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CR20200231A - 1H-PIRROLO (2,3-C) PIRIDIN-7 (6H)-ONAS Y PIRAZOLO (3,4-C) PIRIDIN-7 (6H)-ONAS COMO INHIBIDORES DE PROTEINAS BET (Divisional 2016-0542) - Google Patents

1H-PIRROLO (2,3-C) PIRIDIN-7 (6H)-ONAS Y PIRAZOLO (3,4-C) PIRIDIN-7 (6H)-ONAS COMO INHIBIDORES DE PROTEINAS BET (Divisional 2016-0542)

Info

Publication number
CR20200231A
CR20200231A CR20200231A CR20200231A CR20200231A CR 20200231 A CR20200231 A CR 20200231A CR 20200231 A CR20200231 A CR 20200231A CR 20200231 A CR20200231 A CR 20200231A CR 20200231 A CR20200231 A CR 20200231A
Authority
CR
Costa Rica
Prior art keywords
pyridin
ones
inhibitors
pyrazolo
pyrrolo
Prior art date
Application number
CR20200231A
Other languages
English (en)
Inventor
Nikoo Falahatpisheh
Thomas P Maduskuie Jr
Andrew P Combs
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CR20200231A publication Critical patent/CR20200231A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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  • Rheumatology (AREA)
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Abstract

La presente invención se relaciona con pirrolopiridinonas sustituidas y pirazolopiridinonas sustituidas que constituyen inhibidores de proteínas BET tales como BRD2, BRD3, BRD4 y BRD-t y son útiles en el tratamiento de las enfermedades como el cáncer.
CR20200231A 2014-04-23 2015-04-22 1H-PIRROLO (2,3-C) PIRIDIN-7 (6H)-ONAS Y PIRAZOLO (3,4-C) PIRIDIN-7 (6H)-ONAS COMO INHIBIDORES DE PROTEINAS BET (Divisional 2016-0542) CR20200231A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461983289P 2014-04-23 2014-04-23
PCT/US2015/027047 WO2015164480A1 (en) 2014-04-23 2015-04-22 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS

Publications (1)

Publication Number Publication Date
CR20200231A true CR20200231A (es) 2020-09-11

Family

ID=53055117

Family Applications (2)

Application Number Title Priority Date Filing Date
CR20200231A CR20200231A (es) 2014-04-23 2015-04-22 1H-PIRROLO (2,3-C) PIRIDIN-7 (6H)-ONAS Y PIRAZOLO (3,4-C) PIRIDIN-7 (6H)-ONAS COMO INHIBIDORES DE PROTEINAS BET (Divisional 2016-0542)
CR20160542A CR20160542A (es) 2014-04-23 2015-04-22 1 H-PIRROLO[2,3-c]PIRIDIN-7(6H)-ONAS YPIRAZOLO[3,4-c]PlRIDIN-7(6H)-ONAS COMO INHIBIDORES DE PROTEINAS BET

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20160542A CR20160542A (es) 2014-04-23 2015-04-22 1 H-PIRROLO[2,3-c]PIRIDIN-7(6H)-ONAS YPIRAZOLO[3,4-c]PlRIDIN-7(6H)-ONAS COMO INHIBIDORES DE PROTEINAS BET

Country Status (36)

Country Link
US (7) US9540368B2 (es)
EP (3) EP3134403B1 (es)
JP (2) JP6572237B2 (es)
KR (3) KR20240134245A (es)
CN (1) CN106414442B (es)
AR (1) AR100160A1 (es)
AU (3) AU2015249810B2 (es)
BR (1) BR112016024626B1 (es)
CA (1) CA2946731C (es)
CL (1) CL2016002681A1 (es)
CR (2) CR20200231A (es)
CY (2) CY1122948T1 (es)
DK (2) DK3134403T3 (es)
EA (2) EA039678B1 (es)
EC (1) ECSP16088983A (es)
ES (2) ES2784846T3 (es)
FI (1) FI3674302T3 (es)
HR (2) HRP20230340T1 (es)
HU (2) HUE061770T2 (es)
IL (3) IL248415B (es)
LT (2) LT3674302T (es)
MA (1) MA39985B1 (es)
ME (1) ME03763B (es)
MX (2) MX2016013851A (es)
MY (1) MY180775A (es)
NZ (3) NZ763737A (es)
PE (1) PE20170144A1 (es)
PH (1) PH12016502115A1 (es)
PL (2) PL3134403T3 (es)
PT (2) PT3674302T (es)
RS (2) RS64231B1 (es)
SG (2) SG10201809353TA (es)
SI (2) SI3674302T1 (es)
TW (2) TWI672301B (es)
UA (1) UA119870C2 (es)
WO (1) WO2015164480A1 (es)

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