ATE543497T1 - Substituierte heterozyklische derivate als mittel gegen diabetes und adipositas und verfahren - Google Patents

Substituierte heterozyklische derivate als mittel gegen diabetes und adipositas und verfahren

Info

Publication number: ATE543497T1
Authority: AT; Austria
Prior art keywords: obesity; methods; substituted heterocyclic; agent against; heterocyclic derivatives
Prior art date: 2002-07-09

Application number

AT03763345T

Other languages

English (en)

Inventor

Peter Cheng

Sean Chen

Charles Ding

Timothy Herpin

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-09

Filing date

2003-07-08

Publication date

2012-02-15

2003-07-08 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2012-02-15 Application granted granted Critical

2012-02-15 Publication of ATE543497T1 publication Critical patent/ATE543497T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Child & Adolescent Psychology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03763345T 2002-07-09 2003-07-08 Substituierte heterozyklische derivate als mittel gegen diabetes und adipositas und verfahren ATE543497T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US39455302P	2002-07-09	2002-07-09
PCT/US2003/021331 WO2004004655A2 (en)	2002-07-09	2003-07-08	Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method

Publications (1)

Publication Number	Publication Date
ATE543497T1 true ATE543497T1 (de)	2012-02-15

Family

ID=30115733

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03763345T ATE543497T1 (de)	2002-07-09	2003-07-08	Substituierte heterozyklische derivate als mittel gegen diabetes und adipositas und verfahren

Country Status (23)

Country	Link
US (2)	US6875782B2 (de)
EP (1)	EP1531810B1 (de)
JP (1)	JP4541883B2 (de)
KR (1)	KR101120337B1 (de)
CN (1)	CN1665500A (de)
AT (1)	ATE543497T1 (de)
AU (1)	AU2003248861B2 (de)
BR (1)	BR0312503A (de)
CA (1)	CA2490972C (de)
ES (1)	ES2380319T3 (de)
GE (1)	GEP20084475B (de)
HR (1)	HRP20050001A2 (de)
IL (1)	IL165809A (de)
IS (1)	IS7629A (de)
MX (1)	MXPA05000279A (de)
NO (1)	NO329328B1 (de)
NZ (1)	NZ537251A (de)
PL (1)	PL375230A1 (de)
RS (1)	RS20050002A (de)
RU (1)	RU2325381C2 (de)
UA (1)	UA79296C2 (de)
WO (1)	WO2004004655A2 (de)
ZA (1)	ZA200500029B (de)

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FR2861303A1 (fr) *	2003-10-24	2005-04-29	Sanofi Synthelabo	Utilisation d'un derive de pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique
FR2861302A1 (fr) *	2003-10-24	2005-04-29	Sanofi Synthelabo	Utilisation d'un derive du pyrazole, pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique.
FR2861301B1 (fr) *	2003-10-24	2008-07-11	Sanofi Synthelabo	Utilisation du derive du pyrazole pour la preparation de medicaments utiles dans la prevention et le traitement du syndrome metabolique.
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FR2889191A1 (fr) *	2005-07-28	2007-02-02	Cerep Sa	Composes derives de 5-benzylidene imidazolidine 2,4-dione et leur utilisation en tant qu'antagonistes de mchr-1
EA015169B1 (ru)	2005-09-14	2011-06-30	Такеда Фармасьютикал Компани Лимитед	Применение ингибиторов дипептидилпептидазы
WO2007035629A2 (en)	2005-09-16	2007-03-29	Takeda Pharmaceutical Company Limited	Process for the preparation of pyrimidinedione derivatives
EP1945205A2 (de) *	2005-10-18	2008-07-23	Aegerion Pharmaceuticals	Verfahren und zusammensetzungen zur behandlung von störungen im zusammenhang mit hyperlipidämie bei säugetieren
ES2356097T3 (es) *	2006-05-30	2011-04-04	Astrazeneca Ab	Ácidos 5-fenilamino-1,3,4-oxadiazol-2-ilcarbonilamino-4-fenoxi-ciclohexancarboxílico sustituidos como inhibidores de la acetil coenzima a diacilglicerol aciltransferasa.
CA2651663A1 (en) *	2006-05-30	2007-12-06	Astrazeneca Ab	Chemical compounds
US20080009534A1 (en) *	2006-07-07	2008-01-10	Bristol-Myers Squibb Company	Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
US8217025B2 (en) *	2006-11-17	2012-07-10	Harbor Therapeutics, Inc.	Drug screening and treatment methods
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KR20190104524A (ko)	2016-11-21	2019-09-10	바이킹 테라퓨틱스 인코포레이티드	당원축적질환의 치료 방법
EA201992703A1 (ru)	2017-06-05	2020-04-15	Вайкинг Терапьютикс, Инк.	Композиции для лечения фиброза
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EA202091979A1 (ru)	2018-03-22	2021-06-22	Вайкинг Терапьютикс, Инк.	Кристаллические формы и способы получения кристаллических форм соединения
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2003
- 2003-07-08 RS YUP-2005/0002A patent/RS20050002A/sr unknown
- 2003-07-08 NZ NZ537251A patent/NZ537251A/en not_active IP Right Cessation
- 2003-07-08 KR KR1020057000362A patent/KR101120337B1/ko not_active IP Right Cessation
- 2003-07-08 US US10/616,283 patent/US6875782B2/en not_active Expired - Lifetime
- 2003-07-08 BR BRPI0312503-3A patent/BR0312503A/pt not_active IP Right Cessation
- 2003-07-08 AU AU2003248861A patent/AU2003248861B2/en not_active Ceased
- 2003-07-08 JP JP2004520018A patent/JP4541883B2/ja not_active Expired - Fee Related
- 2003-07-08 EP EP03763345A patent/EP1531810B1/de not_active Expired - Lifetime
- 2003-07-08 WO PCT/US2003/021331 patent/WO2004004655A2/en active Application Filing
- 2003-07-08 GE GEAP8617A patent/GEP20084475B/en unknown
- 2003-07-08 PL PL03375230A patent/PL375230A1/xx not_active Application Discontinuation
- 2003-07-08 MX MXPA05000279A patent/MXPA05000279A/es active IP Right Grant
- 2003-07-08 CA CA2490972A patent/CA2490972C/en not_active Expired - Fee Related
- 2003-07-08 CN CN038160382A patent/CN1665500A/zh active Pending
- 2003-07-08 AT AT03763345T patent/ATE543497T1/de active
- 2003-07-08 ES ES03763345T patent/ES2380319T3/es not_active Expired - Lifetime
- 2003-07-08 RU RU2005103395/04A patent/RU2325381C2/ru not_active IP Right Cessation
- 2003-08-07 UA UAA200501187A patent/UA79296C2/uk unknown
2004
- 2004-12-16 IL IL165809A patent/IL165809A/en not_active IP Right Cessation
- 2004-12-17 NO NO20045529A patent/NO329328B1/no not_active IP Right Cessation
- 2004-12-17 US US11/016,183 patent/US7507757B2/en active Active
2005
- 2005-01-03 ZA ZA200500029A patent/ZA200500029B/xx unknown
- 2005-01-04 HR HR20050001A patent/HRP20050001A2/hr not_active Application Discontinuation
- 2005-01-05 IS IS7629A patent/IS7629A/is unknown

Also Published As

Publication number	Publication date
ES2380319T3 (es)	2012-05-10
US7507757B2 (en)	2009-03-24
KR101120337B1 (ko)	2012-02-29
JP4541883B2 (ja)	2010-09-08
NO329328B1 (no)	2010-09-27
EP1531810A4 (de)	2008-05-28
RU2325381C2 (ru)	2008-05-27
JP2006501187A (ja)	2006-01-12
IS7629A (is)	2005-01-05
US6875782B2 (en)	2005-04-05
HRP20050001A2 (en)	2005-08-31
IL165809A (en)	2010-05-17
BR0312503A (pt)	2007-06-26
US20040063762A1 (en)	2004-04-01
RU2005103395A (ru)	2005-08-10
RS20050002A (en)	2007-09-21
PL375230A1 (en)	2005-11-28
MXPA05000279A (es)	2005-03-31
CA2490972A1 (en)	2004-01-15
UA79296C2 (en)	2007-06-11
NO20045529L (no)	2005-02-03
WO2004004655A2 (en)	2004-01-15
WO2004004655A3 (en)	2004-10-14
AU2003248861B2 (en)	2009-01-22
CA2490972C (en)	2012-05-29
ZA200500029B (en)	2006-06-28
CN1665500A (zh)	2005-09-07
IL165809A0 (en)	2006-01-15
NZ537251A (en)	2007-02-23
US20050119312A1 (en)	2005-06-02
EP1531810A2 (de)	2005-05-25
KR20050025951A (ko)	2005-03-14
GEP20084475B (en)	2008-09-10
AU2003248861A1 (en)	2004-01-23
EP1531810B1 (de)	2012-02-01

Publication	Publication Date	Title
ATE543497T1 (de)	2012-02-15	Substituierte heterozyklische derivate als mittel gegen diabetes und adipositas und verfahren
DE60308210D1 (de)	2006-10-19	Medizinische fassvorrichtung
BRPI0417717A (pt)	2007-04-03	composto, composição farmacêutica, e, uso de um composto
BR0316496A (pt)	2005-10-11	Quinolin-, isoquinolin-, e quinazolin-oxialquilamidas e seu emprego como fungicidas
WO2004004665A3 (en)	2004-03-25	Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
NO20062629L (no)	2006-09-06	Oksazolderivater av tetrackliner
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