HRP20200728T1 - Inhibitori bromodomene - Google Patents
Inhibitori bromodomene Download PDFInfo
- Publication number
- HRP20200728T1 HRP20200728T1 HRP20200728TT HRP20200728T HRP20200728T1 HR P20200728 T1 HRP20200728 T1 HR P20200728T1 HR P20200728T T HRP20200728T T HR P20200728TT HR P20200728 T HRP20200728 T HR P20200728T HR P20200728 T1 HRP20200728 T1 HR P20200728T1
- Authority
- HR
- Croatia
- Prior art keywords
- bromodomain inhibitors
- hydroxypropan
- dimethylphenoxy
- pyrrolo
- carboxamide
- Prior art date
Links
- 102000001805 Bromodomains Human genes 0.000 title 1
- 108050009021 Bromodomains Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- OEDSFMUSNZDJFD-UHFFFAOYSA-N abbv-744 Chemical compound C(C)NC(=O)C1=CC2=C(C(N(C=C2C2=C(C=CC(=C2)C(C)(C)O)OC2=C(C=C(C=C2C)F)C)C)=O)N1 OEDSFMUSNZDJFD-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
Claims (2)
1. Spoj, naznačen time što je N-etil-4-[2-(4-fluor-2,6-dimetilfenoksi)-5-(2-hidroksipropan-2-il)fenil]-6-metil-7-okso-6,7-dihidro-1H-pirolo[2,3-c]piridin-2-karboksamid, ili njegova farmaceutski prihvatljiva sol.
2. Spoj, naznačen time što je N-etil-4-[2-(4-fluor-2,6-dimetilfenoksi)-5-(2-hidroksipropan-2-il)fenil]-6-metil-7-okso-6,7-dihidro-1H-pirolo[2,3-c]piridin-2-karboksamid.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2016079362 | 2016-04-15 | ||
PCT/CN2017/080511 WO2017177955A1 (en) | 2016-04-15 | 2017-04-14 | Bromodomain inhibitors |
EP17781931.5A EP3442972B1 (en) | 2016-04-15 | 2017-04-14 | Bromodomain inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20200728T1 true HRP20200728T1 (hr) | 2020-07-24 |
Family
ID=60042835
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20200728TT HRP20200728T1 (hr) | 2016-04-15 | 2020-05-06 | Inhibitori bromodomene |
Country Status (38)
Country | Link |
---|---|
US (4) | US10633379B2 (hr) |
EP (2) | EP3693369A3 (hr) |
JP (2) | JP6978424B2 (hr) |
KR (1) | KR102250415B1 (hr) |
CN (1) | CN109071534B (hr) |
AR (1) | AR108207A1 (hr) |
AU (2) | AU2017251537B2 (hr) |
BR (1) | BR112018071216A2 (hr) |
CA (1) | CA3018802A1 (hr) |
CL (1) | CL2018002924A1 (hr) |
CO (1) | CO2018011064A2 (hr) |
CR (1) | CR20180541A (hr) |
CY (1) | CY1123025T1 (hr) |
DK (1) | DK3442972T3 (hr) |
DO (1) | DOP2018000227A (hr) |
EC (1) | ECSP18083519A (hr) |
ES (1) | ES2793239T3 (hr) |
HR (1) | HRP20200728T1 (hr) |
HU (1) | HUE050217T2 (hr) |
IL (1) | IL261586B (hr) |
LT (1) | LT3442972T (hr) |
MA (2) | MA44674B1 (hr) |
MD (1) | MD3442972T2 (hr) |
ME (1) | ME03759B (hr) |
MX (1) | MX2018012541A (hr) |
MY (1) | MY190795A (hr) |
PE (1) | PE20190472A1 (hr) |
PH (1) | PH12018501920A1 (hr) |
PL (1) | PL3442972T3 (hr) |
PT (1) | PT3442972T (hr) |
RS (1) | RS60302B1 (hr) |
RU (1) | RU2741808C2 (hr) |
SG (1) | SG11201808003RA (hr) |
SI (1) | SI3442972T1 (hr) |
TW (3) | TWI764237B (hr) |
UA (1) | UA124764C2 (hr) |
UY (1) | UY37205A (hr) |
WO (1) | WO2017177955A1 (hr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3442972T1 (sl) * | 2016-04-15 | 2020-07-31 | Abb Vie Inc. | Inhibitorji bromodomene |
BR112019007591A2 (pt) * | 2016-10-14 | 2019-07-02 | Abbvie Inc | inibidores de bromodomínios |
AU2018254577B2 (en) | 2017-04-21 | 2024-06-13 | Epizyme, Inc. | Combination therapies with EHMT2 inhibitors |
CN112424200B (zh) * | 2018-07-25 | 2022-09-20 | 正大天晴药业集团股份有限公司 | 作为溴区结构域蛋白抑制剂的亚氨基砜类化合物、药物组合物及其医药用途 |
CN110776508B (zh) * | 2018-07-27 | 2021-07-16 | 海创药业股份有限公司 | 一种brd4抑制剂及其制备方法和用途 |
CN110964012B (zh) * | 2018-09-29 | 2021-08-13 | 上海凌达生物医药有限公司 | 一类稠杂环联芳基苄醇类化合物、制备方法和用途 |
AU2019372121A1 (en) | 2018-10-30 | 2021-05-27 | Nuvation Bio Inc. | Heterocyclic compounds as BET inhibitors |
SG11202110099YA (en) * | 2019-03-17 | 2021-10-28 | Shanghai Ringene Biopharma Co Ltd | Pyrrole amidopyridone compound, preparation method therefor and use thereof |
GB201905721D0 (en) * | 2019-04-24 | 2019-06-05 | Univ Dundee | Compounds |
WO2020232214A1 (en) * | 2019-05-14 | 2020-11-19 | Abbvie Inc. | Treating acute myeloid leukemia (aml) with mivebresib, a bromodomain inhibitor |
AU2020299592A1 (en) | 2019-07-02 | 2022-02-17 | Nuvation Bio Inc. | Heterocyclic compounds as BET inhibitors |
CN114258301B (zh) * | 2019-07-30 | 2024-11-08 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
CN112625036A (zh) * | 2019-10-08 | 2021-04-09 | 上海海和药物研究开发股份有限公司 | 一类具有brd4抑制活性的化合物、其制备方法及用途 |
WO2021233371A1 (zh) * | 2020-05-21 | 2021-11-25 | 贝达药业股份有限公司 | 作为溴结构域蛋白质抑制剂的化合物和组合物 |
GB202016977D0 (en) | 2020-10-26 | 2020-12-09 | In4Derm Ltd | Compounds |
JP2023538405A (ja) | 2020-12-01 | 2023-09-07 | 成都苑▲東▼生物制▲薬▼股▲ふん▼有限公司 | 新規n-複素環betブロモドメイン阻害剤、その調製方法及び医薬応用 |
CN115551861B (zh) * | 2021-04-30 | 2024-05-28 | 成都硕德药业有限公司 | 一种新型brd4溴结构域protac蛋白降解剂、其制备方法及医药用途 |
WO2023275542A1 (en) | 2021-06-29 | 2023-01-05 | Tay Therapeutics Limited | Pyrrolopyridone derivatives useful in the treatment of cancer |
CN115611890B (zh) * | 2021-07-15 | 2024-05-31 | 成都硕德药业有限公司 | 一种新型噻吩类bet溴结构域抑制剂、其制备方法及医药用途 |
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DE2845456A1 (de) | 1978-10-19 | 1980-08-14 | Merck Patent Gmbh | 6-arylpyridazin-3-one und verfahren zu ihrer herstellung |
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FR2478640A1 (fr) | 1980-03-24 | 1981-09-25 | Sanofi Sa | Nouvelles thieno (2,3-d) pyridazinones-4 et thieno (2,3-d) pyridazinones-7, leur procede de preparation et leur therapeutique |
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AR109250A1 (es) | 2016-06-09 | 2018-11-14 | Acetylon Pharmaceuticals Inc | Métodos de uso y combinaciones farmacéuticas de inhibidores de hdac con inhibidores de proteínas bet |
US20190134004A1 (en) | 2016-06-16 | 2019-05-09 | The University Of Chicago | Methods and compositions for treating breast and prostate cancer |
WO2017223268A1 (en) | 2016-06-22 | 2017-12-28 | Yale University | COMPOSITIONS AND METHODS OF RESENSITIZING CELLS TO BROMODOMAIN AND EXTRATERMINAL DOMAIN PROTEIN INHIBITORS (BETi) |
CA3039003A1 (en) | 2016-10-14 | 2018-04-19 | Abbvie Inc. | Bromodomain inhibitors |
BR112019007591A2 (pt) | 2016-10-14 | 2019-07-02 | Abbvie Inc | inibidores de bromodomínios |
WO2018095933A1 (en) | 2016-11-22 | 2018-05-31 | Université D'aix-Marseille (Amu) | Method of prognosticating, or for determining the efficiency of a compound for treating cancer |
WO2018130174A1 (zh) | 2017-01-11 | 2018-07-19 | 江苏豪森药业集团有限公司 | 吡咯并[2,3-c]吡啶类衍生物、其制备方法及其在医药上的应用 |
EP3609896A4 (en) | 2017-04-14 | 2020-11-04 | AbbVie Inc. | BROMODOMAIN INHIBITORS |
CN108976278B (zh) | 2017-06-05 | 2021-04-06 | 海创药业股份有限公司 | 一种嵌合分子及其制备和应用 |
CN108690020A (zh) | 2018-07-04 | 2018-10-23 | 清华大学 | 一种靶向降解bet蛋白的化合物及其应用 |
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