[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ATE314365T1 - Cyanopyrrole als progesteronrezeptoragonisten - Google Patents

Cyanopyrrole als progesteronrezeptoragonisten

Info

Publication number
ATE314365T1
ATE314365T1 AT00932005T AT00932005T ATE314365T1 AT E314365 T1 ATE314365 T1 AT E314365T1 AT 00932005 T AT00932005 T AT 00932005T AT 00932005 T AT00932005 T AT 00932005T AT E314365 T1 ATE314365 T1 AT E314365T1
Authority
AT
Austria
Prior art keywords
alkyl
substituted
hydrogen
aminoalkyl
alkoxy
Prior art date
Application number
AT00932005T
Other languages
English (en)
Inventor
Mark A Collins
Valerie A Mackner
Lin Zhi
Todd K Jones
Christopher M Tegley
Jay E Wrobel
James P Edwards
Original Assignee
Wyeth Corp
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Ligand Pharm Inc filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE314365T1 publication Critical patent/ATE314365T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT00932005T 1999-05-04 2000-05-01 Cyanopyrrole als progesteronrezeptoragonisten ATE314365T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18305099P 1999-05-04 1999-05-04
US09/552,544 US6407101B1 (en) 1999-05-04 2000-04-19 Cyanopyrroles
PCT/US2000/011844 WO2000066581A1 (en) 1999-05-04 2000-05-01 Cyanopyrroles as progesterone receptor agonists

Publications (1)

Publication Number Publication Date
ATE314365T1 true ATE314365T1 (de) 2006-01-15

Family

ID=26878699

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00932005T ATE314365T1 (de) 1999-05-04 2000-05-01 Cyanopyrrole als progesteronrezeptoragonisten

Country Status (15)

Country Link
US (5) US6407101B1 (de)
EP (1) EP1173433B1 (de)
JP (2) JP4836331B2 (de)
CN (1) CN1133635C (de)
AT (1) ATE314365T1 (de)
AU (1) AU4980000A (de)
CA (1) CA2372560C (de)
CY (1) CY1105688T1 (de)
DE (1) DE60025189T2 (de)
DK (1) DK1173433T3 (de)
ES (1) ES2256008T3 (de)
HK (1) HK1043990B (de)
MX (1) MXPA01011295A (de)
SI (1) SI1173433T1 (de)
WO (1) WO2000066581A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6462032B1 (en) 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
US6407101B1 (en) * 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6355648B1 (en) * 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
US7268149B2 (en) * 2002-06-25 2007-09-11 Wyeth Cyclothiocarbamate derivatives as progesterone receptor modulators and methods of treating skin disorders
BR0312054A (pt) * 2002-06-25 2005-10-18 Wyeth Corp Uso de derivados de tio-oxindol na preparação de medicamentos úteis no tratamento de condições relacionadas com hormÈnio, e kit farmacêutico
CN1662241A (zh) * 2002-06-25 2005-08-31 惠氏公司 环硫代氨基甲酸酯衍生物在治疗与激素有关的病症中的用途
WO2004000227A2 (en) * 2002-06-25 2003-12-31 Wyeth Use of thio-oxindole derivatives in treatment of skin disorders
JP2006508076A (ja) * 2002-10-11 2006-03-09 リガンド・ファーマシューティカルズ・インコーポレイテッド 選択的プロゲステロン受容体モジュレーター化合物としての５−シクロアルケニル５Ｈ−クロメノ［３，４−ｆ］キノリン誘導体
CA2501833A1 (en) * 2002-10-11 2004-04-22 Ligand Pharmaceuticals Incorporated 5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro-5h-chromeno[3,4-f]quinolines as selective progesterone receptor modulator compounds
US7247625B2 (en) * 2003-10-09 2007-07-24 Wyeth 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators
US7323455B2 (en) * 2004-03-24 2008-01-29 Wyeth 7-aryl 1,5-dihydro-4,1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators
PL1732921T3 (pl) * 2004-04-08 2009-04-30 Wyeth Corp Pochodne tioamidu jako modulatory receptora progesteronowego
WO2005100347A1 (en) 2004-04-08 2005-10-27 Wyeth Methods for minimizing thioamide impurities
PA8631101A1 (es) * 2004-04-27 2006-09-08 Wyeth Corp Proceso de acoplamiento para la generacion de derivados reactivos de pirrol-2-carbonitrilo n-sustituidos con contenido de boro para producir biarilos
AU2005238520B2 (en) * 2004-04-27 2011-09-08 Wyeth Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same
WO2005104711A2 (en) 2004-04-27 2005-11-10 Wyeth Purification of progesterone receptor modulators
TW200603813A (en) * 2004-07-07 2006-02-01 Wyeth Corp Cyclic progestin regimens and kits
GT200500186A (es) * 2004-07-07 2006-03-02 Regimenes anticonceptivos con antagonistas del receptor de progesterona y kits
GT200500183A (es) * 2004-08-09 2006-04-10 Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
GT200500185A (es) * 2004-08-09 2006-04-10 Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
US7496489B2 (en) 2004-08-20 2009-02-24 Wyeth Design of progesterone receptor ligands
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
AR056317A1 (es) * 2005-04-20 2007-10-03 Xenon Pharmaceuticals Inc Compuestos de oxindol y composicion farmaceutica
PE20070182A1 (es) 2005-07-29 2007-03-06 Wyeth Corp Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona
PE20070341A1 (es) * 2005-07-29 2007-04-13 Wyeth Corp Derivados de pirrol como moduladores del receptor de progesterona
PE20070404A1 (es) * 2005-07-29 2007-05-10 Wyeth Corp Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona
JP5649786B2 (ja) 2006-03-07 2015-01-07 ギータ シュロフ ヒト胚性幹細胞およびそれらの誘導体を含む組成物、使用方法、ならびに調製方法
US20070213526A1 (en) * 2006-03-07 2007-09-13 Wyeth Purification of progesterone receptor modulators
EP2073806B1 (de) * 2006-10-12 2012-02-15 Xenon Pharmaceuticals Inc. Verwendung von spiro-oxindol-verbindungen als therapeutika
US20110237567A9 (en) * 2006-10-12 2011-09-29 Xenon Pharmaceuticals Inc. Tricyclic spiro-oxindole derivatives and their uses as therapeutic agents
EP2076514A1 (de) * 2006-10-12 2009-07-08 Xenon Pharmaceuticals Inc. SPIRO(FURO[3,2-C]PYRIDIN-3,3ý-INDOL)-2ý(1ýH)-ONDERIVATE UND VERWANDTE VERBINDUNGEN ZUR BEHANDLUNG VON DURCH NATRIUMKANÄLE VERMITTELTEN KRANKHEITEN WIE SCHMERZEN
US20080319204A1 (en) * 2007-06-25 2008-12-25 Wyeth Process for the synthesis of progesterone receptor modulators
BRPI0819571A2 (pt) * 2007-12-20 2019-09-24 Teva Womenss Health Inc "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica"
US20090197878A1 (en) * 2008-02-01 2009-08-06 Wyeth SUBSTITUTED BENZO[d][1,3]OXAZIN-2(4H)-ONES AND RELATED DERIVATIVES AND THEIR USES FOR MODULATING THE PROGESTERONE RECEPTOR
CN103664973B (zh) * 2008-10-17 2017-04-19 泽农医药公司 螺羟吲哚化合物及其作为治疗剂的用途
US8101647B2 (en) * 2008-10-17 2012-01-24 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
PE20170202A1 (es) 2009-10-14 2017-03-24 Xenon Pharmaceuticals Inc Metodos sinteticos para compuestos espiro-oxoindol
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
MX343215B (es) 2010-02-26 2016-10-27 Xenon Pharmaceuticals Inc Composiciones farmacéuticas del compuesto espiro-oxindol para administración tópica y sus usos como agentes terapéuticos.
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
WO2016127068A1 (en) 2015-02-05 2016-08-11 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635964A (en) 1969-02-10 1972-01-18 Colgate Palmolive Co 5-morpholinyl-2 1-benzisothiazolines
US3914592A (en) * 1974-09-03 1975-10-21 Purex Corp Underwater light circuit
US3917592A (en) 1974-09-27 1975-11-04 Chevron Res Herbicidal N-haloacetyl-1,2-dihydro-4H-3,1-benzoxazine
IT1039699B (it) 1975-07-03 1979-12-10 Prephar Composizione spermicida a base di derivati benzisotiazolici
US4258185A (en) 1978-10-17 1981-03-24 Yoshitomi Pharmaceutical Industries, Ltd. Pyridazinone compounds
EP0022317B1 (de) 1979-06-12 1983-09-21 Fujisawa Pharmaceutical Co., Ltd. 2-Oxo-benzothiazolin-, Benzoxazolin- oder Indolin-Derivate, deren Herstellung und derartige Verbindungen enthaltende pharmazeutische Zusammensetzungen
US4670566A (en) 1979-07-12 1987-06-02 A. H. Robins Company, Incorporated 3-methyl-hio-4-(5-, 6-, or 7-)phenylindolindolin-2-ones
US4440785A (en) 1980-10-30 1984-04-03 A. H. Robins Company, Inc. Methods of using 2-aminobiphenylacetic acids, esters, and metal salts thereof to treat inflammation
US4721721A (en) 1984-12-18 1988-01-26 Rorer Pharmaceutical Corporation 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses
EP0208510B1 (de) 1985-07-09 1991-09-11 Pfizer Inc. Substituierte Oxindol-3-carboxamine als entzündungshemmendes und schmerzstillendes Mittel
US4666913A (en) 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
DE3633861A1 (de) 1986-10-04 1988-04-07 Thomae Gmbh Dr K Neue imidazo-benzoxazinone, ihre herstellung und diese verbindungen enthaltende arzneimittel
JPS63112584A (ja) 1986-10-29 1988-05-17 Yoshitomi Pharmaceut Ind Ltd イミダゾピリジン誘導体
US4822794A (en) 1987-05-08 1989-04-18 Rorer Pharmaceutical Corporation Pyridooxazinone-pyridone compounds, cardiotonic compositions including the same, and their uses
DE3718527A1 (de) 1987-06-03 1988-12-15 Basf Ag Verfahren zur herstellung von 2(5h)-furanonen
EP0303418A3 (de) 1987-08-11 1990-11-07 Smithkline Beecham Laboratoires Pharmaceutiques Substituierte Indolone, verwendbar in der Behandlung von Herz- oder Asthmakrankheiten
DE3733478A1 (de) 1987-10-01 1989-04-13 Schering Ag Antigestagen- und antioestrogenwirksame verbindungen zur geburtseinleitung und zum schwangerschaftsabbruch sowie zur behandlung gynaekologischer stoerungen und hormonabhaengiger tumore
DE3734745A1 (de) 1987-10-09 1989-04-20 Schering Ag Tetrahydropyrrolo(2,1-c)(1,2,4)-thiadiazol-3-ylideniminobenzoxazinone und andere heterocyclisch substituierte azole und azine, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider wirkung
JPH02138183A (ja) 1988-11-17 1990-05-28 Nippon Tokushu Noyaku Seizo Kk 除草性ピロール類
FR2643903A1 (fr) 1989-03-03 1990-09-07 Union Pharma Scient Appl Nouveaux derives de benzimidazole, leurs procedes de preparation, intermediaires de synthese, compositions pharmaceutiques les contenant, utiles notamment pour le traitement des maladies cardiovasculaires, et des ulceres duodenaux
DE3932953A1 (de) 1989-10-03 1991-04-11 Boehringer Mannheim Gmbh Neue 2-bicyclo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3935514A1 (de) 1989-10-25 1991-05-02 Boehringer Mannheim Gmbh Neue bicyclo-imidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
KR0164842B1 (ko) 1990-03-24 1999-01-15 손정삼 신규 벤즈옥사진, 벤조티아진 유도체 및 그 제조방법
TW203049B (de) 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
ES2082959T3 (es) 1990-09-28 1996-04-01 I F L O S A S Di Giorgio E Ald Procedimiento para desarrollar la sintesis de una droga contraceptiva y de control del ciclo menstrual que tiene propiedades anticinetosicas, oncostaticas y terapeuticas para el tratamiento de los tumores de mama y melanomas.
EP0510235A1 (de) 1991-04-26 1992-10-28 Dong-A Pharm. Co., Ltd. Benzoxazin- oder Benzothiazinderivate und Verfahren zu deren Herstellung
JP3108483B2 (ja) 1991-09-30 2000-11-13 日清製粉株式会社 インドール誘導体およびこれを有効成分とする抗潰瘍薬
SE9103752D0 (sv) 1991-12-18 1991-12-18 Astra Ab New compounds
GB9201038D0 (en) 1992-01-16 1992-03-11 Glaxo Group Ltd Chemical compounds
US5808139A (en) 1992-04-21 1998-09-15 Ligand Pharmaceuticals Incorporated Non-steroid progesterone receptor agonist and antagonist and compounds and methods
DE4242451A1 (de) 1992-12-16 1994-06-23 Basf Ag Verfahren zur Herstellung von 5-Ringheterocyclen
ZA939516B (en) 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
SE9302080D0 (sv) 1993-06-16 1993-06-16 Ab Astra New compounds
DE4330234A1 (de) 1993-09-02 1995-03-09 Schering Ag Verwendung von Gestagenen und kompetitiven Progesteronantagonisten zur Herstellung von Arzneimitteln für die weibliche Fertilitätskontrolle sowie Mittel enthaltend ein Gestagen und einen kompetitiven Progesteronantagonisten
DE4335876A1 (de) 1993-10-17 1995-04-20 Schering Ag Kombination von Progesteronantagonisten und Antiöstrogenen mit partialer agonistischer Wirkung für die Hormonsubstitutions-Therapie für peri- und postmenopausale Frauen
DE4344463A1 (de) 1993-12-22 1995-06-29 Schering Ag Kombinationsprodukt zur Kontrazeption
AU1694295A (en) 1994-01-28 1995-08-15 Merck & Co., Inc. Benzoxazinones as inhibitors of hiv reverse transcriptase
US5681817A (en) 1994-02-04 1997-10-28 The Medical College Of Hampton Roads Treatment of ovarian estrogen dependent conditions
EP0765324A1 (de) 1994-06-08 1997-04-02 E.I. Du Pont De Nemours And Company Cyclische sulfonamide derivate als herbizide
ATE264106T1 (de) 1994-11-22 2004-04-15 Balance Pharmaceuticals Inc Verfahren zur empfängnisverhütung
US5521166A (en) 1994-12-19 1996-05-28 Ortho Pharmaceitical Corporation Antiprogestin cyclophasic hormonal regimen
DE69531998T2 (de) 1994-12-22 2004-07-22 Ligand Pharmaceuticals, Inc., San Diego Steroidrezeptor-modulator verbindungen und methoden
US5693647A (en) 1994-12-22 1997-12-02 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
ZA9510926B (en) 1994-12-23 1996-07-03 Schering Ag Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
WO1997013767A1 (de) 1995-10-09 1997-04-17 Chemisch Pharmazeutische Forschungsgesellschaft Mbh Heterocyclisch substituierte 1-indolcarboxamide als cyclooxygenase-2 inhibitoren
DE69710896T2 (de) 1996-06-25 2002-09-26 Akzo Nobel N.V., Arnhem Progestogen-anti-progestogen therapien
EP0961616A4 (de) 1996-09-13 2000-11-22 Trustees Of Board Of Nicht-hormonale verhuetungsmethode
US5874430A (en) 1996-10-02 1999-02-23 Dupont Pharmaceuticals Company 4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same
EP0929533B1 (de) 1996-10-02 2003-09-03 Bristol-Myers Squibb Pharma Company 4,4-disubstituierte 1,4-dihydro-2h-3,1-benzoxazin-2-one die anwendbar sind als hiv-reverstranskriptase-inhibitoren, zwischenprodukte und verfahren zu ihrer herstellung
AU727981B2 (en) 1996-12-18 2001-01-04 Meiji Seika Kaisha Ltd. Novel tetrahydrobenzindolone derivatives
WO1998055116A1 (en) 1997-06-05 1998-12-10 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
AR015425A1 (es) 1997-09-05 2001-05-02 Smithkline Beecham Corp Compuestos de benzotiazol, composicion farmaceutica que los contiene, su uso en la manufactura de un medicamento, procedimiento para su preparacion,compuestos intermediarios y procedimiento para su preparacion
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
KR20010041625A (ko) 1998-03-06 2001-05-25 아스트라제네카 악티에볼라그 신규 용도
EP0978279A1 (de) 1998-08-07 2000-02-09 Pfizer Products Inc. Glycogen-phosphorylase inhibitoren
US6462032B1 (en) * 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
US6417214B1 (en) 1999-05-04 2002-07-09 Wyeth 3,3-substituted indoline derivatives
US6329416B1 (en) * 1999-05-04 2001-12-11 American Home Products Corporation Combination regimens using 3,3-substituted indoline derivatives
US6498154B1 (en) 1999-05-04 2002-12-24 Wyeth Cyclic regimens using quinazolinone and benzoxazine derivatives
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6358948B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6380178B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Cyclic regimens using cyclocarbamate and cyclic amide derivatives
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
US6399593B1 (en) 1999-05-04 2002-06-04 Wyeth Cyclic regimens using cyclic urea and cyclic amide derivatives
US6306851B1 (en) * 1999-05-04 2001-10-23 American Home Products Corporation Cyclocarbamate and cyclic amide derivatives
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6369056B1 (en) 1999-05-04 2002-04-09 American Home Products Corporation Cyclic urea and cyclic amide derivatives
US6339098B1 (en) 1999-05-04 2002-01-15 American Home Products Corporation 2,1-benzisothiazoline 2,2-dioxides
US6391907B1 (en) * 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6358947B1 (en) 1999-05-04 2002-03-19 American Home Products Corporation Tetracyclic progesterone receptor modulator compounds and methods
DE60038108T2 (de) * 1999-05-04 2009-02-12 Wyeth Cyclothiocarbamatderivate als progesteron-rezeptormodulatoren
US6407101B1 (en) * 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6319912B1 (en) 1999-05-04 2001-11-20 American Home Products Corporation Cyclic regimens using 2,1-benzisothiazoline 2,2-dioxides
US6423699B1 (en) 1999-05-04 2002-07-23 American Home Products Corporation Combination therapies using benzimidazolones
US6444668B1 (en) 1999-05-04 2002-09-03 Wyeth Combination regimens using progesterone receptor modulators
US6566372B1 (en) * 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
US7119207B2 (en) 2000-04-10 2006-10-10 Pfizer Inc Benzoamide piperidine containing compounds and related compounds
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
DE10036008A1 (de) * 2000-07-25 2002-02-07 Bosch Gmbh Robert Zündkerze für einen Verbrennungsmotor und Verfahren zur Herstellung einer Zündkerze
WO2004000227A2 (en) 2002-06-25 2003-12-31 Wyeth Use of thio-oxindole derivatives in treatment of skin disorders
US7268149B2 (en) 2002-06-25 2007-09-11 Wyeth Cyclothiocarbamate derivatives as progesterone receptor modulators and methods of treating skin disorders
CN1662241A (zh) 2002-06-25 2005-08-31 惠氏公司 环硫代氨基甲酸酯衍生物在治疗与激素有关的病症中的用途
BR0312054A (pt) 2002-06-25 2005-10-18 Wyeth Corp Uso de derivados de tio-oxindol na preparação de medicamentos úteis no tratamento de condições relacionadas com hormÈnio, e kit farmacêutico
US7019141B2 (en) 2002-10-21 2006-03-28 Irm Llc Quinolones with anti-HIV activity
US7205328B2 (en) 2002-10-21 2007-04-17 Irm Llc Oxindoles with anti-HIV activity
GT200500186A (es) * 2004-07-07 2006-03-02 Regimenes anticonceptivos con antagonistas del receptor de progesterona y kits
GT200500185A (es) * 2004-08-09 2006-04-10 Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
GT200500183A (es) * 2004-08-09 2006-04-10 Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos

Also Published As

Publication number Publication date
US20110039839A1 (en) 2011-02-17
US8476262B2 (en) 2013-07-02
US6982261B2 (en) 2006-01-03
CA2372560A1 (en) 2000-11-09
US6562857B2 (en) 2003-05-13
US6407101B1 (en) 2002-06-18
WO2000066581A8 (en) 2002-05-30
US20020068735A1 (en) 2002-06-06
CN1349531A (zh) 2002-05-15
EP1173433A1 (de) 2002-01-23
HK1043990B (zh) 2006-05-04
US7846924B2 (en) 2010-12-07
JP4836331B2 (ja) 2011-12-14
US20050256110A1 (en) 2005-11-17
MXPA01011295A (es) 2003-07-14
EP1173433B1 (de) 2005-12-28
DK1173433T3 (da) 2006-05-15
JP2011236225A (ja) 2011-11-24
SI1173433T1 (sl) 2006-06-30
JP2002543197A (ja) 2002-12-17
CY1105688T1 (el) 2010-12-22
HK1043990A1 (en) 2002-10-04
DE60025189T2 (de) 2006-09-07
DE60025189D1 (de) 2006-02-02
WO2000066581A1 (en) 2000-11-09
AU4980000A (en) 2000-11-17
ES2256008T3 (es) 2006-07-16
US20030158182A1 (en) 2003-08-21
CN1133635C (zh) 2004-01-07
CA2372560C (en) 2009-09-15

Similar Documents

Publication Publication Date Title
ATE314365T1 (de) Cyanopyrrole als progesteronrezeptoragonisten
HUP0301573A2 (hu) Szubsztituált arilpirazinok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
BG107023A (en) 3-aminoquinazolin-2,4-dione antibacterial agents
YU41299A (sh) Atropizomeri 3-aril-4(3h)-hinazolinona i njihova upotreba kao ampa-receptor antagonista
AP2003002720A0 (en) Carboxamide compounds and their use as antagonists of a human 11 CBY receptor.
MY133223A (en) Neuropeptide y5 receptor antagonists
DE69616480D1 (de) Piperidinderivate als neurokininantagonisten
DE60112974D1 (en) Carbolinderivate
EA200300527A1 (ru) Новые способы лечения синдрома "усталых ног"
DE60216233D1 (en) Carbolinderivate
DE60121461D1 (de) Kondensierte pyridoindolderivate
JO2321B1 (en) 4-phenyl-pyridine derivatives
NZ528997A (en) Sulfonamides
PT1153017E (pt) Compostos biciclicos e sua utilizacao como ligandos do receptor de integrina
EP1189900A4 (de) Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffe
TR200000786T2 (tr) Vitronektin reseptör antagonisti
DE60112960D1 (de) Kondensierte pyridoindolderivate
YU1302A (sh) Derivati aminotiazola i njihova primena kao liganada crf receptora
BG105710A (en) 5ht1 antagonists for antidepressant therapy
DE69707141D1 (de) N-benzensulfonyl-l-prolinderivate als bradykininrezeptor b2 antagonisten
MXPA03003971A (es) Derivados de indol como inhibidores de pde5.
DE60121048D1 (de) PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
TWI255813B (en) Compounds for use as alphavbeta3 receptor antagonists
DE60137451D1 (de) N-substituierte Amide als NK1 Rezeptor Antagonisten
TR200001926T2 (tr) Vasküler başağrılarına karşı lokal anesteziklerin yeni kullanımı

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1173433

Country of ref document: EP

REN Ceased due to non-payment of the annual fee