EA202092146A1 - Производные пиразотетрагидроизохинолина в качестве положительных модуляторов допаминового d1 рецептора - Google Patents
Производные пиразотетрагидроизохинолина в качестве положительных модуляторов допаминового d1 рецептораInfo
- Publication number
- EA202092146A1 EA202092146A1 EA202092146A EA202092146A EA202092146A1 EA 202092146 A1 EA202092146 A1 EA 202092146A1 EA 202092146 A EA202092146 A EA 202092146A EA 202092146 A EA202092146 A EA 202092146A EA 202092146 A1 EA202092146 A1 EA 202092146A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrazotetrahydroisoquinoline
- dopamine
- receptor
- derivatives
- positive modulators
- Prior art date
Links
- 102000004076 Dopamine D1 Receptors Human genes 0.000 title 1
- 108090000511 Dopamine D1 Receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- OEDUIFSDODUDRK-UHFFFAOYSA-N 5-phenyl-1h-pyrazole Chemical compound N1N=CC=C1C1=CC=CC=C1 OEDUIFSDODUDRK-UHFFFAOYSA-N 0.000 abstract 1
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000003281 allosteric effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Изобретение предлагает некоторые соединения (фенил-(пиразол)-3,4-дигидроизохинолин-2(1H)-ил)этан-1-она формулы I в качестве D1 позитивных аллостерических модуляторов (ПАМ) и их фармацевтические композиции. В изобретении также предложены способы применения соединения формулы I или его фармацевтически приемлемой соли для лечения некоторых симптомов болезни Паркинсона, шизофрении, СДВГ или болезни Альцгеймера.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862660622P | 2018-04-20 | 2018-04-20 | |
| PCT/US2019/027842 WO2019204418A1 (en) | 2018-04-20 | 2019-04-17 | Pyrazo-tetrahydroisoquinoline derivatives as dopamine d1 receptor positive modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202092146A1 true EA202092146A1 (ru) | 2021-01-25 |
Family
ID=66324031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202092146A EA202092146A1 (ru) | 2018-04-20 | 2019-04-17 | Производные пиразотетрагидроизохинолина в качестве положительных модуляторов допаминового d1 рецептора |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US10611751B2 (ru) |
| EP (1) | EP3781560B1 (ru) |
| JP (1) | JP7083916B2 (ru) |
| KR (1) | KR102520872B1 (ru) |
| CN (1) | CN111971282B (ru) |
| AR (1) | AR114467A1 (ru) |
| AU (1) | AU2019256350B2 (ru) |
| BR (1) | BR112020019934A2 (ru) |
| CA (1) | CA3097692C (ru) |
| CL (1) | CL2020002697A1 (ru) |
| CO (1) | CO2020012678A2 (ru) |
| CR (1) | CR20200481A (ru) |
| EA (1) | EA202092146A1 (ru) |
| EC (1) | ECSP20066271A (ru) |
| ES (1) | ES2927142T3 (ru) |
| IL (1) | IL278045B2 (ru) |
| JO (1) | JOP20200263A1 (ru) |
| MA (1) | MA52286A (ru) |
| MX (1) | MX2020010914A (ru) |
| MY (1) | MY197645A (ru) |
| NZ (1) | NZ767900A (ru) |
| PE (1) | PE20201151A1 (ru) |
| PH (1) | PH12020551713A1 (ru) |
| SA (1) | SA520420382B1 (ru) |
| SG (1) | SG11202009938TA (ru) |
| TW (1) | TWI725408B (ru) |
| UA (1) | UA125271C2 (ru) |
| WO (1) | WO2019204418A1 (ru) |
| ZA (1) | ZA202006439B (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220029687A (ko) | 2019-07-01 | 2022-03-08 | 유씨비 바이오파마 에스알엘 | D1 양성 알로스테릭 조절제로서의 치환된 테트라히드로이소퀴놀린 유도체 |
| CN113993857B (zh) | 2019-07-01 | 2024-01-02 | Ucb生物制药有限责任公司 | 作为d1正变构调节剂的取代的四氢异喹啉衍生物 |
| EP4263522B1 (en) | 2020-12-18 | 2024-10-02 | UCB Biopharma SRL | Dihydroisoquinolinyl derivatives |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68910999T2 (de) | 1988-02-19 | 1994-03-24 | Smithkline Beecham Farma | 1,2,3,4-Tetrahydroisoquinoline, Verfharen zu ihrer Herstellung und ihre Verwendung als Kappa-Rezeptor Agonisten. |
| US5236934A (en) | 1992-08-26 | 1993-08-17 | E. I. Du Pont De Nemours And Company | 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders |
| AU2001259592B2 (en) | 2000-05-11 | 2005-02-24 | Bristol-Myers Squibb Co. | Tetrahydroisoquinoline analogs useful as growth hormone secretagogues |
| US7601739B2 (en) | 2003-08-08 | 2009-10-13 | Virgina Commonwealth University | Compounds having antiestrogenic and tissue selective estrogenic properties, and compounds with anti-androgenic properties for treatment of prostate cancer and androgen receptor dependent diseases |
| AR095883A1 (es) | 2013-04-18 | 2015-11-18 | Astellas Pharma Inc | Compuestos de acetamida heterocíclica |
| JO3316B1 (ar) * | 2013-05-30 | 2019-03-13 | Lilly Co Eli | مركبات 3، 4-داي هيدرو أيزو كوينولين -2(1h)-يل |
| EP3204374B1 (en) | 2014-10-08 | 2019-04-03 | UCB Biopharma SPRL | Isoindoline derivatives |
| CN107001278B (zh) * | 2014-10-08 | 2020-11-24 | Ucb生物制药私人有限公司 | 四氢异喹啉衍生物 |
| AR105025A1 (es) | 2015-06-19 | 2017-08-30 | Astellas Pharma Inc | Compuesto de imidazodiazepina |
| AR106332A1 (es) * | 2015-10-23 | 2018-01-03 | Lilly Co Eli | Forma cristalina de 2-(2,6-diclorofenil)-1-[(1s,3r)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1h)-il]etanona |
| JP6908623B2 (ja) | 2016-04-13 | 2021-07-28 | ユーシービー バイオファルマ エスアールエル | テトラヒドロイソキノリン誘導体 |
| EP3418270A1 (en) | 2017-06-19 | 2018-12-26 | Universidad Complutense De Madrid | Novel biphenylsulfoximines as allosteric modulators of the dopamine d1 receptor |
| US20210040074A1 (en) | 2018-03-06 | 2021-02-11 | The United States Of America,As Represented By The Secretary,Department Of Health And Human Services | Positive allosteric modulators of dopamine 1 receptor and method of use thereof |
-
2019
- 2019-04-03 TW TW108111844A patent/TWI725408B/zh active
- 2019-04-04 AR ARP190100882A patent/AR114467A1/es unknown
- 2019-04-17 NZ NZ767900A patent/NZ767900A/en unknown
- 2019-04-17 BR BR112020019934-6A patent/BR112020019934A2/pt unknown
- 2019-04-17 JO JOP/2020/0263A patent/JOP20200263A1/ar unknown
- 2019-04-17 MX MX2020010914A patent/MX2020010914A/es unknown
- 2019-04-17 MY MYPI2020005419A patent/MY197645A/en unknown
- 2019-04-17 UA UAA202005900A patent/UA125271C2/uk unknown
- 2019-04-17 KR KR1020207029608A patent/KR102520872B1/ko active IP Right Grant
- 2019-04-17 SG SG11202009938TA patent/SG11202009938TA/en unknown
- 2019-04-17 PE PE2020001478A patent/PE20201151A1/es unknown
- 2019-04-17 CN CN201980027079.8A patent/CN111971282B/zh active Active
- 2019-04-17 WO PCT/US2019/027842 patent/WO2019204418A1/en active Application Filing
- 2019-04-17 CA CA3097692A patent/CA3097692C/en active Active
- 2019-04-17 MA MA052286A patent/MA52286A/fr unknown
- 2019-04-17 JP JP2020557950A patent/JP7083916B2/ja active Active
- 2019-04-17 US US16/386,684 patent/US10611751B2/en active Active
- 2019-04-17 EA EA202092146A patent/EA202092146A1/ru unknown
- 2019-04-17 IL IL278045A patent/IL278045B2/en unknown
- 2019-04-17 EP EP19720352.4A patent/EP3781560B1/en active Active
- 2019-04-17 CR CR20200481A patent/CR20200481A/es unknown
- 2019-04-17 AU AU2019256350A patent/AU2019256350B2/en active Active
- 2019-04-17 ES ES19720352T patent/ES2927142T3/es active Active
-
2020
- 2020-10-09 PH PH12020551713A patent/PH12020551713A1/en unknown
- 2020-10-13 CO CONC2020/0012678A patent/CO2020012678A2/es unknown
- 2020-10-16 CL CL2020002697A patent/CL2020002697A1/es unknown
- 2020-10-16 ZA ZA2020/06439A patent/ZA202006439B/en unknown
- 2020-10-19 SA SA520420382A patent/SA520420382B1/ar unknown
- 2020-10-19 EC ECSENADI202066271A patent/ECSP20066271A/es unknown
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