HRP20220389T1 - Pripravci koji sadrže bakterijske sojeve - Google Patents
Pripravci koji sadrže bakterijske sojeve Download PDFInfo
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- HRP20220389T1 HRP20220389T1 HRP20220389TT HRP20220389T HRP20220389T1 HR P20220389 T1 HRP20220389 T1 HR P20220389T1 HR P20220389T T HRP20220389T T HR P20220389TT HR P20220389 T HRP20220389 T HR P20220389T HR P20220389 T1 HRP20220389 T1 HR P20220389T1
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- preceding patent
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- 230000001580 bacterial effect Effects 0.000 title claims 11
- 239000000203 mixture Substances 0.000 title claims 3
- 238000002360 preparation method Methods 0.000 claims 17
- 208000006673 asthma Diseases 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 108020004465 16S ribosomal RNA Proteins 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 241000186012 Bifidobacterium breve Species 0.000 claims 2
- 210000000068 Th17 cell Anatomy 0.000 claims 2
- 201000009961 allergic asthma Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
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- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
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- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
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- 108020001027 Ribosomal DNA Proteins 0.000 claims 1
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- 229920002472 Starch Polymers 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
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- 230000036428 airway hyperreactivity Effects 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 1
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- NGFMICBWJRZIBI-UHFFFAOYSA-N alpha-salicin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UHFFFAOYSA-N 0.000 claims 1
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- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 claims 1
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Classifications
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
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Claims (15)
1. Pripravak, naznačen time, da sadrži bakterijski soj koji ima genom sa slijedom koji je najmanje 90% istovjetan slijedu SEQ ID NO: 2, za uporabu u postupku liječenja ili prevencije alergijske astme, eozinofilne astme ili hiperreaktivnosti dišnih puteva povezane s astmom.
2. Pripravak za uporabu prema patentnom zahtjevu 1, naznačen time, da bakterijski soj ima genom sa slijedom koji je najmanje 92%, 94%, 95%, 96%, 97%, 98% ili 99% istovjetan slijedu SEQ ID NO: 2 preko 100% od navedenog SEQ ID NO: 2.
3. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da bakterijski soj koristi sljedeće izvore ugljikohidrata: amidon, amigdalin, arbutin, celobioza, eskulin, galaktoza, gentiobioza, glukoza, glikogen, fruktoza, fukoza, laktoza, maltoza, manoza, manitol, melibioza, melezitoza, metil α-D-glukopiranozid, N-acetilglukozamin, riboza, saharoza, salicin, sorbitol, trehaloza, turanoza i ksilitol.
4. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da bakterijski soj dostavlja isti uzorak kao bakterija koja je deponirana pod pristupnim brojem NCIMB 42380, kada se analizira putem restrikcijske analize amplificirane ribosomalne DNA, prilikom uporabe restrikcijskog enzima Sau3Al.
5. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da bakterijski soj ima neznatnu adherenciju na Caco-2 stanice u YCFA u usporedbi s Bifidobacterium breve.
6. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da bakterijski soj proizvodi više vezanih površinskih eksopolisaharida u usporedbi s Bifidobacterium breve.
7. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da bakterijski soj ima slijed 16s rRNA koji je najmanje 99%, 99,5% ili 99,9% istovjetan slijedu SEQ ID NO: 1, ili time, da bakterijski soj ima slijed 16s rRNA koji je predstavljen sa SEQ ID NO: 1.
8. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da bakterijski soj sadrži najmanje 5, 10, 20, 50 ili sve gene iz Tablice 1.
9. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da je bakterijski soj deponiran pod pristupnim brojem NCIMB 42380.
10. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da je za uporabu u postupku smanjivanja eozinofilnog upalnog odgovora u liječenju ili prevenciji astme.
11. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da je za uporabu u smanjivanju peribronhijalne infiltracije u liječenju alergijske astme.
12. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da je za uporabu kod pacijenta s povišenim razinama eozinofila, što se ustanovljuje putem uzorkovanja krvi ili analizom sputuma.
13. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da je za uporabu u postupku smanjivanja proizvodnje IL-17 stanica ili smanjivanja diferencijacije Th17 stanica u liječenju ili prevenciji astme; i/ili time, da je pripravak za uporabu kod pacijenta s povišenim razinama IL-17 ili Th17 stanica.
14. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da se pripravak formulira kao probiotik, i ne kombinira se s prebiotičkim spojem.
15. Pripravak za uporabu prema bilo kojem prethodnom patentnom zahtjevu, naznačen time, da je pripravak za oralnu primjenu, i/ili time, da pripravak sadrži jedan ili više farmaceutski prihvatljivih pomoćnih sredstava ili nosača, i/ili time, da se bakterija liofilizira.
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| CN111356464A (zh) | 2017-07-05 | 2020-06-30 | 伊夫罗生物科学公司 | 使用动物双歧杆菌乳亚种治疗癌症的组合物及方法 |
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