[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

FR2583984B1 - Formulation pharmaceutique lyophilisee d'activateur tissulaire du plasminogene, procede pour la preparer, recipient obture la contenant et sel d'activateur tissulaire du plasminogene - Google Patents

Formulation pharmaceutique lyophilisee d'activateur tissulaire du plasminogene, procede pour la preparer, recipient obture la contenant et sel d'activateur tissulaire du plasminogene

Info

Publication number
FR2583984B1
FR2583984B1 FR8607552A FR8607552A FR2583984B1 FR 2583984 B1 FR2583984 B1 FR 2583984B1 FR 8607552 A FR8607552 A FR 8607552A FR 8607552 A FR8607552 A FR 8607552A FR 2583984 B1 FR2583984 B1 FR 2583984B1
Authority
FR
France
Prior art keywords
tissue activator
plasminogen tissue
same
salt
pharmaceutical formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8607552A
Other languages
English (en)
Other versions
FR2583984A1 (fr
Inventor
Michael Denis Johnston
Henry Berger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858513358A external-priority patent/GB8513358D0/en
Priority claimed from GB858521705A external-priority patent/GB8521705D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of FR2583984A1 publication Critical patent/FR2583984A1/fr
Application granted granted Critical
Publication of FR2583984B1 publication Critical patent/FR2583984B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FR8607552A 1985-05-28 1986-05-27 Formulation pharmaceutique lyophilisee d'activateur tissulaire du plasminogene, procede pour la preparer, recipient obture la contenant et sel d'activateur tissulaire du plasminogene Expired FR2583984B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858513358A GB8513358D0 (en) 1985-05-28 1985-05-28 Formulation
GB858521705A GB8521705D0 (en) 1985-08-31 1985-08-31 Formulation

Publications (2)

Publication Number Publication Date
FR2583984A1 FR2583984A1 (fr) 1987-01-02
FR2583984B1 true FR2583984B1 (fr) 1989-06-02

Family

ID=26289290

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8607552A Expired FR2583984B1 (fr) 1985-05-28 1986-05-27 Formulation pharmaceutique lyophilisee d'activateur tissulaire du plasminogene, procede pour la preparer, recipient obture la contenant et sel d'activateur tissulaire du plasminogene

Country Status (22)

Country Link
US (2) US4929444A (fr)
JP (1) JPH0759517B2 (fr)
AU (1) AU567236B2 (fr)
BE (1) BE904830A (fr)
CA (1) CA1300008C (fr)
CH (1) CH665356A5 (fr)
DE (1) DE3617752A1 (fr)
DK (1) DK163173C (fr)
ES (2) ES8800601A1 (fr)
FI (1) FI85335C (fr)
FR (1) FR2583984B1 (fr)
GB (1) GB2176702B (fr)
GR (1) GR861366B (fr)
HU (1) HU195733B (fr)
IL (1) IL78938A (fr)
IT (1) IT1191926B (fr)
LU (1) LU86444A1 (fr)
NL (1) NL8601355A (fr)
NO (1) NO171345C (fr)
NZ (1) NZ216307A (fr)
PT (1) PT82646B (fr)
SE (1) SE462016B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI85334C (fi) * 1985-05-28 1992-04-10 Wellcome Found Foerfarande foer framstaellning av en vattenbaserad, vaevnadsplasminogenaktivator (t-pa) innehaollande, koncentrerad parenterad loesning.
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
IE59895B1 (en) * 1986-05-12 1994-04-20 Wellcome Found Medicaments containing tissue plasminogen activator
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5342616A (en) * 1988-06-20 1994-08-30 The Wellcome Foundation Limited Method of administering tissue plasminogen activator
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
WO1992011866A1 (fr) * 1991-01-14 1992-07-23 Duke University SEQUENCE DE LAMININE UTILES COMME ACTIVATEUR DE tPA
PT786257E (pt) * 1992-06-03 2003-12-31 Genentech Inc Variantes de glicosilacao do activador de plasminogenio tissular com propriedades terapeuticas meloradas
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
EP0857210B1 (fr) * 1995-10-23 2003-09-03 The Children's Medical Center Corporation Compositions therapeutiques anti-angiogenese et procedes associes
KR100477280B1 (ko) * 1995-12-13 2005-07-18 아보트 러보러터리즈 맥관형성에의한질환치료제
DE69719265T2 (de) * 1996-09-06 2003-12-04 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute, Kumamoto Medizinische Zusammensetzung die Gewebeplasminogenaktivator und Nikotinamid enthält
EP1432437A2 (fr) * 2001-09-07 2004-06-30 Global Biotech Inc. Formulation contenant un activateur de plasminogene de type urokinase de tissu humain
US20040091465A1 (en) * 2002-06-26 2004-05-13 Zachary Yim Therapeutic antiangiogenic compositions and methods
US20050053980A1 (en) * 2003-06-20 2005-03-10 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
WO2006113914A2 (fr) * 2005-04-20 2006-10-26 Fred Hutchinson Cancer Research Center Procedes, compositions et articles manufactures permettant d'ameliorer la capacite de survie de cellules, de tissus, d'organes et d'organismes

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (fr) * 1973-12-03 1977-11-04 Fabre Sa Pierre
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
NL191755C (nl) * 1982-10-29 1996-07-02 Mitsui Toatsu Chemicals Plasminogeenactivator en trombolytisch middel.
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
EP0156169B1 (fr) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha Solution aqueuse d'un activateur tissulaire du plasminogène dissous à une concentration élevée et un procédé d'obtention
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
EP0201153A3 (fr) * 1985-02-09 1987-10-07 Beecham Group Plc Enzyme modifié et son procédé de préparation
GB8513358D0 (en) * 1985-05-28 1985-07-03 Wellcome Found Formulation
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法

Also Published As

Publication number Publication date
IT8648065A0 (it) 1986-05-27
BE904830A (fr) 1986-11-27
FR2583984A1 (fr) 1987-01-02
GB8612780D0 (en) 1986-07-02
LU86444A1 (fr) 1986-12-05
NO862096L (no) 1986-12-01
AU5796486A (en) 1986-12-04
SE8602405L (sv) 1986-11-29
GR861366B (en) 1986-09-29
FI85335C (fi) 1992-04-10
IT1191926B (it) 1988-03-31
PT82646A (en) 1986-06-01
DK246786D0 (da) 1986-05-27
ES555353A0 (es) 1987-11-16
HUT41638A (en) 1987-05-28
CH665356A5 (de) 1988-05-13
FI862227A0 (fi) 1986-05-27
NL8601355A (nl) 1986-12-16
ES8800601A1 (es) 1987-11-16
HU195733B (en) 1988-07-28
DK163173C (da) 1992-06-22
DK163173B (da) 1992-02-03
NO171345B (no) 1992-11-23
SE462016B (sv) 1990-04-30
GB2176702A (en) 1987-01-07
SE8602405D0 (sv) 1986-05-27
DE3617752C2 (fr) 1988-06-30
AU567236B2 (en) 1987-11-12
IL78938A (en) 1993-02-21
ES8802439A1 (es) 1988-06-01
DE3617752A1 (de) 1986-12-04
PT82646B (pt) 1989-01-30
US4968617A (en) 1990-11-06
CA1300008C (fr) 1992-05-05
JPH06183995A (ja) 1994-07-05
IL78938A0 (en) 1986-09-30
US4929444A (en) 1990-05-29
ES557374A0 (es) 1988-06-01
NZ216307A (en) 1989-10-27
FI862227A (fi) 1986-11-29
GB2176702B (en) 1989-07-05
DK246786A (da) 1986-11-29
FI85335B (fi) 1991-12-31
NO171345C (no) 1993-03-03
JPH0759517B2 (ja) 1995-06-28

Similar Documents

Publication Publication Date Title
FR2583984B1 (fr) Formulation pharmaceutique lyophilisee d'activateur tissulaire du plasminogene, procede pour la preparer, recipient obture la contenant et sel d'activateur tissulaire du plasminogene
FR2593393B1 (fr) Solution aqueuse a usage parenteral d'activateur tissulaire du plasminogene, procede pour la preparer et recipient obture la contenant
FR2569402B1 (fr) Derives d'acide 3,5-pyridine-dicarboxylique, procede pour leur preparation et composition pharmaceutique les contenant
FR2595351B1 (fr) Derives d'indole, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2583429B1 (fr) Vecteur d'expression de l'interferon u dans les cellules de mammifere, procede pour sa mise en oeuvre et produit obtenu et composition pharmaceutique contenant l'interferon u
HUT43808A (en) Process for production of new derivatives of n-/2'-aminphenil/-benzamid and medical preparatives containing thereof as active substance
FR2501204B1 (fr) Derives d'un acide quinoleine-carboxylique, procede pour les preparer et medicament en contenant
PT83896A (fr) Procede pour la preparation de nouveaux conjuges de la vinblas-tine et de ses derives et de compositions pharmaceutiques les contenant
FR2642065B1 (fr) Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant
FR2569702B1 (fr) Nouvelle 4'-deschlororebeccamycine, composition pharmaceutique la contenant et procede pour sa preparation
HUT42510A (en) Process for preparing biologically active derivatives of humane gamma-interferone and pharmaceutical compositions containing such compounds
PT79365A (fr) Procede de preparation de derives d'imidazoline et de compositions pharmaceutiques les contenant
FR2584405B1 (fr) Sels de furosemide, composition pharmaceutique les contenant et leur procede de preparation
FR2628419B1 (fr) Nouveaux sels antiviraux, compositions pharmaceutiques les contenant et procede pour les preparer
FR2551359B3 (fr) Procede et appareil pour la preparation de produits contenant de l'air emprisonne
FR2446819B1 (fr) Derives 6-alkyles d'acide 1,2-dihydro-2-oxonicotinique et composition pharmaceutique les contenant
FR2600061B1 (fr) Derives d'indole, composition pharmaceutique les contenant et procede pour leur preparation
FR2548539B1 (fr) Composition pharmaceutique contenant un lubrifiant liquide et procede pour ameliorer la dissolution de capsules en gelatine dure ou de comprimes contenant des formules therapeutiques et un lubrifiant
PT79712A (fr) Procede de preparation de compositions nutritives contenant de l'acide alpha-cetoisocaproique ou un de ses sels et de medicaments les contenant
PT66489B (fr) Procede pour la preparation des produits pharmaceutique contenant polihydroxiphenil cromanones
FR2616434B1 (fr) Composes de carboxymethyle, procede pour les preparer et medicament les contenant
FR2563519B1 (fr) Derives d'iminothiazolidine, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2605623B1 (fr) Procede de preparation de particules magnetiques d'hexaferrites, particules obtenues et produits les contenant
FR2617403B1 (fr) Procede de preparation de derives des acides nucleiques et procede de preparation d'une composition medicale les contenant
PT74952A (fr) Procede de preparation de derives heterocycliques d'amidoximes et de compositions pharmaceutiques les contenant

Legal Events

Date Code Title Description
ST Notification of lapse
ST Notification of lapse