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HUP0101701A3 - Substituted betha-alanines and pharmaceutical compositions comprising them - Google Patents

Substituted betha-alanines and pharmaceutical compositions comprising them

Info

Publication number
HUP0101701A3
HUP0101701A3 HU0101701A HUP0101701A HUP0101701A3 HU P0101701 A3 HUP0101701 A3 HU P0101701A3 HU 0101701 A HU0101701 A HU 0101701A HU P0101701 A HUP0101701 A HU P0101701A HU P0101701 A3 HUP0101701 A3 HU P0101701A3
Authority
HU
Hungary
Prior art keywords
betha
alanines
substituted
pharmaceutical compositions
pharmaceutical
Prior art date
Application number
HU0101701A
Other languages
English (en)
Original Assignee
Aventis Pharma Ltd West Mallin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9727532.5A external-priority patent/GB9727532D0/en
Application filed by Aventis Pharma Ltd West Mallin filed Critical Aventis Pharma Ltd West Mallin
Publication of HUP0101701A2 publication Critical patent/HUP0101701A2/hu
Publication of HUP0101701A3 publication Critical patent/HUP0101701A3/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2632-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/272-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
HU0101701A 1997-12-23 1998-12-23 Substituted betha-alanines and pharmaceutical compositions comprising them HUP0101701A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9727532.5A GB9727532D0 (en) 1997-12-23 1997-12-23 Chemical compounds
US9260298P 1998-07-13 1998-07-13
PCT/GB1998/003859 WO1999033789A1 (en) 1997-12-23 1998-12-23 SUBSTITUTED β-ALANINES

Publications (2)

Publication Number Publication Date
HUP0101701A2 HUP0101701A2 (hu) 2001-11-28
HUP0101701A3 true HUP0101701A3 (en) 2003-02-28

Family

ID=26312873

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101701A HUP0101701A3 (en) 1997-12-23 1998-12-23 Substituted betha-alanines and pharmaceutical compositions comprising them

Country Status (19)

Country Link
EP (1) EP1042279B1 (hu)
JP (1) JP4555469B2 (hu)
KR (1) KR20010033520A (hu)
CN (1) CN1163477C (hu)
AT (1) ATE289991T1 (hu)
AU (1) AU747907B2 (hu)
BR (1) BR9814376A (hu)
CA (1) CA2316235A1 (hu)
CZ (1) CZ20002342A3 (hu)
DE (1) DE69829215T2 (hu)
ES (1) ES2235383T3 (hu)
HK (1) HK1034508A1 (hu)
HU (1) HUP0101701A3 (hu)
IL (1) IL136584A (hu)
NO (1) NO20003273L (hu)
NZ (1) NZ505363A (hu)
SK (1) SK9372000A3 (hu)
TR (1) TR200001947T2 (hu)
WO (1) WO1999033789A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1049665A1 (en) * 1998-01-23 2000-11-08 Novartis AG (Novartis SA) (Novartis Inc.) Vla-4 antagonists
ES2297943T3 (es) * 1998-12-23 2008-05-01 Aventis Pharma Limited Dihidro-benzo(1,4)oxacinas y tetrahidroquinoxalinas.
CN1213025C (zh) * 1999-02-18 2005-08-03 霍夫曼-拉罗奇有限公司 硫代酰胺衍生物
SK8692002A3 (en) 1999-12-28 2003-06-03 Pfizer Prod Inc Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
DE10019755A1 (de) * 2000-04-20 2001-11-08 Bayer Ag Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten
FR2812633A1 (fr) * 2000-08-04 2002-02-08 Aventis Cropscience Sa Derives de phenyl(thio)urees et phenyl(thio)carbamates fongicides
GB2369357A (en) * 2000-10-09 2002-05-29 Bayer Ag Aliphatic, cyclic amino carboxylic acids as integrin antagonists
GB2367816A (en) 2000-10-09 2002-04-17 Bayer Ag Urea- and thiourea-containing derivatives of beta-amino acids
EP1330432A2 (en) 2000-11-04 2003-07-30 Aventis Pharma Limited Substituted alkanoic acids
US7157487B2 (en) 2000-12-28 2007-01-02 Daiichi Pharmaceutical Co., Ltd. Vla-4 inhibitors
GB2377933A (en) 2001-07-06 2003-01-29 Bayer Ag Succinic acid derivatives useful as integrin antagonists
EP1650205B1 (en) 2003-07-24 2012-04-25 Daiichi Sankyo Company, Limited Cyclohexanecarboxylic acid compound
JP2008539246A (ja) * 2005-04-28 2008-11-13 フェリング ベスローテン フェンノートシャップ Ibd治療のための新規化合物の使用
EP1961750B1 (en) 2005-12-13 2013-09-18 Daiichi Sankyo Company, Limited Vla-4 inhibitory drug
US20100150915A1 (en) 2007-02-20 2010-06-17 Stewart Edward J Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
NZ318926A (en) * 1995-08-30 1999-04-29 Searle & Co Alpha v beta 3 integrin (vitronectin) inhibitors or anatagonists derived from benzoic acid for treating diseases of cell adhesion
AU2536097A (en) * 1996-03-29 1997-10-22 G.D. Searle & Co. Para-substituted phenylpropanoic acid derivatives as integrin antagonists
DK0889877T3 (da) * 1996-03-29 2001-10-01 Searle & Co Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer
KR20010031557A (ko) * 1997-10-31 2001-04-16 추후제출 치환 아닐리드

Also Published As

Publication number Publication date
KR20010033520A (ko) 2001-04-25
HUP0101701A2 (hu) 2001-11-28
BR9814376A (pt) 2000-10-10
WO1999033789A1 (en) 1999-07-08
NO20003273D0 (no) 2000-06-22
CN1163477C (zh) 2004-08-25
JP2001527061A (ja) 2001-12-25
IL136584A0 (en) 2001-06-14
NO20003273L (no) 2000-06-22
DE69829215T2 (de) 2005-07-21
AU747907B2 (en) 2002-05-30
TR200001947T2 (tr) 2001-01-22
AU1771999A (en) 1999-07-19
SK9372000A3 (en) 2002-03-05
CZ20002342A3 (cs) 2001-11-14
HK1034508A1 (en) 2001-10-26
NZ505363A (en) 2005-02-25
EP1042279A1 (en) 2000-10-11
CA2316235A1 (en) 1999-07-08
CN1283181A (zh) 2001-02-07
ES2235383T3 (es) 2005-07-01
JP4555469B2 (ja) 2010-09-29
IL136584A (en) 2005-03-20
DE69829215D1 (de) 2005-04-07
ATE289991T1 (de) 2005-03-15
EP1042279B1 (en) 2005-03-02

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees