HRP20050001A2 - Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method - Google Patents

Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method Download PDF

Info

Publication number: HRP20050001A2
Authority: HR; Croatia
Prior art keywords: compound; mmol; image; solution; vacuo
Prior art date: 2002-07-09

Application number

HR20050001A

Other languages

English (en)

Croatian (hr)

Inventor

T.W. Cheng Peter

Z. Ding Charles

Chen Sean

F. Herpin Timothy

Original Assignee

Bristol-Myers Squibb Company A Delaware (Usa) Corp

Oration

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-09

Filing date

2005-01-04

Publication date

2005-08-31

2005-01-04 Application filed by Bristol-Myers Squibb Company A Delaware (Usa) Corp, Oration filed Critical Bristol-Myers Squibb Company A Delaware (Usa) Corp

2005-08-31 Publication of HRP20050001A2 publication Critical patent/HRP20050001A2/hr

Links

239000003472 antidiabetic agent Substances 0.000 title claims abstract description 23
239000000883 anti-obesity agent Substances 0.000 title claims abstract description 7
229940125710 antiobesity agent Drugs 0.000 title claims abstract description 7
238000000034 method Methods 0.000 title claims description 22
230000003178 anti-diabetic effect Effects 0.000 title claims description 12
229940125708 antidiabetic agent Drugs 0.000 title abstract description 10
125000000623 heterocyclic group Chemical group 0.000 title description 5
150000001875 compounds Chemical class 0.000 claims abstract description 322
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 22
229910052799 carbon Inorganic materials 0.000 claims abstract description 18
239000000203 mixture Substances 0.000 claims description 112
-1 cycloheteroalkyl Chemical group 0.000 claims description 107
125000000217 alkyl group Chemical group 0.000 claims description 55
239000003112 inhibitor Substances 0.000 claims description 55
125000003118 aryl group Chemical group 0.000 claims description 38
239000000126 substance Substances 0.000 claims description 26
150000002148 esters Chemical class 0.000 claims description 24
125000001072 heteroaryl group Chemical group 0.000 claims description 19
238000003786 synthesis reaction Methods 0.000 claims description 19
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NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 18
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Obesity (AREA)
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Heart & Thoracic Surgery (AREA)
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Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HR20050001A 2002-07-09 2005-01-04 Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method HRP20050001A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US39455302P	2002-07-09	2002-07-09
PCT/US2003/021331 WO2004004655A2 (en)	2002-07-09	2003-07-08	Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method

Publications (1)

Publication Number	Publication Date
HRP20050001A2 true HRP20050001A2 (en)	2005-08-31

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HR20050001A HRP20050001A2 (en)	2002-07-09	2005-01-04	Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method

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US (2)	US6875782B2 (es)
EP (1)	EP1531810B1 (es)
JP (1)	JP4541883B2 (es)
KR (1)	KR101120337B1 (es)
CN (1)	CN1665500A (es)
AT (1)	ATE543497T1 (es)
AU (1)	AU2003248861B2 (es)
BR (1)	BR0312503A (es)
CA (1)	CA2490972C (es)
ES (1)	ES2380319T3 (es)
GE (1)	GEP20084475B (es)
HR (1)	HRP20050001A2 (es)
IL (1)	IL165809A (es)
IS (1)	IS7629A (es)
MX (1)	MXPA05000279A (es)
NO (1)	NO329328B1 (es)
NZ (1)	NZ537251A (es)
PL (1)	PL375230A1 (es)
RS (1)	RS20050002A (es)
RU (1)	RU2325381C2 (es)
UA (1)	UA79296C2 (es)
WO (1)	WO2004004655A2 (es)
ZA (1)	ZA200500029B (es)

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CA2490972C (en)	2012-05-29
GEP20084475B (en)	2008-09-10
US6875782B2 (en)	2005-04-05
RU2005103395A (ru)	2005-08-10
NO20045529L (no)	2005-02-03
NZ537251A (en)	2007-02-23
RU2325381C2 (ru)	2008-05-27
KR101120337B1 (ko)	2012-02-29
IL165809A (en)	2010-05-17
IS7629A (is)	2005-01-05
RS20050002A (en)	2007-09-21
JP4541883B2 (ja)	2010-09-08
JP2006501187A (ja)	2006-01-12
US20050119312A1 (en)	2005-06-02
EP1531810A2 (en)	2005-05-25
WO2004004655A2 (en)	2004-01-15
WO2004004655A3 (en)	2004-10-14
ATE543497T1 (de)	2012-02-15
CA2490972A1 (en)	2004-01-15
UA79296C2 (en)	2007-06-11
US20040063762A1 (en)	2004-04-01
ZA200500029B (en)	2006-06-28
KR20050025951A (ko)	2005-03-14
EP1531810A4 (en)	2008-05-28
EP1531810B1 (en)	2012-02-01
CN1665500A (zh)	2005-09-07
IL165809A0 (en)	2006-01-15
NO329328B1 (no)	2010-09-27
BR0312503A (pt)	2007-06-26
AU2003248861A1 (en)	2004-01-23
ES2380319T3 (es)	2012-05-10
AU2003248861B2 (en)	2009-01-22
MXPA05000279A (es)	2005-03-31
PL375230A1 (en)	2005-11-28
US7507757B2 (en)	2009-03-24

Publication	Publication Date	Title
HRP20050001A2 (en)	2005-08-31	Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
US7951793B2 (en)	2011-05-31	Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
RU2327692C2 (ru)	2008-06-27	Окса- и тиазолпроизводные в качестве антидиабетических агентов и агентов против ожирения
US6673815B2 (en)	2004-01-06	Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
US6727271B2 (en)	2004-04-27	Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
US20030092697A1 (en)	2003-05-15	Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
US20080009534A1 (en)	2008-01-10	Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
WO2008006043A2 (en)	2008-01-10	1,3-oxazole derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents
US20030040516A1 (en)	2003-02-27	Pyrazinone inhibitors of fatty acid binding protein and method
EP1939188A1 (en)	2008-07-02	Oxa-and thiazole derivatives useful as antidiabetic and antiobesity agents

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