BR9814376A - Composto ou um pró-medicamento correspondente, ou um sal farmaceuticamente aceitável ou solvato de um tal composto ou um pró-medicamento deste, uso destes, composição farmacêutica, processo para o tratamento de um paciente humano ou animal não humano sofrendo de, ou sujeito a, condições que podem ser melhoradas pela admnistração de um inibidor da adesão celular mediada por &4ß1, e, resina - Google Patents
Composto ou um pró-medicamento correspondente, ou um sal farmaceuticamente aceitável ou solvato de um tal composto ou um pró-medicamento deste, uso destes, composição farmacêutica, processo para o tratamento de um paciente humano ou animal não humano sofrendo de, ou sujeito a, condições que podem ser melhoradas pela admnistração de um inibidor da adesão celular mediada por &4ß1, e, resinaInfo
- Publication number
- BR9814376A BR9814376A BR9814376-0A BR9814376A BR9814376A BR 9814376 A BR9814376 A BR 9814376A BR 9814376 A BR9814376 A BR 9814376A BR 9814376 A BR9814376 A BR 9814376A
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- prodrug
- human
- pharmaceutically acceptable
- solvate
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 229940002612 prodrug Drugs 0.000 title abstract 4
- 239000000651 prodrug Substances 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 title abstract 3
- 239000012453 solvate Substances 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000011347 resin Substances 0.000 title abstract 2
- 229920005989 resin Polymers 0.000 title abstract 2
- 230000021164 cell adhesion Effects 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229940126601 medicinal product Drugs 0.000 abstract 2
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 abstract 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 abstract 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Polyamides (AREA)
Abstract
"COMPOSTO OU UM PRó-MEDICAMENTO CORRESPONDENTE, OU UM SAL FARMACEUTICAMENTE ACEITáVEL OU SOLVATO DE UM TAL COMPOSTO OU UM PRó-MEDICAMENTO DESTE, USO DESTES, COMPOSIçãO FARMACêUTICA, PROCESSO PARA O TRATAMENTO DE UM PACIENTE HUMANO OU ANIMAL NãO HUMANO SOFRENDO DE, OU SUJEITO A, CONDIçõES QUE PODEM SER MELHORADAS PELA ADMINISTRAçãO DE UM INIBIDOR DA ADESãO CELULAR MEDIADA POR <244>4<225>1, E, RESINA" A invenção é direcionada a compostos fisiologicamente ativos de fórmula geral (I), em que R¹ é hidrogênio, halogênio, alquila inferior ou alcóxi inferior; X¹, X² e X^ 6^ independentemente representam N ou CR²; e um de X³, X^ 4^ e X^ 5^ representa CR³ e os outros independentemente representam N ou CR² [onde R² é hidrogênio, halogênio, alquila inferior ou alcóxi inferior; e R³ representa um grupo -L¹-(CH~ 2~)~ n~-C(=O)-N(R^ 4^)-CH~ 2~-CH~ 2~-Y]; e seus pró-medicamentos, e sais e solvatos farmaceuticamente aceitáveis de tais compostos e seus pró-medicamentos. Tais compostos têm propriedades farmacêuticas valiosas, em particular a capacidade de regular a interação de VCAM-1 e fibronectina com a integrina VLA-4(<244>4<225>1).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9727532.5A GB9727532D0 (en) | 1997-12-23 | 1997-12-23 | Chemical compounds |
| US9260298P | 1998-07-13 | 1998-07-13 | |
| PCT/GB1998/003859 WO1999033789A1 (en) | 1997-12-23 | 1998-12-23 | SUBSTITUTED β-ALANINES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9814376A true BR9814376A (pt) | 2000-10-10 |
Family
ID=26312873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9814376-0A BR9814376A (pt) | 1997-12-23 | 1998-12-23 | Composto ou um pró-medicamento correspondente, ou um sal farmaceuticamente aceitável ou solvato de um tal composto ou um pró-medicamento deste, uso destes, composição farmacêutica, processo para o tratamento de um paciente humano ou animal não humano sofrendo de, ou sujeito a, condições que podem ser melhoradas pela admnistração de um inibidor da adesão celular mediada por &4ß1, e, resina |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1042279B1 (pt) |
| JP (1) | JP4555469B2 (pt) |
| KR (1) | KR20010033520A (pt) |
| CN (1) | CN1163477C (pt) |
| AT (1) | ATE289991T1 (pt) |
| AU (1) | AU747907B2 (pt) |
| BR (1) | BR9814376A (pt) |
| CA (1) | CA2316235A1 (pt) |
| CZ (1) | CZ20002342A3 (pt) |
| DE (1) | DE69829215T2 (pt) |
| ES (1) | ES2235383T3 (pt) |
| HK (1) | HK1034508A1 (pt) |
| HU (1) | HUP0101701A3 (pt) |
| IL (1) | IL136584A (pt) |
| NO (1) | NO20003273L (pt) |
| NZ (1) | NZ505363A (pt) |
| SK (1) | SK9372000A3 (pt) |
| TR (1) | TR200001947T2 (pt) |
| WO (1) | WO1999033789A1 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1049665A1 (en) * | 1998-01-23 | 2000-11-08 | Novartis AG (Novartis SA) (Novartis Inc.) | Vla-4 antagonists |
| ES2297943T3 (es) * | 1998-12-23 | 2008-05-01 | Aventis Pharma Limited | Dihidro-benzo(1,4)oxacinas y tetrahidroquinoxalinas. |
| CN1213025C (zh) * | 1999-02-18 | 2005-08-03 | 霍夫曼-拉罗奇有限公司 | 硫代酰胺衍生物 |
| SK8692002A3 (en) | 1999-12-28 | 2003-06-03 | Pfizer Prod Inc | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases |
| DE10019755A1 (de) * | 2000-04-20 | 2001-11-08 | Bayer Ag | Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten |
| FR2812633A1 (fr) * | 2000-08-04 | 2002-02-08 | Aventis Cropscience Sa | Derives de phenyl(thio)urees et phenyl(thio)carbamates fongicides |
| GB2369357A (en) * | 2000-10-09 | 2002-05-29 | Bayer Ag | Aliphatic, cyclic amino carboxylic acids as integrin antagonists |
| GB2367816A (en) | 2000-10-09 | 2002-04-17 | Bayer Ag | Urea- and thiourea-containing derivatives of beta-amino acids |
| EP1330432A2 (en) | 2000-11-04 | 2003-07-30 | Aventis Pharma Limited | Substituted alkanoic acids |
| US7157487B2 (en) | 2000-12-28 | 2007-01-02 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitors |
| GB2377933A (en) | 2001-07-06 | 2003-01-29 | Bayer Ag | Succinic acid derivatives useful as integrin antagonists |
| EP1650205B1 (en) | 2003-07-24 | 2012-04-25 | Daiichi Sankyo Company, Limited | Cyclohexanecarboxylic acid compound |
| JP2008539246A (ja) * | 2005-04-28 | 2008-11-13 | フェリング ベスローテン フェンノートシャップ | Ｉｂｄ治療のための新規化合物の使用 |
| EP1961750B1 (en) | 2005-12-13 | 2013-09-18 | Daiichi Sankyo Company, Limited | Vla-4 inhibitory drug |
| US20100150915A1 (en) | 2007-02-20 | 2010-06-17 | Stewart Edward J | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| NZ318926A (en) * | 1995-08-30 | 1999-04-29 | Searle & Co | Alpha v beta 3 integrin (vitronectin) inhibitors or anatagonists derived from benzoic acid for treating diseases of cell adhesion |
| AU2536097A (en) * | 1996-03-29 | 1997-10-22 | G.D. Searle & Co. | Para-substituted phenylpropanoic acid derivatives as integrin antagonists |
| DK0889877T3 (da) * | 1996-03-29 | 2001-10-01 | Searle & Co | Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer |
| KR20010031557A (ko) * | 1997-10-31 | 2001-04-16 | 추후제출 | 치환 아닐리드 |
-
1998
- 1998-12-23 KR KR1020007007022A patent/KR20010033520A/ko not_active Application Discontinuation
- 1998-12-23 HU HU0101701A patent/HUP0101701A3/hu unknown
- 1998-12-23 AU AU17719/99A patent/AU747907B2/en not_active Ceased
- 1998-12-23 NZ NZ505363A patent/NZ505363A/en unknown
- 1998-12-23 DE DE69829215T patent/DE69829215T2/de not_active Expired - Lifetime
- 1998-12-23 IL IL13658498A patent/IL136584A/xx not_active IP Right Cessation
- 1998-12-23 EP EP98962586A patent/EP1042279B1/en not_active Expired - Lifetime
- 1998-12-23 ES ES98962586T patent/ES2235383T3/es not_active Expired - Lifetime
- 1998-12-23 CZ CZ20002342A patent/CZ20002342A3/cs unknown
- 1998-12-23 BR BR9814376-0A patent/BR9814376A/pt not_active Application Discontinuation
- 1998-12-23 SK SK937-2000A patent/SK9372000A3/sk unknown
- 1998-12-23 AT AT98962586T patent/ATE289991T1/de not_active IP Right Cessation
- 1998-12-23 CN CNB988125005A patent/CN1163477C/zh not_active Expired - Fee Related
- 1998-12-23 CA CA002316235A patent/CA2316235A1/en not_active Abandoned
- 1998-12-23 TR TR2000/01947T patent/TR200001947T2/xx unknown
- 1998-12-23 WO PCT/GB1998/003859 patent/WO1999033789A1/en active Search and Examination
- 1998-12-23 JP JP2000526473A patent/JP4555469B2/ja not_active Expired - Lifetime
-
2000
- 2000-06-22 NO NO20003273A patent/NO20003273L/no not_active Application Discontinuation
-
2001
- 2001-07-27 HK HK01105254A patent/HK1034508A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010033520A (ko) | 2001-04-25 |
| HUP0101701A2 (hu) | 2001-11-28 |
| WO1999033789A1 (en) | 1999-07-08 |
| NO20003273D0 (no) | 2000-06-22 |
| HUP0101701A3 (en) | 2003-02-28 |
| CN1163477C (zh) | 2004-08-25 |
| JP2001527061A (ja) | 2001-12-25 |
| IL136584A0 (en) | 2001-06-14 |
| NO20003273L (no) | 2000-06-22 |
| DE69829215T2 (de) | 2005-07-21 |
| AU747907B2 (en) | 2002-05-30 |
| TR200001947T2 (tr) | 2001-01-22 |
| AU1771999A (en) | 1999-07-19 |
| SK9372000A3 (en) | 2002-03-05 |
| CZ20002342A3 (cs) | 2001-11-14 |
| HK1034508A1 (en) | 2001-10-26 |
| NZ505363A (en) | 2005-02-25 |
| EP1042279A1 (en) | 2000-10-11 |
| CA2316235A1 (en) | 1999-07-08 |
| CN1283181A (zh) | 2001-02-07 |
| ES2235383T3 (es) | 2005-07-01 |
| JP4555469B2 (ja) | 2010-09-29 |
| IL136584A (en) | 2005-03-20 |
| DE69829215D1 (de) | 2005-04-07 |
| ATE289991T1 (de) | 2005-03-15 |
| EP1042279B1 (en) | 2005-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL.8: C07C 275/42, C07D 207/27, C07D 209/04, C07D 213/06, C07D 233/58, C07D 285/06, C07D 295/02, C07D 295/125, C07D 307/36, C07D 317/50, C07D 333/10, A61K 31/17, A61K 31/341, A61K 31/36, A61K 31/381, A61K 31/40, A61K 31/404, A61K 31/4164, A61K 31/433, A61K 31/44, A61K 31/445, A61K 31/5375, Ipc: C07C 275/42 (2007.10), C07D 207/27 (2007.10), C07D |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI. |