannabinoid receptor modulators
US7687481B2 (en) 2006-03-10 2010-03-30 Jenrin Discovery, Inc. Cannabinoid receptor antagonists/inverse agonists useful for treating obesity
CN106125048B (zh) 2016-07-11 2019-05-24 浙江大华技术股份有限公司 一种声源定位方法及装置
EP1903052A3 (en) 2006-07-28 2008-04-02 Faust Pharmaceuticals SA APJ receptor ligands and uses thereof
JP2010500336A (ja) 2006-08-09 2010-01-07 ファイザー・プロダクツ・インク 炭酸脱水酵素阻害剤として有用な複素環
UY30892A1 (es) 2007-02-07 2008-09-02 Smithkline Beckman Corp Inhibidores de la actividad akt
JP5464395B2 (ja) 2008-02-01 2014-04-09 大陽日酸株式会社 重水素化された芳香環又は複素環を有する化合物の製造方法
WO2009154754A2 (en) 2008-06-17 2009-12-23 Concert Pharmaceuticals, Inc. Synthesis of deuterated morpholine derivatives
WO2010033511A1 (en) 2008-09-16 2010-03-25 Concert Pharmaceuticals, Inc. Deuterated 2-amino-3-hydroxypropanoic acid derivatives
US20120028888A1 (en) 2008-11-04 2012-02-02 Jay Janz Apj receptor compounds
US8252790B2 (en) * 2008-11-21 2012-08-28 Raqualia Pharma Inc. Pyrazole-3-carboxamide derivative having 5-HT2B receptor antagonist activity
US20100160323A1 (en) 2008-12-23 2010-06-24 Alexander Bischoff NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE
CN101519430A (zh) 2009-03-20 2009-09-02 中国农业大学 一类新型保幼激素合成抑制剂-苯丙-甘-亮三肽酰胺类似物
US8835436B2 (en) 2009-07-10 2014-09-16 Green Cross Corporation Arylpiperazine-containing imidazole 4-carboxamide derivatives and pharmaceutical composition comprising same
DE102009036604A1 (de) 2009-07-30 2011-02-03 Aicuris Gmbh & Co. Kg Substituierte Bis-Arylpyrazolamide mit terminaler primärer Amidfunktionalisierung und ihre Verwendung
WO2011156557A2 (en) * 2010-06-11 2011-12-15 Thomas James B Compounds active at the neurotensin receptor
WO2012160015A1 (en) 2011-05-23 2012-11-29 Sanofi Process for the preparation of deuterated compounds containing n-alkyl groups
WO2012166387A1 (en) 2011-05-31 2012-12-06 Theravance, Inc. Neprilysin inhibitors
PL2736888T3 (pl) 2011-07-26 2016-04-29 Sanofi Sa Pochodne kwasu 3-heteroaroiloamino-propionowego i ich zastosowanie jako środków farmaceutycznych
WO2013079223A1 (en) 2011-12-02 2013-06-06 Phenex Pharmaceuticals Ag Pyrrolo carboxamides as modulators of orphan nuclear receptor rar-related orphan receptor-gamma (rorϒ, nr1f3) activity and for the treatment of chronic inflammatory and autoimmune diseases
JP2013231000A (ja) 2012-04-27 2013-11-14 Dainippon Sumitomo Pharma Co Ltd 3−アミノメチルピラゾール誘導体
SG11201407919WA (en) 2012-05-31 2014-12-30 Phenex Pharmaceuticals Ag Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ror[gamma]
JO3215B1 (ar) 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy
CA3124804C (en) 2012-09-18 2023-08-22 Auspex Pharmaceuticals, Inc. Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2
CA2885272A1 (en) * 2012-09-21 2014-03-27 Sanofi Benzoimidazole-carboxylic acid amide derivatives as apj receptor modulators
WO2014053533A1 (en) 2012-10-05 2014-04-10 Sanofi Use of substituted 3-heteroaroylamino-propionic acid derivatives as pharmaceuticals for prevention/treatment of atrial fibrillation
JP2016503798A (ja) 2012-12-20 2016-02-08 コンサート ファーマシューティカルズ インコーポレイテッド 重水素化alk阻害剤
EP3401314B1 (en) 2013-03-15 2023-11-08 Araxes Pharma LLC Covalent inhibitors of kras g12c
EP2984098A2 (en) 2013-04-12 2016-02-17 Achillion Pharmaceuticals, Inc. Deuterated nucleoside prodrugs useful for treating hcv
PE20161022A1 (es) 2013-10-17 2016-11-12 Vertex Pharma Cocristales de (s)-n-metil-8-(1-((2'-metil-[4,5´-bipirimidin]-6-il)amino)propan-2-il)quinolina-4-carboxamida y sus derivados deuterados como inhibidores de proteinas quinasa dependientes de adn
US20170174633A1 (en) * 2014-03-25 2017-06-22 Research Triangle Institute Pyrazole compounds selective for neurotensin 2 receptor
WO2015184011A2 (en) 2014-05-28 2015-12-03 Sanford-Burnham Medical Research Institute Agonists of the apelin receptor and methods of use thereof
BR112016028119A2 (pt) 2014-06-06 2017-08-22 Res Triangle Inst Agonistas receptores de apelina (apj) e usos dos mesmos
CN108602806B (zh) 2015-12-09 2022-07-12 研究三角协会 改进的爱帕琳肽受体(apj)激动剂及其用途
CA3033913A1 (en) 2016-10-12 2018-04-19 Research Triangle Institute Heterocyclic apelin receptor (apj) agonists and uses thereof
CA3145074A1 (en) 2019-08-29 2021-03-04 Research Triangle Institute Methods and uses for apelin receptor agonists

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CO2018005871A2 (es) 2018-07-10
CN108602806A (zh) 2018-09-28
USRE49594E1 (en) 2023-08-01
WO2017100558A1 (en) 2017-06-15
MX2022002026A (es) 2022-03-11
MA43417A (fr) 2018-10-17
CA3006205A1 (en) 2017-06-15
HK1255452A1 (zh) 2019-08-16
US20210070767A1 (en) 2021-03-11
AU2016366310C1 (en) 2021-09-09
KR20180090852A (ko) 2018-08-13
AU2016366310B2 (en) 2021-05-20
US10954247B2 (en) 2021-03-23
US10100059B2 (en) 2018-10-16
CN108602806B (zh) 2022-07-12
RU2766148C1 (ru) 2022-02-08
US11535630B2 (en) 2022-12-27
ZA201803301B (en) 2019-07-31
JP7195356B2 (ja) 2022-12-23
EP3386976A1 (en) 2018-10-17
IL259634A (en) 2018-07-31
US20180265518A1 (en) 2018-09-20
BR112018011784A2 (pt) 2018-12-04
AU2016366310B8 (en) 2021-06-03
JP2021100934A (ja) 2021-07-08
US20170166577A1 (en) 2017-06-15
RU2021133849A (ru) 2022-03-21
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