ATE252091T1 - Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatoren - Google Patents
Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatorenInfo
- Publication number
- ATE252091T1 ATE252091T1 AT00959401T AT00959401T ATE252091T1 AT E252091 T1 ATE252091 T1 AT E252091T1 AT 00959401 T AT00959401 T AT 00959401T AT 00959401 T AT00959401 T AT 00959401T AT E252091 T1 ATE252091 T1 AT E252091T1
- Authority
- AT
- Austria
- Prior art keywords
- ppars
- zol
- biaryl
- thia
- oxa
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15116299P | 1999-08-27 | 1999-08-27 | |
| PCT/US2000/023358 WO2001016120A1 (en) | 1999-08-27 | 2000-08-23 | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE252091T1 true ATE252091T1 (de) | 2003-11-15 |
Family
ID=22537578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00959401T ATE252091T1 (de) | 1999-08-27 | 2000-08-23 | Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatoren |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6417212B1 (de) |
| EP (1) | EP1206457B1 (de) |
| JP (1) | JP2003508389A (de) |
| AR (1) | AR025386A1 (de) |
| AT (1) | ATE252091T1 (de) |
| AU (1) | AU7073400A (de) |
| CA (1) | CA2382966A1 (de) |
| DE (1) | DE60005973T2 (de) |
| DK (1) | DK1206457T3 (de) |
| ES (1) | ES2204684T3 (de) |
| PE (1) | PE20010529A1 (de) |
| PT (1) | PT1206457E (de) |
| WO (1) | WO2001016120A1 (de) |
Families Citing this family (88)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7655699B1 (en) | 1992-04-22 | 2010-02-02 | Eisai Inc. | Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors |
| AU8588798A (en) * | 1997-07-25 | 1999-02-16 | Institut Pasteur | Human peroxisome proliferator activated receptor gamma (ppargamma) gene re gulatory sequences and uses therefor |
| WO2002009691A1 (en) * | 2000-08-02 | 2002-02-07 | Pharmanutrients | Methods and compositions for the prevention and treatment of syndrome x |
| EP1310494B1 (de) * | 2000-08-11 | 2012-01-25 | Nippon Chemiphar Co., Ltd. | Ppar-delta aktivatoren |
| WO2002016332A1 (en) * | 2000-08-23 | 2002-02-28 | Eli Lilly And Company | Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists |
| US6982278B2 (en) * | 2000-08-23 | 2006-01-03 | Eli Lilly And Company | Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists |
| KR20030027054A (ko) | 2000-08-23 | 2003-04-03 | 일라이 릴리 앤드 캄파니 | 옥사졸릴-아릴프로피온산 유도체 및 ｐｐａｒ효능제로서의 그의 용도 |
| GB0029974D0 (en) | 2000-12-08 | 2001-01-24 | Glaxo Group Ltd | Chemical compounds |
| GB0031109D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| US7105551B2 (en) * | 2000-12-20 | 2006-09-12 | Smithkline Beecham Corporation | Thiazole derivatives for treating PPAR related disorders |
| EP1911462A3 (de) | 2001-01-26 | 2011-11-30 | Schering Corporation | Zusammensetzungen enthaltend einen Sterolabsorptionshemmer |
| GB0113231D0 (en) | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical compounds |
| NZ529351A (en) * | 2001-06-07 | 2006-01-27 | Lilly Co Eli | Modulators of peroxisome proliferator activated receptors |
| ES2275887T3 (es) * | 2001-06-07 | 2007-06-16 | Eli Lilly And Company | Moduladores de receptores activados por proliferadores de peroxisoma (ppar). |
| AR036237A1 (es) * | 2001-07-27 | 2004-08-25 | Bayer Corp | Derivados del acido indan acetico, intermediarios, y metodo para su preparacion, composicion farmaceutica y el uso de dichos derivados para la manufactura de un medicamento |
| US20110065129A1 (en) | 2001-07-27 | 2011-03-17 | Lowe Derek B | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
| WO2003016291A1 (fr) * | 2001-08-10 | 2003-02-27 | Nippon Chemiphar Co., Ltd. | Activateur du recepteur $g(d) sensible au proliferateur de peroxysome |
| JP4269052B2 (ja) | 2001-09-14 | 2009-05-27 | アムジエン・インコーポレーテツド | 連結ビアリール化合物 |
| GB0127916D0 (en) * | 2001-11-21 | 2002-01-16 | Rowett Res Inst | Method |
| TW200303742A (en) * | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| CA2468846A1 (en) * | 2001-11-30 | 2003-06-12 | Eli Lilly And Company | Peroxisome proliferator activated receptor agonists |
| WO2003072102A1 (en) | 2002-02-25 | 2003-09-04 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
| US6867224B2 (en) | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
| US6833380B2 (en) | 2002-03-07 | 2004-12-21 | Warner-Lambert Company, Llc | Compounds that modulate PPAR activity and methods of preparation |
| WO2003091211A1 (fr) * | 2002-03-28 | 2003-11-06 | Sumitomo Pharmaceuticals Co., Ltd. | Composes d'heteroaryle |
| US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| US6716842B2 (en) | 2002-04-05 | 2004-04-06 | Warner-Lambert Company, Llc | Antidiabetic agents |
| UA79755C2 (en) * | 2002-04-16 | 2007-07-25 | Bayer Pharmaceuticals Corp | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
| BR0311834A (pt) | 2002-06-19 | 2005-04-12 | Lilly Co Eli | Composto, composição farmacêutica, métodos para mudular um receptor ativado por proliferador de peroxisoma, para tratar e prevenir diabetes mellitus em um mamìfero e para tratar sìndrome x em um mamìfero, e, uso de um composto ou seu sal farmaceuticamente aceitável |
| US7192970B2 (en) * | 2002-11-26 | 2007-03-20 | Chipscreen Biosciences, Ltd. | Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity |
| US7396850B2 (en) | 2003-01-06 | 2008-07-08 | Eli Lilly And Company | Pyrazole derivative as PPAR modulator |
| US7319170B2 (en) * | 2003-01-17 | 2008-01-15 | Merck & Co., Inc. | N-cyclohexylaminocarbonyl benzensulfonmide derivatives |
| EP1597248B1 (de) | 2003-02-14 | 2007-12-26 | Eli Lilly And Company | Sulfonamid-derivate als ppar-modulatoren |
| US20070105959A1 (en) * | 2003-03-11 | 2007-05-10 | Shinya Kusuda | Cynnamyl alcohol derivative compounds and drugs containing the compounds as active ingredient |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| US7244763B2 (en) | 2003-04-17 | 2007-07-17 | Warner Lambert Company Llc | Compounds that modulate PPAR activity and methods of preparation |
| SA04250253B1 (ar) * | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| RU2349587C2 (ru) * | 2003-09-22 | 2009-03-20 | Оно Фармасьютикал Ко., Лтд. | Производное фенилуксусной кислоты и его применение |
| JP2007527416A (ja) * | 2003-10-31 | 2007-09-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ペルオキシソーム増殖因子活性化受容体（ｐｐａｒ）二重作動薬として有用なフェノキシ酢酸誘導体 |
| US20070208021A1 (en) * | 2004-03-30 | 2007-09-06 | Daiichi Pharmaceutical Co., Ltd. | Phenoxyacetic Acid Derivatives and Drug Comprising The Same |
| EP1742923B1 (de) * | 2004-04-28 | 2009-05-27 | F.Hoffmann-La Roche Ag | Pyrazolphenylderivate als ppar-aktivatoren |
| CN100344618C (zh) | 2004-05-24 | 2007-10-24 | 北京摩力克科技有限公司 | 作为hPPARα和hPPARγ激动剂的N－芳丙烯酰基取代的酪氨酸衍生物 |
| EP1749000A4 (de) * | 2004-05-25 | 2009-12-30 | Metabolex Inc | Bicyclische substituierte triazole als ppar-modulatoren und verfahren zu deren herstellung |
| JP2008500357A (ja) * | 2004-05-25 | 2008-01-10 | メタボレックス インコーポレーティッド | Ｐｐａｒのモジュレーターとしての置換されたトリアゾールおよびこれらの調製方法 |
| GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| FR2874379B1 (fr) * | 2004-08-17 | 2006-10-27 | Galderma Res & Dev | Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar et leur utilisation dans des compositions cosmetiques ou pharmaceutiques |
| FR2874378B1 (fr) * | 2004-08-17 | 2006-10-27 | Galderma Res & Dev | Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar et leur utilisation dans des compositions cosmetiques ou pharmaceutiques |
| KR20070047308A (ko) | 2004-08-17 | 2007-05-04 | 갈데르마 리써어치 앤드 디벨로프먼트 | Ｐｐａｒ 유형 수용체를 활성화시키는 신규 이방향족화합물, 및 미용 또는 약학적 조성물에서의 그의 용도 |
| ATE413167T1 (de) * | 2004-08-17 | 2008-11-15 | Galderma Res & Dev | Neuartige biaromatische ppar-rezeptoren aktivierende zusammensetzungen und ihre verwendung in kosmetischen oder pharmazeutischen zusammensetzungen |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| EP1817282B1 (de) | 2004-11-23 | 2011-07-20 | AstraZeneca AB | Zur behandlung von atemwegserkrankungen geeignete phenoxyessigsäurederivate |
| JP5155171B2 (ja) | 2005-10-06 | 2013-02-27 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| WO2007052023A2 (en) * | 2005-11-05 | 2007-05-10 | Astrazeneca Ab | Novel compounds |
| US20080293775A1 (en) * | 2005-12-15 | 2008-11-27 | Astrazeneca Ab | Substituted Diphenylethers, -Amines, -Sulfides and -Methanes for the Treatment of Respiratory Disease |
| US8023825B2 (en) * | 2006-04-04 | 2011-09-20 | Cisco Technology, Inc. | Optical switching architectures for nodes in WDM mesh and ring networks |
| AU2007239283B2 (en) | 2006-04-18 | 2013-02-07 | Nippon Chemiphar Co., Ltd. | Activating agent for peroxisome proliferator activated receptor delta |
| WO2007147336A1 (en) * | 2006-06-13 | 2007-12-27 | Shanghai Institue Of Materia Medica, Chinese Academy Of Sciences | Heterocyclic non-nucleoside compounds, their peparation, pharmaceutical composition and their use as antiviral agents |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| CA2721339C (en) | 2008-04-15 | 2017-01-24 | Nippon Chemiphar Co., Ltd. | Activating agent for peroxisome proliferator activated receptor |
| NZ592603A (en) * | 2008-10-21 | 2013-02-22 | Metabolex Inc | Aryl gpr120 receptor agonists and uses thereof |
| WO2012027331A1 (en) | 2010-08-27 | 2012-03-01 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| GB201112091D0 (en) | 2011-07-14 | 2011-08-31 | Gt Biolog Ltd | Bacterial strains isolated from pigs |
| GB201117313D0 (en) | 2011-10-07 | 2011-11-16 | Gt Biolog Ltd | Bacterium for use in medicine |
| GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
| EA202090948A1 (ru) | 2014-12-23 | 2020-11-30 | 4Д Фарма Рисерч Лимитед | Иммуномодуляция |
| PT3193901T (pt) | 2014-12-23 | 2018-06-29 | 4D Pharma Res Ltd | Polipéptido de pirina e modulação imunitária |
| MA41060B1 (fr) | 2015-06-15 | 2019-11-29 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| ES2748812T3 (es) | 2015-06-15 | 2020-03-18 | 4D Pharma Res Ltd | Composiciones que comprenden cepas bacterianas |
| SG10201912323VA (en) | 2015-06-15 | 2020-02-27 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| ME03595B (de) | 2015-06-15 | 2020-07-20 | 4D Pharma Res Ltd | Zusammensetzungen mit bakterienstämmen |
| MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| LT3209310T (lt) | 2015-11-20 | 2018-04-25 | 4D Pharma Research Limited | Kompozicijos, apimančios bakterinius kamienus |
| GB201520497D0 (en) | 2015-11-20 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520638D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| GB201520631D0 (en) | 2015-11-23 | 2016-01-06 | 4D Pharma Res Ltd | Compositions comprising bacterial strains |
| BR112018067689A2 (pt) | 2016-03-04 | 2019-01-08 | 4D Pharma Plc | composições compreendendo cepas bacterianas do gênero blautia para tratar a hipersensibilidade visceral |
| GB201612191D0 (en) | 2016-07-13 | 2016-08-24 | 4D Pharma Plc | Compositions comprising bacterial strains |
| TWI802545B (zh) | 2016-07-13 | 2023-05-21 | 英商４Ｄ製藥有限公司 | 包含細菌菌株之組合物 |
| GB201621123D0 (en) | 2016-12-12 | 2017-01-25 | 4D Pharma Plc | Compositions comprising bacterial strains |
| MA48941A (fr) | 2017-05-22 | 2020-04-08 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
| TW201907931A (zh) | 2017-05-24 | 2019-03-01 | 英商4D製藥研究有限公司 | 包含細菌菌株之組合物 |
| PL3600363T3 (pl) | 2017-06-14 | 2021-06-14 | 4D Pharma Research Limited | Kompozycje zawierające szczepy bakteryjne |
| SI3638271T1 (sl) | 2017-06-14 | 2021-01-29 | 4D Pharma Research Limited | Sestavki, ki vsebujejo bakterijske seve |
| EP3804737B1 (de) | 2017-06-14 | 2022-05-18 | 4D Pharma Research Limited | Zusammensetzungen mit bakterienstämmen |
| WO2019036024A1 (en) | 2017-08-17 | 2019-02-21 | Bristol-Myers Squibb Company | 2- (1,1'-BIPHENYL) -1H-BENZO [D] IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS AGONISTS OF APELIN AND APJ FOR THE TREATMENT OF CARDIOVASCULAR DISEASES |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089514A (en) | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
| JPH07505647A (ja) * | 1992-04-10 | 1995-06-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 複素環化合物および２型糖尿病の治療におけるそれらの使用 |
| PL176885B1 (pl) | 1992-07-03 | 1999-08-31 | Smithkline Beecham Plc | Kompozycja farmaceutyczna |
| GB9225386D0 (en) | 1992-12-04 | 1993-01-27 | Smithkline Beecham Plc | Novel compounds |
| GB9326171D0 (en) | 1993-12-22 | 1994-02-23 | Smithkline Beecham Plc | Novel compounds |
| WO1996004261A1 (en) | 1994-07-29 | 1996-02-15 | Smithkline Beecham Plc | Benzoxazoles and pryridine derivatives useful in the treatment of the type ii diabetes |
| US5902726A (en) | 1994-12-23 | 1999-05-11 | Glaxo Wellcome Inc. | Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma |
| US7115728B1 (en) | 1995-01-30 | 2006-10-03 | Ligand Pharmaceutical Incorporated | Human peroxisome proliferator activated receptor γ |
| CA2215387A1 (en) | 1995-03-20 | 1996-09-26 | Michael R. Briggs | Modulators of ob gene and screening methods therefor |
| US6022897A (en) * | 1995-04-25 | 2000-02-08 | The Salk Institute For Biological Studies | Selective modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof |
| JPH08325250A (ja) | 1995-05-31 | 1996-12-10 | Sumitomo Metal Ind Ltd | 新規置換フェノール誘導体 |
| JPH08325264A (ja) | 1995-05-31 | 1996-12-10 | Sumitomo Metal Ind Ltd | 新規２−芳香環置換−３−フェニルプロピオン酸またはアクリル酸誘導体 |
| US5939442A (en) * | 1995-06-07 | 1999-08-17 | The Salk Institute For Biological Studies | Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof |
| EP0859608B1 (de) * | 1995-09-18 | 2004-02-11 | Ligand Pharmaceuticals, Inc. | Behandlung von niddm (nichtinsulinabhängige diabetes mellitus) mit rxr agonisten |
| GB9600464D0 (en) * | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
| DE69723680T9 (de) * | 1996-02-02 | 2004-11-04 | Merck & Co., Inc. | Antidiabetische mittel |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| FR2749583B1 (fr) * | 1996-06-07 | 1998-08-21 | Lipha | Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant |
| AU4050797A (en) * | 1996-08-02 | 1998-02-25 | Ligand Pharmaceuticals Incorporated | Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators |
| EE03765B1 (et) | 1996-08-19 | 2002-06-17 | Japan Tobacco Inc. | Propioonhappe derivaadid ja nende kasutamine |
| US6586455B1 (en) * | 1996-12-31 | 2003-07-01 | The Salk Institute For Biological Studies | Treatment of liposarcomas using a combination of thiazolidinediones and retinoid X receptor selective agonists |
| US5814647A (en) * | 1997-03-04 | 1998-09-29 | Board Of Regents, The University Of Texas System | Use of troglitazone and related compounds for the treatment of the climacteric symptoms |
| WO1998043081A1 (en) * | 1997-03-26 | 1998-10-01 | Ligand Pharmaceuticals Incorporated | Treatment of gastrointestinal disease with ppar modulators |
| WO1998054220A1 (en) * | 1997-05-30 | 1998-12-03 | Dana-Farber Cancer Institute | PGC-1, A NOVEL BROWN FAT PPARη COACTIVATOR |
| US5925657A (en) * | 1997-06-18 | 1999-07-20 | The General Hospital Corporation | Use of PPARγ agonists for inhibition of inflammatory cytokine production |
| AU8588798A (en) * | 1997-07-25 | 1999-02-16 | Institut Pasteur | Human peroxisome proliferator activated receptor gamma (ppargamma) gene re gulatory sequences and uses therefor |
| KR20010024533A (ko) * | 1997-10-17 | 2001-03-26 | 오흘러 로스 제이. | 퀴놀린 유도체의 치료적 용도 |
| WO1999019313A1 (en) * | 1997-10-27 | 1999-04-22 | Dr. Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
| ES2252874T3 (es) * | 1997-12-12 | 2006-05-16 | Purdue Research Foundation | Utilizacion de acido linoleico conjugado para tratamiento de la diabetes mellitus tipo ii. |
| ATE352545T1 (de) * | 1997-12-19 | 2007-02-15 | Merck & Co Inc | Arylthiazolidindion-derivate |
| AU1887999A (en) * | 1998-01-29 | 1999-08-16 | Dr. Reddy's Research Foundation | Novel alkanoic acids and their use in medicine, process for their preparation and pharmaceutical compositions containing them |
| EP1067109B1 (de) * | 1998-03-10 | 2009-12-09 | Ono Pharmaceutical Co., Ltd. | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
| GB2335597A (en) | 1998-03-27 | 1999-09-29 | Glaxo Group Ltd | Stereoisomers of Troglitazone in the Treatment of Diabetes |
| WO1999051740A2 (en) * | 1998-04-06 | 1999-10-14 | Janssen Pharmaceutica N.V. | Nucleotide sequence expressing human fatty acid transport protein and corresponding aminoacid, use for the regulation of fatty acids metabolism |
| ES2226377T3 (es) * | 1998-05-11 | 2005-03-16 | Takeda Chemical Industries, Ltd. | Derivados de acido oxiimino-alcalino con actividad hipoglucemica e hipolipidemica. |
| US6541669B1 (en) * | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| PT1098639E (pt) * | 1998-07-21 | 2005-06-30 | Smithkline Beecham Plc | A utilizacao de intensificadores de captacao da glicose para reduzir a apoptose |
| MA26662A1 (fr) * | 1998-07-21 | 2004-12-20 | Smithkline Beecham Plc | Derives de thiazolidinedione, compositions pharmaceutiques les contenant et leur utilisation |
| GB9817118D0 (en) * | 1998-08-07 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
-
2000
- 2000-08-23 AT AT00959401T patent/ATE252091T1/de not_active IP Right Cessation
- 2000-08-23 AU AU70734/00A patent/AU7073400A/en not_active Abandoned
- 2000-08-23 US US09/644,457 patent/US6417212B1/en not_active Expired - Fee Related
- 2000-08-23 PT PT00959401T patent/PT1206457E/pt unknown
- 2000-08-23 DK DK00959401T patent/DK1206457T3/da active
- 2000-08-23 JP JP2001519687A patent/JP2003508389A/ja not_active Withdrawn
- 2000-08-23 EP EP00959401A patent/EP1206457B1/de not_active Expired - Lifetime
- 2000-08-23 DE DE60005973T patent/DE60005973T2/de not_active Expired - Lifetime
- 2000-08-23 ES ES00959401T patent/ES2204684T3/es not_active Expired - Lifetime
- 2000-08-23 WO PCT/US2000/023358 patent/WO2001016120A1/en active IP Right Grant
- 2000-08-23 CA CA002382966A patent/CA2382966A1/en not_active Abandoned
- 2000-08-25 PE PE2000000876A patent/PE20010529A1/es not_active Application Discontinuation
- 2000-08-25 AR ARP000104410A patent/AR025386A1/es unknown
-
2002
- 2002-04-11 US US10/121,373 patent/US6610696B2/en not_active Expired - Fee Related
-
2003
- 2003-05-07 US US10/434,425 patent/US6825222B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6417212B1 (en) | 2002-07-09 |
| AR025386A1 (es) | 2002-11-27 |
| EP1206457A1 (de) | 2002-05-22 |
| ES2204684T3 (es) | 2004-05-01 |
| AU7073400A (en) | 2001-03-26 |
| US20040019090A1 (en) | 2004-01-29 |
| DE60005973T2 (de) | 2004-05-13 |
| US6610696B2 (en) | 2003-08-26 |
| DK1206457T3 (da) | 2004-02-16 |
| PE20010529A1 (es) | 2001-05-18 |
| US20030045558A1 (en) | 2003-03-06 |
| JP2003508389A (ja) | 2003-03-04 |
| PT1206457E (pt) | 2004-03-31 |
| US6825222B2 (en) | 2004-11-30 |
| WO2001016120A1 (en) | 2001-03-08 |
| CA2382966A1 (en) | 2001-03-08 |
| EP1206457B1 (de) | 2003-10-15 |
| DE60005973D1 (de) | 2003-11-20 |
| WO2001016120A9 (en) | 2002-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60005973D1 (de) | Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatoren | |
| DE60036803D1 (de) | Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel | |
| ATE254123T1 (de) | Benzazolderivate und ihre verwendung als jnk modulatoren | |
| DE60010333D1 (de) | Substituierte oxazole und thiazole derivate als hppar-alpha aktivatore | |
| DE60123210D1 (de) | Picolinsäure-derivate und ihre verwendung als fungizide | |
| DE69836346D1 (de) | Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer | |
| DE50008597D1 (de) | Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel | |
| DE60139477D1 (de) | 2-cyanopyrrolidin-derivate und ihre verwendung als arzneimittel | |
| ATA5422000A (de) | Oximderivate und ihre verwendung als latente säuren | |
| DE60039539D1 (de) | 4-aminopiperidin-derivate und ihre verwendung als arzneimittel | |
| EE200200251A (et) | Uued N-asabitsükloamiidi derivaadid ja nende kasutamine | |
| DE60016326D1 (de) | Wasser-absorbierende Zusammensetzung und ihre Verwendung | |
| DE59710422D1 (de) | Acylmercapto-triazolyl-derivate und ihre verwendung als mikrobizide | |
| DE69926800D1 (de) | Benzoheterozyklen und ihre verwendung als mek inhibitoren | |
| DE59710580D1 (de) | Thiocyano-triazolyl-derivate und ihre verwendung als mikrobizide | |
| DE60004658D1 (de) | Thiazolidindionderivat und seine verwendung als antidiabetikum | |
| ATE362469T1 (de) | 2,7-disubstituierteindole und ihre verwendung als 5-ht6 modulatoren | |
| ATE221529T1 (de) | Oxadiazolinderivate und ihre verwendung als insektizide | |
| DE60037183D1 (de) | Neue amidinbenzylamin-derivate und ihre verwendung als thrombin-inhibitoren | |
| ATE247109T1 (de) | Substituierte benzoylisoxazole und ihre verwendung als herbizide | |
| DE60009911D1 (de) | Aminothiazolderivate und ihre verwendung als crf-rezeptor-liganden | |
| PT1246817E (pt) | Derivados de 4-fenil-1-piperazinilo, -piperidinilo e -tetra-hidropiridilo | |
| DE50008549D1 (de) | Triazolotriazinone und ihre verwendung | |
| ATE316087T1 (de) | Isothiazol-derivate und ihre verwendung als schädlingsbekämpfungsmittel | |
| DE69917777D1 (de) | Benzazol-verbindungen und ihre verwendung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1206457 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |