ATE289991T1 - Substituierte beta-alaninen - Google Patents
Substituierte beta-alaninenInfo
- Publication number
- ATE289991T1 ATE289991T1 AT98962586T AT98962586T ATE289991T1 AT E289991 T1 ATE289991 T1 AT E289991T1 AT 98962586 T AT98962586 T AT 98962586T AT 98962586 T AT98962586 T AT 98962586T AT E289991 T1 ATE289991 T1 AT E289991T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- alanines
- prodrugs
- halogen
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9727532.5A GB9727532D0 (en) | 1997-12-23 | 1997-12-23 | Chemical compounds |
US9260298P | 1998-07-13 | 1998-07-13 | |
PCT/GB1998/003859 WO1999033789A1 (en) | 1997-12-23 | 1998-12-23 | SUBSTITUTED β-ALANINES |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE289991T1 true ATE289991T1 (de) | 2005-03-15 |
Family
ID=26312873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98962586T ATE289991T1 (de) | 1997-12-23 | 1998-12-23 | Substituierte beta-alaninen |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1042279B1 (de) |
JP (1) | JP4555469B2 (de) |
KR (1) | KR20010033520A (de) |
CN (1) | CN1163477C (de) |
AT (1) | ATE289991T1 (de) |
AU (1) | AU747907B2 (de) |
BR (1) | BR9814376A (de) |
CA (1) | CA2316235A1 (de) |
CZ (1) | CZ20002342A3 (de) |
DE (1) | DE69829215T2 (de) |
ES (1) | ES2235383T3 (de) |
HK (1) | HK1034508A1 (de) |
HU (1) | HUP0101701A3 (de) |
IL (1) | IL136584A (de) |
NO (1) | NO20003273L (de) |
NZ (1) | NZ505363A (de) |
SK (1) | SK9372000A3 (de) |
TR (1) | TR200001947T2 (de) |
WO (1) | WO1999033789A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1294576A (zh) * | 1998-01-23 | 2001-05-09 | 诺瓦提斯公司 | Vla-4拮抗剂 |
WO2000039103A1 (en) * | 1998-12-23 | 2000-07-06 | Aventis Pharma Limited | Dihydro-benzo(1,4)oxazines and tetrahydroquinoxalines |
BR0008280A (pt) * | 1999-02-18 | 2001-11-06 | Hoffmann La Roche | Derivados de tioamida |
BR0016818A (pt) | 1999-12-28 | 2002-10-01 | Pfizer Prod Inc | Inibidores não-peptidila de adesão celular dependente de vla-4 úteis no tratamento de doenças inflamatórias, auto-imunes e respiratórias |
DE10019755A1 (de) * | 2000-04-20 | 2001-11-08 | Bayer Ag | Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten |
FR2812633A1 (fr) * | 2000-08-04 | 2002-02-08 | Aventis Cropscience Sa | Derives de phenyl(thio)urees et phenyl(thio)carbamates fongicides |
GB2369357A (en) * | 2000-10-09 | 2002-05-29 | Bayer Ag | Aliphatic, cyclic amino carboxylic acids as integrin antagonists |
GB2367816A (en) | 2000-10-09 | 2002-04-17 | Bayer Ag | Urea- and thiourea-containing derivatives of beta-amino acids |
EP1330432A2 (de) * | 2000-11-04 | 2003-07-30 | Aventis Pharma Limited | Substituierte alkansäuren |
RU2290403C2 (ru) | 2000-12-28 | 2006-12-27 | Дайити Фармасьютикал Ко., Лтд. | Ингибиторы vla-4 |
GB2377933A (en) | 2001-07-06 | 2003-01-29 | Bayer Ag | Succinic acid derivatives useful as integrin antagonists |
ES2382806T3 (es) | 2003-07-24 | 2012-06-13 | Daiichi Sankyo Company, Limited | Compuesto ácido ciclohexanocarboxílico |
EP1874283A4 (de) * | 2005-04-28 | 2011-11-02 | Ferring Bv | Verwendung neuer verbindungen zur behandlung von ibd |
EP1961750B1 (de) | 2005-12-13 | 2013-09-18 | Daiichi Sankyo Company, Limited | Vla-4-hemmendes arzneimittel |
AU2008219007A1 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
PL186370B1 (pl) * | 1995-08-30 | 2003-12-31 | Searle & Co | Związki, pochodne kwasu aminobenzoesowego, zawierające je kompozycje farmaceutyczne oraz zastosowanie tych związków |
AU2337097A (en) * | 1996-03-29 | 1997-10-22 | G.D. Searle & Co. | Meta-substituted phenylene derivatives and their use as alphavbeta3 integrin antagonists or inhibitors |
AU2536097A (en) * | 1996-03-29 | 1997-10-22 | G.D. Searle & Co. | Para-substituted phenylpropanoic acid derivatives as integrin antagonists |
SK5462000A3 (en) * | 1997-10-31 | 2001-02-12 | Aventis Pharma Ltd | Substituted anilides |
-
1998
- 1998-12-23 NZ NZ505363A patent/NZ505363A/en unknown
- 1998-12-23 TR TR2000/01947T patent/TR200001947T2/xx unknown
- 1998-12-23 DE DE69829215T patent/DE69829215T2/de not_active Expired - Lifetime
- 1998-12-23 JP JP2000526473A patent/JP4555469B2/ja not_active Expired - Lifetime
- 1998-12-23 CZ CZ20002342A patent/CZ20002342A3/cs unknown
- 1998-12-23 BR BR9814376-0A patent/BR9814376A/pt not_active Application Discontinuation
- 1998-12-23 IL IL13658498A patent/IL136584A/xx not_active IP Right Cessation
- 1998-12-23 EP EP98962586A patent/EP1042279B1/de not_active Expired - Lifetime
- 1998-12-23 WO PCT/GB1998/003859 patent/WO1999033789A1/en active Search and Examination
- 1998-12-23 CA CA002316235A patent/CA2316235A1/en not_active Abandoned
- 1998-12-23 ES ES98962586T patent/ES2235383T3/es not_active Expired - Lifetime
- 1998-12-23 AU AU17719/99A patent/AU747907B2/en not_active Ceased
- 1998-12-23 CN CNB988125005A patent/CN1163477C/zh not_active Expired - Fee Related
- 1998-12-23 AT AT98962586T patent/ATE289991T1/de not_active IP Right Cessation
- 1998-12-23 SK SK937-2000A patent/SK9372000A3/sk unknown
- 1998-12-23 HU HU0101701A patent/HUP0101701A3/hu unknown
- 1998-12-23 KR KR1020007007022A patent/KR20010033520A/ko not_active Application Discontinuation
-
2000
- 2000-06-22 NO NO20003273A patent/NO20003273L/no not_active Application Discontinuation
-
2001
- 2001-07-27 HK HK01105254A patent/HK1034508A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO20003273D0 (no) | 2000-06-22 |
TR200001947T2 (tr) | 2001-01-22 |
JP2001527061A (ja) | 2001-12-25 |
HUP0101701A2 (hu) | 2001-11-28 |
CN1283181A (zh) | 2001-02-07 |
KR20010033520A (ko) | 2001-04-25 |
CN1163477C (zh) | 2004-08-25 |
BR9814376A (pt) | 2000-10-10 |
EP1042279A1 (de) | 2000-10-11 |
NZ505363A (en) | 2005-02-25 |
HK1034508A1 (en) | 2001-10-26 |
ES2235383T3 (es) | 2005-07-01 |
CZ20002342A3 (cs) | 2001-11-14 |
AU1771999A (en) | 1999-07-19 |
AU747907B2 (en) | 2002-05-30 |
CA2316235A1 (en) | 1999-07-08 |
DE69829215T2 (de) | 2005-07-21 |
JP4555469B2 (ja) | 2010-09-29 |
EP1042279B1 (de) | 2005-03-02 |
NO20003273L (no) | 2000-06-22 |
IL136584A0 (en) | 2001-06-14 |
SK9372000A3 (en) | 2002-03-05 |
DE69829215D1 (de) | 2005-04-07 |
IL136584A (en) | 2005-03-20 |
HUP0101701A3 (en) | 2003-02-28 |
WO1999033789A1 (en) | 1999-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |