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MX2015001728A - HETEROCICLOS DE 5 MIEMBROS QUE CONTIENEN NITROGENO SUSTITUIDO CON CARBOXAMINDA O SULFONAMIDA COMO MODULADORES PARA EL RECEPTOR NUCLEAR DE ORFAN RORy. - Google Patents

HETEROCICLOS DE 5 MIEMBROS QUE CONTIENEN NITROGENO SUSTITUIDO CON CARBOXAMINDA O SULFONAMIDA COMO MODULADORES PARA EL RECEPTOR NUCLEAR DE ORFAN RORy.

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Publication number
MX2015001728A
MX2015001728A MX2015001728A MX2015001728A MX2015001728A MX 2015001728 A MX2015001728 A MX 2015001728A MX 2015001728 A MX2015001728 A MX 2015001728A MX 2015001728 A MX2015001728 A MX 2015001728A MX 2015001728 A MX2015001728 A MX 2015001728A
Authority
MX
Mexico
Prior art keywords
modulators
nuclear receptor
carboxamide
orphan nuclear
substituted nitrogen
Prior art date
Application number
MX2015001728A
Other languages
English (en)
Other versions
MX364453B (es
Inventor
Christian Gege
Olaf Kinzel
Christoph Steeneck
Gerald Kleymann
Thomas Hoffmann
Original Assignee
Phenex Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46754230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2015001728(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Phenex Pharmaceuticals Ag filed Critical Phenex Pharmaceuticals Ag
Publication of MX2015001728A publication Critical patent/MX2015001728A/es
Publication of MX364453B publication Critical patent/MX364453B/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invención proporciona moduladores del receptor nuclear de orfan ROR? y métodos para tratar enfermedades transmitidas por ROR?, y administrar estos moduladores ROR? novedosos a un humano o mamífero que necesita del mismo. Específicamente, la presente invención proporciona compuestos cíclicos que contienen carboxamida de la fórmula (1) a la fórmula (5) y los enantiómeros, diastereómeros, tautómeros, N-óxidos, solvatos y sales farmacéuticamente aceptables del mismo.
MX2015001728A 2012-08-09 2013-05-29 Heterociclos de 5 miembros que contienen nitrógeno sustituido con carboxaminda o sulfonamida como moduladores para el receptor nuclear de orfan ror?. MX364453B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261681296P 2012-08-09 2012-08-09
EP12005789 2012-08-09
PCT/EP2013/001594 WO2014023367A1 (en) 2012-08-09 2013-05-29 Carboxamide or sulfonamide substituted nitrogen-containing 5-membered heterocycles as modulators for the orphan nuclear receptor ror gamma

Publications (2)

Publication Number Publication Date
MX2015001728A true MX2015001728A (es) 2015-04-14
MX364453B MX364453B (es) 2019-04-26

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MX2015001728A MX364453B (es) 2012-08-09 2013-05-29 Heterociclos de 5 miembros que contienen nitrógeno sustituido con carboxaminda o sulfonamida como moduladores para el receptor nuclear de orfan ror?.

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US (1) US9458104B2 (es)
EP (2) EP2882710B1 (es)
JP (1) JP6097829B2 (es)
KR (1) KR101732973B1 (es)
CN (1) CN104603105B (es)
AR (1) AR091193A1 (es)
AU (1) AU2013301914B2 (es)
BR (1) BR112015002738A2 (es)
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CL (1) CL2015000300A1 (es)
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HK (1) HK1211584A1 (es)
IL (1) IL236695A (es)
IN (1) IN2015DN01815A (es)
JO (1) JO3215B1 (es)
MX (1) MX364453B (es)
NO (1) NO344067B1 (es)
NZ (1) NZ704512A (es)
PE (1) PE20150463A1 (es)
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UA (1) UA115145C2 (es)
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ZA (1) ZA201500534B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI659019B (zh) * 2014-02-28 2019-05-11 日商帝人製藥股份有限公司 吡唑醯胺衍生物
CA2953637C (en) * 2014-05-28 2022-11-29 Glaxosmithkline Intellectual Property Development Limited Piperazine derivatives as ror-gamma modulators
BR112016028119A2 (pt) 2014-06-06 2017-08-22 Res Triangle Inst Agonistas receptores de apelina (apj) e usos dos mesmos
JOP20200117A1 (ar) 2014-10-30 2017-06-16 Janssen Pharmaceutica Nv كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t
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